Isothiocyanate sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the tgf-β/smad signaling pathway

Molecular Nutrition and Food Research

Volumn 54, Issue 10, 2010, Pages 1486-1496

  Kaminski, Bettina M ^a   Loitsch, Stefan M ^a   Ochs, Meike J ^a   Reuter, Kerstin C ^a   Steinhilber, Dieter ^a   Stein, Jurgen ^a,b   Ulrich, Sandra ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Katharina Kasper Hospital   (Germany)

Author keywords

C myc; Colorectal cancer; Ornithine decarboxylase; Sulforaphane; Transforming growth factor signaling

Indexed keywords

ANTINEOPLASTIC AGENT; DNA BINDING PROTEIN; ISOTHIOCYANIC ACID DERIVATIVE; MESSENGER RNA; ORNITHINE DECARBOXYLASE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; SMAD PROTEIN; SMAD3 PROTEIN; SMAD3 PROTEIN, HUMAN; SMAD4 PROTEIN; SMAD4 PROTEIN, HUMAN; SULFORAFAN; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; THIOCYANIC ACID DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ARTICLE; CELL PROLIFERATION; CELL STRAIN CACO 2; COLORECTAL TUMOR; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; SIGNAL TRANSDUCTION;

ANTICARCINOGENIC AGENTS; CACO-2 CELLS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOTHIOCYANATES; ORNITHINE DECARBOXYLASE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD3 PROTEIN; SMAD4 PROTEIN; THIOCYANATES; TRANSFORMING GROWTH FACTOR BETA;

EID: 79952199543     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201000105     Document Type: Article

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