Psychobiological differences between depression and somatization

Journal of Psychosomatic Research

Volumn 68, Issue 5, 2010, Pages 495-502

  Rief, Winfried ^a   Hennings, Anika ^a   Riemer, Sabine ^a   Euteneuer, Frank ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Depression; Genetics; HPA axis; Immunology; Serotonin; Somatization

Indexed keywords

AMINO ACID; FATTY ACID; OMEGA 3 FATTY ACID;

ARTICLE; DEPRESSION; DISEASE CLASSIFICATION; GENETIC POLYMORPHISM; HEREDITY; HERITABILITY; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; ILLNESS BEHAVIOR; IMMUNITY; IMMUNOLOGY; PAIN THRESHOLD; PSYCHOBIOLOGY; SELF CONCEPT; SEROTONINERGIC SYSTEM; SOMATIZATION;

DEPRESSIVE DISORDER; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; ILLNESS BEHAVIOR; PITUITARY-ADRENAL SYSTEM; PSYCHOPHYSIOLOGIC DISORDERS; SEROTONIN; SOMATOFORM DISORDERS;

EID: 77953810187     PISSN: 00223999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychores.2010.02.001     Document Type: Article

References (93)

1. Katon W Depression: relationship to somatization and chronic medical illness. J Clin Psychiatry 1984, 45:4-12.
2. Katon W, Lin E, vonKorff M, Russo J, Lipscomb P, Bush T Somatization: a spectrum of severity. Am J Psychiatry 1991, 148:34-40.
3. Rief W, Schaefer S, Hiller W, Fichter MM Lifetime diagnoses in patients with somatoform disorders: which came first ?. Eur Arch Psychiatry Clin Neurosci 1992, 241:236-240.
4. Vaccarino AL, Sills TL, Evans KR, Kalali AH Multiple pain complaints in patients with major depressive disorder. Psychosom Med 2009, 71:159-162.
5. Mayou R, Sharpe M, Kirmayer LJ, Simon G, Kroenke K Somatoform disorders: time for a new approach in DSM-V. Am J Psychiatry 2005, 162:847-855.
6. Kielholz P Masked depression 1973, Huber, Bern.
7. Klauenberg S, Maier C, Assion H-J, Hoffman A, Krumova EK, Magerl W Depression and changed pain perception: hints for a central disinhibition mechanism. Pain 2008, 140:332-343.
8. Nimnuan C, Rabe-Hesketh S, Wessely S, Hotopf M How many functional somatic syndromes?. J Psychosom Res 2001, 51:549-557.
9. Rief W The specificity of chronic fatigue, neurasthenia, and somatoform disorders. Somatoform Disorders. Series of the World Psychiatric Association (WPA) on "Evidence and Experience in Psychiatry" 2005, 313-316. APA, Washington (DC). M. Maj, H.S. Akishal, J.E. Mezzich, A. Okasha (Eds.).
10. Wessely S, Nimnuan C, Sharpe M Functional somatic syndromes - one or many?. Lancet 1999, 354:936-939.
11. Rief W, Barsky AJ Psychobiological perspectives on somatoform disorders. Psychoneuroendocrinology 2005, 30:996-1002.
12. Lucki I The spectrum of behaviors influenced by serotonin. Biol Psychiatry 1998, 44:151-162.
13. Suzuki R, Rygh LJ, Dickenson AH Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends Pharmacol Sci 2004, 25:613-617.
14. Watkins LR, Maier SF Immune regulation of central nervous system functions: from sickness responses to pathological pain. J Intern Med 2005, 257:139-155.
15. Wichers MC, Kenis G, Koek GH, Robaeys G, Nicolson NA, Maes M Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol. J Psychosom Res 2007, 62:207-214.
16. Maes M Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms. Curr Opin Psychiatry 2009, 22:75-83.
17. Vreeburg SA, Hoogendijk WJG, van Pelt J, DeRijk RH, Verhagen JCM, van Dyck R, et al. Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study. Arch Gen Psychiatry 2009, 66:617-626.
18. Su KP Biological mechanism of antidepressant effect of omega-3 fatty acids: How does fish oil act as a 'mind-body interface'?. Neurosignals 2009, 17:144-152.
19. Canli T, Ferri J, Duman EA Genetics of emotion regulation. Neuroscience 2009, 164:43-54.
20. Guze SB Genetics of Briquet's syndrome and somatization disorder. A review of family, adoption, and twin studies. Ann Clin Psychiatry 1993, 5:225-230.
21. Torgersen S Genetics of somatoform disorders. Arch Gen Psychiatry 1986, 43:502-505.
22. Lembo AJ, Zaman M, Krueger RF, Tomenson BM, Creed FH Psychiatric disorder, irritable bowel syndrome, and extra-intestinal symptoms in a population-based sample of twins. Am J Gastroenterol 2009, 104:686-694.
23. Buskila D, Sarzi-Puttini P Genetic aspects of fibromyalgia syndrome. Arthritis Res Ther 2006, 8:218. 10.1186/ar2005.
24. Rief W, Pilger F, Ihle D, Verkerk R, Scharpe S, Maes M Psychobiological aspects of somatoform disorders: contributions of monoaminergic transmitter systems. Neuropsychobiology 2004, 49:24-29.
25. Bah J, Lindstrom M, Westberg L, Manneras L, Ryding E, Henningsson S Serotonin transporter gene polymorphisms: effect on serotonin transporter availability in the brain of suicide attempters. Psychiatry Res 2008, 162:221-229.
26. Glatt CE, Freimer NB Association analysis of candidate genes for neuropsychiatric disease: the perpetual campaign. Trends Genet 2002, 18:307-312.
27. Hranilovic D, Stefulj J, Schwab S, Borrmann-Hassenbach M, Albus M, Jernej B Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatry 2004, 55:1090-1094.
28. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 301:386-388.
29. Risch N, Herrell R, Lehner T, Liang KY, Eaves L, Hoh J Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 2009, 301:2462-2471.
30. Hennings A, Zill P, Rief W Serotonin transporter gene promoter polymorphism and somatoform symptoms. J Clin Psychiatry 2009, 70:1536-1539.
31. Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Yoon JS Modification by two genes of associations between general somatic health and incident depressive syndrome in older people. Psychosom Med 2009, 71:286-291.
32. Narita M, Nishigami N, Narita N, Yamaguti K, Okado N, Watanabe Y, et al. Association between serotonin transporter gene polymorphism and chronic fatigue syndrome. Biochem Biophys Res Commun 2003, 311:264-266.
33. Ojima K, Watanabe N, Narita N, Narita M Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population. Biopsychosoc Med 2007, 3:1. 10.1186/1751-0759-1-3.
34. Barsky AJ Amplification, somatization, and the somatoform disorders. Psychosomatics 1992, 33:28-34.
35. Nielsen CS, Stubhaug A, Price DD, Vassend O, Czajkowski N, Harris JR Individual differences in pain sensitivity: Genetic and environmental contributions. Pain 2008, 136:21-29.
36. Norbury TA, MacGregor AJ, Urwin J, Spector TD, McMahon SB Heritability of responses to painful stimuli in women: a classical twin study. Brain 2007, 130:3041-3049.
37. Jensen KB, Lonsdorf TB, Schalling M, Kosek E, Ingvar M Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val158met polymorphism. PLoS One 2009, 4:e6016.
38. Coghill RC, McHaffie JG, Yen Y-F Neural correlates of interindividual differences in the subjective experience of pain. PNAS 2003, 100:8538-8542.
39. Kerr JR, Petty R, Burke B, Gough J, Fear D, Sinclair LI, et al. Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis. J Infect Dis 2008, 197:1171-1184.
40. Maletic V, Raison CL Neurobiology of depression, fibromyalgia and neuropathic pain. Front Biosci 2009, 14:5291-5338.
41. Dantzer R Cytokine-induced sickness behavior: where do we stand?. Brain Behav Immun 2001, 15:7-24.
42. Dantzer R Somatization: a psychoneuroimmunological perspective. Psychoneuroendocrinology 2005, 30:947-952.
43. Lekander M, Elofsson S, Neve IM, Hansson LO, Unden AL Self-rated health is related to levels of circulating cytokines. Psychosom Med 2004, 66:559-563.
44. Vollmer-Conna U Acute sickness behaviour: an immune system-to-brain communication?. Psychol Med 2001, 31:761-767.
45. Watkins LR, Maier SF The pain of being sick: implications of immune-to-brain communication for understanding pain. Ann Rev Psychol 2000, 51:29-57.
46. Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, et al. Nociceptors are interleukin-1{beta} sensors. J Neurosci 2008, 28:14062-14073.
47. Dinan TG Inflammatory markers in depression. Curr Opin Psychiatry 2008, 22:32-36.
48. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry 2010, 64:446-457.
49. Elovainio M, Aalto A-M, Kivimaki M, Pirkola S, Sundvall J, Lonnqvist J, et al. Depression and C-reactive protein: Population-Based Health 2000 Study. Psychosom Med 2009, 71:423-430.
50. Howren MB, Lamkin DM, Suls J Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med 2009, 71:171-186.
51. Beratis S, Katrivanou A, Georgiou S, Monastirli A, Pasmatzi E, Gourzis P, et al. Major depression and risk of depressive symptomatology associated with short-term and low-dose interferon-alpha treatment. J Psychosom Res 2005, 58:15-18.
52. Tyring S, Gottlieb A, Papp K, Gordon K, Leonardi C, Wang A, et al. Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial. Lancet 2006, 367:29-35.
53. Stewart JC, Rand KL, Muldoon MF, Kamarck TW A prospective evaluation of the directionality of the depression-inflammation relationship. Brain Behav Immun 2009, 23:936-944.
54. Bilbo SD, Schwarz JM Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci 2009, 3. 10.3389/neuro.08.014.2009.
55. Maier SF, Watkins LR Cytokines for psychologists: implications for bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev 1998, 105:83-107.
56. Bob P, Raboch J, Maes M, Susta M, Pavlat J, Jasova D, et al. Depression, traumatic stress and interleukin-6. J Affect Disord 2010, 120:231-234.
57. Miller GE, Rohleder N, Cole SW Chronic interpersonal stress predicts activation of pro- and anti-inflammatory signaling pathways 6 months later. Psychosom Med 2009, 71:57-62.
58. Schmidt ED, Aguilera G, Binnekade R, Tilders FJH Single administration of interleukin-1 increased corticotropin releasing hormone and corticotropin releasing hormone-receptor mRNA in the hypothalamic paraventricular nucleus which paralleled long-lasting (weeks) sensitization to emotional stressors. Neuroscience 2003, 116:275-283.
59. O'Connor M-F, Irwin MR, Wellisch DK When grief heats up: pro-inflammatory cytokines predict regional brain activation. NeuroImage 2009, 47:891-896.
60. Drevets WC, Savitz J, Trimble M The subgenual anterior cingulate cortex in mood disorders. CNS Spectr 2008, 13:663-681.
61. Koyama T, McHaffie JG, Laurienti PJ, Coghill RC The subjective experience of pain: where expectations become reality. PNAS 2005, 102:12950-12955.
62. Harrison NA, Brydon L, Walker C, Gray MA, Steptoe A, Critchley HD Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol Psychiatry 2009, 66:407-414.
63. Wang X-M, Hamza M, Wu T-X, Dionne RA Upregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation: correlation to clinical pain. Pain 2009, 142:275-283.
64. Edwards RR, Kronfli T, Haythornthwaite JA, Smith MT, McGuire L, Page GG Association of catastrophizing with interleukin-6 responses to acute pain. Pain 2008, 140:135-140.
65. Rief W, Hiller W, Margraf J Cognitive aspects in hypochondriasis and the somatization syndrome. J Abnorm Psychol 1998, 107:587-595.
66. Maes M, Meltzer HY, Scharpe S, Cooreman W, Uyttenbroeck W, Suy E, et al. Psychomotor retardation, anorexia, weight loss, sleep disturbances and loss of energy as psychopathological correlates of hyperhaptoglobinemia during major depression. Psychiatry Res 1993, 47:229-241.
67. Joyce PR, Hawes CR, Mulder RT, Sellman JD, Wilson DA, Boswell DR Elevated levels of acute phase plasma proteins in major depression. Biol Psychiatry 1992, 32:1035-1041.
68. Maes M, Scharpe S, Van Grootel L, Uyttenbroeck W, Cooreman W, Cosyns P, et al. Higher ?1-antitrypsin, haptoglobin, ceruloplasmin and lower retinol binding protein plasma levels during depression: further evidence for the existence of an inflammatory response during that illness. J Affect Disord 1992, 24:183-192.
69. Maes M Evidence for an immune response in major depression: a review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 1995, 19:11-38.
70. Rief W, Pilger F, Ihle D, Bosmans E, Egyed B, Maes M Immunological differences between patients with major depression and somatization syndrome. Psychiatry Res 2001, 105:165-174.
71. Robertson MJ, Schacterle RS, Mackin GA, Wilson SN, Bloomingdale KL, Ritz J, et al. Lymphocyte subset differences in patients with chronic fatigue syndrome, multiple sclerosis and major depression. Clin Exp Immunol 2005, 141:326-332.
72. Tak LM, Bakker SJL, Slaets JPJ, Rosmalen JGM Is high-sensitive C-reactive protein a biomarker for functional somatic symptoms? A population-based study. Brain Behav Immun 2009, 23:1014-1019.
73. Maes M, Mihaylova I, Leunis JC Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression. Neuro Endocrinol Lett 2007, 28:861-867.
74. Lyall M, Peakman M, Wessely S A systematic review and critical evaluation of the immunology of chronic fatigue syndrome. J Psychosom Res 2003, 55:79-90.
75. Anisman H Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder. J Psychiatry Neurosci 2008, 34:4-20.
76. Pukhalsky AL, Shmarina GV, Alioshkin VA, Sabelnikov A HPA axis exhaustion and regulatory T cell accumulation in patients with a functional somatic syndrome: Recent view on the problem of Gulf War veterans. J Neuroimmunol 2008, 196:133-138.
77. Song C, Horrobin DF, Leonard BE The comparison of changes in behavior, neurochemistry, endocrine, and immune functions after different routes, doses and durations of administrations of IL-1 beta in rats. Pharmacopsychiatry 2006, 39:88-99.
78. Raison CL, Capuron L, Miller AH Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006, 27:24-31.
79. Meewisse M-L, Reitsma JB, De Vries G-J, Gersons BPR, Olff M Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis. Br J Psychiatry 2007, 191:387-392.
80. Miller GE, Chen E, Zhou ES If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol Bull 2007, 133:25-45.
81. Naring GWB, van Lankveld W, Geenen R Somatoform dissociation and traumatic experiences in patients with rheumatoid arthritis and fibromyalgia. Clin Exp Rheumatol 2007, 25:872-877.
82. Ji G, Neugebauer V Differential effects of CRF1 and CRF2 receptor antagonists on pain-related sensitization of neurons in the central nucleus of the amygdala. J Neurophysiol 2007, 97:3893-3904.
83. Ji G, Neugebauer V Pro- and anti-nociceptive effects of corticotropin-releasing factor (CRF) in central amygdala neurons are mediated through different receptors. J Neurophysiol 2008, 99:1201-1212.
84. Dinan TG Novel approaches to the treatment of depression by modulating the hypothalamic-pituitary-adrenal axis. Hum Psychopharmacol 2001, 16:89-93.
85. Thomson F, Craighead M Innovative approaches for the treatment of depression: targeting the HPA axis. Neurochem Res 2008, 33:691-707.
86. Ehlert U, Nater UM, Böhmelt AH High and low unstimulated salivary cortisol levels correspond to different symptoms of functional gastrointestinal disorders. J Psychosom Res 2005, 59:7-10.
87. Heim C, Ehlert U, Hellhammer D The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 2000, 25:1-35.
88. Ille R, Spona J, Zickl M, Hofmann P, Lahousen T, Dittrich N "Add-on"-therapy with an individualized preparation consisting of free amino acids for patients with a major depression. Eur Arch Psychiatry Clin Neurosci 2007, 257:222-229.
89. Tiemeier H, van Tuijl HR, Hofman A, Kiliaan AJ, Breteler MMB Plasma fatty acid composition and depression are associated in the elderly: The Rotterdam Study. Am J Clin Nutr 2003, 78:40-46.
90. Frasure-Smith N, Lespérance F, Julien P Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes. Biol Psychiatry 2004, 55:891-896.
91. Young G, Conquer J Omega-3 fatty acids and neuropsychiatric disorders. Reprod Nutr Dev 2005, 45:1-28.
92. Riemer S, Maes M, Christophe A, Rief W Lowered -3 PUFAs are related to major depression, but not to somatization syndrome. J Affect Disord 2009, epub ahead of print.
93. Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett 2009, 30:470-476.