Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6192-6196

  Bolchi, Cristiano ^a   Pallavicini, Marco ^a   Rusconi, Chiara ^a   Diomede, Luisa ^b   Ferri, Nicola ^a   Corsini, Alberto ^a   Fumagalli, Laura ^a   Pedretti, Alessandro ^a   Vistoli, Giulio ^a   Valoti, Ermanno ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Antiproliferative agents; Antitumors; Farnesyltransferase; Peptidomimetic inhibitors

Indexed keywords

AMINE; BENZAMIDE DERIVATIVE; DIOXANE DERIVATIVE; FARNESYL TRANS TRANSFERASE; HYDROXYL GROUP; METHIONINE; METHYL GROUP; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SIMVASTATIN;

AMIDATION; ARTICLE; CELL PROLIFERATION; CHEMICAL REACTION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ETHERIFICATION; FARNESYLATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; SMOOTH MUSCLE FIBER; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

AORTA; CELL PROLIFERATION; CELLS, CULTURED; DIOXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ETHERS; FARNESYLTRANSTRANSFERASE; HUMANS; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; MYOCYTES, SMOOTH MUSCLE; PROTEASE INHIBITORS; STEREOISOMERISM;

EID: 35148896320     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.015     Document Type: Article

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