Ginkgo extract EGb 761 ® shields from slowly accumulating neurodegenerative-like changes in a newly developed cell culture model induced by the combined action of low doses of antimycin A1 and 2-deoxy-d-glucose

Journal of Neural Transmission

Volumn 118, Issue 8, 2011, Pages 1247-1254

  Plaschke, Konstanze ^a   Bergmann, Marion ^a   Kopitz, Jürgen ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Aging; Ginkgo biloba; Mitochondria; Neurodegeneration; Neuroprotection; Oxidative stress

Indexed keywords

ANTIMYCIN A1; DEOXYGLUCOSE; GINKGO BILOBA EXTRACT; MITOCHONDRIAL DNA;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL FUNCTION; CELL STRESS; HUMAN; HUMAN CELL; LIPID OXIDATION; MITOCHONDRION; NERVE DEGENERATION; NEUROBLASTOMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANTIMYCIN A; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; DEOXYGLUCOSE; DRUG THERAPY, COMBINATION; HUMANS; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PLANT EXTRACTS; TIME FACTORS;

EID: 80051586839     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-011-0637-2     Document Type: Article

References (35)

1. R Abdel-Kader S Hauptmann U Keil I Scherping K Leuner A Eckert WE Müller 2007 Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761) Pharmacol Res 56 493 502 17977008 10.1016/j.phrs.2007.09.011 1:CAS:528:DC%2BD2sXhtlGgsrvM (Pubitemid 350148165)
2. B Ahlemeyer J Krieglstein 2003 Neuroprotective effects of Ginkgo biloba extract Cell Mol Life Sci 60 1779 1792 14523543 10.1007/s00018-003-3080-1 1:CAS:528:DC%2BD3sXotF2jt70%3D (Pubitemid 37222578)
3. RS Balaban S Nemoto T Finkel 2005 Mitochondria, oxidants, and aging Cell 120 483 495 15734681 10.1016/j.cell.2005.02.001 1:CAS:528:DC%2BD2MXitVWnurg%3D (Pubitemid 40269763)
4. Bergmeyer HU, Bernt E (1974) Lactate dehydrogenase. UV-assay with pyruvate and NADH. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 574-579
5. JL Biedler L Helson BA Spengler 1973 Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture Cancer Res 33 2643 2652 4748425 1:STN:280:DyaE2c%2FitFCluw%3D%3D
6. O Colak A Sahin O Alatas M Inal B Yasar H Kiper 1998 The effect of Ginkgo biloba on the activity of catalase and lipid peroxidation in experimental strangulation ileus Int J Clin Lab Res 28 69 71 9594365 10.1007/BF02874083 1:CAS:528:DyaK1cXktFSrt78%3D
7. A Eckert U Keil S Kressmann K Schindowski S Leutner S Leutz WE Müller 2003 Effects of EGb 761 Ginkgo biloba extract on mitochondrial function and oxidative stress Pharmacopsychiatry 36 Suppl 1 S15 S23 13130384 1:CAS:528:DC%2BD3sXnvVSltr4%3D
8. A Eckert U Keil I Scherping S Hauptmann WE Müller 2005 Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761 Ann N Y Acad Sci 1056 474 485 16387710 10.1196/annals.1352.023 (Pubitemid 43031000)
9. J Emerit M Edeas F Bricaire 2004 Neurodegenerative diseases and oxidative stress Biomed Pharmacother 58 39 46 14739060 10.1016/j.biopha.2003.11.004 1:CAS:528:DC%2BD2cXltVKmtw%3D%3D (Pubitemid 38117047)
10. A Erol 2009 Unraveling the molecular mechanisms behind the metabolic basis of sporadic Alzheimer's disease J Alzheimers Dis 17 267 276 19221404 1:CAS:528:DC%2BD1MXmvVOiur0%3D
11. H Esterbauer RJ Schaur H Zollner 1991 Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Free Radic Biol Med 11 81 128 1937131 10.1016/0891-5849(91)90192-6 1:CAS:528:DyaK3MXmsFSnsbo%3D (Pubitemid 121003917)
12. C Frezza S Cipolat L Scorrano 2007 Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts Nat Protoc 2 287 295 17406588 10.1038/nprot.2006.478 1:CAS:528:DC%2BD2sXhtFGntbrF (Pubitemid 47040043)
13. X Kang J Chen Z Xu H Li B Wang 2007 Protective effects of Ginkgo biloba extract on paraquat-induced apoptosis of PC12 cells Toxicol In Vitro 21 1003 1009 17509817 10.1016/j.tiv.2007.02.004 1:CAS:528:DC%2BD2sXovFKktr0%3D (Pubitemid 47238224)
14. J Kopitz C von Reitzenstein K Sinz M Cantz 1996 Selective ganglioside desialylation in the plasma membrane of human neuroblastoma cells Glycobiology 6 367 376 8724144 10.1093/glycob/6.3.367 1:STN:280:DyaK28zht1Grug%3D%3D (Pubitemid 26156455)
15. J Kopitz FG Holz E Kaemmerer F Schutt 2004 Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration Biochimie 86 825 831 15589692 10.1016/j.biochi.2004.09.029 1:CAS:528:DC%2BD2cXhtVKksLbE (Pubitemid 39602762)
16. C Labarca K Paigen 1980 A simple, rapid, and sensitive DNA assay procedure Anal Biochem 102 344 352 6158890 10.1016/0003-2697(80)90165-7 1:CAS:528:DyaL3cXhsF2qurk%3D (Pubitemid 10115803)
17. Z Li K Ya W Xiao-Mei Y Lei L Yang QZ Ming 2008 Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity J Cell Biochem 103 564 575 17647269 10.1002/jcb.21427 1:CAS:528:DC%2BD1cXhsFOnsL4%3D (Pubitemid 351171927)
18. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275 14907713 1:CAS:528: DyaG38XhsVyrsw%3D%3D
19. I Maitra L Marcocci MT Droy-Lefaix L Packer 1995 Peroxyl radical scavenging activity of Ginkgo biloba extract EGb 761 Biochem Pharmacol 49 1649 1655 7786306 10.1016/0006-2952(95)00089-I 1:CAS:528:DyaK2MXmt1ShsLo%3D
20. PI Moreira X Zhu X Wang HG Lee A Nunomura RB Petersen G Perry MA Smith 2010 Mitochondria: a therapeutic target in neurodegeneration Biochim Biophys Acta 1802 212 220 19853657 1:CAS:528:DC%2BD1MXhsFanurnJ
21. MS Parihar EA Kunz GJ Brewer 2008 Age-related decreases in NAD(P)H and glutathione cause redox declines before ATP loss during glutamate treatment of hippocampal neurons J Neurosci Res 86 2339 2352 18438923 10.1002/jnr.21679 1:CAS:528:DC%2BD1cXptlaltr8%3D
22. L Petrozzi G Ricci NJ Giglioli G Siciliano M Mancuso 2007 Mitochondria and neurodegeneration Biosci Rep 27 87 104 17486441 10.1007/s10540-007-9038-z 1:CAS:528:DC%2BD2sXmsVOjtbw%3D (Pubitemid 46940938)
23. K Plaschke J Kopitz MA Weigand E Martin HJ Bardenheuer 2000 The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia Neurosci Lett 284 109 112 10771174 10.1016/S0304-3940(00)00988-5 1:CAS:528:DC%2BD3cXisFGksbY%3D (Pubitemid 30193211)
24. G Rimbach S Wolffram C Watanabe L Packer K Gohil 2003 Effect of Ginkgo biloba (EGb 761) on differential gene expression Pharmacopsychiatry 36 Suppl 1 S95 S99 13130396 1:CAS:528:DC%2BD3sXnvVSlt7w%3D
25. C Rodolfo F Ciccosanti GD Giacomo M Piacentini GM Fimia 2010 Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases Expert Rev Proteomics 7 519 542 20653508 10.1586/epr.10.43 1:CAS:528:DC%2BC3cXpsVahsrs%3D
26. LM Sayre G Perry MA Smith 2008 Oxidative stress and neurotoxicity Chem Res Toxicol 21 172 188 18052107 10.1021/tx700210j (Pubitemid 351219718)
27. H Scholtyssek W Damerau R Wessel I Schimke 1997 Antioxidative activity of ginkgolides against superoxide in an aprotic environment Chem Biol Interact 106 183 190 9413545 10.1016/S0009-2797(97)00067-7 1:CAS:528:DyaK2sXntVOitrY%3D (Pubitemid 27515085)
28. F Schutt B Ueberle M Schnölzer FG Holz J Kopitz 2002 Proteome analysis of lipofuscin in human retinal pigment epithelial cells FEBS Lett 528 217 221 12297308 10.1016/S0014-5793(02)03312-4 1:CAS:528:DC%2BD38Xnt1Klu7Y%3D (Pubitemid 35258027)
29. F Schutt M Bergmann FG Holz J Kopitz 2003 Proteins modified by malondialdehyde, 4-hydroxynonenal, or advanced glycation end products in lipofuscin of human retinal pigment epithelium Invest Ophthal Vis Sci 44 3663 3668 12882821 10.1167/iovs.03-0172 (Pubitemid 36909809)
30. C Shi L Zhao B Zhu Q Li DT Yew Z Yao J Xu 2009 Dosage effects of EGb761 on hydrogen peroxide-induced cell death in SH-SY5Y cells Chem Biol Interact 180 389 397 19414004 10.1016/j.cbi.2009.04.008 1:CAS:528:DC%2BD1MXnsFaku7o%3D
31. C Shi L Zhao B Zhu Q Li DT Yew Z Yao J Xu 2009 Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells Chem Biol Interact 181 115 123 19464278 10.1016/j.cbi.2009.05.010 1:CAS:528: DC%2BD1MXptValtb4%3D
32. C Shi J Liu F Wu DT Yew 2010 Ginkgo biloba extract in Alzheimer's disease: from action mechanisms to medical practice Int J Mol Sci 11 107 123 20162004 10.3390/ijms11010107 1:CAS:528:DC%2BC3cXhtVyhs7c%3D
33. JV Smith Y Luo 2004 Studies on molecular mechanisms of Ginkgo biloba extract Appl Microbiol Biotechnol 64 465 472 14740187 10.1007/s00253-003-1527-9 1:CAS:528:DC%2BD2cXjtFyis74%3D (Pubitemid 38686154)
34. EA Tendi F Bosetti SF Dasgupta AM Stella K Drieu SI Rapoport 2002 Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells Neurochem Res 27 319 323 11958534 10.1023/A:1014963313559 1:CAS:528:DC%2BD3sXjsFGg (Pubitemid 34273574)
35. Y Xu C Cui C Pang Y Christen Y Luo 2007 Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells Eur J Neurosci 26 2931 2939 18001288 10.1111/j.1460-9568.2007.05905.x (Pubitemid 350115515)