The application of gradient reversed-phase high-performance liquid chromatography to the pKa and log kw determination of polyprotic analytes

Journal of Chromatography A

Volumn 1214, Issue 1-2, 2008, Pages 109-114

  Wiczling, Paweł ^a   Waszczuk Jankowska, Małgorzata ^a   Markuszewski, Michał Jan ^a   Kaliszan, Roman ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Gradient RP HPLC; pH; pKa; Polyprotic analytes

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; PINCH EFFECT;

ANALYTES; DATA SETS; EXPERIMENTAL DATUMS; GRADIENT RP HPLC; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIES; LIPOPHILICITY PARAMETERS; ORGANIC MODIFIERS; PH CHANGES; PKA; POLYPROTIC ANALYTES; RP-HPLC; SPECIAL EMPHASES; THEORETICAL MODELS;

PH EFFECTS;

CHLORPHENIRAMINE; CLOZAPINE; LABETALOL; OPIPRAMOL; ORGANIC COMPOUND; QUINIDINE;

ARTICLE; LIPOPHILICITY; PH; PKA; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THEORETICAL MODEL;

ALGORITHMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; MODELS, THEORETICAL; PROTON-MOTIVE FORCE; SOLVENTS;

EID: 56549101330     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.10.085     Document Type: Article

References (36)

1. Albert A., and Serjeant E.P. The Determination of Ionization Constants: A Laboratory Manual. 3rd ed. (1984), Chapman & Hall, New York
2. Cleveland J.A., Benko M.H., Gluck S.J., and Walbroehl Y.M. J. Chromatogr. A 652 (1993) 301
3. Bellini S., Uhrova M., and Deyl Z. J. Chromatogr. A 772 (1997) 91
4. Horváth C., Melander W., and Molnár I. Anal. Chem. 49 (1977) 142
5. Van de Venne J.L.M., Hendrix J.L.H.M., and Deelder R.S. J. Chromatogr. 167 (1978) 1
6. Barbosa J., Toro I., and Sanz-Nebot V. J Chromatogr. A 823 (1998) 497
7. Beltrán J.L., Sanli N., Fonrodona G., Barrón D., Özkan G., and Barbosa J. Anal. Chim. Acta 484 (2003) 253
8. LoBrutto R., Jones A., Kazakevich Y.V., and McNair H.M. J. Chromatogr. A 913 (2001) 173
9. Wiczling P., Markuszewski M.J., and Kaliszan R. Anal. Chem. 76 (2004) 3069
10. Kaliszan R., Wiczling P., and Markuszewski M.J. J Chromatogr. A 1060 (2004) 165
11. Wiczling P., Markuszewski M.J., Kaliszan M., and Kaliszan R. Anal. Chem. 77 (2005) 449-458
12. Wiczling P., Kawczak P., Nasal A., and Kaliszan R. Anal. Chem. 78 (2006) 239
13. Chiang P.C., Foster K.A., Whittle M.C., Su C.C., and Pretzer D.K. J. Liq. Chrom. Relat. Technol. 29 (2006) 2291
14. Freiling E.C. J. Am. Chem. Soc. 77 (1955) 2067
15. Snyder L.C. Chromatogr. Rev. 7 (1964) 1
16. Nikitas P., and Pappa-Louisi A. Anal. Chem. 77 (2005) 5670
17. Jano I., Hardcastle J.E., Zhao K., and Vermillion-Salsbury R. J. Chromatogr. A 762 (1997) 63
18. Jano I., and Hardcastle J.E. J. Chromatogr. B 717 (1998) 39
19. Hardcastle J.E., He M., Begum B., and Vermillion-Salsbury R. J. Chromatogr. A 691 (1995) 225
20. Nikitas P., and Pappa-Louisi A. J. Chromatogr. A 971 (2002) 47
21. Snyder L.R., and Dolan J.W. Adv. Chromatogr. 38 (1998) 115
22. Snyder L.R., Kirkland J.J., and Glajch J.L. Practical HPLC Method Development. 2nd ed. (1997), Willey-Interscience, New York
23. Schoenmakers P.J., Billiet H.A.H., and De Galan L. J. Chromatogr. 185 (1979) 179
24. Pappa-Louisi A., Nikitas P., Balkatzopoulou P., and Malliakas C. J. Chromatogr. A 1033 (2004) 29
25. Torres-Lapasió J.R., García-Alvarez-Coque M.C., Rosés M., and Bosch E. J. Chromatogr. A 955 (2002) 19
26. Bosch E., Bou P., Allemann H., and Rosés M. Anal. Chem. 68 (1996) 3651
27. Lopes Marques R.M., and Schoenmakers P.J. J. Chromatogr. 592 (1992) 157
28. Berges R., Sanz-Nebot V., and Barbosa J. J. Chromatogr. A 869 (2000) 27
29. Yasuda M. Bull. Chem. Soc. Jpn. 32 (1959) 429
30. Wiczling P., and Kaliszan M. Anal. Chem. 80 (2008) 7855
31. Snyder L.R., Dolan J.W., and Gant J.R. J. Chromatogr. 165 (1979) 3
32. Rosés M. J. Chromatogr. A 1037 (2004) 283
33. IUPAC. Compendium of Analytical Nomenclature. Definitive Rules. 3rd ed. (1997), Blackwell, Oxford
34. P. Howard, W. Meylan (Eds.) Physical/Chemical Property Database (PHYSPROP); Syracuse Research Corp.; Environmental Science Center; North Syracuse, NY, 1999 http://www.syrres.com/esc/physdemo.htm.
35. Avdeef A. Absorption and Drug Development Solubility, Permeability, and Charge State (2003), John Wiley & Sons
36. Dean J.A. Lang's Handbook of Chemistry. 13th ed. (1985), McGraw-Hill Book Company, England