Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma

Cancer Research

Volumn 63, Issue 8, 2003, Pages 1759-1763

  Ulaner, Gary A ^a   Huang, Hsuan Ying ^b   Otero, Jesse ^a   Zhao, Zhiquan ^b   Ben Porat, Leah ^b   Satagopan, Jaya M ^b   Gorlick, Richard ^b   Meyers, Paul ^b   Healey, John H ^b   Huvos, Andrew G ^b   Hoffman, Andrew R ^a   Ladanyi, Marc ^b  

^a STANFORD UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

ADULT; AGE; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER SURVIVAL; CHROMOSOME ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG RESPONSE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; OSTEOSARCOMA; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROGNOSIS; SAMPLE; SURVIVAL RATE; TELOMERE;

ADULT; AGE FACTORS; BONE NEOPLASMS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; OSTEOSARCOMA; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TELOMERASE; TELOMERE;

EID: 0344837710     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Granger, M. P., Wright, W. E., and Shay, J. W, Telomerase in cancer and aging. Crit. Rev. Oncol. Hematol., 41: 29-40, 2002.
2. Maser, R. S., and DePinho, R. A. Connecting chromosomes, crisis, and cancer. Science (Wash. DC), 297: 565-569, 2002.
3. Bryan, T, M., Englezou, A., Dalla-Pozza, L., Dunham, M. A., and Reddel, R. R. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat. Med., 3: 1271-1274, 1997.
4. Henson, J. D., Neumann, A. A., Yeager, T. R., and Reddel, R. R. Alternative lengthening of telomeres in mammalian cells. Oncogene, 21: 598-610, 2002.
5. Scheel, C., Schaefer, K. L., Jauch, A., Keller, M., Wai, D., Brinkschmidt, C., van Valen, F., Boecker, W., Dockhorn-Dworniczak, B., and Poremba, C. Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas. Oncogene, 20: 3835-3844, 2001.
6. Meyers, P. A., Gorlick, R., Heller, G., Casper, E., Lane, J., Huvos, A. G., and Healey, J. H. Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol. J. Clin. Oncol., 16: 2452-2458, 1998.
7. Ulaner, G. A., Hu, J. F., Vu, T. H., Giudice, L. C., and Hoffman, A. R. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res., 58: 4168-4172, 1998.
8. Kleinschmidt-DeMasters, B. K., Hashizumi, T. L., Sze, C. I., Lillehei, K. O., Shroyer, A. L., and Shroyer, K. R. Telomerase expression shows differences across multiple regions of oligodendroglioma versus high grade astrocytomas but shows correlation with Mib-1 labelling. J. Clin. Pathol, 51: 284-293, 1998.
9. Yan, P., Benhattar, J., Coindre, J. M., and Guillou, L. Telomerase activity and hTERT mRNA expression can be heterogeneous and does not correlate with telomere length in soft tissue sarcomas. Int. J. Cancer, 98: 851-856, 2002.
10. Gisselsson, D., Jonson, T., Petersen, A., Strombeck, B., Dal Cin, P., Hoglund, M., Mitelman, F., Mertens, F., and Mandahl, N. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc. Natl. Acad. Sci. USA, 98: 12683-12688, 2001.
11. Gupta, J., Han, L. P., Wang, P., Gallie, B. L., and Bacchetti, S. Development of retinoblastoma in the absence of telomerase activity. J. Natl. Cancer Inst. (Bethesda), 88: 1152-1157, 1996.
12. Seger, Y. R., Garci, Cao, M., Piccinin, S., Cunsolo, C. L., Doglioni, C., Blasco, M. A., Hannon, G. J., and Maestro, R. Transformation of normal human cells in the absence of telomerase activation. Cancer Cell, 2: 401-413, 2002.
13. Lee, K. H., Rudolph, K. L., Ju, Y. J., Greenberg, R. A., Cannizzaro, L., Chin, L., Weiler, S. R., and DePinho, R. A. Telomere dysfunction alters the chemotherapeutic profile of transformed cells. Proc. Natl. Acad. Sci. USA, 98: 3381-3386, 2001.
14. Bielack, S. S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., Zoubek, A., Jurgens, H., and Winkler, K. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J. Clin. Oncol., 20: 776-790, 2002.
15. Perrem, K., Colgin, L. M., Neumann, A. A., Yeager, T. R., and Reddel, R. R. Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol. Cell. Biol., 21: 3862-3875, 2001.
16. Kyrion, G., Boakye, K. A., and Lustig, A. J. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol. Cell. Biol., 12: 5159-5173, 1992.
17. Krauskopf, A., and Blackburn, E. H. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature (Lond.), 383: 354-357, 1996.
18. Artandi, S. E., Alson, S., Tietze, M. K., Sharpless, N. E., Ye, S., Greenberg, R. A., Castrillon, D. H., Horner, J. W., Weiler, S. R., Carrasco, R. D., and DePinho, R. A. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl. Acad. Sci. USA, 99: 8191-8196, 2002.
19. Stewart, S. A., Hahn, W. C., O'Connor, B. F., Banner, E. N., Lundberg, A. S., Modha, P., Mizuno, H., Brooks, M. W., Fleming, M., Zimonjic, D. B., Popescu, N. C., and Weinberg, R. A. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc. Natl. Acad. Sci. USA, 99: 12606-12611, 2002.
20. Chang, S., Khoo, C. M., Naylor, M. L., Maser, R. S., and DePinho, R. A. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev., 17: 88-100, 2003.