Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics

ACS Chemical Neuroscience

Volumn 2, Issue 8, 2011, Pages 433-449

  Robichaud, Albert J ^a   Engers, Darren W ^b,c,d   Lindsley, Craig W ^b,c,d   Hopkins, Corey R ^b,c,d  

^a LUNDBECK RESEARCH USA   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

allosteric modulator; anxiety; Class C GPCR; cognitive disorders; Metabotropic glutamate receptor 4; neurodegenerative disorders; orthosteric ligand; pain; Parkinson's disease; psychiatric disorders

Indexed keywords

2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; FLUMAZENIL; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; L AP4; L SOP; LSP1 2111; LSP1 3081; LSP1 3154; LSP1 3155; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR 4 AGONIST; METABOTROPIC RECEPTOR 4 NEGATIVE ALLOSTERIC MODULATOR; METABOTROPIC RECEPTOR 4 POSITIVE ALLOSTERIC MODULATOR; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N PHENYL 7 (HYDROXYIMINO)CYCLOPROPA[B]CHROMEN 1A CARBOXAMIDE; PCEP 7; RITANSERIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VU 0001171; VU 0003423; VU 0080241; VU 0130734; VU 0155041; VU 0361737; VU 0364439; VU 100635;

ALLOSTERISM; DRUG POTENCY; DRUG POTENTIATION; DRUG SOLUBILITY; HUMAN; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ALLOSTERIC MODULATOR; ANXIETY; CLASS C GPCR; COGNITIVE DISORDERS; METABOTROPIC GLUTAMATE RECEPTOR 4; NEURODEGENERATIVE DISORDERS; ORTHOSTERIC LIGAND; PAIN; PARKINSON'S DISEASE; PSYCHIATRIC DISORDERS;

ALLOSTERIC REGULATION; ANIMALS; CENTRAL NERVOUS SYSTEM AGENTS; DRUG DISCOVERY; GLUTAMIC ACID; HUMANS; LIGANDS; NEURODEGENERATIVE DISEASES; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 80051716135     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn200043e     Document Type: Review

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