Telomere maintenance in wilms tumors: First evidence for the presence of alternative lengthening of telomeres mechanism

Genes Chromosomes and Cancer

Volumn 50, Issue 10, 2011, Pages 823-829

  Venturini, Lorenza ^a   Daidone, Maria Grazia ^a   Motta, Rosita ^a   Collini, Paola ^a   Spreafico, Filippo ^a   Terenziani, Monica ^a   Piva, Luigi ^a   Radice, Paolo ^a,b   Perotti, Daniela ^a   Zaffaroni, Nadia ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b IFOM Fondazione Istituto   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APB PROTEIN; CELL PROTEIN; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS INCLUSION BODY; CELL ORGANELLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; MALE; NEPHROBLASTOMA; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PULSED FIELD GEL ELECTROPHORESIS; RESTRICTION FRAGMENT; SCHOOL CHILD; TELOMERE; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

ADOLESCENT; ADULT; AGED; CELL LINE, TUMOR; CHILD; CHILD, PRESCHOOL; ELECTROPHORESIS, GEL, PULSED-FIELD; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KIDNEY NEOPLASMS; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; NEOPLASM STAGING; NUCLEIC ACID AMPLIFICATION TECHNIQUES; TELOMERASE; TELOMERE; TELOMERE HOMEOSTASIS; WILMS TUMOR;

EID: 80051560666     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20903     Document Type: Article

References (32)

1. Beckwith JB. 1983. Wilms' tumor and other renal tumors of childhood: A selective review from the National Wilms' Tumor Study Pathology Center. Hum Pathol 14: 481-492.
2. Brambilla C, Folini M, Gandellini P, Daprai L, Daidone MG, Zaffaroni N. 2004. Oligomer-mediated modulation of hTERT alternative splicing induces telomerase inhibition and cell growth decline in human prostate cancer cells. Cell Mol Life Sci 61: 1764-1774.
3. Cerone MA, Londono-Vallejo JA, Bacchetti S. 2001. Telomere maintenance by telomerase and by recombination can coexist in human cells. Hum Mol Genet 10: 1945-1952.
4. Costa A, Daidone MG, Daprai L, Villa R, Cantù S, Pilotti S, Mariani L, Gronchi A, Henson JD, Reddel RR, Zaffaroni N. 2006. Telomere maintenance mechanisms in liposarcomas: Association with histologic subtypes and disease progression. Cancer Res 66: 8918-8924.
5. Dome JS, Chung S, Bergemann T, Umbricht CB, Saji M, Carey LA, Grundy PE, Perlman EJ, Breslow NE, Sukumar S. 1999. High telomerase reverse transcriptase (hTERT) messenger RNA level correlates with tumor recurrence in patients with favourable histology Wilms' tumor. Cancer Res 59: 4301-4307.
6. Dome JS, Bockhold CA, Li SM, Baker SD, Green DM, Perlman EJ, Hill DA, Breslow NE. 2005. High telomerase RNA expression level is an adverse prognostic factor for favorable-histology Wilms' tumor. J Clin Oncol 23: 9138-9145.
7. Dunham MA, Neumann AA, Fasching CL, Reddel RR. 2000. Telomere maintenance by recombination in human cells. Nat Genet 26: 447-450.
8. Ford LP, Zou Y, Pongracz K, Gryaznov SM, Shay JW, Wright WE. 2001. Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells. J Biol Chem 276: 32198-32203.
9. Grant JD, Broccoli D, Muquit M, Manion FJ, Tisdall J, Ochs MF. 2001. Telometric: A tool providing simplified, reproducible measurements of telomeric DNA from constant field agarose gels. Biotechniques 31: 1314-1316.
10. Grobelny JV, Kulp-McEliece M, Broccoli D. 2001. Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway. Hum Mol Genet 10: 1953-1961.
11. Hakin-Smith V, Jellinek DA, Levy D, Carroll T, Teo M, Timperley WR, McKay MJ, Reddel RR, Royds JA. 2003. Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme. Lancet 361: 836-838.
12. Henson JD and Reddel RR. 2010. Assaying and investigating alternative lengthening of telomeres activity in human cells and cancers. FEBS Lett 584: 3800-3811.
13. Henson JD, Neumann AA, Yeager TR, Reddel RR. 2002. Alternative lengthening of telomeres in mammalian cells (Review). Oncogene 21: 598-610.
14. Henson JD, Hannay JA, McCarthy SW, Royds JA, Yeager TR, Robinson RA, Wharton SB, Jellinek DA, Arbuckle SM, Yoo J, Robinson BG, Learoyd DL, Stalley PD, Bonar SF, Yu D, Pollock RE, Reddel RR. 2005. A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. Clin Cancer Res 11: 217-225.
15. Jeyapalan JN, Mendez-Bermudez A, Zaffaroni N, Dubrova YE, Royle NJ. 2008. Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies. Int J Cancer 122: 2414-2421.
16. Johnson JE, Varkonyi RJ, Schwalm J, Cragle R, Klein-Szanto A, Patchefsky A, Cukierman E, von Mehren M, Broccoli D. 2005. Multiple mechanisms of telomere maintenance exist in liposarcomas. Clin Cancer Res 11: 5347-5355.
17. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015.
18. Li CM, Guo M, Borczuk A, Powell CA, Wei M, Thaker HM, Friedman R, Klein U, Tycko B. 2002. Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition. Am J Pathol 160: 2181-2190.
19. Montgomery E, Argani P, Hicks JL, DeMarzo AM, Meeker AK. 2004. Telomere lengths of translocation-associated and nontranslocation-associated sarcomas differ dramatically. Am J Pathol 164: 1523-1529.
20. Perrem K, Colgin LM, Neumann AA, Yeager TR, Reddel RR. 2001. Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol Cell Biol 21: 3862-3875.
21. Sanders RP, Drissi R, Billups CA, Daw NC, Valentine MB, Dome JS. 2004. Telomerase expression predicts unfavorable outcome in osteosarcoma. J Clin Oncol 22: 3790-3797.
22. Seger YR, García-Cao M, Piccinin S, Cunsolo CL, Doglioni C, Blasco MA, Hannon GJ, Maestro R. 2002. Transformation of normal human cells in the absence of telomerase activation. Cancer Cell 2: 401-413.
23. Shalaby T, Hiyama E, Grotzer MA. 2010. Telomere maintenance as therapeutic target in embryonal tumours. Anticancer Agents Med Chem 10: 196-212.
24. Stewart JL, Baird KM, Farr CJ. 2001. All's well that ends well. Trends Cell Biol 11: 279-280.
25. Tabori U, Dome JS. 2007. Telomere biology of pediatric cancer. Cancer Invest 25: 197-208.
26. Ulaner GA, Huang HY, Otero J, Zhao Z, Ben-Porat L, Satagopan JM, Gorlick R, Meyers P, Healey JH, Huvos AG, Hoffman AR, Ladanyi M. 2003. Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma. Cancer Res 63: 1759-1763.
27. Villa R, Folini M, Perego P, Supino R, Setti E, Daidone MG, Zunino F, Zaffaroni N. 2000. Telomerase activity and telomere length in human ovarian cancer and melanoma cell lines: Correlation with sensitivity to DNA damaging agents. Int J Oncol 16: 995-1002.
28. Villa R, Porta CD, Folini M, Daidone MG, Zaffaroni N. 2001. Possible regulation of telomerase activity by transcription and alternative splicing of telomerase reverse transcriptase in human melanoma. J Invest Dermatol 116: 867-873.
29. Villa R, Daidone MG, Motta R, Venturini L, De Marco C, Vannelli A, Kusamura S, Baratti D, Deraco M, Costa A, Reddel RR, Zaffaroni N. 2008. Multiple mechanisms of telomere maintenance exist and differentially affect clinical outcome in diffuse malignant peritoneal mesothelioma. Clin Cancer Res 14: 4134-4140.
30. Wittmann S, Wunder C, Zirn B Furtwängler R, Wegert J, Graf N, Gessler M. 2008. New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms' tumors. Genes Chromosomes Cancer 47: 386-395.
31. Yeager TR, Neumann AA, Englezou A, Huschtscha LI, Noble JR, Reddel RR. 1999. Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res 59: 4175-4179.
32. Zaffaroni N, Villa R, Pastorino U, Cirincione R, Incarbone M, Alloisio M, Curto M, Pilotti S, Daidone MG. 2005. Lack of telomerase activity in lung carcinoids is dependent on human telomerase reverse transcriptase transcription and alternative splicing and is associated with long telomeres. Clin Cancer Res 11: 2832-2839.