Association of PPARGC1A and CAPNS1 gene polymorphisms and expression with meat quality traits in pigs

Meat Science

Volumn 89, Issue 4, 2011, Pages 478-485

  Gandolfi, G ^a,b   Cinar, M U ^a   Ponsuksili, S ^c   Wimmers, K ^c   Tesfaye, D ^a   Looft, C ^a   Jungst H ^a   Tholen, E ^a   Phatsara, C ^a,d   Schellander, K ^a   Davoli, R ^b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^d CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

CAPNS1; DNA polymorphisms; Gene expression; Meat quality; Pigs; PPARGC1A

Indexed keywords

CAPNS1; DNA POLYMORPHISMS; MEAT QUALITY; PIGS; PPARGC1A;

ALKYLATION; CYTOLOGY; MAMMALS; MEATS; METHYLATION; NUCLEIC ACIDS;

GENE EXPRESSION;

PIERIS BRASSICAE; SUIDAE; SUS;

CALPAIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA COACTIVATOR-1; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; CHEMISTRY; COOKING; CPG ISLAND; DNA METHYLATION; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC MARKER; GENETICS; GENOTYPE; MEAT; METABOLISM; PH; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; SKELETAL MUSCLE; SWINE;

ANIMALS; CALPAIN; COOKING; CPG ISLANDS; DNA METHYLATION; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; HYDROGEN-ION CONCENTRATION; MEAT; MUSCLE, SKELETAL; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; SWINE; TRANSCRIPTION FACTORS;

EID: 80051855377     PISSN: 03091740     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.meatsci.2011.05.015     Document Type: Article

References (44)

1. Asangani I.A., Rasheed S.A., Leupold J.H., Post S., Allgayer H. NRF-1, and AP-1 regulate the promoter of the human calpain small subunit 1 (CAPNS1) gene. Gene 2008, 410:197-206.
2. Bee G., Anderson A.L., Lonergan S.M., Huff-Lonergan E. Rate and extent of pH decline affect proteolysis of cytoskeletal proteins and water-holding capacity in pork. Meat Science 2007, 76:359-365.
3. Bird A.P. CpG-rich islands and the function of DNA methylation. Nature 1986, 321:209-213.
4. Chung, H. Y., & Davis, M. E. (in press). Effects of calpain genotypes on meat tenderness and carcass traits of Angus bulls. Molecular Biology Report. doi:10.1007/s11033-010-0589-x.
5. Ciobanu D.C., Bastiaansen J.W., Lonergan S.M., Thomsen H., Dekkers J.C., Plastow G.S., et al. New alleles in calpastatin gene are associated with meat quality traits in pigs. Journal of Animal Science 2004, 82:2829-2839.
6. Costello S., O'Doherty E., Troy D.J., Ernst C.W., Kim K.S., Stapleton P., et al. Association of polymorphisms in the calpain I, calpain II and growth hormone genes with tenderness in bovine M. longissimus. Meat Science 2007, 75:551-557.
7. Curi R.A., Chardulo L.A., Giusti J., Silveira A.C., Martins C.L., de Oliveira H.N. Assessment of GH1, CAPN1 and CAST polymorphisms as markers of carcass and meat traits in Bos indicus and Bos taurus-Bos indicus cross beef cattle. Meat Science 2010, 86:915-920.
8. Daitoku H., Yamagata K., Matsuzaki H., Hatta M., Fukamizu A. Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes 2003, 52:642-649.
9. Davoli R., Gandolfi G., Braglia S., Comella M., Zambonelli P., Buttazzoni L., et al. New SNP of the porcine perilipin 2 (PLIN2) gene, association with carcass traits and expression analysis in skeletal muscle. Molecular Biology Report 2011, 38:1575-1583.
10. de Koning D.J., Harlizius B., Rattink A.P., Groenen M.A., Brascamp E.W., van Arendonk J.A. Detection and characterization of quantitative trait loci for meat quality traits in pigs. Journal of Animal Science 2001, 79:2812-2819.
11. Drögemüller C., Leeb T. Molecular characterization of the porcine gene CAPNS1 encoding the small subunit 1 of calpain on SSC6q1.1->q1.2. Cytogenetic and Genome Research 2002, 98:206-209.
12. Erkens T., Bilek K., Van Zeveren A., Peelman L.J. Two new splice variants in porcine PPARGC1A. BMC Research Notes 2008, 1:138.
13. Erkens T., De Smet S., Van den Maagdenberg K., Stinckens A., Buys N., Van Zeveren A., et al. Association analysis of PPARGC1A mutations with meat quality parameters in a commercial hybrid pig population. Czech Journal of Animal Science 2010, 55:200-208.
14. Erkens T., Rohrer G.A., Van Zeveren A., Peelman L.J. SNP detection in the porcine PPARGC1A promoter region and 3 UTR, and an association analysis in a Landrace-Duroc-Yorkshire population. Czech Journal of Animal Science 2009, 54:408-416.
15. Erkens T., Vandesompele J., Van Zeveren A., Peelman L.J. Correlation between porcine PPARGC1A mRNA expression and its downstream target genes in backfat and longissimus dorsi muscle. Journal of Applied Genetics 2009, 50:361-369.
16. Fischer K. Drip loss in pork: Influencing factors and relation to further meat quality traits. Journal of Animal Breeding and Genetics 2007, 124:12-18.
17. Gandolfi G., Pomponio L., Ertbjerg P., Karlsson A.H., Nanni Costa L., Lametsch R., et al. Investigation on CAST, CAPN1 and CAPN3 porcine gene polymorphisms and expression in relation to post-mortem calpain activity in muscle and meat quality. Meat Science 2011, 88:694-700.
18. Goll D.E., Thompson V.F., Li H., Wei W., Cong J. The calpain system. Physiological Reviews 2003, 83:731-801.
19. Goll D.E., Thompson V.F., Taylor R.G., Christiansen J.A. Role of the calpain system in muscle growth. Biochimie 1992, 74:225-237.
20. Grau R., Hamm R. On the water holding capacity of mammal muscles. II. On the determination of the water holding of muscles. Zeitschrift für Lebensmittel-Untersuchung und-Forschung 1957, 105:446-460.
21. Handschin C., Spiegelman B.M. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocrine Reviews 2006, 27:728-735.
22. Hofmann K., Hamm R., Bluchel E. New information on the determination of water binding in meat by the filter paper press method. Fleischwirtschaft 1982, 62:87-94.
23. Huff-Lonergan E., Lonergan S.M. New frontiers in understanding drip loss in pork: Recent insights on the role of postmortem muscle biochemistry. Journal of Animal Breeding and Genetics 2007, 124:19-26.
24. Jacobs K., Rohrer G., van Poucke M., Piumi F., Yerle M., Barthenschlager H., et al. Porcine PPARGC1A (peroxisome proliferative activated receptor gamma coactivator 1A): Coding sequence, genomic organization, polymorphisms and mapping. Cytogenetic and Genome Research 2006, 112:106-113.
25. Kayan A., Uddin M.J., Cinar M.U., Große-Brinkhaus C., Phatsara C., Wimmers K., et al. Investigation on interferon alpha-inducible protein 6 (IFI6) gene as a candidate for meat and carcass quality in pig. Meat Science 2011, 88:755-760.
26. Khatib H., Zaitoun I., Wiebelhaus-Finger J., Chang Y.M., Rosa G.J.M. The association of bovine PPARGC1A and OPN genes with milk composition in two independent Holstein cattle populations. Journal of Dairy Science 2007, 90:2966-2970.
27. Kim J.M., Lee K.T., Lim K.S., Park E.W., Lee Y.S., Hong K.C. Effects of p.C430S polymorphism in the PPARGC1A gene on muscle fibre type composition and meat quality in Yorkshire pigs. Animal Genetics 2010, 41:642-645.
28. Kunej T., Wu X.L., Berlic T.M., Michal J.J., Jiang Z., Dovc P. Frequency distribution of a Cys430Ser polymorphism in peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) gene sequence in Chinese and Western pig breeds. Journal of Animal Breeding and Genetics 2005, 122:7-11.
29. Lawson M.A. The role of integrin degradation in post-mortem drip loss in pork. Meat Science 2004, 68:559-566.
30. Lin J., Wu H., Tarr P.T., Zhang C.Y., Wu Z., Boss O., et al. Transcriptional co-activator PGC-1 α drives the formation of slow-twitch muscle fibres. Nature 2002, 418:797-801.
31. Liu G., Jennen D.G.J., Tholen E., Juengst H., Kleinwachter T., Holker M., et al. A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population. Animal Genetics 2007, 38:241-252.
32. Melody J.L., Lonergan S.M., Rowe L.J., Huiatt T.W., Mayes M.S., Huff-Lonergan E. Early postmortem biochemical factors influence tenderness and water-holding capacity of three porcine muscles. Journal of Animal Science 2004, 82:1195-1205.
33. Ponsuksili S., Jonas E., Murani E., Phatsara C., Srikanchai T., Walz C., et al. Trait correlated expression combined with expression QTL analysis reveals biological pathways and candidate genes affecting water holding capacity of muscle. BMC Genomics 2008, 9:367.
34. Ponsuksili S., Murani E., Phatsara C., Jonas E., Walz C., Schwerin M., et al. Expression profiling of muscle reveals transcripts differentially expressed in muscle that affect water-holding capacity of pork. Journal of Agricultural and Food Chemistry 2008, 56:10311-10317.
35. Puigserver P., Spiegelman B.M. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocrine Reviews 2003, 24:78-90.
36. Rai A.J., Kamath R.M., Gerald W., Fleisher M. Analytical validation of the GeXP analyzer and design of a workflow for cancer-biomarker discovery using multiplexed gene-expression profiling. Analytical and Bioanalytical Chemistry 2009, 393:1505-1511.
37. Rohrer G.A., Thallman R.M., Shackelford S., Wheeler T., Koohmaraie M. A genome scan for loci affecting pork quality in a Duroc-Landrace F2 population. Animal Genetics 2006, 37:17-27.
38. Rozen S., Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods in Molecular Biology 2000, 132:365-386.
39. Soria L.A., Corva P.M., Branda Sica A., Villarreal E.L., Melucci L.M., Mezzadra C.A., et al. Association of a novel polymorphism in the bovine PPARGC1A gene with growth, slaughter and meat quality traits in Brangus steers. Molecular and Cellular Probes 2009, 23:304-308.
40. Stachowiak M., Szydlowski M., Cieslak J., Switonski M. SNPs in the porcine PPARGC1a gene: interbreed differences and their phenotypic effects. Cellular & Molecular Biology Letters 2007, 12:231-239.
41. Sultan K.R., Dittrich B.T., Pette D. Calpain activity in fast, slow, transforming, and regenerating skeletal muscles of rat. American Journal of Physiology - Cell Physiology 2000, 279:C639-C647.
42. Warner R.D., Greenwood P.L., Pethick D.W., Ferguson D.M. Genetic and environmental effects on meat quality. Meat Science 2010, 86:171-183.
43. Weikard R., Kuhn C., Goldammer T., Freyer G., Schwerin M. The bovine PPARGC1A gene: molecular characterization and association of an SNP with variation of milk fat synthesis. Physiological Genomics 2005, 21:1-13.
44. ZDS Zentral Verband der Deutschen Schweineprodukion e.V. Richtlinie fuer dieStationspruefung auf Mastleistung, Schlachtkoerperwert und Fleischbeschaffenheit beim Schwein. Ausschuss fuer Leistungsprüfung und Zuchtwertschaetzung, Bonn, Germany 2004.