Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease

Toxicology and Applied Pharmacology

Volumn 232, Issue 2, 2008, Pages 236-243

  Bradford, Blair U ^a   O'Connell, Thomas M ^b   Han, Jun ^a   Kosyk, Oksana ^a   Shymonyak, Svitlana ^a   Ross, Pamela K ^a   Winnike, Jason ^b   Kono, Hiroshi ^c   Rusyn, Ivan ^a  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Alcohol; Liver; Metabolomics; Mouse

Indexed keywords

ACEGLUTAMIDE; ADRENIC ACID; ALANINE AMINOTRANSFERASE; ALCOHOL; AMINOACYLASE; CARBOHYDRATE; CORN OIL; DOPAMINE; GLUTATHIONE; LACTIC ACID; LEVODOPA; PROTEIN; TAURINE; THYROID HORMONE; TYROSINE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL LIVER CIRRHOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; C57BL 6 MOUSE; CONTROLLED STUDY; FATTY LIVER; GLYCOLYSIS; HEPATITIS; HYPOXIA; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; LACTATE BLOOD LEVEL; LIPID PEROXIDATION; LIVER INJURY; LIVER NECROSIS; MALE; METABOLOMICS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; THROMBOCYTOPOIESIS; URINALYSIS;

ALCOHOL DRINKING; ANIMALS; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; ETHANOL; LIVER DISEASES, ALCOHOLIC; MALE; MICE; MICE, INBRED C57BL;

MUS; ZEA MAYS;

EID: 52049096143     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.06.022     Document Type: Article

References (45)

1. Arteel G.E., Iimuro Y., Yin M., Raleigh J.A., and Thurman R.G. Chronic senteral ethanol treatment causes hypoxia in rat liver tissue in vivo. Hepatology 25 (1997) 920-926
2. Arteel G.E., Uesugi T., Bevan L.N., Gabele E., Wheeler M.D., McKim S.E., and Thurman R.G. Green tea extract protects against early alcohol-induced liver injury in rats. Biol. Chem. 383 (2002) 663-670
3. Bakker J. Blood lactate levels. Current Opinion in Critical Care. 5 (1999) 234-238
4. Bhopale K.K., Wu H., Boor P.J., Popov V.L., Ansari G.A., and Kaphalia B.S. Metabolic basis of ethanol-induced hepatic and pancreatic injury in hepatic alcohol dehydrogenase deficient deer mice. Alcohol 39 (2006) 179-188
5. Bleyman M.A., and Thurman R.G. Comparison of acute and chronic ethanol administration on rates of ethanol elimination in the rat in vivo. Biochem. Pharmacol. 28 (1979) 2027-2030
6. Bradford B.U., Kono H., Isayama F., Kosyk O., Wheeler M.D., Akiyama T.E., Bleye L., Krausz K.W., Gonzalez F.J., Koop D.R., and Rusyn I. Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver. Hepatology 41 (2005) 336-344
7. Donohue T.M., Curry-McCoy T.V., Nanji A.A., Kharbanda K.K., Osna N.A., Radio S.J., Todero S.L., White R.L., and Casey C.A. Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats. Alcohol. Clin. Exp. Res.. (2007)
8. Donohue Jr. T.M., Curry-McCoy T.V., Todero S.L., White R.L., Kharbanda K.K., Nanji A.A., and Osna N.A. l-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury. Alcohol. Clin. Exp. Res. 31 (2007) 1053-1060
9. Droenner P., Schmitt G., Aderjan R., and Zimmer H. A kinetic model describing the pharmacokinetics of ethyl glucuronide in humans. Forensic. Sci. Int. 126 (2002) 24-29
10. Enomoto N., Yamashina S., Kono H., Schemmer P., Rivera C.A., Enomoto A., Nishiura T., Nishimura T., Brenner D.A., and Thurman R.G. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Hepatology 29 (1999) 1680-1689
11. Enomoto N., Ikejima K., Yamashina S., Enomoto A., Nishiura T., Nishimura T., Brenner D.A., Schemmer P., Bradford B.U., Rivera C.A., Zhong Z., and Thurman R.G. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Am. J. Physiol. Gastrointest. Liver. Physiol. 279 (2000) G100-G106
12. Fischer M., You M., Matsumoto M., and Crabb D.W. Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J. Biol. Chem. 278 (2003) 27997-28004
13. Gerlo E., Van Coster R., Lissens W., Winckelmans G., De Meirleir L., and Wevers R. Gas chromatographic-mass spectrometric analysis of N-acetylated amino acids: the first case of aminoacylase I deficiency. Anal. Chim. Acta. 571 (2006) 191-199
14. Gyamfi M.A., Damjanov I., French S., and Wan Y.J. The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury. Biochem. Pharmacol. 75 (2008) 981-995
15. Han J., Danell R.M., Patel J.R., Gumerov D.R., Scarlett C.O., Speir J.P., Parker C.E., Rusyn I., Zeisel S., and Borchers C.H. Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry. Metabolomics 4 (2008) 128-140
16. Isayama F., Froh M., Bradford B.U., McKim S.E., Kadiiska M.B., Connor H.D., Mason R.P., Koop D.R., Wheeler M.D., and Arteel G.E. The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice. Free. Radic. Biol. Med. 35 (2003) 1568-1581
17. Ji S., Lemasters J.J., Christenson V., and Thurman R.G. Periportal and pericentral pyridine nucleotide fluorescence from the surface of the perfused liver: evaluation of the hypothesis that chronic treatment with ethanol produces pericentral hypoxia. Proc. Natl. Acad. Sci. U. S. A. 79 (1982) 5415-5419
18. Kono H., Bradford B.U., Yin M., Sulik K.K., Koop D.R., Peters J.M., Gonzalez F.J., McDonald T., Dikalova A., Kadiiska M.B., Mason R.P., and Thurman R.G. CYP2E1 is not involved in early alcohol-induced liver injury. Am. J. Physiol 277 (1999) G1259-G1267
19. Kono H., Rusyn I., Yin M., Gabele E., Yamashina S., Dikalova A., Kadiiska M.B., Connor H.D., Mason R.P., Segal B.H., Bradford B.U., Holland S.M., and Thurman R.G. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J. Clin. Invest 106 (2000) 867-872
20. Koshkin V., and Dunford H.B. Reaction of prostaglandin endoperoxide synthase with cis,cis-eicosa-11,14-dienoic acid. J. Biol. Chem. 273 (1998) 6046-6049
21. Lieber C.S., and DeCarli L.M. The feeding of alcohol in liquid diets: two decades of applications and 1982 update. Alcohol. Clin. Exp. Res. 6 (1982) 523-531
22. Llacuna L., Mari M., Garcia-Ruiz C., Fernandez-Checa J.C., and Morales A. Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. Hepatology 44 (2006) 561-572
23. London R.E., and Houck D.R. Introduction to metabolomics and metabolomic profiling. In: Hamadeh H.K., and Afshari C.A. (Eds). Toxicogenomics Principles and Applications (2004), John Wiley & Sons, Hoboken, NJ 299-340
24. Mann C.J., Kaduce T.L., Figard P.H., and Spector A.A. Docosatetraenoic acid in endothelial cells: formation, retroconversion to arachidonic acid, and effect on prostacyclin production. Arch. Biochem. Biophys. 244 (1986) 813-823
25. Mitchell M.E. Carnitine metabolism in human subjects. I. Normal metabolism. Am. J. Clin. Nutr. 31 (1978) 293-306
26. Nanji A.A., Mendenhall C.L., and French S.W. Beef fat prevents alcoholic liver disease in the rat. Alcohol. Clin. Exp. Res. 13 (1989) 15-19
27. Nanji A.A., Sadrzadeh S.M., Thomas P., and Yamanaka T. Eicosanoid profile and evidence for endotoxin tolerance in chronic ethanol-fed rats. Life. Sci. 55 (1994) 611-620
28. Nicholas P.C., Kim D., Crews F.T., and Macdonald J.M. Proton nuclear magnetic resonance spectroscopic determination of ethanol-induced formation of ethyl glucuronide in liver. Anal. Biochem. 358 (2006) 185-191
29. Nicholas P.C., Kim D., Crews F.T., and Macdonald J.M. (1)H NMR-based metabolomic analysis of liver, serum and brain following ethanol administration in rats. Chem. Res. Toxicol. 21 (2008) 408-420
30. Purohit V., and Brenner D.A. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Hepatology 43 (2006) 872-878
31. Purohit V., Khalsa J., and Serrano J. Mechanisms of alcohol-associated cancers: introduction and summary of the symposium. Alcohol 35 (2005) 155-160
32. Racine S.X., Le Toumelin P., Adnet F., Cohen Y., Cupa M., Hantz E., and Le Moyec L. N-acetyl functions and acetate detected by nuclear magnetic resonance spectroscopy of urine to detect renal dysfunction following aminoglycoside and/or glycopeptide antibiotic therapy. Nephron. Physiol. 97 (2004) 53-57
33. Ronis M.J., Lumpkin C.K., Ingelman-Sundberg M., and Badger T.M. Effects of short-term ethanol and nutrition on the hepatic microsomal monooxygenase system in a model utilizing total enteral nutrition in the rat. Alcohol. Clin. Exp. Res. 15 (1991) 693-699
34. Schoenfeld H., Von Heymann C., Lau A., Krocker D., Neuner B., Schink T., Schwenk W., and Spies C.D. The effect of stress-reducing, low-dose ethanol infusion on frequency of bleeding complications in long-term alcoholic patients undergoing major surgery. Am. Surg. 73 (2007) 192-198
35. Shin H.K., and Linkswiler H.M. Tryptophan and methionine metabolism of adult females as affected by vitamin B-6 deficiency. J. Nutr. 104 (1974) 1348-1355
36. Sibley D., and Jerrells T.R. Alcohol consumption by C57BL/6 mice is associated with depletion of lymphoid cells from the gut-associated lymphoid tissues and altered resistance to oral infections with Salmonella typhimurium. J. Infect. Dis. 182 (2000) 482-489
37. Simon J.A., Fong J., Bernert Jr. J.T., and Browner W.S. Relation of smoking and alcohol consumption to serum fatty acids. Am. J. Epidemiol. 144 (1996) 325-334
38. Thurman R.G. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am. J. Physiol 275 (1998) G605-G611
39. Thurman R.G., Paschal D., Abu-Murad C., Pekkanen L., Bradford B.U., Bullock K., and Glassman E. Swift increase in alcohol metabolism (SIAM) in the mouse: comparison of the effect of short-term ethanol treatment on ethanol elimination in four inbred strains. J. Pharmacol. Exp. Ther. 223 (1982) 45-49
40. Tsukamoto H., Reidelberger R.D., French S.W., and Largman C. Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am. J. Physiol 247 (1984) R595-R599
41. Tsukamoto H., Gaal K., and French S.W. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology 12 (1990) 599-608
42. Williamson J.R., Scholz R., Browning E.T., Thurman R.G., and Fukami M.H. Metabolic effects of ethanol in perfused rat liver. J. Biol. Chem. 244 (1969) 5044-5054
43. Wurst F.M., Kempter C., Seidl S., and Alt A. Ethyl glucuronide-a marker of alcohol consumption and a relapse marker with clinical and forensic implications. Alcohol. Alcohol. 34 (1999) 71-77
44. Yin M., Wheeler M.D., Kono H., Bradford B.U., Gallucci R.M., Luster M.I., and Thurman R.G. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology 117 (1999) 942-952
45. Yuki T., and Thurman R.G. The swift increase in alcohol metabolism. Time course for the increase in hepatic oxygen uptake and the involvement of glycolysis. Biochem. J. 186 (1980) 119-126