Antioxidative activity of ginkgolides against superoxide in an aprotic environment

Chemico-Biological Interactions

Volumn 106, Issue 3, 1997, Pages 183-190

  Scholtyssek, Hardy ^a   Damerau, Werner ^a,b   Wessel, Ralf ^b   Schimke, Ingolf ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Antioxidant properties; Ginkgo biloba; Radicals

Indexed keywords

ANTIOXIDANT; GINKGO BILOBA EXTRACT;

ARTICLE; CHEMICAL REACTION; DRUG DETERMINATION; DRUG EFFECT; DRUG ISOLATION; GINKGO BILOBA; NONHUMAN; OXIDATION REDUCTION REACTION;

ANTIOXIDANTS; CYCLOPENTANES; DIMETHYL SULFOXIDE; DITERPENES; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; FURANS; GINKGO BILOBA; GINKGOLIDES; PLANT EXTRACTS; SPECTROPHOTOMETRY, ULTRAVIOLET; SUPEROXIDES;

GINKGO BILOBA;

EID: 0030732519     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(97)00067-7     Document Type: Article

References (22)

1. F.V. De Feudis, Pharmacological activities and clinical applications, in: Ginkgo biloba Extract Egb761, Edition Scientifiques Elsevier, Paris, 1991, pp. 1-8.
2. M. Joyeux, A. Lobstein, R. Anton, F. Mortier, Comparative antilipoperoxidant, antinecrotic and scavenging properties of terpenes and biflavones from Ginkgo and some flavonoids, Planta Med. 61 (1995) 126-129.
3. N. Haramaki, L. Packer, MT. Droy-Lefaix, Y. Christen, Antioxidant actions and health implications of Ginkgo biloba extract, in: Handbook of Antioxidants, Edition Enrique Cadenas/Lester Packer, New York, 1996, pp. 487-510.
4. J. Maitra, L. Marcocci, M.T. Drog-Lefaix, L. Packer, Peroxylradical scavenging activity of Ginkgo biloba extract Egb761, Biochem. Pharmacol. 49 (1995) 1649-1655.
5. J. Pincemail, M. Dupuis, C. Nasr, Superoxide anion scavenging effect and superoxide dismutase activity of Ginkgo biloba extract, Experientia 45 (1989) 708-712.
6. M. Diwok, B. Kuklinski, B. Ernst, Superoxide dismutase activity of Ginkgo biloba extract, Z. Gesamte Inn. Med. 47 (1992) 308-311.
7. L. Marcocci, J.J. Maguire, M.T. Drog-Lefaix, L. Packer, The nitric oxide scavenging property of Ginkgo biloba extract Egb761, Biochem. Biophys. Res. Commun. 201 (1994) 748-755.
8. L.J. Yan, M.T. Drog-Lefaix, L. Packer, Ginkgo biloba extract protects human low density lipoproteins against oxidative modification mediated by copper, Biochem. Biophys. Res. Commun. 212 (1995) 360-366.
9. K. Köse, P. Dogan, Lipoperoxidation induced by hydrogen peroxide in erythrocyte membranes. 1. Protective effect of Ginkgo biloba extract (EGb 761), J. Int. Med. Res. 23 (1995) 1-8.
10. P. Braquet, The Ginkgolides: Potent platelet activating factor antagonists isolated from Ginkgo biloba L.: chemistry, pharmacology and clinical applications, Drugs Future 12 (1987) 643-699.
11. J. Torras, J.R. Bordalba, D. Seron, R. Moliner, M. Carrera, J. Valles, A. Martinez-Castelao, J, Alsina, J.M. Grino, Protective effect of the PAF antagonist BN 52021 in an experimental renal warm ischemia model, Transplant. Int. 6 (1993) 236.
12. B. Spinnewyn, N. Blavet, F. Clostre, Effects of Ginkgo biloba extract on a cerebral ischemia model in gerbils, Presse Med. 15 (1986) 1511-1515.
13. D.L. Birkle, P. Kurian, P. Braquet, N.G. Bazan, Platelet-activating factor antagonist BN52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock, Neurochem. J. 51 (1988) 1900-1905.
14. N.W.R. Wickham, G.M. Vercelotti, H.Q. Yin, C.F. Moldow, H.S. Jacob, Neutrophils are primed to release toxic oxidants by contact with thrombin-stimulated endothelium; role of endothelial cell-generated platelet activating factor, Clin. Res. 35 (1987) 603.
15. K. Weinges, M. Hepp, H. Jaggy, Isolierung und Strukturaufklärung eines neuen Ginkgolids, Liebigs Ann. Chem. (1987) 521-626.
16. K. Weinges, M. Rümmler, H. Schick, Herstellung von 1,10-Dihydroxy- und 1,7,10-Trihydroxyginkgolid aus 1,3,7,10-Tetrahydroxyginkgolid, Liebigs Ann. Chem. (1993) 1023-1027.
17. 2 DMSO solutions, FEBS Lett. 135 (1981) 265-267.
18. K. Reszka, C.F. Chignell, Spin-trapping of the superoxide radical in aprotic solvents, Free Rad. Res. Commun. 14 (1991) 97-106.
19. 2 with unsaturated fatty acids, J. Biol. Chem. 258 (1983) 4759-4761.
20. J.M. Gebicki, B.H.J. Bielski, Comparism of the capacities of the perhydroxyl and the superoxide radicals to initiate chain oxidation of linoleic acid, J. Am. Chem. Soc. 103 (1981) 7020-7022.
21. A. Dabrowski, A. Gabryelewicz, L. Chyczewski, The effect of platelet activating factor antagonist (BN 52021) on cerulein-induced acute pancreatitis with reference to oxygen radicals, Int. J. Pancreatol. 8 (1991) 1-11.
22. M.T. Droy-Lefaix, Y. Drouet, G. Geraud, D. Hosford, P. Braquet, Superoxide dismutase (SOD) and the PAF-antagonist (BN 52021) reduce small intestinal damage induced by ischemia-reperfusion, Free Rad. Res. Commun. 12-13 (2) (1991) 725-735.