Structure-activity relationships of GHRP-6 azapeptide ligands of the CD36 Scavenger Receptor by solid-phase submonomer azapeptide synthesis

Journal of the American Chemical Society

Volumn 133, Issue 32, 2011, Pages 12493-12506

  Sabatino, David ^a,b   Proulx, Caroline ^a   Pohankova, Petra ^a   Ong, Huy ^a   Lubell, William D ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b SETON HALL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AQUEOUS MEDIA; AROMATIC CATIONS; AROMATIC RESIDUES; AZAPEPTIDES; BINDING AFFINITIES; BINDING STUDIES; BIOLOGICAL FUNCTIONS; CD SPECTRA; CLASS B; DEPROTECTION; INTRAMOLECULAR CYCLIZATIONS; LIGAND-RECEPTOR BINDING; MICHAEL ACCEPTORS; MICHAEL ADDUCTS; N-TERMINALS; PEPTIDE SEQUENCES; PHOSPHAZENE BASE; POLYPROLINE; RANDOM COIL; RECEPTOR BINDING; SALT BRIDGES; SCAVENGER RECEPTOR; SECONDARY STRUCTURES; SEMICARBAZONES; SIDE-CHAINS; SOLID PHASE SYNTHESIS; SOLID-PHASE; STRUCTURAL STUDIES; STRUCTURE ACTIVITY RELATIONSHIPS; SYNTHETIC PEPTIDE; TYPE II;

AMINO ACIDS; AROMATIC COMPOUNDS; BINDING ENERGY; CHELATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES;

LIGANDS;

CD36 ANTIGEN; HEXARELIN; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; LIGAND; MONOMER; RADIOLIGAND; SCAVENGER RECEPTOR B; SEMICARBAZONE;

AFFINITY LABELING; ALKYLATION; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CIRCULAR DICHROISM; CONJUGATE; CONTROLLED STUDY; CYCLIZATION; DEPROTECTION REACTION; DIASTEREOISOMER; DRUG CONFORMATION; DRUG RECEPTOR BINDING; HEART MUSCLE FIBER MEMBRANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; LIGAND BINDING; MICHAEL ADDITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; RAT; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD36; AZA COMPOUNDS; OLIGOPEPTIDES; PROTEIN BINDING; RATS; SOLID-PHASE SYNTHESIS TECHNIQUES; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051580579     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja203007u     Document Type: Article

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