Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats

Inflammation Research

Volumn 46, Issue 11, 1997, Pages 461-466

  Matsushita, M ^a   Masaki, M ^a   Yagi, Y ^a   Tanaka, T ^a   Wakitani, K ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

Anti inflammatory agent; Gastric ulcer; Indomethacin; JTE 522; Prostaglandin H synthase 2

Indexed keywords

INDOMETACIN; PROSTAGLANDIN SYNTHASE INHIBITOR; TILMACOXIB; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ANTIPYRETIC ACTIVITY; ARTICLE; DRUG THERAPY; FEVER; HYPERALGESIA; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PAW EDEMA; PLACENTA; RAT; SEMINAL VESICLE; SHEEP;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; BENZENESULFONATES; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; HYPERALGESIA; INDOMETHACIN; ISOENZYMES; MALE; MEMBRANE PROTEINS; OXAZOLES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

EID: 0030725896     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050225     Document Type: Article

References (29)

1. Needleman P, Turk J, Jakschik BA, Morrison AR, Lefkouwith JB. Arachidonic acid metabolism. Ann Rev Biochem 1986;55:69-102.
2. Davies P, Bailey PJ, Goldenberg MM, Ford-Hutchinson AW. The role of arachidonic acid oxygenation products in pain and inflammation. Ann Rev Immunol 1984;2:335-57.
3. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 1971;231:232-4.
4. Xei W, Chipman JG, Robertson DL, Erikson RL, Simmons DL. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by RNA splicing. Proc Natl Acad Sci USA 1991;88:2692-6.
5. DeWitt DL, Smith WL. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc Natl Acad Sci USA 1988;85:1412-6.
6. DeWitt DL, El-Harith EA, Kraemer SA, Andrews MJ, Yao EF, Armstrong RL, et al. The aspirin and home-binding sites of ovine and murine prostaglandin endoperoxide synthase. J Biol Chem 1990;265:5192-8.
7. Yokoyama C, Tanabe T, Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem Biophys Res Commun 1989;165:888-94.
8. Xie W, Robertson DL, Simmons DL. Mitogen-inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs. Drug Devel Res 1992;25:249-65.
9. Smith WL, Marnett LJ. Prostaglandin endoperoxide synthases. Metal Ions Biol Syst 1994;30:163-99.
10. Kennedy BP, Chan CC, Culp SA, Cromlish WA. Cloning and expression of rat prostaglandin endoperoxide synthase (cyclooxygenase)-2 cDNA. Biochem Biophys Res Commun 1993;197:494-500.
11. Masferrer JL, Zweifel BS, Manning PT, Hauser SD, Leahy KM, Smith WG, et al. Selective inhibition of inducible cyclooxygenase-2 in vivo is anti-inflammatory and nonulcerogenic. Proc Natl Acad Sci USA 1994;91:3228-32.
12. Harada Y, Hatanaka K, Saito M, Majima M, Ogino M, Kawamura M, et al. Detection of inducible prostaglandin H synthase-2 in cells in the exudate of rat carrageenin-induced pleurisy. Biomed Res 1994;15:127-30.
13. Zimmerman M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983;16:109-10.
14. Takahashi Y, Reddy GR, Ueda N, Yamamoto S, Area S. Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells. J Biol Chem 1993;268:16443-8.
15. Randall LO, Selitto JJ. A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn Ther 1957;111:409-19.
16. Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 1962;111:544-7.
17. Winder CV, Lembke LA, Stephens MD. Comparative bioassay of drugs in adjuvant-induced arthritis in rats. Arthritis Rheum 1969;12:472-82.
18. Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 1994;47:55-9.
19. Seibert K, Zhang Y, Leahy K, Hauser S, Masferrer J, Perkins W, et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci USA 1994;91:12013-7.
20. Gans KR, Galbraith W, Roman RJ, Haber SB, Kerr JS, Schmidt WK, et al. Anti-inflammatory and safety profile of DuP697, a novel orally effective prostaglandin synthesis inhibitor. J Pharmacol Exp Ther 1990;254:180-7.
21. Malmberg AB, Yaksh TL. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J Pharmacol Exp Ther 1992;263:136-46.
22. Beiche F, Scheuerer S, Brune K, Geisslinger G, Goppelt-Struebe M. Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation. FEBS Lett 1996;390:165-9.
23. 2 and amino acids evoked by paw formalin injection: a mycrodialysis study in unanesthetized rats. J Neurosci 1995;15:2768-76.
24. Dinchuk JE, Car BD, Focht RJ, Johnston JJ, Jaffee BD, Covinbton MB, et al. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 1995;378:406-9.
25. Futaki N, Yoshikawa K, Hamasaka Y, Arai I, Higuchi S, lizuka H, et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent antinociceptive and antipyretic effects, which causes minimal stomach lesions. Gen Pharmac 1993;24:105-10.
26. Damas J, Remacle-Volon G. Mast cell amines and the oedema induced by zymosan and carrageenans in rats. Eur J Pharmacol 1986;121:367-76.
27. Calhoun W, Chang J, Carlson RP. Effect of selected anti-inflammatory agents and other drugs on zymosan, arachidonic acid. PAF and carrageenan-induced paw edema in the mouse. Agents Actions 1987;21:306-9.
28. Langenbach RL, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, et al. Prostaglandin synthase I gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 1995;83:483-92.
29. Mizuno H, Sakamoto C, Matsuda K, Wada K, Uchida T, Noguchi H, et al. Induction of cyclooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice, Gastroenterology 1997;112:387-97.