Agonist-specific voltage sensitivity at the dopamine D 2S receptor - Molecular determinants and relevance to therapeutic ligands

Neuropharmacology

Volumn 61, Issue 5-6, 2011, Pages 937-949

  Sahlholm, Kristoffer ^a   Barchad Avitzur, Ofra ^b   Marcellino, Daniel ^a   Gómez Soler, Maricel ^c   Fuxe, Kjell ^a   Ciruela, Francisco ^c   Rhem, Peter ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Dopamine agonist; Dopamine receptor; Electrophysiology; G protein coupled receptor; Radioligand; Voltage sensitivity

Indexed keywords

APOMORPHINE; BROMOCRIPTINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; LISURIDE; PERGOLIDE; PIRIBEDIL; PRAMIPEXOLE; PROPYLNORAPOMORPHINE; ROPINIROLE; ROTIGOTINE;

AMINO ACID COMPOSITION; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; DRUG BINDING SITE; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SENSITIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY; XENOPUS;

ANIMALS; APOMORPHINE; BENZOTHIAZOLES; CELL CULTURE TECHNIQUES; DOPAMINE; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; INDOLES; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PATCH-CLAMP TECHNIQUES; PIRIBEDIL; PROTEIN BINDING; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; SENSITIVITY AND SPECIFICITY; SERINE; TETRAHYDRONAPHTHALENES; THIOPHENES; TRANSFECTION; XENOPUS;

EID: 80051784241     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.06.022     Document Type: Article

References (36)

1. A. Alachkar, J.M. Brotchie, and O.T. Jones Binding of dopamine and 3-methoxytyramine as l-DOPA metabolites to human alpha(2)-adrenergic and dopaminergic receptors Neurosci. Res. 67 2010 245 249
2. Y. Ben-Chaim, O. Tour, N. Dascal, I. Parnas, and H. Parnas The M2 muscarinic G-protein-coupled receptor is voltage-sensitive J. Biol. Chem. 278 2003 22482 22491
3. Y. Ben-Chaim, B. Chanda, N. Dascal, F. Bezanilla, I. Parnas, and H. Parnas Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptor Nature 444 2006 106 109 (Pubitemid 44684765)
4. M. Bünemann, M. Frank, and M.J. Lohse Gi protein activation in intact cells involves subunit rearrangement rather than dissociation Proc. Natl. Acad. Sci. U S A 100 2003 16077 16082 (Pubitemid 38021117)
5. 2 dopamine receptor on ligand binding J. Neurochem. 74 2000 358 366 (Pubitemid 30012789)
6. 2 receptors J. Neurochem. 59 1992 627 635
7. C.Z. Floresca, and J.A. Schetz Dopamine receptor microdomains involved in molecular recognition and the regulation of drug affinity and function J. Recept. Signal. Transduct. Res. 24 2004 207 239 (Pubitemid 39332217)
8. I.S. Gurung, J. Martinez-Pinna, and M.P. Mahaut-Smith Novel consequences of voltage-dependence to G-protein-coupled P2Y1 receptors Br. J. Pharmacol. 154 2008 882 889 (Pubitemid 351821594)
9. 2 receptor Adv. Pharmacol. 42 1998 412 415
10. T. Jespersen, M. Grunnet, K. Angelo, D.A. Klaerke, and S.P. Olesen Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes Biotechniques 32 2002 536 538
11. Y.M. Kupchik, O. Barchad-Avitzur, J. Wess, Y. Ben-Chaim, I. Parnas, and H. Parnas A novel fast mechanism for GPCR-mediated signal transduction - control of neurotransmitter release J. Cell Biol. 192 2011 137 151
12. Y.M. Kupchik, G. Rashkovan, L. Ohana, T. Keren-Raifman, N. Dascal, H. Parnas, and I. Parnas Molecular mechanisms that control initiation and termination of physiological depolarization-evoked transmitter release Proc. Natl. Acad. Sci. U S A 105 2008 4435 4440 (Pubitemid 351754398)
13. T. Kvernmo, J. Houben, and I. Sylte Receptor-binding and pharmacokinetic properties of dopaminergic agonists Curr. Top. Med. Chem. 8 2008 1049 1067
14. 2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta J. Physiol. 392 1987 397 416 (Pubitemid 18014315)
15. M.P. Mahaut-Smith, J. Martinez-Pinna, and I.S. Gurung A role for membrane potential in regulating GPCRs? Trends Pharmacol. Sci. 29 2008 421 429
16. 3 receptors Mol. Pharmacol. 46 1994 299 312
17. 2 receptor Eur. J. Pharmacol. 227 1992 205 214
18. J. Martinez-Pinna, I.S. Gurung, M.P. Mahaut-Smith, and A. Morales Direct voltage control of endogenous lysophosphatidic acid G-protein-coupled receptors in Xenopus oocytes J. Physiol. 588 2010 1683 1693
19. E.G. Moreno-Galindo, J.A. Sãnchez-Chapula, F.B. Sachse, J.A. Rodriguez-Paredes, M. Tristani-Firouzi, and R.A. Navarro-Polanco Relaxation gating of the acetylcholine-activated inward rectifier K+ current (IKACh) is mediated by intrinsic voltage-sensitivity of the muscarinic receptor J. Physiol. 589 2011 1755 1767
20. A. Mrejeru, A. Wei, and J.M. Ramirez Calcium-activated non-selective cation currents are involved in generation of tonic and bursting activity in dopamine neurons of the substantia nigra pars compacta J. Physiol. 589 2011 2497 2514
21. R.A. Navarro-Polanco, E.G. Moreno Galindo, T. Ferrer-Villada, M. Arias, J.R. Rigby, J.A. Sãnchez-Chapula, and M. Tristani-Firouzi Conformational changes in the M2 muscarinic receptor induced by membrane voltage and agonist binding J. Physiol. 589 2011 1741 1753
22. R. Nygaard, T.M. Frimurer, B. Holst, M.M. Rosenkilde, and T.W. Schwartz Ligand binding and micro-switches in 7TM receptor structures Trends Pharmacol. Sci. 30 2009 249 259
23. L. Ohana, O. Barchad, I. Parnas, and H. Parnas The metabotropic glutamate G-protein-coupled receptors mGluR3 and mGluR1a are voltage-sensitive J. Biol. Chem. 281 2006 24204 24215 (Pubitemid 44274194)
24. I. Parnas, and H. Parnas Control of neurotransmitter release: from Ca2+ to voltage dependent G-protein coupled receptors Pflugers Arch. 460 2010 975 990
25. V.K. Prabhakar, and J.R. Davis Hyperprolactinaemia Best Pract. Res. Clin. Obstet. Gynaecol. 22 2008 341 353 (Pubitemid 351292328)
26. 2 receptor Synapse 62 2008 476 480 (Pubitemid 351614773)
27. 2-like dopamine receptors Biochem. Biophys. Res. Commun. 374 2008 496 501
28. 2S receptor is agonist-specific Biochem. Biophys. Res. Commun. 377 2008 1216 1221
29. 2 receptor in schizophrenia Expert Opin. Ther. Targets 10 2006 515 531 (Pubitemid 44165124)
30. 2(High) receptors Synapse 61 2007 1013 1018 (Pubitemid 350271782)
31. G. Swaminath, X. Deupi, T.W. Lee, W. Zhu, F.S. Thian, T.S. Kobilka, and B. Kobilka Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists J. Biol. Chem. 280 2005 22165 22171 (Pubitemid 40827872)
32. M.M. Torrice, K.S. Bower, H.A. Lester, and D.A. Dougherty Probing the role of the cation-pi interaction in the binding sites of GPCRs using unnatural amino acids Proc. Natl. Acad. Sci. U S A 106 2009 11919 11924
33. 2 receptors Nature 408 2000 199 203
34. F. Van Goor, D. Zivadinovic, A.J. Martinez-Fuentes, and S.S. Stojilkovic Dependence of pituitary hormone secretion on the pattern of spontaneous voltage-gated calcium influx. Cell type-specific action potential secretion coupling J. Biol. Chem. 276 2001 33840 33846
35. 2S dopamine receptor: evidence for multiple, agonist-specific active conformations Mol. Pharmacol. 54 1998 435 444 (Pubitemid 28368834)
36. 2 dopamine receptor using site-directed mutagenesis J. Neurochem. 66 1996 394 402 (Pubitemid 26010805)