Decursin from Angelica gigas Nakai induces apoptosis in RC-58T/h/SA#4 primary human prostate cancer cells via a mitochondria-related caspase pathway

Food and Chemical Toxicology

Volumn 49, Issue 10, 2011, Pages 2517-2523

  Choi, Sa Ra ^a   Lee, Ju Hye ^a   Kim, Jae Yong ^a   Park, Kyoung Wuk ^a   Jeong, Il Yun ^b   Shim, Ki Hwan ^c   Lee, Mi Kyung ^a   Seo, Kwon Il ^a  

^a Sunchon National University   (South Korea)

^b Korea Atomic Energy Research Institute   (South Korea)

^c Gyeongsang National University   (South Korea)

Author keywords

Angelica gigas Nakai; Apoptosis; Decursin; RC 58T h SA 4 cells

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DECURSIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT MEDICINAL PRODUCT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; UNCLASSIFIED DRUG; BENZOPYRAN DERIVATIVE; BUTYRIC ACID DERIVATIVE; PIBENZIMOL;

ANGELICA; ANGELICA GIGAS; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL PROLIFERATION INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRION; PROSTATE CANCER; PROTEIN CLEAVAGE; PROTEIN SECRETION; UPREGULATION; CELL SURVIVAL; CHEMISTRY; DNA FRAGMENTATION; DRUG EFFECT; ENZYMOLOGY; FLUORESCENCE MICROSCOPY; MALE; METABOLISM; NEOPLASM; PATHOLOGY; PLANT ROOT; PROSTATE TUMOR; TUMOR CELL LINE;

ANGELICA GIGAS;

ANGELICA; APOPTOSIS; BENZOPYRANS; BISBENZIMIDAZOLE; BUTYRIC ACIDS; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMANS; MALE; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; NEOPLASMS, HORMONE-DEPENDENT; PLANT ROOTS; PROSTATIC NEOPLASMS;

EID: 80051865822     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.06.016     Document Type: Article

References (41)

1. Adhami V.M., Aziz H.M., Readgan-Shaw S.R., Nihai M., Mukhtar H., Ahmad N. Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol. Cancer Ther. 2004, 3:933-940.
2. Ahn K.S., Sim W.S., Lee I.K., Seu Y.B., Kim I.H. Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. Planta Med. 1997, 63:360-361.
3. Ahn Q., Jeong S.J., Lee H.J., Kwon H.Y., Han I., Kim H.S., Lee H.J., Lee E.O., Ahn K.S., Jung M.H., Zhu S., Chen C.Y., Kim S.H. Inhibition of cyclooxygenase-2-dependent survivin mediates decursin-induced apoptosis in human KBM-5 myeloid leukemia cells. Cancer Lett. 2010, 298:212-221.
4. Alimirah F., Chen J., Basrawala Z., Xin H., Choubey D. DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation. FEBS Lett. 2006, 580:2294-2300.
5. Budihardjo I., Oliver H., Lutter M., Luo X., Wang X. Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev. Biol. 1999, 15:269-290.
6. Chen T., Zheng W., Wong Y.S., Yang F. Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadizole derivative. Biomed. Pharmacother. 2008, 62:77-84.
7. Dejeana L.M., Martinez-Caballero S., Manon S., Kinnally K.W. Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins. Biochim. Biophys. Acta 2006, 1762:191-201.
8. Green D.R., Reed J.C. Mitochondria and apoptosis. Science (New York, N.Y.) 1998, 281:1309-1312.
9. Gross A., Yin X.M., Wang K., Wei M.C., Jockel J., Milliman C., Erdju-ment-Bromage H., Tempst P., Korsmeyer S.J. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J. Biol. Chem. 1999, 274:1156-1163.
10. Gu Y., Li H., Miki J., Kim K.H., Furusato B., Sesterhen I.A., Chu W.S., McLeod D.G., Srivastava S., Ewing C.M., Isaacs W.B., Rhim J.S. Phenotypic characterization of telomerase-immortalized primary non-malignant and malignant tumor-derived human prostate epithelial cell lines. Exp. Cell Res. 2006, 312:831-834.
11. Hajra K.M., Liu J.R. Apoptosome dysfunction in human cancer. Apoptosis 2004, 9:691-704.
12. Horoszewicz J.S., Leong S.S., Kawinski E., Karr J.P., Rosenthal H., Chu T.M., Mirand E.A., Murphy G.P. LNCaP model of human prostatic carcinoma. Cancer Res. 1983, 43:1809-1818.
13. Hu W., Kavanag J.J. Anticancer therapy targeting the apoptotic pathway. Lancet Oncol. 2003, 4:721-729.
14. Jiang C., Lee H.J., Li G.X., Guo J., Malewicz B., Zhao Y., Lee E.O., Lee H.J., Lee J.H., Kim M.S., Kim S.H., Lu J. Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer. Cancer Res. 2006, 66(1):453-463.
15. Jiang C., Guo J., Wang Z., Xiao B., Lee H.J., Lee E.O., Kim S.H., Lu J. Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells. Breast Cancer Res. 2007, 9:R77.
16. Joo S.S., Park D.S., Shin S.H., Jeon J.H., Kim T.K., Choi Y.J., Lee S.H., Kim J.S., Park S.K., Hwang B.Y., Lee D.I., Kim Y.B. Anti-allergic effects and mechanisms of action of the ethanolic extract of Angelica gigas in dinitrofluorobenzene-induced inflammation models. Environ. Toxicol. Pharmacol. 2010, 30:127-133.
17. Jung M.H., Lee S.H., Ahn E.M., Lee Y.M. Decursin and decursinol angelate inhibit VEGF-induced angiogensis via suppression of the VEGFR-2-signaling pathway. Carcinogenesis 2009, 30:655-661.
18. Kang S.Y., Lee K.Y., Sung S.H., Park M.J., Kim Y.C. Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationship. J. Nat. Prod. 2001, 64:683-685.
19. Kang S.Y., Lee K.Y., Park M.J., Kim Y.C., Markelonis G.J., Oh T.H. Decursin form Angelica gigas mitigates amnesia induced by scopolamine in mice. Neurobiol. Learn Mem. 2003, 79:11-18.
20. Kim D.H., Jung W.Y., Park S.J., Kim J.M., Lee S.J., Kim Y.C., Ryu J.H. Anti-amnesic effect of ESP-102 on Aβ1-42-induced memory impairment in mice. Pharmacol. Biochem. Behav. 2010, 97:239-248.
21. Konoshima M., Chi H.J., Hata K. Coumarins from the root of Angelica gigas Nakai. Chem. Pharm. Bull. 1968, 16:1139-1140.
22. Lee S., Lee Y.S., Jung S.H., Shin K.H., Kim B.K., Kang S.S. Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. Arch. Pharmacol. Res. 2003, 26:727-730.
23. Lee S., Shin D.S., Kim J.S., Oh K.B., Kang S.S. Antibacterial coumarins from Angelica gigas roots. Arch. Pharmacol. Res. 2003, 26:449-452.
24. Lu X.H., Liang H., Zhao Y.Y. Isolation and identification of the ligustilide compounds from the root of Angelica sinensis. Zhongguo Zhong Yao Za Zhi 2003, 28:423-425.
25. Manin M., Baron S., Goossens K., Beaudoin C., Jean C., Veyssiere G., Verhoeven G., Morel L. Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells. Biochem. J. 2002, 366:729-736.
26. Mukhtar H., Ahmad N. Cancer chemoprevention: future holds in multiple agents. Toxicol. Appl. Pharmacol. 1999, 158:207-210.
27. Nesslany F., Simar-Meintieres S., Ficheux H., Marzin D. Aloe-emodin-induced DNA fragmentation in the mouse in vivo comet assay. Mutat. Res. 2009, 678:13-19.
28. Penninger J.M., Kroemer G. Mitochondria, AIF and caspase-rivaling for cell death execution. Nat. Cell Biol. 2003, 5:97-99.
29. Petrylak D.P. The current role of chemotherapy in metastatic hormone-refractory prostate cancer. Urology 2005, 65:3-7.
30. Ravagnan L., Roumier T., Kroemer G. Mitochondria, the killer organelles and their weapons. J. Cell Physiol. 2002, 192:131-137.
31. Rhim J.S. In vitro human cell culture models for the study of prostate cancer. Prostate Cancer Prostatic Dis. 2000, 3:229-235.
32. Son S.H., Kim M.J., Chung W.Y., Son J.A., Kim Y.S., Kim Y.C., Kang S.S., Lee S.K., Park K.K. Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase. Cancer Lett. 2009, 280:86-92.
33. Sprick M.R., Walczak H. The interplay between the Bcl-2 family and death receptor-mediated apoptosis. Biochim. Biophys. Acta 2004, 1664:125-132.
34. Susin S.A., Lorenzo H.K., Zamzami N., Marzo I., Snow B.E., Brothers G.M., Mangion J., Jacotot E., Costantini P., Loeffler M. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999, 397:441-446.
35. Susin S.A., Daugas E., Ravagnan L. Two distinct pathways leading to nuclear apoptosis. J. Exp. Med. 2000, 192:571-579.
36. Wang C., Youle R.J. The role of mitochondria in apoptosis. Annu. Rev. Genet. 2009, 43:95.
37. Waxman D.J., Schwartz P.S. Harnessing apoptosis for improved anticancer gene therapy. Cancer Res. 2003, 63(24):8563-8572.
38. Whiteman M., Chu S.H., Siau J.L., Rose P., Sabapathy K., Schantz J.T., Cheung N.S., Spencer J.P., Armstrong J.S. The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways. Cell Signal. 2007, 19(4):705-714.
39. Yamada H., Kiyohara H., Cyong J.C., Otsuka Y. Studies on polysaccharides from Angelica acutiloba - IV. Characterization of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa. Mol. Immunol. 1985, 22(3):295-304.
40. Yasunaga Y., Nakamura K., Ko D., Srivastava S., Moul J.W., Sesterhenn I.A., McLeod D.G., Rhim J.S. A novel human cancer culture model for the study of prostate cancer. Oncogene 2001, 20:8036-8041.
41. Yim D.S., Singh R.P., Agarwal C.P., Lee S.K., Chi H.J., Agarwa R.J. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res. 2005, 65(3):1035-1044.