The effect of edelfosine on CTP:Cholinephosphate cytidylyltransferase activity in leukemic cell lines

Leukemia Research

Volumn 20, Issue 11-12, 1996, Pages 947-951

  Vogler, William R ^a,b   Shoji, Mamoru ^a   Hayzer, David J ^a   Xie, Y P ^a   Renshaw, Mary ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

CTP:cholinephosphate cytidylyltransferase; Edelfosine; HL60; K562; PCR

Indexed keywords

ALKYLLYSOPHOSPHOLIPID; CARBON 14; CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; CITICOLINE; EDELFOSINE; PHOSPHATIDYLCHOLINE;

ARTICLE; CELL STRAIN HL 60; CELL STRAIN K 562; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME PURIFICATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PHOSPHOLIPID SYNTHESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE; DNA, COMPLEMENTARY; DNA, NEOPLASM; DRUG RESISTANCE, NEOPLASM; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; NEOPLASM PROTEINS; NUCLEOTIDYLTRANSFERASES; PHOSPHOLIPID ETHERS; POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED;

EID: 0030294127     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(96)00070-7     Document Type: Article

References (26)

1. 1. Munder P. G., Modolell M., Bausert W., Oettgen H. F. & Westphal O. (1981) Alkyllysophospholipids in cancer therapy. In Augmenting Agents in Cancer Therapy (Hersh E. M., Ed.), pp. 441-458. Raven Press, New York.
2. 2. Munder P. G., Weltzien H. U. & Modolell M. (1976) Lysolecithin analogs: a new class of immunopotentiators. Immunodeficiency and immunostimulation. In Seventh International Symposium on Immunopathology (Mescher P. A., Ed.), pp. 411-424. Schwabe & Co., Basel/Stuttgart.
3. 3. Andreesen R., Modolell M., Weltzien H. U., Eibl H., Common H. H., Lohs G. W. & Munder P. G. (1978) Selective destruction of human leukemic cells by alkyl-lysophospholipids. Cancer Res. 38, 3894.
4. 4. Modelell M., Andreesen R., Pahlke W., Brugger U. & Munder P. G. (1979) Disturbance of phospholipid metabolism by the selective destruction of tumor cells by alkyl-lysophospholipids. Cancer Res. 39, 4681.
5. 5. Vogler W. R., Whigham E., Bennett W. D. & Olson A. C. (1985) The effect of alkyl-lysophospholipids on phosphatidylcholine biosynthesis in leukemic cell lines. Expl Hematol. 13, 629.
6. 6. Hoffman D. R., Hadju J. & Snyder F. (1984) Cytotoxicity of platelet activating factor and related alkyl-phospholipid analogs in human leukemic cells, polymorphonuclear neutrophils, and skin fibroblasts. Blood 63, 545.
7. 7. Verdonck L. F., Witteveen E. O., Heugten H. G. van, Rozemuller E. & Rijksen G. (1990) Selective killing of malignant cells from leukemic patients by alkyl-lysophospholipid. Cancer Res. 50, 4020.
8. 8. Planting A. S. T., Stoter G. & Verweij J. (1993) Phase II study of daily oral miltefosine (hexadecylphosphocholine) in advanced colorectal cancer. Eur. J. Cancer 29A, 518.
9. 9. Shoji M., Raynor R. L., Berdel W. E., Vogler W. R. & Kuo J. F. (1988) Effects of thioether phospholipid BM 41.440 on protein kinase C and phorbol ester-induced differentiation of human leukemia HL60 and KG-1 cells. Cancer Res. 48, 6669.
10. 10. Powis G., Seewald M. J., Gratas C., Melder D., Riebow J. & Modest E. J. (1992) Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 52, 2835.
11. 11. Zheng B., Oishi K., Shoji M., Effil H., Berdel W. E., Hadju J. & Vogler W. R. (1990) Inhibition of protein kinase C, (Na-K-ATPase) and sodium pump by synthetic phospholipid analogues. Cancer Res. 50, 3025.
12. 12. Vogler W. R. & Olson A. C. (1987) The effect of alkyl-lysophospholipids on phosphatidylcholine biosynthesis. In Die Zellmembrane als Angriffspunck der Tumortherapie (Unger C., Eibl H. & Nagel G. A., Eds), pp. 80-92. W. Zuckschwerdt Verlag, Munich.
13. 13. Tidwell T., Guzman G. & Vogler W. R. (1981) The effect of alkyl-lysophospholipids on leukemic cell lines. I. differential action on two human leukemic cell lines, HL60 and K562. Blood 57, 794.
14. 14. Weinhold P. A. & Feldman D. A. (1992) Choline-phosphate cytidylyltransferase. In Methods in Enzymology (Dennis E. A. & Vance D. E., Eds), pp. 248-258. Academic Press, San Diego.
15. 15. Laemmli U. K. (1970) Cleavage of structured protein during the assembly of the head of bacteriophage T4. Nature 227, 680.
16. 16. Bensadown A. & Weinstein D. (1976) Assays of proteins in the presence of interfering materials. Anal. Biochem. 70, 241.
17. 17. Sambrook J., Fritsch E. F. & Maniatis T. (1995) In Molecular Cloning (Sambrook J., Fritsch E. F. & Maniatis T., Eds), p. 1200. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
18. 18. Kalmar G. B., Kay R. J., LaChance A. C. & Cornell R. B. (1994) Primary structure and expression of a human CTP:phosphocholine cytidylyltransferase. Biochim. Biophys. Acta 1219, 328.
19. 19. Sleight R. & Kent C. (1980) Regulation of phosphatidylcholine biosynthesis in cultured chick embryonic muscle treated with phospholipase C. J. Biol. Chem. 255, 10644.
20. 20. Pelech S. L., Pritchard P. H., Brindley D. N. & Vance D. E. (1983) Fatty acids promote translocation of CTP:phosphocholine cytidylyltransferase to the endoplasmic reticulum and stimulate rat hepatic phosphatidylcholine synthesis. J. Biol. Chem. 258, 6782.
21. 21. Pelech S. L., Cook H. W., Paddon H. B. & Vance D. E. (1984) Membrane-bound CTP:phosphocholine cytidylyltransferase regulates the rate of phosphatidylcholine synthesis in HeLa cells treated with unsaturated fatty acids. Biochim. Biophys. acta 795, 433.
22. 22. Watkins J. D. & Kent C. (1991) Regulation of CTP:phosphocholine cytidylyltransferase and subcellular location of phosphorylation in Chinese hamster ovary cells. J. Biol. Chem. 266, 21113.
23. 23. Pelech S. L. & Vance D. E. (1982) Regulation of rat liver cytosolic CTP:phosphocholine cytidylyltransferase by phosphorylation and dephosphorylation. J. Biol. Chem. 257, 14198.
24. 24. Kiss Z., Deli E., Vogler W. R. & Kuo J. F. (1987) Antileukemia agent alkyl-lysophospholipid regulates phosphorylation of distinct proteins in HL60 and K562 cells promoted by phorbol ester. Biochem. Biophys. Res. Commun. 142, 661.
25. 25. Geilen C. G., Wieder T. & Reutter W. (1991) Hexadecylphosphocholine inhibits translocation of CTP:phosphocholine cytidylyltransferase in Madin-Darby canine kidney cells. J. Biol. Chem 267, 6719.
26. 26. Unger C., Eibl H., Heyden H. W. von, Peukert M., Sindermann H. & Nagel G. A. (1990) Phase I study with daily hexadecylphosphocholine in patients with malignant disease. J. Cancer Res. Clin. Oncol. 116, 993.