Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model

Clinical Pharmacology and Therapeutics

Volumn 65, Issue 3, 1999, Pages 336-347

  Ehrich, Elliot W ^a   Dallob, Aimee ^b   De Lepeleire, Inge ^b   Van Hecken, Anne ^b   Riendeau, Denis ^b   Yuan, Weiying ^b   Porras, Arturo ^b   Wittreich, Johanna ^b   Seibold, James R ^b   De Schepper, Paul ^b   Mehlisch, Donald R ^b   Gertz, Barry J ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CYCLOOXYGENASE 2 INHIBITOR; IBUPROFEN; INDOMETACIN; LIPOPOLYSACCHARIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; ROFECOXIB; THROMBOXANE B2; UNCLASSIFIED DRUG;

ADULT; ANALGESIA; ANALGESIC ACTIVITY; ANIMAL CELL; ARTICLE; CHO CELL; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DENTAL SURGERY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SELECTIVITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TOOTH PAIN;

EID: 0033064312     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(99)70113-X     Document Type: Article

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