Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5408-5412

  Bolchi, Cristiano ^a   Pallavicini, Marco ^a   Bernini, Sergio K ^a   Chiodini, Giuseppe ^a   Corsini, Alberto ^a   Ferri, Nicola ^a   Fumagalli, Laura ^a   Straniero, Valentina ^a   Valoti, Ermanno ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Antiproliferative agents; Antitumors; Farnesyltransferase; Peptidomimetic inhibitors; Prenylation inihibitors

Indexed keywords

IMIDAZOLE DERIVATIVE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; PEPTIDOMIMETIC AGENT; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; SIMVASTATIN; THIAZOLE DERIVATIVE;

ANIMAL CELL; AORTA; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; DRUG DESIGN; DRUG PENETRATION; DRUG SYNTHESIS; ENZYME ACTIVITY; NONHUMAN; RAT; SMOOTH MUSCLE FIBER;

ANIMALS; AORTA; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; IMIDAZOLES; MOLECULAR STRUCTURE; MYOCYTES, SMOOTH MUSCLE; PEPTIDOMIMETICS; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

RATTUS;

EID: 80051925890     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.003     Document Type: Article

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