Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India

Journal of Ethnopharmacology

Volumn 136, Issue 1, 2011, Pages 123-128

  Dua, Virendra K ^a,b   Verma, Gaurav ^a,c   Agarwal, Dau Dayal ^c   Kaiser, Marcel ^d,e   Brun, Reto ^d,e  

^a National Institute of Malaria Research   (India)

^b NATIONAL INSTITUTE OF MALARIA RESEARCH   (India)

^c JIWAJI UNIVERSITY   (India)

^d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^e UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Antiprotozoal activity; Garhwal region; Herbal formulation; Leishmania donovani; Plasmodium falciparum; Selectivity index; Traditional medicinal plants; Trypanosoma brucei rhodesiense; Trypanosoma cruzi

Indexed keywords

ADHATODA VASICA EXTRACT; AINSLIAEA APTERA EXTRACT; AJUGA BRACTEOSA EXTRACT; ANTIMALARIAL AGENT; ANTIPROTOZOAL AGENT; ANTITRYPANOSOMAL AGENT; ARTEMISIA ROXBURGHIANA EXTRACT; BENZNIDAZOLE; CAESALPINIA BONDUCELLA EXTRACT; CESTRUM NOCTURNUM EXTRACT; CHLOROFORM; CHLOROQUINE; EPIPACTIS HELLEBORINE EXTRACT; GLORIOSA SUPERBA EXTRACT; HOLARRHENA ANTIDYSENTERICA EXTRACT; HYPOXANTHINE; INDIGOFERA CASSIODIS EXTRACT; LEUCAS CEPHALOTES EXTRACT; MELARSOPROL; MILTEFOSINE; MUKIA MADERASAPATANA EXTRACT; NEPETA HINDOSTANA EXTRACT; PEPPERMINT; PETROLEUM ETHER; PLANT EXTRACT; PODOPHYLLOTOXIN; PYRIMETHAMINE; ROYLEA CINEREA EXTRACT; SWERTIA CILIATA EXTRACT; UNCLASSIFIED DRUG; VIOLA CANESCENS EXTRACT;

AINSLIAEA APTERA; AJUGA BRACTEOSA; AMASTIGOTE; ANIMAL CELL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ANTIPROTOZOAL ACTIVITY; ARTEMISIA ROXBURGHIANA; ARTICLE; CAESALPINIA BONDUCELLA; CESTRUM NOCTURNUM; CHAGAS DISEASE; CONTROLLED STUDY; CYTOTOXICITY; EPIPACTIS HELLEBORINE; ERYTHROCYTE; ETHNOPHARMACOLOGY; GLORIOSA SUPERBA; HOLARRHENA ANTIDYSENTERICA; IC 50; IN VITRO STUDY; INDIA; INDIGOFERA CASSIODIS; LEISHMANIA DONOVANI; LEUCAS CEPHALOTES; MEDICINAL PLANT; MICROTITER PLATE ASSAY; MUKIA MADERASAPATANA; MYOBLAST; NEPETA HINDOSTANA; NONHUMAN; PLASMODIUM FALCIPARUM; RAT; ROYLEA CINEREA; SWERTIA CILIATA; TRADITIONAL MEDICINE; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE; VIOLA CANESCENS;

ANIMALS; ANTIMALARIALS; ANTIPROTOZOAL AGENTS; ARTEMISIA; CELL LINE; INDIA; INHIBITORY CONCENTRATION 50; LEISHMANIA DONOVANI; MEDICINE, TRADITIONAL; MYOBLASTS; NEPETA; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PLASMODIUM FALCIPARUM; RATS; TRYPANOCIDAL AGENTS; TRYPANOSOMA; VIOLA;

ARTEMISIA ROXBURGHIANA; CEPHALOTES; LEISHMANIA DONOVANI; LEUCAS; NEPETA; PLASMODIUM FALCIPARUM; PROTOZOA; RATTUS; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI; VIOLA CANESCENS;

EID: 79958110299     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.04.024     Document Type: Article

References (32)

1. Ahmed, S.A., Gogal, R.M., Walsh, J.E., 1994. A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H] thymidine incorporation assay. The Journal of Immunological Methods 170, 211-224. (Pubitemid 24122510)
2. Al-Bashir, N.T., Rassam, M.B., Al-Rawi, B.M., 1992. Axenic cultivation of amastigotes of Leishmania donovani and Leishmania major and their infectivity. Annals of Tropical Medicine and Parasitology 86, 487-502. (Pubitemid 23040789)
3. Baltz, T., Baltz, D., Giroud, C., Crockett, J., 1985. Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi. T. rhodesiense and T. gambiense. EMBO Journal 4, 1273-1277.
4. Beroa, J., Ganfona, H., Jonville, M.C., Frédérich, M., Gbaguidi, F., DeMol, P., Moudachirouc, M., Quetin-Leclercq, J., 2009. In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria. Journal of Ethnopharmacology 122, 439-444.
5. Brun, R., Blum, J., Chappuis, F., Burri, C., 2010. Human African trypanosomiasis. Lancet 375, 148-159.
6. Buckner, F.S., Verlinde, C.L., La Flamme, A.C., van Voorhis, W.C., 1996. Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing betagalactosidase. Antimicrobial Agents and Chemotherapy 40, 2592-2597.
7. Chandel, S., Bagai, U., 2010. Antiplasmodial activity of Ajuga bracteosa against Plasmodium berghei infected BALB/C mice. Indian Journal of Medical Research 131, 440-444.
8. Chopra, A.K., Khanna, D.R., Prasad, G., Malik, D.S., Bhutiani, R., 2007. Medicinal Plants: Conservation, Cultivation and Utilization. Daya Publishing House, Trinagar, Delhi.
9. Dash, V.B., 1987. Materia Medica of Indo-Tibetan Medicine. Classics India Publication, Delhi, pp. 323-324.
10. Dua, V.K., Verma, G., Dash, A.P., 2009. Antiprotozoal activity of some xanthones isolated from the roots of Andrographis paniculata. Phytotherapy Research 23, 126-128.
11. Gaur, R.D., 1999. Flora of the District Garhwal of North West Himalaya. Transmedia Publication, Srinagar (Garhwal).
12. Hoet, S., Opperdoes, F., Brun, R., Quetin-Leclercq, J., 2004. Natural products active against African trypanosomes: a step towards new drugs. Natural Product Reports 21, 353-364. (Pubitemid 38865718)
13. Kirmizibekmez, H., Calis, I., Perozzo, R., Brun, R., Dönmez, A.A., Linden, A., Rüedi, P., Tasdemir, D., 2004. Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP reductase, a crucial enzyme in fatty acid biosynthesis. Planta Medica 70, 711-717. (Pubitemid 39178930)
14. Matile, H., Pink, J.R.L., 1990. Plasmodium falciparum malaria parasite cultures and their use in immunology. In: Lefkovits, I., Pernis, B. (Eds.), Immunological Methods. Academic Press, San Diego, CA, USA, pp. 221-234.
15. Moon, H.I., Jung, J.C., Lee, J., 2007. Antiplasmodial activity of triterpenoids isolated from whole plants of Viola genus from South Korea. Parasitology Research 100, 641-644. (Pubitemid 46011281)
16. Mukerji, B., Ghosh, B.K., Siddons, L.B., 1943. The search for an anti-malarial drug in the indigenous materia medica. Part II. Caesalpinia bonducella. Indian Medical Gazette 78, 285-286.
17. Ndjakou Lenta, B., Vonthron-Sénécheau, C., Fongang Soh, R., Tantangmo, F., Ngouela, S., Kaiser, M., Tsamo, E., Anton, R., Weniger, B., 2007. In vitro antiprotozoal activities and cytotoxicity of some selected Cameroonian medicinal plants. Journal of Ethnopharmacology 20, 8-12.
18. Nour, A.M., Khalid, S.A., Kaiser, M., Brun, R., Abdallah, W.E., Schmidt, T.J., 2009. The antiprotozoal activity of sixteen Asteraceae species native to Sudan and bioactivity-guided isolation of Xanthanolides from Xanthium brasilicum. Planta Medica 75, 1363-1368.
19. Orhan, I., Sener, B., Kaiser, M., Brun, R., Tasdemir, D., 2010. Inhibitory activity of marine sponge-derived natural products against parasitic protozoa. Marine Drugs 15, 47-58.
20. Osorio, E., Arango, G.J., Jiménez, N., Alzate, F., Ruiz, G., Gutierrez, D., Paco, M.A., Giménez, A., Robledo, S., 2007. Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae. Journal of Ethnopharmacology 22, 630-635. (Pubitemid 46617110)
21. Page, C., Page, M., Noel, C., 1993. A new fluorimetric assay for cytotoxicity measurements in vitro. International Journal of Oncology 3, 473-476. (Pubitemid 23271916)
22. Prakash, O., Bhakuni, D.S., Kapil, R.S., Subba Rao, G.S.R., Ravindranath, B., 1979. Diterpenoids of Roylea calycina (Roxb.) Briq. Journal of the Chemical Society Perkin Transactions 1, 1305-1308.
23. Räz, B., Iten, M., Grether-Bühler, Y., Kaminsky, R., Brun, R., 1997. The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T. b. rhodesiense and T. b. gambiense) in vitro. Acta Tropica 68, 139-147. (Pubitemid 27438330)
24. Saeed, M., Arshad, M., Ahmad, M., Ahmad, E., Ishaque, M., 2004. Ethnophytotherapies for the treatment of various diseases by the local people of selected area of NWFP (Pakistan). Pakistan Journal of Biological Science 7, 1104-1108.
25. Simonsen, H.T., Nordskjold, J.B., Smitt, U.W., Nyman, U., Palpu, P., Joshi, P., Varughese, G., 2001. In vitro screening of Indian medicinal plants for antiplasmodial activity. Journal of Ethnopharmacology 74, 195-204.
26. Spencer, C.F., Koniuszy, F.R., Rogers, E.F., Shavel, J.J., Easton, N.R., Kaczka, E.A., Kuehl, J.F.A., Phillips, R.F., Walti, A., Folkers, K., Malanga, C., Seeler, A.O., 1947. Survey of plants for antimalarial activity. Lloydia 10, 145-174.
27. Stuart, K., Brun, R., Croft, S., Fairlamb, A., Gürtler, R.E., McKerrow, J., Reed, S., Tarleton, R., 2008. Kinetoplastids: related protozoan pathogens, different diseases. The Journal of Clinical Investigation 118, 1301-1310. (Pubitemid 351500422)
28. Usmanghani, K., Saeed, A., Alam, M.T., 1997. Indusy Unic Medicine; Traditional Medicine of Herbal, Animal and Mineral Origin in Pakistan. B.C.C. and T. Press (University of Karachi), Karachi, pp. 469-470.
29. Valecha, N., Biswas, S., Badoni, V., Bhandari, K.S., Sati, O.P., 1994. Antiplasmodial activity of Artemisia japonica, Artemisia maritime and Artemisia nilegarica. Indian Journal of Pharmacology 26, 144-146. (Pubitemid 24212445)
30. Weenen, H., Nkunya, M.H.H., Bray, D.H., Mwasumbi, L.B., Kinabo, L.S., Kilimali, V.A.E.B., 1990. Antimalarial activity of Tanzanian medicinal plants. Planta Medica 56, 368-370. (Pubitemid 20339434)
31. Weniger, B., Vonthron-Senecheau, C., Kaiser, M., Brun, R., Anton, R., 2006. Comparative antiplasmodial, leishmanicidal and antitrypanosomal activities of several biflavonoids. Phytomedicine 13, 176-180. (Pubitemid 43120317)
32. World Health Organization, 2010. Malaria Fact sheet No. 94. www.who.int/entity/mediacentre/factsheets/fs094/en/ (assessed 14.07.10).