Ochratoxin A and β2-microglobulinuria in healthy individuals and in chronic interstitial nephropathy patients in the Centre of Tunisia: A hot spot of Ochratoxin A exposure

Toxicology

Volumn 199, Issue 2-3, 2004, Pages 185-193

  Hassen, Wafa ^a   Abid, Salwa ^a   Achour, Abdellatif ^a,b   Creppy, Edmond ^c   Bacha, Hassen ^a  

^a UNIVERSITY OF MONASTIR   (Tunisia)

^b FATTOUMA BOURGUIBA UNIVERSITY HOSPITAL   (Tunisia)

^c UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

2 Microglobulinuria; Centre of Tunisia; Chronic interstitial nephropathy; Ochratoxin A

Indexed keywords

BETA GLOBULIN; OCHRATOXIN; BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CARCINOGEN;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; INTERSTITIAL NEPHRITIS; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; PRIORITY JOURNAL; BLOOD; CHRONIC DISEASE; ENDEMIC DISEASE; FOOD CONTAMINATION; MIDDLE AGED; TUNISIA; URINE;

ADULT; BETA 2-MICROGLOBULIN; BIOLOGICAL MARKERS; CARCINOGENS; CHRONIC DISEASE; ENDEMIC DISEASES; FEMALE; FOOD CONTAMINATION; HUMANS; MALE; MIDDLE AGED; NEPHRITIS, INTERSTITIAL; OCHRATOXINS; TUNISIA;

EID: 2442453452     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.02.027     Document Type: Article

References (48)

1. Abid S., Hassen W., Achour A., Skhiri H., Maaroufi K., Ellouz F., Creppy E., Bacha H. Ochratoxin A and human chronic nephropathy in Tunisia: is the situation endemic? Hum. Exp. Tox. 22:2003;77-84
2. Achour, A., El May, M., Bacha, H., Hammami, M., Maaroufi, K., Creppy, E.E., 1993. Néphropathies interstitielles chroniques. Approches cliniques et étiologiques: Ochratoxine A. In: Creppy, E.E., Castegnaro, M., Dirheimer, G. (Eds.), Human Ochratoxicosis and its Pathologies, vol. 231. Collection Colloque. John Libbey Eurotext. INSERM, Paris, pp. 227-234.
3. Aleraj B., et al., 1996. Laboratory diagnosis of endemic nephropthy. In: Endemic nephropathy in Croatia. Zagreb Academia Croatia Scientiarum Medicarum, p. 81.
4. Bacha H., Hadidane R., Regnault C., Ellouz F., Dirheimer G. Mycotoxines et Mycotoxicoses en Tunisie. Cah. Méd. Tun. Nut. 49:1986;34-35
5. Bacha H., Hadidane R., Regnault C., Ellouz F., Creppy E.E., Dirheimer G. Monitoring and identification of fungal toxins in food products, animals feed and cereals in Tunisia. J. Sto. Pro. Res. 4:1988;199-206
6. Bacha, H., Maaroufi, K., Achour, A., Hammami, M., Ellouz, F. and Creppy, E.E., 1993. Ochratoxines et Ochratoxicoses Humaines en Tunisie. In: Creppy, E.E., Castegnaro, M., Dirheimer, G. (Eds.), Human Ochratoxicosis and its Pathologies, vol. 231. John Libbey Eurotext, pp. 111-121.
7. Bacha H., Maaroufi K., Ghédira-Chékir L., Abid S., Chérif A., Achour A., Creppy E.E. Mycotoxins and mycotoxicosis in Tunisia: What do we know and what do we need to know? J. Toxicol. Tox. Rev. 18(3-4):1998;254-262
8. Bauer J., Gareis M. Ochratoxin A in the food chain. Z. Vet. B. 34:1987;613-627
9. Cosyns J.P., Jadoul M., Squifflet J.P., De Placon J.P., Fergula D., Van Ypersele De Strihou C. Chinese herbs nephropathy: a clue to Balkan endemic nepropathy. Kidney Int. 45:1994;1680-1688
10. Creppy E.E., Stormer F.C., Röschenthler R., Dirheimer G. Effects of two metabolites of ochrotoxin A (4R)-4-hydroxyochratoxin A and ochratoxin α on immune response in mice. Infect. Immun. 39:1983;1015-1018
11. Creppy E.E., Kane A., Dirheimer G., Lafarge-Frayssinet C., Mousset S., Frayssinet C. Genotoxicity of ochratoxin A in mice: DNA single-strand break evaluation in spleen, liver and Kidney. Toxicol. Lett. 28:1985;29-35
12. Dwivedi P., Burns R.B. Immunosuppressive effects of ochratoxin A in young turkeys. Avian Pathol. 14:1985;213-225
13. FAO/WHO Expert Committee on Food Additives, 2002. Evaluation of certain mycotoxins in food. Fifty-sixth report of the Joint World Health Organ. Tech. Rep. Ser. 906, i-viii, pp. 1-62.
14. Gad, S.C., Neil, C.S., 1982. Statistic for toxicologists. In: Wallace Hayes A. (Ed.), Principales and Methods of Toxicology, student ed. Raven Press, New York, pp. 273-279.
15. Gaon J., Grigs R.C., Vasiljevic M., Alibegovic S. Investigation of chronic nephropathy in Yougoslavia. I. Lead as possible as a etiologic agent. Acta Med. Iugosl. 16:1962;347-353
16. Golinski P. Ochratoxin A in human organism as a result of food and feed contamination. Rocz. AR Poznaniu. 168:1987;1-61
17. Hall P.W., Vasiljevic M. Beta 2-microglobulin excretion as an index of renal tubular disorders with special reference to endemic Balkan nephropathy. J. Lab. Clin. Med. 81(6):1973;897-904
18. Hassen, W., Abid, S., Achour, A., Maaroufi, K., Creppy, E., Bacha, H., 2003. Ochratoxin A and human nephropathy in Tunisia: a ten year survey. Ann. Toxicol. Anal. 14(1).
19. Hennig, A., Fink Gremmels, J., Leistner, L., 1991. Mutagenicity and effects of ochratoxin A on the frequency of sister chromatid exchange after metabolic activation. In: Castegnaro, M., Plestina R., Dirheimer G., Chernozemski I.N., Bartsch H. (Eds.) Dans Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours. Lyon, IARC Sci. Publ. No. 115, pp. 255-260.
20. 2-Microglobulin studies in endemic Balkan nephropathy. Kidney Int. 40(34):1991;38-40
21. Hult K., Gatenbeck S. A spectrophotometric procedure using carboxypeptidase A for the quantitative mesurments of Ochratoxin A. J. Ass. Off. Anal. Chem. 59:1976;128-129
22. Karlsson F.A., Lenkei R. Urinary excretion of albumin and beta2-microglobulin in a population from an area where Balkan nephropathy is endemic. Scand. J. Clin. Lab. Invest. 37(2):1977;169-173
23. Krogh P., Axelsen N.H., Elling F., Hansen N.G., Hald B., Jenson J.H., Larsen A.E., Madsen A., Mortensen H.P., Moler T., Peterson O.K., Burnkov V., Rostguard M., Aulund O. Experimental porcine nephropathy: changes of renal function and structure induced by ochratoxin A-contaminated feed. Acta Pathol. Microbiol. Scand. Sect. A. 246:1974;1-21
24. Krogh P., Hald B., Plestina R., Ceovic S. Balkan (endemic) nephropathy and foodborn ochratoxin A: preliminary results of survey of foodstuffs. Acta Pathol. Microbiol. Scand. Sect. A. 246(Suppl):1977;1-21
25. Krogh, P., 1987. Ochratoxins in food. In: Krogh, P. (Ed.), Mycotoxins in Food. Harcourt Brace Jovanovich, London, pp. 97-121.
26. Krogh P. Role of ochratoxin in disease causation. Food Chem. Toxicol. 30:1992;213-224
27. Kuiper-Goodman T., Scott P.M. Risk assessment of the mycotoxin ochratoxin A. Biomed. Environ. Sci. 2:1989;179-248
28. Maaroufi K., Achour A., Hammami M., El May M., Betbeder A.M., Ellouz F., Creppy E.E., Bacha H. Ochratoxins in human blood and nephropathy in Tunisia. Hum. Exp. Toxicol. 14:1995a;609-615
29. Maaroufi K., Achour A., Betbeder A.M., Hammami M., Ellouz F., Creppy E.E., Bacha H. Foodstuffs and human blood contamination by the mycotoxin ochratoxin A: correlation with chronic interstitial nephropathy in Tunisia. Arch. Toxicol. 69:1995b;552-558
30. Maaroufi K., Zakhama A., Baudrimont I., Achour A., Betbeder A.M., Abid S., Ellouz F., Dhouib S., Creppy E.E., Bacha H. Karyomegaly of tubular cells as early stage marker of the nephrotoxicity induced by Ochratoxin A in rats. Hum. Exp. Toxicol. 18:1999;410-415
31. Maksimovic Z.J. Selenium deficiency and Balkan nephropathy. Kidney Int. 40(3):1991;S12-S14
32. Malir F., Jergeova Z., Severa J., Cerna M., Smid J., Betbeder A.M., Baudrimont I., Creppy E.E. The level of ochratoxin A in blood serum of adults in the Czeh Republic. Rev. Med. Vet. 149:1998;710
33. Mayura K., Parker R., Berndt W.O., Philips T.D. Ochratoxin A induced teratogenesis in rats: partial protection by phenylalanine. Appl. Env. Micro. 48:1984;1186-1188
34. Obrecht-Pflumio S., Chassat T., Dirheimer G., Marzin D. Genotoxicity of ochratoxin A by Salmonelle mutagenicity test after bioactivation by mouse kidney microsomes. Gen. Tox. Environ. Mut. 446:1999;95-102
35. Peraica M., Domijan A.M., Fuchs R., Lucic A., Radic B. The occurrence of ochratoxin A in blood in general population of Croatia. Tox. Lett. 110:1999;105-112
36. Petkova-Bocharova, T., Castegnaro, M., 1991. Ochratoxin A in human blood in relation to balkan endemic nephropathy and urinary tract tumours in Bulgaria, in: Castegnaro, M., Plestina, R., Dirheimer, G., Chernozemsky, I.V., Bartsch, H. (Eds.), Mycotoxin, Endemic Nephropathy and Urinary Tract Tumours. IARC Sci. Publ. No. 115, International Agency for research on Cancer, Lyon, pp. 135-137.
37. Pfohl-Leskowicz A., Grosse Y., Kane A., Creppy E.E., Dirheimer G. Differentiel DNA-adducts formation and disapperance in three mice tissus after treatement by the mycotoxin ochratoxin A. Mutat. Res. 289:1993;265-273
38. Pfohl-Leskowicz A., Petkova-Bocharova T., Chernozemsky I.N., Castegnaro M. Balkan endemic nephropathy and associated urinary tract tumors: a review on aetiological causes and the potentiel role of mycotoxins. Food Addit. Contam. 19(3):2002;282-302
39. Piscator M., Kostial K., Plestina R. Urinary excretion of cadmium and zinc among woman with endemic nephropathy. Trace. Elem. Med. 1:1984;1134-1138
40. Petrinska-Veskovska, S., 1960. In: Medizina I Fizkultura. Sofia, pp. 72-90.
41. Plestina R. Some features of Balkan endemic nephropathy. Food Chem. Toxicol. 30:1992;177-181
42. 2-Microglobulin in Balkan endemic nephropathy. Pathol. Biol. 26:1978;317-320
43. Sostaric, B., Vukelic, M., 1991. Characteristics of Urinary Tract Tumors in the Area of Balkan Endemic Nephropayhy in Croatia. IARC Sci. Publ. No. 115, pp. 29-35.
44. Stoev S.D., Daskalov H., Radic B., Domijan A.M., Peraica M. Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarifiecl mycotoxin aetiology. Vet. Res. 33(1):2002;83-93
45. Tatu C.A., Orem W.H., Finkelman R.B., Feder G.L. The etiology of Balkan endemic nephropathy: still more questions than answers. Env. Health. Perspect. 106:1998;689-700
46. Van der Merwe K.J., Steyn P.S., Fourie L., Scott D.B., Theron J.J. Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh. Nature. 205:1965;1112-1113
47. Vladisav S. Balkan endemic nephropathy. A Reaprrisal after forty years. Med. Biol. 6(1):1999;53-58
48. Vukelic M., Sostaric B., Belicza M. Pathomorphology of Balkan endemic nephropathy. Food Chem. Toxicol. 30:1992;193-200