HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro

Journal of Biological Chemistry

Volumn 282, Issue 11, 2007, Pages 8005-8010

  Grobler, Jay A ^a   Dornadula, Geetha ^a   Rice, Michele R ^a   Simcoe, Amy L ^a   Hazuda, Daria J ^a   Miller, Michael D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ASSAYS; HUMAN IMMUNODEFICIENCY VIRUS; REVERSE TRANSCRIPTASE INHIBITORS;

BIOASSAY; BIOCHEMISTRY; DISEASES; DNA; SYNTHESIS (CHEMICAL); TRANSCRIPTION;

ENZYME INHIBITION;

DNA; PRIMER DNA; PRIMER RNA; RNA; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; 3 [(4,7 DICHLORO 2 BENZOXAZOLYLMETHYL)AMINO] 5 ETHYL 6 METHYL 2(1H) PYRIDONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZOXAZOLE DERIVATIVE; EFAVIRENZ; ENZYME INHIBITOR; LIGAND; OXAZINE DERIVATIVE; PYRIDONE DERIVATIVE;

ARTICLE; DNA SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; PRIORITY JOURNAL; VIRUS REPLICATION; WILD TYPE; ANTIBIOTIC RESISTANCE; BIOLOGICAL MODEL; CHEMISTRY; DOSE RESPONSE; GENETIC TRANSCRIPTION; IC 50; METABOLISM; STATISTICS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; BENZOXAZOLES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, VIRAL; ENZYME INHIBITORS; HIV-1 REVERSE TRANSCRIPTASE; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, GENETIC; OXAZINES; PYRIDONES; REVERSE TRANSCRIPTASE INHIBITORS; STOCHASTIC PROCESSES; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

EID: 34247202070     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M608274200     Document Type: Article

References (20)

1. Telesnitsky, A., and Goff, S. P. (1997) in Retroviruses (Coffin, J. M., Hughes, S. H., and Varmus, H. E., eds) pp. 121-160, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
2. Gilboa, E., Mitra, S. W., Goff, S., and Baltimore, D. (1979) Cell 18, 93-100
3. Goff, S. P. (1990) J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 3, 817-831
4. Ding, J., Das, K., Tantillo, C., Zhang, W., Clark, A. D., Jessen, S., Lu, X., Hsiou, Y., Jacobo-Molina, A., Andries, K., Pauwels, R., Moereels, H., Koymans, L., Janssen, P. A. J., Smith, R. H., Koepke, M. K., Michejda, C. J., Hughes, S. H., and Arnold, E. (1995) Structure (Lond.) 3, 365-379
5. Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., and Steitz, T. A. (1992) Science 256, 1783-1790
6. Spence, R. A., Kati, W. M., Anderson, K. S., and Johnson, K. A. (1995) Science 267, 988-993
7. Esnouf, R., Ren, J. S., Ross, C., Jones, Y., Stammers, D., and Stuart, D. (1995) Nat. Struct. Biol. 2, 303-308
8. Rittinger, K., Divita, G., and Goody, R. S. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 8046-8049
9. Gopalakrishnan, V., and Benkovic, S. (1994) J. Biol. Chem. 269, 4110-4115
10. Palaniappan, C., Fay, P. J., and Bambara, R. A. (1995) J. Biol. Chem. 270, 4861-4869
11. Shaw-Reid, C. A., Feuston, B., Munshi, V., Getty, K., Krueger, J., Hazuda, D. J., Parniak, M. A., Miller, M. D., and Lewis, D. (2005) Biochemistry 44, 1595-1606
12. Quan, Y. D., Rong, L. W., Liang, C., and Wainberg, M. A. (1999) J. Virol. 73, 6700-6707
13. Quan, Y. D., Liang, C., Inouye, P., and Wainberg, M. A. (1998) Nucleic Acids Res. 26, 5692-5698
14. Shaw-Reid, C. A., Munshi, V., Graham, P., Wolfe, A., Witmer, M., Danzeisen, R., Olsen, D. B., Carroll, S. S., Embrey, M., Wai, J. S., Miller, M. D., Cole, J. L., and Hazuda, D. J. (2003) J. Biol. Chem. 278, 2777-2780
15. Gotte, M., Maier, G., Onori, A. M., Cellai, L., Wainberg, M. A., and Heumann, H. (1999) J. Biol. Chem. 274, 11159-11169
16. Carroll, S. S., Olsen, D. B., Bennett, C. D., Gotlib, L., Graham, D. J., Condra, J. H., Stern, A. M., Shafer, J. A., and Kuo, L. C. (1993) J. Biol. Chem. 268, 276-281
17. Sarafianos, S. G., Das, K., Tantillo, C., Clark, A. D., Ding, J., Whitcomb, J. M., Boyer, P. L., Hughes, S. H., and Arnold, E. (2001) EMBO J. 20, 1449-1461
18. Kvaratskhelia, M., Budihas, S. R., and Le Grice, S. F. J. (2002) J. Biol. Chem. 277, 16689-16696
19. Gotte, M., Kameoka, M., McLellan, N., Cellai, L., and Wainberg, M. A. (2001) J. Biol. Chem. 276, 6711-6719
20. Palaniappan, C., Kim, J. K., Wisniewski, M., Fay, P. J., and Bambara, R. A. (1998) J. Biol. Chem. 273, 3808-3816