Tofu (soybean curd) lowers serum lipid levels and modulates hepatic gene expression involved in lipogenesis primarily through its protein, not isoflavone, component in rats

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 16, 2011, Pages 8976-8984

  Takahashi, Yoko ^a   Konishi, Tomokazu ^b  

^a NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

^b AKITA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

isoflavone; lipid metabolism; liver; microarray; principal component analysis; soy protein; tofu (soybean curd)

Indexed keywords

ISOFLAVONES; LIPID METABOLISM; PRINCIPAL COMPONENTS; SOY PROTEIN; TOFU (SOYBEAN CURD);

BIOSYNTHESIS; BODY FLUIDS; FATTY ACIDS; GLYCEROL; METABOLISM; PHYSIOLOGY; PRINCIPAL COMPONENT ANALYSIS; PROTEINS; RATS;

GENE EXPRESSION;

ANTIDIABETIC AGENT; ISOFLAVONE DERIVATIVE; LIPID; SOYBEAN PROTEIN;

ANIMAL; ARTICLE; BLOOD; DIET; GENE EXPRESSION; GENETICS; LIPOGENESIS; LIVER; MALE; METABOLISM; RAT; SOYBEAN; SPRAGUE DAWLEY RAT;

ANIMALS; DIET; GENE EXPRESSION; HYPOGLYCEMIC AGENTS; ISOFLAVONES; LIPIDS; LIPOGENESIS; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; SOY FOODS; SOYBEAN PROTEINS;

GLYCINE MAX; RATTUS;

EID: 80051716926     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf201403u     Document Type: Article

References (32)

1. Koba, S.; Sasaki, J. Treatment of hyperlipidemia from Japanese evidence Atheroscler. Thromb. 2006, 13, 267-280
2. Hadigan, C. Dietary habits and their association with metabolic abnormalities in human immunodeficiency virus-related lipodystrophy Clin. Infect. Dis. 2003, 37, S101-S104 (Pubitemid 37102732)
3. Omoni, A. O.; Aluko, R. E. Soybean foods and their benefits: potential mechanisms of action Nutr. Rev. 2005, 63, 272-283 (Pubitemid 41176916)
4. Ho, S. C.; Woo, J. L.; Leung, S. S.; Sham, A. L.; Lam, T. H.; Janus, E. D. Intake of soy products is associated with better plasma lipid profiles in the Hong Kong Chinese population J. Nutr. 2000, 130, 2590-2593
5. Nagata, C.; Takatsuka, N.; Kurisu, Y.; Shimizu, H. Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women J. Nutr. 1998, 128, 209-213 (Pubitemid 28124988)
6. Ashton, E.; Ball, M. Effects of soy as tofu vs meat on lipoprotein concentrations Eur. J. Clin. Nutr. 2000, 54, 14-19 (Pubitemid 30102767)
7. Sagara, M.; Kanda, T.; NJelekera, M.; Teramoto, T.; Armitage, L.; Birt, N.; Birt, C.; Yamori, Y. Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland J. Am. Coll. Nutr. 2004, 23, 85-91 (Pubitemid 38202292)
8. Potter, S. M. Overview of proposed mechanisms for the hypocholesterolemic effect of soy J. Nutr. 1995, 125, S606-S611
9. Torres, N.; Torre-Villalvazo, I.; Tovar, A. R. Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders J. Nutr. Biochem. 2006, 17, 365-373 (Pubitemid 44250959)
10. Xiao, C. W.; Mei, J.; Wood, C. M. Effect of soy proteins and isoflavones on lipid metabolism and involved gene expression Front. Biosci. 2008, 13, 2660-2673 (Pubitemid 351599710)
11. Sacks, F. M.; Lichtenstein, A.; Van Horn, L.; Harris, W.; Kris-Etherton, P.; Winston, M. American Heart Association Nutrition Committee: Soy protein, isoflavones, and cardiovascular health: an American Heart Association Science Advisory for professionals from the Nutrition Committee Circulation 2006, 113, 1034-1044 (Pubitemid 43879479)
12. Lee, Y. M.; Choi, J. S.; Kim, M. H.; Jung, M. H.; Lee, Y. S.; Song, J. Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets Nutrition 2006, 22, 956-964 (Pubitemid 44234007)
13. Takahashi, Y.; Ide, T. Effects of soy protein and isoflavone on hepatic fatty acid synthesis and oxidation and mRNA expression of uncoupling proteins and peroxisome proliferator-activated receptor gamma in adipose tissues of rats J. Nutr. Biochem. 2008, 19, 682-693
14. de Kok, T. M.; van Breda, S. G.; Manson, M. M. Mechanisms of combined action of different chemopreventive dietary compounds: a review Eur. J. Nutr. 2008, 47, 51S-59S
15. The Council for Science and Technology, Ministry of Education, Culture, Sports, Science, and Technology. Standard Tables of Food Composition in Japan, 5 th revised and enlarged ed.; National Printing Bureau: Tokyo, Japan, 2005.
16. Petruzzelli, M.; Lo Sasso, G.; Portincasa, P.; Palasciano, G.; Moschetta, A. Targeting the liver in the metabolic syndrome: evidence from animal models Curr. Pharm. Des. 2007, 13, 2199-2207 (Pubitemid 47074053)
17. Reeves, P. G.; Nielsen, F. H.; Fahey, G. C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet J. Nutr. 1993, 123, 1939-1951 (Pubitemid 23342492)
18. Konishi, T. Three-parameter lognormal distribution ubiquitously found in cDNA microarray data and its application to parametric data treatment. BMC Bioinformatics 2004, 5, 5 [online].
19. Konishi, T.; Konishi, F.; Takasaki, S.; Inoue, K.; Nakayama, K.; Konagaya, A. Coincidence between transcriptome analyses on different microarray platforms using a parametric framework. PLoS One 2008, 3, e3555 [online].
20. NetAffx Annotation File, Rat230-2 Annotations, release 27. http://www.affymetrix.com/support/technical/byproduct.affx?product=rat230-20 (accessed Nov 20, 2008).
21. Gene Ontology Biological Process, http://rgd.mcw.edu/ (accessed Nov 20, 2008).
22. Jackson, J. E. A User'S Guide to Principal Components, 1 st ed.; Wiley: New York, 1991.
23. The R Project for Statistical Computing, http://www.R-project.org (accessed Dec 15, 2008).
24. de Hoon, M. J.; Imoto, S.; Nolan, J.; Miyano, S. Open source clustering software Bioinformatics 2004, 20, 1453-1454 (Pubitemid 38931415)
25. Takahashi, Y.; Odbayar, T. O.; Ide, T. A comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver J. Clin. Biochem. Nutr. 2009, 44, 223-230
26. Lim, J. S.; Adachi, Y.; Takahashi, Y.; Ide, T. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats Br. J. Nutr. 2007, 97, 85-95 (Pubitemid 46662062)
27. Horton, J. D. Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis Biochem. Soc. Trans. 2002, 30, 1091-1095 (Pubitemid 36002414)
28. Reddy, J. K.; Hashimoto, T. Peroxisomal β-oxidation and peroxisome proliferator-activated receptor α: an adaptive metabolic system Annu. Rev. Nutr. 2001, 21, 193-230 (Pubitemid 32695270)
29. Noriega-López, L.; Tovar, A. R.; Gonzalez-Granillo, M.; Hernández-Pando, R.; Escalante, B.; Santillán-Doherty, P.; Torres, N. Pancreatic insulin secretion in rats fed a soy protein high fat diet depends on the interaction between the amino acid pattern and isoflavones J. Biol. Chem. 2007, 282, 20657-20666 (Pubitemid 47100008)
30. Peluso, M. R.; Winters, T. A.; Shanahan, M. F.; Banz, W. J. A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats J. Nutr. 2000, 130, 2333-2342
31. Chajuss, D. Soy protein concentrate: technology, properties, and applications. In Soybeans as Functional Foods and Ingredients; Liu, K. S., Ed.; American Oil Chemists' Society, AOCS Press: Champaign, IL, 2004; pp 130-143.
32. Taub, R. Liver regeneration: from myth to mechanism Mol. Cell. Biol. 2004, 5, 836-847 (Pubitemid 39336277)