The association of bovine PPARGC1A and OPN genes with milk composition in two independent Holstein cattle populations

Journal of Dairy Science

Volumn 90, Issue 6, 2007, Pages 2966-2970

  Khatib, H ^a   Zaitoun, I ^a   Wiebelhaus Finger, J ^a   Chang, Y M ^b   Rosa, G J M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Candidate gene; OPN; PPARGC1A; Single nucleotide polymorphism

Indexed keywords

BOS; BOVINAE;

LIPID; MILK PROTEIN; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL; ARTICLE; CATTLE; CHEMISTRY; FEMALE; GENETIC VARIABILITY; GENETICS; LACTATION; MILK; PHYSIOLOGY; QUANTITATIVE TRAIT LOCUS; SECRETION;

ANIMALS; CATTLE; FEMALE; LACTATION; LIPIDS; MILK; MILK PROTEINS; OSTEOPONTIN; PPAR GAMMA; QUANTITATIVE TRAIT LOCI; VARIATION (GENETICS);

EID: 34547693521     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2006-812     Document Type: Article

References (17)

1. Cohen, M., E. Seroussi, M. R. Band, H. A. Lewin, J. K. Drackley, D. M. Larkin, A. Everts-van der Wind, J. Heon-Lee, J. J. Loor, M. Shani, J. I. Weller, and M. Ron. 2004. SPP1 is a candidate gene for the QTL affecting milk protein concentration on BTA6 in Israeli Holstein. 29th Int. Soc. Anim. Genetics, Tokyo, Japan.
2. Cohen-Zinder, M., E. Seroussi, D. M. Larkin, J. J. Loor, A. Everts-van der Wind, J. H. Lee, J. K. Drackley, M. R. Band, A. G. Hernandez, M. Shani, H. A. Lewin, J. I. Weller, and M. Ron. 2005. Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle. Genome Res. 15:936-944.
3. Dekkers, J. C. M., and F. Hospital. 2002. The use of molecular genetics in the improvement of agricultural populations. Nat. Rev. Genet. 3:22-32.
4. de Koning, D. J. 2006. Conflicting candidates for cattle QTLs. Trends Genet. 22:301-305.
5. Gonda, M. G., Y. M. Chang, G. E. Shook, M. T. Collins, and B. W. Kirkpatrick. 2006. Genetic variation of Mycobacterium avium ssp. paratuberculosis infection in US Holsteins. J. Dairy Sci. 89:1804-1812.
6. Khatib, H., E. Heifetz, and J. C. Dekkers. 2005. Association of the protease inhibitor gene with production traits in Holstein dairy cattle. J. Dairy Sci. 88:1208-1213.
7. Khatkar, M. S., P. C. Thomson, I. Tammen, and H. W. Raadsma. 2004. Quantitative trait loci mapping in dairy cattle: Review and meta-analysis. Genet. Sel. Evol. 36:163-190.
8. Leonard, S., H. Khatib, V. Schutzkus, Y. M. Chang, and C. Maltecca. 2005. Effects of the osteopontin gene variants on milk production traits in dairy cattle. J. Dairy Sci. 88:4083-4086.
9. Nemir, M., D. Bhattacharyya, X. Li, K. Singh, A. B. Mukherjee, and B. B. Mukherjee. 2000. Targeted inhibition of osteopontin expression in the mammary gland causes abnormal morphogenesis and lactation deficiency. J. Biol. Chem. 275:969-976.
10. Olsen, H. G., S. Lien, M. Gautier, H. Nilsen, A. Roseth, P. R. Berg, K. K. Sundsaasen, M. Svendsen, and T. H. Meuwissen. 2005. Mapping of a milk production quantitative trait locus to a 420-kb region on bovine chromosome 6. Genetics 169:275-283.
11. Pollak, E. J. 2005. Application and impact of new genetic technologies on beef cattle breeding: a 'real world' perspective. Aust. J. Exp. Agric. 45:739-748.
12. Ron, M., D. Kliger, E. Feldmesser, E. Seroussi, E. Ezra, and J. I. Weller. 2001. Multiple quantitative trait locus analysis of bovine chromosome 6 in the Israeli Holstein population by a daughter design. Genetics 159:727-735.
13. Rothschild, M., and M. Soller. 1997. Candidate gene analysis to detect genes controlling traits of economic importance in domestic live-stock. Probe 8:13-20.
14. SAS Institute. 1999. SAS OnlineDoc, Version 8. SAS Institute Inc., Cary, NC.
15. Schnabel, R. D., J. J. Kim, M. S. Ashwell, T. S. Sonstegard, C. P. Van Tassell, E. E. Connor, and J. F. Taylor. 2005. Fine-mapping milk production quantitative trait loci on BTA6: Analysis of the bovine osteopontin gene. Proc. Natl. Acad. Sci. USA 102:6896-6901.
16. Soller, M. 1994. Marker assisted selection - An overview. Anim. Biotechnol. 3:193-201.
17. Weikard, R., C. Kuhn, T. Goldammer, G. Freyer, and M. Schwerin. 2005. The bovine PPARGC1A gene: Molecular characterization and association of an SNP with variation of milk fat synthesis. Physiol. Genomics 21:1-13.