Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats

British Journal of Nutrition

Volumn 97, Issue 1, 2007, Pages 85-95

  Lim, Jin Seon ^a,b   Adachi, Yoshikazu ^b   Takahashi, Yoko ^a   Ide, Takashi ^a  

^a NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

^b IBARAKI UNIVERSITY   (Japan)

Author keywords

Fatty acid oxidation; Fatty acid synthesis; Sesame lignan; Sesamin; Sesamolin

Indexed keywords

FATTY ACID; LIGNAN; LIPID; LIVER ENZYME; MESSENGER RNA; SESAMIN; SESAMOLIN; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; DGAT1 PROTEIN, RAT; DIACYLGLYCEROL ACYLTRANSFERASE; EDIBLE OIL; FATTY ACID SYNTHASE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; PRIMER DNA;

ANIMAL EXPERIMENT; ARTICLE; BIOACCUMULATION; BIOAVAILABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; LIPOGENESIS; LIVER METABOLISM; MALE; NONHUMAN; RAT; SESAME; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; ENZYMOLOGY; GENETICS; LIPID METABOLISM; LIVER; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; SPRAGUE DAWLEY RAT;

RATTUS; SESAMUM INDICUM;

ANIMALS; BASE SEQUENCE; DIACYLGLYCEROL O-ACYLTRANSFERASE; DIETARY FATS, UNSATURATED; DIOXOLES; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; LIGNANS; LIPID METABOLISM; LIVER; MALE; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 33847142332     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507252699     Document Type: Article

References (41)

1. Ashakumary L, Rouyer IA, Takahashi Y, Ide T, Fukuda N, Aoyama T, Hashimoto T, Mizugaki M & Sugano M (1999) Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat. Metabolism 48, 1303-1313.
2. Baulande S, Lasnier F, Lucas M & Pairault J (2001) Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage. J Biol Chem 276, 33336-33344.
3. Chomczynski P & Sacchi N (1987) Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162, 156-159.
4. Folch J, Lees M & Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226, 497-509.
5. Fukuda Y, Nagata M, Osawa T & Namiki M (1986) Contribution of lignan analogues to antioxidative activity of refined unroasted sesame seed oil. J Am Oil Chem Soc 63, 1027-1031.
6. Hirose N, Doi F, Ueki T, Akazawa K, Chijiiwa K, Sugano M, Akimato K, Shimizu S & Yamada H (1992) Suppressive effect of sesamin against 7,12-dimethylbenz[a]anthracene induced rat mammary carcinogenesis. Anticancer Res 12, 1259-1266.
7. Hirose N, Inoue T, Nishihara K, Sugano M, Akimoto K, Shimizu S & Yamada H (1991) Inhibition of cholesterol absorption and synthesis in rats by sesamin. J Lipid Res 32, 629-638.
8. Horton JD, Goldstein JL & Brown MS (2002) SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109, 1125-1131.
9. Ide T (2005) Interaction of fish oil and conjugated linoleic acid in affecting hepatic activity of lipogenic enzymes and gene expression in liver and adipose tissue. Diabetes 54, 412-423.
10. Ide T, Ashakumary L, Takahashi Y, Kushiro M, Fukuda N & Sugano M (2001) Sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. Biochim Biophys Acta 1534, 1-13.
11. Ide T, Hong DD, Ranasinghe P, Takahashi Y, Kushiro M & Sugano M (2004) Interaction of dietary fat types and sesamin on hepatic fatty acid oxidation in rats. Biochim Biophys Acta 1682, 80-91.
12. Ide T, Okamatsu H & Sugano M (1978) Regulation by dietary fats of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in rat liver. J Nutr 108, 601-612.
13. Ide T, Oku H & Sugano M (1982) Reciprocal responses to clofibrate in ketogenesis and triglyceride and cholesterol secretion in isolated rat liver. Metabolism 31, 1065-1072.
14. Ide T & Ontko JA (1981) Increased secretion of very low density lipoprotein triglyceride following inhibition of long chain fatty acid oxidation in isolated rat liver. J Biol Chem 256, 10247-10255.
15. Ikeda S, Kagaya M, Kobayashi K, Tohyama T, Kiso Y, Higuchi N & Yamashita K (2003) Dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid. J Nutr Sci Vitaminol 49, 270-276.
16. Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B & Gross RW (2004) Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279, 48968-48975.
17. Johansson LE, Hoffstedt J, Parikh H, Carlsson E, Wabitsch M, Bondeson AG, Hedenbro J, Tornqvist H, Groop L & Ridderstrale M (2006) Variation in the adiponutrin gene influences its expression and associates with obesity. Diabetes 55, 826-833.
18. Kang MH, Kawai Y, Naito M & Osawa T (1999) Dietary defatted sesame flour decreases susceptibility to oxidative stress in hypercholesterolemic rabbits. J Nutr 129, 1885-1890.
19. Katsuzaki H, Kawakishi S & Osawa T (1994) Sesaminol glucosides in sesame seeds. Phytochemistry 35, 773-776.
20. Kim HJ, Takahashi M & Ezaki O (1999) Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs. J Biol Chem 274, 25892-25898.
21. Kinlaw WB, Church JL, Harmon J & Mariash CN (1995) Direct evidence for a role of the 'spot 14' protein in the regulation of lipid synthesis. J Biol Chem 270, 16615-16618.
22. Kushiro M, Masaoka T, Hageshita S, Takahashi Y, Ide T & Sugano M (2002) Comparative effect of sesamin and episesamin on the activity and gene expression of enzymes in fatty acid oxidation and synthesis in rat liver. J Nutr Biochem 13, 289-295.
23. Kushiro M, Takahashi Y & Ide T (2004) Species differences in the physiological activity of dietary lignan (sesamin and episesamin) in affecting hepatic fatty acid metabolism. Br J Nutr 91, 377-386.
24. Moazzami AA, Andersson RE & Kamal-Eldin A (2006) HPLC analysis of sesaminol glucosides in sesame seeds. J Agric Food Chem 54, 633-638.
25. Nakano D, Itoh C, Ishii F, Kawanishi H, Takaoka M, Kiso Y, Tsuruoka N, Tanaka T & Matsumura, Y (2003) Effects of sesamin on aortic oxidative stress and endothelial dysfunction in deoxycorticosterone acetate-salt hypertensive rats. Biol Pharm Bull 26, 1701-1705.
26. Noguchi T, Ikeda K, Sasaki Y, Yamamoto J, Seki J, Yamagata K, Nara Y, Hara H, Kakuta H & Yamori Y (2001) Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. Hypertens Res 24, 735-742.
27. Ogawa H, Sasagawa S, Murakami T & Yoshizumi H (1995) Sesame lignans modulate cholesterol metabolism in the stroke-prone spontaneously hypertensive rat. Clin Exp Pharmacol Physiol 22, S310-S312.
28. Pennacchiotti GL, Maldonado EN & Aveldano MI (2001) Major clofibrate effects on liver and plasma lipids are independent of changes in polyunsaturated fatty acid composition induced by dietary fat. Lipids 36, 121-127.
29. Reddy JK & Hashimoto T (2001) Peroxisomal β-oxidation and peroxisome proliferator-activated receptor α: An adaptive metabolic system. Annu Rev Nutr 21, 193-230.
30. Reeves PG, Nielsen FH & Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939-1951.
31. Rustan AC, Christiansen EN & Drevon CA (1992) Serum lipids, hepatic glycerolipid metabolism and peroxisomal fatty acid oxidation in rats fed ω-3 and ω-6 fatty acids. Biochem J 283, 333-339.
32. Schoonjans K, Staels B & Auwerx J (1996) Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37, 907-925.
33. Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA & Gould SJ (1998) Expression of PEX11β mediates peroxisome proliferation in the absence of extracellular stimuli. J Biol Chem 273, 29607-29614.
34. Shimomura I, Bashmakov Y, Ikemoto S, Horton JD, Brown MS & Goldstein JL (1999) Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci U S A 96, 13656-13661.
35. Simpson AE (1997) The cytochrome P450 4 (CYP4) family. Gen Pharmacol 28, 351-359.
36. Sirato-Yasumoto S, Katsuta M, Okuyama Y, Takahashi Y & Ide T (2001) Effect of sesame seeds rich in sesamin and sesamolin on fatty acid oxidation in rat liver. J Agric Food Chem 49, 2647-2651.
37. Umeda-Sawada R, Ogawa M & Igarashi O (1999) The metabolism and distribution of sesame lignans (sesamin and episesamin) in rats. Lipids 34, 633-637.
38. Windmueller HG & Spaeth AE (1967) De novo synthesis of fatty acid in perfused rat liver as a determinant of plasma lipoprotein production. Arch Biochem Biophys 122, 362-369.
39. Yamashita K, Iizuka Y, Imai T & Namiki M. (1995) Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low α-tocopherol diet. Lipids 30, 1019-1028.
40. Yanagita T, Satoh M, Nomura H, Enomoto N & Sugano M (1987) Alteration of hepatic phospholipids in rats and mice by feeding di-(2-ethylhexyl)adipate and di-(2-ethylhexyl)phthalate. Lipids 22, 572-577.
41. Yasumoto S, Katsuta M, Sugiura M, Okuyama Y, Honda Y & Komeichi M (2003) New high-lignan-content sesame 'Gomazou'. Bull Natl Inst Crop Sci 4, 45-58.