Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice

Journal of Immunology

Volumn 187, Issue 4, 2011, Pages 1591-1600

  Sheng, Huiming ^a   Hassanali, Saleema ^a   Nugent, Courtney ^a   Wen, Li ^b   Hamilton Williams, Emma ^c   Dias, Peter ^a   Dai, Yang D ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CELL DESTRUCTION; CONTROLLED STUDY; CYTOKINE RELEASE; EXOSOME; FEMALE; IMMUNOSTIMULATION; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULINOMA; INSULITIS; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET CELL; PRIORITY JOURNAL; SEX DIFFERENCE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL;

ANIMALS; ANTIGEN-PRESENTING CELLS; CELL LINE, TUMOR; CELL-DERIVED MICROPARTICLES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; EXOSOMES; FEMALE; HUMANS; INSULIN-SECRETING CELLS; INSULINOMA; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED NOD; MICE, SCID; MYELOID DIFFERENTIATION FACTOR 88; SEX CHARACTERISTICS; TH1 CELLS;

EID: 80051953807     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100231     Document Type: Article

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