메뉴 건너뛰기




Volumn 7, Issue 2, 2011, Pages 136-144

Molecular prognostic and predictive markers in colorectal cancer: Current status

Author keywords

Biomarkers; Chemotherapy; Colorectal cancer; Markers; Predictive; Prognostic; Targeted therapies

Indexed keywords

ACETYLSALICYLIC ACID; ANTINEOPLASTIC AGENT; APC PROTEIN; B RAF KINASE; BEVACIZUMAB; CELECOXIB; CETUXIMAB; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; FATTY ACID SYNTHASE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PHARMACOLOGICAL BIOMARKER; PROTEIN P53; THYMIDYLATE SYNTHASE; VASCULOTROPIN;

EID: 80051794463     PISSN: 15563790     EISSN: 15563804     Source Type: Journal    
DOI: 10.1007/s11888-011-0091-4     Document Type: Review
Times cited : (18)

References (51)
  • 2
    • 6944230093 scopus 로고    scopus 로고
    • Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging
    • DOI 10.1093/jnci/djh275
    • O'Connell JB, Maggard MA, Ko CY. Colon cancer survival rates with the new American joint committee on cancer sixth edition staging. J Natl Cancer Inst. 2004;96:1420-5. (Pubitemid 39429665)
    • (2004) Journal of the National Cancer Institute , vol.96 , Issue.19 , pp. 1420-1425
    • O'Connell, J.B.1    Maggard, M.A.2    Ko, C.Y.3
  • 3
    • 67650315187 scopus 로고    scopus 로고
    • Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSCIA trial
    • Andre T, Boni C, Navarro M, et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSCIA trial. J Clin Oncol. 2009;27:3109-16.
    • (2009) J Clin Oncol , vol.27 , pp. 3109-3116
    • Andre, T.1    Boni, C.2    Navarro, M.3
  • 4
    • 33749852995 scopus 로고    scopus 로고
    • Therapy for metastatic colorectal cancer
    • DOI 10.1634/theoncologist.11-9-981
    • Goldberg RM. Therapy for metastatic colorectal cancer. Oncologist. 2006;11:981-7. (Pubitemid 44564805)
    • (2006) Oncologist , vol.11 , Issue.9 , pp. 981-987
    • Goldberg, R.M.1
  • 6
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008; 359:1757-1765.
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 8
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med. 1988;319:525-32.
    • (1988) N Engl J Med , vol.319 , pp. 525-532
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 9
    • 53049087109 scopus 로고    scopus 로고
    • Genomic and epigenetic instability in colorectal cancer pathogenesis
    • Grady WM, Carethers JM. Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology 2008; 135:1079-1099.
    • (2008) Gastroenterology , vol.135 , pp. 1079-1099
    • Grady, W.M.1    Carethers, J.M.2
  • 11
    • 14544300998 scopus 로고    scopus 로고
    • Systematic review of microsatellite instability and colorectal cancer prognosis
    • DOI 10.1200/JCO.2005.01.086
    • Popat S, Hubner R, Houlston RS. Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol. 2005;23:609-18. (Pubitemid 46224239)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.3 , pp. 609-618
    • Popat, S.1    Hubner, R.2    Houlston, R.S.3
  • 12
    • 77949274921 scopus 로고    scopus 로고
    • Microsatellite instability (MSI) in stage II and III colon cancer treated with 5FU-LV or 5FU-LV and irinotecan (PETAC 3-EORTC 40993-SAKK60/00 trial)
    • [Abstract: 4001]. Presented at the 2009 Annual Meeting of the ASCO. Orlando, Florida; May 29-June 2, 2009
    • Tejpar S, Bosman F, Delorenzi M, et al. Microsatellite instability (MSI) in stage II and III colon cancer treated with 5FU-LV or 5FU-LV and irinotecan (PETAC 3-EORTC 40993-SAKK60/00 trial). J Clin Oncol. 2009;27:15s. [Abstract: 4001]. Presented at the 2009 Annual Meeting of the ASCO. Orlando, Florida; May 29-June 2, 2009.
    • (2009) J Clin Oncol , vol.27
    • Tejpar, S.1    Bosman, F.2    Delorenzi, M.3
  • 13
    • 77954748953 scopus 로고    scopus 로고
    • Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracilbased adjuvant therapy in colon cancer
    • Sargent DJ, Marsoni S, Monges G, et al. Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracilbased adjuvant therapy in colon cancer. J Clin Oncol 2010; 28:3219-26.
    • (2010) J Clin Oncol , vol.28 , pp. 3219-3226
    • Sargent, D.J.1    Marsoni, S.2    Monges, G.3
  • 14
    • 64649096900 scopus 로고    scopus 로고
    • Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and leukemia group B protocol 89803
    • Bertagnolli MM, Niedzwiecki D, Compton CC, et al. Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: cancer and leukemia group B protocol 89803. J Clin Oncol. 2009;27:1814-21.
    • (2009) J Clin Oncol , vol.27 , pp. 1814-1821
    • Bertagnolli, M.M.1    Niedzwiecki, D.2    Compton, C.C.3
  • 15
    • 73149107502 scopus 로고    scopus 로고
    • KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89802
    • Ogino S, Meyerhardt JA, Irahara N, et al. KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89802. Clin Cancer Res. 2009;15:7322-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 7322-7329
    • Ogino, S.1    Meyerhardt, J.A.2    Irahara, N.3
  • 18
    • 75749102647 scopus 로고    scopus 로고
    • Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 6000 trial
    • Roth AD, Tejpar S, Delorenzi M, et al. Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 6000 trial. J Clin Oncol. 2010;28:466-74.
    • (2010) J Clin Oncol , vol.28 , pp. 466-474
    • Roth, A.D.1    Tejpar, S.2    Delorenzi, M.3
  • 19
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26:1626-34.
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peters, M.3
  • 20
    • 77955229821 scopus 로고    scopus 로고
    • Biomarkers predictive for outcome on patients with metastatic colorectal cancer treated with first-line FOLFOX4 plus or minus cetuximab: Updated data from the OPUS study [Abstract: 428]
    • Presented at the. Orlando, Florida; January 22-24
    • Bokemeyer C, Bondarenko I, Hartmann JT, et al. Biomarkers predictive for outcome on patients with metastatic colorectal cancer treated with first-line FOLFOX4 plus or minus cetuximab: updated data from the OPUS study [Abstract: 428]. Presented at the 2010 Gastrointestinal Cancers Symposium. Orlando, Florida; January 22-24, 2010
    • (2010) 2010 Gastrointestinal Cancers Symposium
    • Bokemeyer, C.1    Bondarenko, I.2    Hartmann, J.T.3
  • 21
    • 72449142814 scopus 로고    scopus 로고
    • Predictive biomarkers to improve treatment of metastatic colorectal cancer; Outcomes with cetuximab plus FOLFIRI in the CRYSTAL trial
    • [Abstract: 4068]. Presented at the 2009 Annual Meeting of the ASCO. Orlando, Florida; May 29-June 2, 2009
    • Kohne C, Stroiakovski D, Chang-chien C, et al. Predictive biomarkers to improve treatment of metastatic colorectal cancer; outcomes with cetuximab plus FOLFIRI in the CRYSTAL trial. J Clin Oncol. 2009;27:15s. [Abstract: 4068]. Presented at the 2009 Annual Meeting of the ASCO. Orlando, Florida; May 29-June 2, 2009.
    • (2009) J Clin Oncol , vol.27
    • Kohne, C.1    Stroiakovski, D.2    Chang-Chien, C.3
  • 22
    • 71449100773 scopus 로고    scopus 로고
    • A meta-analysis of the CRYSTAL and OPUS studies combining cetuximab with chemotherapy as 1st line treatment for patients with metastatic colorectal cancer: Results according to KRAS and BRAF mutation status
    • [Abstract: 6077]. Presented at the 2009 ECCO/ESMO Multidisciplinary Congress Meeting. Berlin, Germany; September 20-24, 2009
    • Van Cutsem E, Rougier P, Kohne C, et al. A meta-analysis of the CRYSTAL and OPUS studies combining cetuximab with chemotherapy as 1st line treatment for patients with metastatic colorectal cancer: results according to KRAS and BRAF mutation status. Eur J Cancer. 2009;7:324. [Abstract: 6077]. Presented at the 2009 ECCO/ESMO Multidisciplinary Congress Meeting. Berlin, Germany; September 20-24, 2009.
    • (2009) Eur J Cancer , vol.7 , pp. 324
    • Van Cutsem, E.1    Rougier, P.2    Kohne, C.3
  • 23
    • 34249785078 scopus 로고    scopus 로고
    • Role of BRAF-V600E in the serrated pathway of colorectal tumourigenesis
    • DOI 10.1002/path.2160
    • Minoo P, Moyer MP, Jass JR. Role of BRAF-V600E in the serrated pathway of colorectal tumorigenesis. J Pathol. 2007;212:124-33. (Pubitemid 46852090)
    • (2007) Journal of Pathology , vol.212 , Issue.2 , pp. 124-133
    • Minoo, P.1    Moyer, M.P.2    Jass, J.R.3
  • 24
    • 22244472992 scopus 로고    scopus 로고
    • Poor survival associated with the BRAF V600E mutation in microsatellitestable colon cancers
    • Samowitz WS, Sweeney C, Herrick J, et al. Poor survival associated with the BRAF V600E mutation in microsatellitestable colon cancers. Cancer Res. 2005;65:6063-9.
    • (2005) Cancer Res , vol.65 , pp. 6063-6069
    • Samowitz, W.S.1    Sweeney, C.2    Herrick, J.3
  • 25
    • 58249089525 scopus 로고    scopus 로고
    • CpG island methylator phenotype, microsatelite instability, BRAF mutation and clinical outcome in colon cancer
    • Ogino S, Nosho K, Kirkner GJ, et al. CpG island methylator phenotype, microsatelite instability, BRAF mutation and clinical outcome in colon cancer. Gut. 2009;5858:90-6.
    • (2009) Gut , vol.5858 , pp. 90-96
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3
  • 26
    • 77955266489 scopus 로고    scopus 로고
    • Cetuximab plus FOLFIRI: Final data from the CRYSTAL study on the association of KRAS and BRAF biomarker status with treatment outcome
    • [Abstract: 3570]. Presented at the 2010 Annual Meeting of the ASCO. Chicago, Illinois; June 4-8, 2010
    • Van Cutsem E, Lang G, Folprecht M, et al. Cetuximab plus FOLFIRI: final data from the CRYSTAL study on the association of KRAS and BRAF biomarker status with treatment outcome. J Clin Oncol. 2010;28:15s. [Abstract: 3570]. Presented at the 2010 Annual Meeting of the ASCO. Chicago, Illinois; June 4-8, 2010.
    • (2010) J Clin Oncol , vol.28
    • Van Cutsem, E.1    Lang, G.2    Folprecht, M.3
  • 27
    • 25144456860 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of the relationship between chromosome 18q genotype, DCC status and colorectal cancer prognosis
    • DOI 10.1016/j.ejca.2005.04.039, PII S0959804905005472
    • Popat S, Houlston RS. A systematic review and meta-analysis of the relationship between chromosome 18q genotype, DCC status and colorectal cancer prognosis. Eur J Cancer. 2005;41:2060-70. (Pubitemid 41337947)
    • (2005) European Journal of Cancer , vol.41 , Issue.14 , pp. 2060-2070
    • Popat, S.1    Houlston, R.S.2
  • 28
    • 0344483890 scopus 로고    scopus 로고
    • Expression of the deleted in colorectal cancer gene is related to prognosis in DNA diploid and low proliferative colorectal adenocarcinoma
    • Sun XF, Rutten S, Zhang H, et al. Expression of the deleted in colorectal cancer gene is related to prognosis in DNA diploid and low proliferative colorectal adenocarcinoma. J Clin Oncol. 1999;17:1745-50. (Pubitemid 29269243)
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.6 , pp. 1745-1750
    • Sun, X.-F.1    Rutten, S.2    Zhang, H.3    Nordenskjold, Bo.4
  • 30
    • 79961010319 scopus 로고    scopus 로고
    • Presence of 18q loss of heterozygosity (LOH) and disease free and overall survival in stage II colon cancer: CALGB Protocol 89803
    • [Abstract: 4012]. Presented at the 2009 Annual Meeting of the ASCO. Orlando, Florida; May 29-June 2, 2009
    • Bertagnolli MM, Niedzwiecki D, Hall M, et al. Presence of 18q loss of heterozygosity (LOH) and disease free and overall survival in stage II colon cancer: CALGB Protocol 89803. J Clin Oncol. 2009;27:15s. [Abstract: 4012]. Presented at the 2009 Annual Meeting of the ASCO. Orlando, Florida; May 29-June 2, 2009.
    • (2009) J Clin Oncol , vol.27
    • Bertagnolli, M.M.1    Niedzwiecki, D.2    Hall, M.3
  • 31
    • 32544444419 scopus 로고    scopus 로고
    • The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: Influence of tumor site, type of mutation, and adjuvant treatment
    • DOI 10.1200/JCO.2005.00.471
    • Russo A, Bazan V, Iacopetta B, et al. The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutations: influence of tumor site, type of mutation, and adjuvant treatment. J Clin Oncol. 2005;23:7518-28. (Pubitemid 46291815)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.30 , pp. 7518-7528
    • Russo, A.1    Bazan, V.2    Iacopetta, B.3    Kerr, D.4    Soussi, T.5    Gebbia, N.6
  • 32
    • 0037440051 scopus 로고    scopus 로고
    • Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study
    • DOI 10.1200/JCO.2003.05.044
    • Allegra CJ, Paik S, Colangelo LH, et al. Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a national cancer institute-national surgical adjuvant breast and bowel project collaborative study. J Clin Oncol. 2003;21:241-50. (Pubitemid 46606152)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.2 , pp. 241-250
    • Allegra, C.J.1    Paik, S.2    Colangelo, L.H.3    Parr, A.L.4    Kirsch, I.5    Kim, G.6    Klein, P.7    Johnston, P.G.8    Wolmark, N.9    Wieand, H.S.10
  • 33
    • 24944525406 scopus 로고    scopus 로고
    • Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients
    • Westra JL, Schaapveld M, Hollema H, et al. Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. J Clin Oncol. 2005;23:5635-43.
    • (2005) J Clin Oncol , vol.23 , pp. 5635-5643
    • Westra, J.L.1    Schaapveld, M.2    Hollema, H.3
  • 34
    • 33845355719 scopus 로고    scopus 로고
    • A prospective, blinded analysis of thymidylate synthase and p53 expression as prognostic markers in the adjuvant treatment of colorectal cancer
    • DOI 10.1093/annonc/mdl301, Special Issue: Gender and the Politics of Scale
    • Popat S, Chen Z, Zhao D, et al. A prospective, blinded analysis of thymidylate synthase and p53 expression a prognostic markers in the adjuvant treatment of colorectal cancer. Ann Oncol. 2006;17:1810-7. (Pubitemid 44884057)
    • (2006) Annals of Oncology , vol.17 , Issue.12 , pp. 1810-1817
    • Popat, S.1    Chen, Z.2    Zhao, D.3    Pan, H.4    Hearle, N.5    Chandler, I.6    Shao, Y.7    Aherne, W.8    Houlston, R.S.9
  • 36
    • 1442290323 scopus 로고    scopus 로고
    • Thymidylate-synthase expression and prognosis in colorectal cancer: A systematic review and meta-analysis
    • DOI 10.1200/JCO.2004.05.064
    • Popat S, Matakidou A, Houlston RS. Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis. J Clin Oncol. 2004;22:529-36. (Pubitemid 41079782)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.3 , pp. 529-536
    • Popat, S.1    Matakidou, A.2    Houlston, R.S.3
  • 37
    • 43049134491 scopus 로고    scopus 로고
    • Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
    • DOI 10.1093/annonc/mdm599
    • Soong R, Shah N, Salto-Tellez M, et al. Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy. Ann Oncol. 2009;19:915-9. (Pubitemid 351627307)
    • (2008) Annals of Oncology , vol.19 , Issue.5 , pp. 915-919
    • Soong, R.1    Shah, N.2    Salto-Tellez, M.3    Tai, B.C.4    Soo, R.A.5    Han, H.C.6    Ng, S.S.7    Tan, W.L.8    Zeps, N.9    Joseph, D.10    Diasio, R.B.11    Iacopetta, B.12
  • 39
    • 53849090995 scopus 로고    scopus 로고
    • Prognostic and predictive factors in colorectal cancer
    • Zlobec I, Lugli A. Prognostic and predictive factors in colorectal cancer. Postgrad Med J. 2008;84:403-11.
    • (2008) Postgrad Med J , vol.84 , pp. 403-411
    • Zlobec, I.1    Lugli, A.2
  • 40
    • 80051791807 scopus 로고    scopus 로고
    • Wt Kras and gene expression levels of VEGFR2, EGFR, and ERCC-1 associated with progression-free survival (PFS) in patients with metastatic colorectal cancer treated with first line 5-FU or capecitabine with oxaliplatin and bevacizumab (FOLFOX/BV or XELOX/BV)
    • [Abstract: 4056]. Presented at the 2009 Annual Meeting of the ASCO. Orlando, Florida; May 29-June 2, 2009
    • El-Khoueiry A, Pohl A, Danenberg K, et al. Wt Kras and gene expression levels of VEGFR2, EGFR, and ERCC-1 associated with progression-free survival (PFS) in patients with metastatic colorectal cancer treated with first line 5-FU or capecitabine with oxaliplatin and bevacizumab (FOLFOX/BV or XELOX/BV). J Clin Oncol. 2009;27:15s. [Abstract: 4056]. Presented at the 2009 Annual Meeting of the ASCO. Orlando, Florida; May 29-June 2, 2009.
    • (2009) J Clin Oncol , vol.27
    • El-Khoueiry, A.1    Pohl, A.2    Danenberg, K.3
  • 41
    • 11144224065 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression: A significant prognostic indicator for patients with colorectal cancer
    • DOI 10.1158/1078-0432.CCR-04-0653
    • Soumaoro LT, Uetake H, Higuchi T, et al. Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. Clin Cancer Res. 2004;10:8465-71. (Pubitemid 40053411)
    • (2004) Clinical Cancer Research , vol.10 , Issue.24 , pp. 8465-8471
    • Soumaoro, L.T.1    Uetake, H.2    Higuchi, T.3    Takagi, Y.4    Enomoto, M.5    Sugihara, K.6
  • 42
    • 58149340659 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is an independent predictor of poor prognosis in colon cancer
    • Ogino S, Kirkner GJ, Nosho K, et al. Cyclooxygenase-2 is an independent predictor of poor prognosis in colon cancer. Clin Cancer Res. 2008;14:8221-7.
    • (2008) Clin Cancer Res , vol.14 , pp. 8221-8227
    • Ogino, S.1    Kirkner, G.J.2    Nosho, K.3
  • 43
    • 68849123400 scopus 로고    scopus 로고
    • Aspirin use and survival after diagnosis of colorectal cancer
    • Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA. 2009;302:649-58.
    • (2009) JAMA , vol.302 , pp. 649-658
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 44
    • 57349138824 scopus 로고    scopus 로고
    • A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer
    • Ogino S, Nosho K, Kirkner GJ, et al. A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer. J Natl Cancer Inst. 2008;100:1734-8.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1734-1738
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3
  • 45
    • 77951630296 scopus 로고    scopus 로고
    • Primary prevention of colorectal cancer
    • Chan AT, Giovannucci EL. Primary prevention of colorectal cancer. Gastroenterology. 2010;138:2029-43.
    • (2010) Gastroenterology , vol.138 , pp. 2029-2043
    • Chan, A.T.1    Giovannucci, E.L.2
  • 46
    • 57449112521 scopus 로고    scopus 로고
    • Cohort study of fatty acid synthase expression and patient survival in colon cancer
    • Ogino S, Nosho K, Meyerhardt JA, et al. Cohort study of fatty acid synthase expression and patient survival in colon cancer. J Clin Oncol. 2008;26:5713-20.
    • (2008) J Clin Oncol , vol.26 , pp. 5713-5720
    • Ogino, S.1    Nosho, K.2    Meyerhardt, J.A.3
  • 48
    • 77249143960 scopus 로고    scopus 로고
    • Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer
    • Smith JJ, Deane NG, Wu F, et al. Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology. 2010;138:958-68.
    • (2010) Gastroenterology , vol.138 , pp. 958-968
    • Smith, J.J.1    Deane, N.G.2    Wu, F.3
  • 49
    • 77957582401 scopus 로고    scopus 로고
    • Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin
    • O'Connell MJ, Lavery I, Yothers G, et al. Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin. J Clin Oncol. 2010;28:3937-44.
    • (2010) J Clin Oncol , vol.28 , pp. 3937-3944
    • O'Connell, M.J.1    Lavery, I.2    Yothers, G.3
  • 51
    • 77954722923 scopus 로고    scopus 로고
    • Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis
    • Tenesa A, Theodoratou E, Din FV, et al. Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis. Clin Cancer Res. 2010;16:3754-9.
    • (2010) Clin Cancer Res , vol.16 , pp. 3754-3759
    • Tenesa, A.1    Theodoratou, E.2    Din, F.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.