PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:Phosphocholine cytidylyltransferase activity

Journal of Biological Chemistry

Volumn 286, Issue 33, 2011, Pages 28940-28947

  González Bulnes, Patricia ^a   Bobenchik, April M ^b   Augagneur, Yoann ^b   Cerdan, Rachel ^c   Vial, Henri J ^c   Llebaria, Amadeu ^a   Mamoun, Choukri Ben ^b  

^a INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; AMINO ACIDS; BIOCHEMISTRY; FATTY ACIDS; PHOSPHOLIPIDS;

ANTIMALARIAL ACTIVITY; CYTIDYLYLTRANSFERASE; HUMAN MALARIA PARASITE; MEMBRANE PHOSPHOLIPIDS; METABOLIC ANALYSIS; PHOSPHATIDYLCHOLINE; PHOSPHOETHANOLAMINE; PLASMODIUM FALCIPARUM;

ENZYME INHIBITION;

AG 84; ANTIMALARIAL AGENT; CHOLINE; CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; CHOLINEPHOSPHOTRANSFERASE; FATTY ACID; PG 11; PG 12; PG 14; PG 18; PG 21; PHOSPHOETHANOLAMINE; PHOSPHOLIPID; SERINE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LEISHMANIA; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN METHYLATION; TRYPANOSOMA;

PLASMODIUM FALCIPARUM; TRYPANOSOMA;

EID: 80051684435     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.268946     Document Type: Article

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