Effects of soy protein and isoflavone on hepatic fatty acid synthesis and oxidation and mRNA expression of uncoupling proteins and peroxisome proliferator-activated receptor γ in adipose tissues of rats

Journal of Nutritional Biochemistry

Volumn 19, Issue 10, 2008, Pages 682-693

  Takahashi, Yoko ^a   Ide, Takashi ^a  

^a NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

Author keywords

Adipose tissue; Gene expression; Isoflavone; Liver; Serum lipids; Soy protein

Indexed keywords

CASEIN; ISOFLAVONE; MESSENGER RNA; METHANOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; SOYBEAN PROTEIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; DOSE RESPONSE; ENZYME ACTIVITY; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; GENE EXPRESSION; MALE; NONHUMAN; RAT;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; FATTY ACIDS; ISOFLAVONES; LIPIDS; LIVER; MALE; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SOYBEAN PROTEINS;

ANIMALIA; RATTUS;

EID: 50949105525     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2007.09.003     Document Type: Article

References (59)

1. Torres N., Torre-Villalvazo I., and Tovar A.R. Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders. J Nutr Biochem 17 (2006) 365-373
2. Lovati M.R., Manzoni C., Canavesi A., Sirtori M., Vaccarino V., Marchi M., et al. Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients. J Clin Invest 80 (1987) 1498-1502
3. Sugano M., Tanaka K., and Ide T. Secretion of cholesterol, triglyceride and apolipoprotein A-I by isolated perfused liver from rats fed soybean protein and casein or their amino acid mixtures. J Nutr 112 (1982) 855-862
4. Ascencio C., Torres N., Isoard-Acosta F., Gomez-Perez F.J., Hernandez-Pando R., and Tovar A.R. Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. J Nutr 134 (2004) 522-529
5. Tovar A.R., Torre-Villalvazo I., Ochoa M., Elias A.L., Ortiz V., Aguilar-Salinas C.A., et al. Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats. J Lipid Res 46 (2005) 1823-1832
6. Demonty I., Lamarche B., and Jones P.J. Role of isoflavones in the hypocholesterolemic effect of soy. Nutr Rev 61 (2003) 189-203
7. Mezei O., Banz W.J., Steger R.W., Peluso M.R., Winters T.A., and Shay N. Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr 133 (2003) 1238-1243
8. Mezei O., Li Y., Mullen E., Ross-Viola J.S., and Shay N.F. Dietary isoflavone supplementation modulates lipid metabolism via PPARα-dependent and -independent mechanisms. Physiol Genomics 26 (2006) 8-14
9. Fukui K., Tachibana N., Fukuda Y., Takamatsu K., and Sugano M. Ethanol washing does not attenuate the hypocholesterolemic potential of soy protein. Nutrition 20 (2004) 984-990
10. Davis J., Higginbotham A., O'connor T., Moustaid-Moussa N., Tebbe A., Kim Y.C., et al. Soy protein and isoflavones influence adiposity and development of metabolic syndrome in the obese male ZDF rat. Ann Nutr Metab 51 (2007) 42-52
11. Fukui K., Tachibana N., Wanezaki S., Tsuzaki S., Takamatsu K., Yamamoto T., et al. Isoflavone-free soy protein prepared by column chromatography reduces plasma cholesterol in rats. J Agric Food Chem 50 (2002) 5717-5721
12. Reeves P.G., Nielsen F.H., and Fahey Jr. G.C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123 (1993) 1939-1951
13. Fried S.K., and Rao S.P. Sugars, hypertriglyceridemia, and cardiovascular disease. Am J Clin Nutr 78 (2003) 873S-880S
14. Kabir Y., and Ide T. Activity of hepatic fatty acid oxidation enzymes in rats fed alpha-linolenic acid. Biochim Biophys Acta 1304 (1996) 105-119
15. Folch J., Lees M., Sloane G., and Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226 (1957) 497-509
16. Ide T., Oku H., and Sugano M. Reciprocal responses to clofibrate in ketogenesis and triglyceride and cholesterol secretion in isolated rat liver. Metabolism 10 (1982) 1065-1072
17. Fletcher M.J. A colorimetric method for estimating serum triglycerides. Clin Chim Acta 22 (1968) 393-397
18. Siakotos A.N., Rouser G., and Fleischer S. Phospholipid composition of human, bovine and frog myelin isolated on a large scale from brain and spinal cord. Lipids 4 (1969) 239-242
19. Kelley D.S., Nelson G.J., and Hunt J.E. Effect of prior nutritional status on the activity of lipogenic enzymes in primary monolayer cultures of rat hepatocytes. Biochem J 235 (1986) 87-90
20. Takeda Y., Suzuki F., and Inoue H. ATP citrate lyase (citrate-cleavage enzyme). Methods Enzymol 13 (1969) 153-160
21. Kelley D.S., and Kletzien R.F. Ethanol modulation of the hormonal and nutritional regulation of glucose 6-phosphate dehydrogenase activity in primary cultures of rat hepatocytes. Biochem J 217 (1984) 543-549
22. Beutler E., and Kuhl W. Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism. J Lab Clin Med 106 (1985) 573-577
23. Hsu R.Y., and Lardy H.A. Malic enzyme. Methods Enzymol 13 (1969) 230-235
24. Osumi T., and Hashimoto T. Acyl-CoA oxidase of rat liver: a new enzyme for fatty acid oxidation. Biochem Biophys Res Commun 83 (1978) 479-485
25. Markwell M.A., McGroarty E.J., Bieber L.L., and Tolbert N.E. The subcellular distribution of carnitine acyltransferases in mammalian liver and kidney. A new peroxisomal enzyme. J Biol Chem 248 (1973) 3426-3432
26. Steinman H.M., and Hill R.L. Bovine liver crotonase (enoyl coenzyme A hydratase). EC 4.2.1.17 l-3-hydroxyacyl-CoA hydrolyase. Methods Enzymol 35 (1975) 136-151
27. Hiltunen J.K., Palosaari P.M., and Kunau W.H. Epimerization of 3-hydroxyacyl-CoA esters in rat liver. Involvement of two 2-enoyl-CoA hydratases. J Biol Chem 264 (1989) 13536-13540
28. Miyazawa S., Osumi T., and Hashimoto T. The presence of a new 3-oxoacyl-CoA thiolase in rat liver peroxisomes. Eur J Biochem 103 (1980) 589-596
29. Ide T. Interaction of fish oil and conjugated linoleic acid in affecting hepatic activity of lipogenic enzymes and gene expression in liver and adipose tissue. Diabetes 54 (2005) 412-423
30. Lim J.S., Adachi Y., Takahashi Y., and Ide T. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. Br J Nutr 97 (2007) 85-95
31. Horton J.D., Goldstein J.L., and Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109 (2002) 1125-1131
32. Ferré P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 53 (2004) S43-S50
33. Erlanson-Albertsson C. Uncoupling proteins - a new family of proteins with unknown function. Nutr Neurosci 5 (2002) 1-11
34. Ide T., Ashakumary L., Takahashi Y., Kushiro M., Fukuda N., and Sugano M. Sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. Biochim Biophys Acta 1534 (2001) 1-13
35. Xu J., Cho H., O'Malley S., Park J.H., and Clarke S.D. Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms. J Nutr 132 (2002) 3333-3339
36. Cha J.Y., and Repa J.J. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem 282 (2007) 743-751
37. Kim S., Shin H.J., Kim S.Y., Kim J.H., Lee Y.S., Kim D.H., et al. Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARα. Mol Cell Endocrinol 220 (2004) 51-58
38. Akahoshi A., Koba K., Ichinose F., Kaneko M., Shimoda A., Nonaka K., et al. Dietary protein modulates the effect of CLA on lipid metabolism in rats. Lipids 39 (2004) 25-30
39. Halminski M.A., Marsh J.B., and Harrison E.H. Differential effects of fish oil, safflower oil and palm oil on fatty acid oxidation and glycerolipid synthesis in rat liver. J Nutr 121 (1991) 1554-1561
40. Sirato-Yasumoto S., Katsuta M., Okuyama Y., Takahashi Y., and Ide T. Effect of sesame seeds rich in sesamin and sesamolin on fatty acid oxidation in rat liver. J Agric Food Chem 49 (2001) 2647-2651
41. Borradaile N.M., de Dreu L.E., Wilcox L.J., Edwards J.Y., and Huff M.W. Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms. Biochem J 366 (2002) 531-539
42. Voshol P.J., Haemmerle G., Ouwens D.M., Zimmermann R., Zechner R., Teusink B., et al. Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology 144 (2003) 3456-3462
43. 100/100 mice fed trans-10,cis-12 conjugated linoleic acid. J Lipid Res 47 (2006) 2647-2655
44. Morifuji M., Sanbongi C., and Sugiura K. Dietary soya protein intake and exercise training have an additive effect on skeletal muscle fatty acid oxidation enzyme activities and mRNA levels in rats. Br J Nutr 96 (2006) 469-475
45. Banz W.J., Davis J., Peterson R., and Iqbal M.J. Gene expression and adiposity are modified by soy protein in male Zucker diabetic fatty rats. Obes Res 12 (2004) 1907-1913
46. Nedergaard J., Petrovic N., Lindgren E.M., Jacobsson A., and Cannon B. PPARγ in the control of brown adipocyte differentiation. Biochim Biophys Acta 1740 (2005) 293-304
47. Kelly L.J., Vicario P.P., Thompson G.M., Candelore M.R., Doebber T.W., Ventre J., et al. Peroxisome proliferator-activated receptors γ and α mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology 139 (1998) 4920-4927
48. Potter S.M., Jimenez-Flores R., Pollack J., Lone T.A., and Berber-Jimenez R. Protein-saponin interaction and its influence on blood lipids. J Agric Food Chem 41 (1993) 1287-1291
49. Leveille G.A., Romsos D.R., Yeh Y., and O'Hea E.K. Lipid biosynthesis in the chick. A consideration of site of synthesis, influence of diet and possible regulatory mechanisms. Poult Sci 54 (1975) 1075-1093
50. Boyd M.E., Albright E.B., Foster D.W., and McGarry J.D. In vitro reversal of the fasting state of liver metabolism in the rat. Reevaluation of the roles of insulin and glucose. J Clin Invest 68 (1981) 142-152
51. McGarry J.D. Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between. Biochem Soc Trans 29 (2001) 241-245
52. Slauter R.W., and Yamazaki R.K. Glucagon and fasting do not activate peroxisomal fatty acid beta-oxidation in rat liver. Arch Biochem Biophys 233 (1984) 197-202
53. Sivitz W.I., Fink B.D., and Donohoue P.A. Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression. Endocrinology 140 (1999) 1511-1519
54. Scarpace P.J., Nicolson M., and Matheny M. UCP2, UCP3 and leptin gene expression: modulation by food restriction and leptin. J Endocrinol 159 (1998) 349-357
55. Holder C.L., Churchwell M.I., and Doerge D.R. Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS. J Agric Food Chem 47 (1999) 3764-3770
56. Kawakami Y., Tsurugasaki W., Nakamura S., and Osada K. Comparison of regulative functions between dietary soy isoflavones aglycone and glucoside on lipid metabolism in rats fed cholesterol. J Nutr Biochem 16 (2005) 205-212
57. King R.A. Daidzein conjugates are more bioavailable than genistein conjugates in rats. Am J Clin Nutr 68 (1998) 1496S-1499S
58. Setchell K.D., Brown N.M., and Lydeking-Olsen E. The clinical importance of the metabolite equol - a clue to the effectiveness of soy and its isoflavones. J Nutr 132 (2002) 3577-3584
59. Gu L., House S.E., Prior R.L., Fang N., Ronis M.J., Clarkson T.B., et al. Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women. J Nutr 136 (2006) 1215-1221