메뉴 건너뛰기




Volumn 417, Issue 2, 2011, Pages 264-273

A high-throughput screening fluorescence polarization assay for fatty acid adenylating enzymes in Mycobacterium tuberculosis

Author keywords

Adenylate forming enzymes; Adenylation; Fluorescence polarization; High throughput screening; Mycobacterium tuberculosis

Indexed keywords

BIOCHEMISTRY; ENZYMES; FLUORESCENCE; KETONES; LIPIDS; POLARIZATION;

EID: 80051552656     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2011.06.037     Document Type: Article
Times cited : (12)

References (52)
  • 1
    • 84857064093 scopus 로고    scopus 로고
    • World Health Organization accessed on 16.05.11
    • World Health Organization, Fact Sheet on Tuberculosis, > http://www.who.int/tb/publications/2010/factsheet-tb-2010-rev21feb11.pdf > (accessed on 16.05.11).
    • Fact Sheet on Tuberculosis
  • 2
    • 12844278679 scopus 로고    scopus 로고
    • Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis
    • DOI 10.1128/CMR.18.1.81-101.2005
    • K. Takayama, C. Wang, and G.S. Besra Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis Clin. Microbiol. Rev. 18 2005 81 101 (Pubitemid 40170662)
    • (2005) Clinical Microbiology Reviews , vol.18 , Issue.1 , pp. 81-101
    • Takayama, K.1    Wang, C.2    Besra, G.S.3
  • 4
    • 0028061607 scopus 로고
    • Mycobacterial cell wall: Structure and role in natural resistance to antibiotics
    • V. Jarlier, and H. Nikaido Mycobacterial cell wall: structure and role in natural resistance to antibiotics FEMS Microbiol. Lett. 123 1994 11 18 (Pubitemid 24312557)
    • (1994) FEMS Microbiology Letters , vol.123 , Issue.1-2 , pp. 11-18
    • Jarlier, V.1    Nikaido, H.2
  • 5
    • 0030200404 scopus 로고    scopus 로고
    • Drug sensitivity and environmental adaptation of mycobacterial cell wall components
    • DOI 10.1016/0966-842X(96)10031-7
    • C.E. Barry 3rd, and K. Mdluli Drug sensitivity and environmental adaptation of mycobacterial cell wall components Trends Microbiol. 4 1996 275 281 (Pubitemid 26251780)
    • (1996) Trends in Microbiology , vol.4 , Issue.7 , pp. 275-281
    • Barry III, C.E.1    Mdluli, K.2
  • 6
    • 26444488572 scopus 로고    scopus 로고
    • The dimycocerosate ester polyketide virulence factors of mycobacteria
    • DOI 10.1016/j.plipres.2005.07.001, PII S0163782705000299
    • K.C. Onwueme, C.J. Vos, J. Zurita, J.A. Ferreras, and L.E. Quadri The dimycocerosate ester polyketide virulence factors of mycobacteria Prog. Lipid Res. 44 2005 259 302 (Pubitemid 41429297)
    • (2005) Progress in Lipid Research , vol.44 , Issue.5 , pp. 259-302
    • Onwueme, K.C.1    Vos, C.J.2    Zurita, J.3    Ferreras, J.A.4    Quadri, L.E.N.5
  • 7
    • 4544298326 scopus 로고    scopus 로고
    • A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
    • DOI 10.1038/nature02837
    • M.B. Reed, P. Domenech, C. Manca, H. Su, A.K. Barczak, B.N. Kreiswirth, G. Kaplan, and C.E. Barry 3rd A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response Nature 431 2004 84 87 (Pubitemid 39215112)
    • (2004) Nature , vol.430 , Issue.7004 , pp. 84-87
    • Reed, M.B.1    Domenech, P.2    Manca, C.3    Su, H.4    Barczak, A.K.5    Krelswirth, B.H.6    Kaplan, G.7    Barry III, C.E.8
  • 8
    • 33749675294 scopus 로고    scopus 로고
    • Sulfate metabolism in mycobacteria
    • DOI 10.1002/cbic.200600224
    • M.W. Schelle, and C.R. Bertozzi Sulfate metabolism in mycobacteria ChemBioChem 7 2006 1516 1524 (Pubitemid 44555996)
    • (2006) ChemBioChem , vol.7 , Issue.10 , pp. 1516-1524
    • Schelle, M.W.1    Bertozzi, C.R.2
  • 12
    • 1842577641 scopus 로고    scopus 로고
    • Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria
    • DOI 10.1038/nature02384
    • O.A. Trivedi, P. Arora, V. Sridharan, R. Tickoo, D. Mohanty, and R.S. Gokhale Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria Nature 428 2004 441 445 (Pubitemid 38419691)
    • (2004) Nature , vol.428 , Issue.6981 , pp. 441-445
    • Trivedi, O.A.1    Arora, P.2    Sridharan, V.3    Tickoo, R.4    Mohanty, D.5    Gokhale, R.S.6
  • 15
    • 21644469444 scopus 로고    scopus 로고
    • Promiscuous fatty acyl CoA ligases produce acyl-CoA and acyl-SNAC precursors for polyketide biosynthesis
    • DOI 10.1021/ja052991s
    • P. Arora, A. Vats, P. Saxena, D. Mohanty, and R.S. Gokhale Promiscuous fatty acyl CoA ligases produce acyl-CoA and acyl-SNAC precursors for polyketide biosynthesis J. Am. Chem. Soc. 127 2005 9388 9389 (Pubitemid 40934750)
    • (2005) Journal of the American Chemical Society , vol.127 , Issue.26 , pp. 9388-9389
    • Arora, P.1    Vats, A.2    Saxena, P.3    Mohanty, D.4    Gokhale, R.S.5
  • 16
    • 77949511370 scopus 로고    scopus 로고
    • Dissecting the role of critical residues and substrate preference of a fatty acyl-CoA synthetase (FadD13) of Mycobacterium tuberculosis
    • G. Khare, V. Gupta, R.K. Gupta, R. Gupta, R. Bhat, and A.K. Tyagi Dissecting the role of critical residues and substrate preference of a fatty acyl-CoA synthetase (FadD13) of Mycobacterium tuberculosis PLoS One 4 2009 e8387
    • (2009) PLoS One , vol.4 , pp. 8387
    • Khare, G.1    Gupta, V.2    Gupta, R.K.3    Gupta, R.4    Bhat, R.5    Tyagi, A.K.6
  • 17
    • 0345701347 scopus 로고    scopus 로고
    • Genes required for mycobacterial growth defined by high density mutagenesis
    • DOI 10.1046/j.1365-2958.2003.03425.x
    • C.M. Sassetti, D.H. Boyd, and E.J. Rubin Genes required for mycobacterial growth defined by high density mutagenesis Mol. Microbiol. 48 2003 77 84 (Pubitemid 36411469)
    • (2003) Molecular Microbiology , vol.48 , Issue.1 , pp. 77-84
    • Sassetti, C.M.1    Boyd, D.H.2    Rubin, E.J.3
  • 18
    • 33947662068 scopus 로고    scopus 로고
    • Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids
    • DOI 10.1039/b616817p
    • R.S. Gokhale, P. Saxena, T. Chopra, and D. Mohanty Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids Nat. Prod. Rep. 24 2007 267 277 (Pubitemid 46496566)
    • (2007) Natural Product Reports , vol.24 , Issue.2 , pp. 267-277
    • Gokhale, R.S.1    Saxena, P.2    Chopra, T.3    Mohanty, D.4
  • 19
    • 15744389881 scopus 로고    scopus 로고
    • The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: Identification of the carboxylation product and determination of the acyl-CoA carboxylase components
    • DOI 10.1074/jbc.M408578200
    • D. Portevin, C. de Sousa-D'Auria, H. Montrozier, C. Houssin, A. Stella, M.A. Laneelle, F. Bardou, C. Guilhot, and M. Daffe The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components J. Biol. Chem. 280 2005 8862 8874 (Pubitemid 40409576)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.10 , pp. 8862-8874
    • Portevin, D.1    De Sousa-D'Auria, C.2    Montrozier, H.3    Houssin, C.4    Stella, A.5    Laneelle, M.-A.6    Bardou, F.7    Guilhot, C.8    Daffe, M.9
  • 22
    • 0036947767 scopus 로고    scopus 로고
    • Involvement of the fadD33 gene in the growth of Mycobacterium tuberculosis in the liver of BALB/c mice
    • L. Rindi, L. Fattorini, D. Bonanni, E. Iona, G. Freer, D. Tan, G. Deho, G. Orefici, and C. Garzelli Involvement of the fadD33 gene in the growth of Mycobacterium tuberculosis in the liver of BALB/c mice Microbiology 148 2002 3873 3880 (Pubitemid 36097449)
    • (2002) Microbiology , vol.148 , Issue.12 , pp. 3873-3880
    • Rindi, L.1    Fattorini, L.2    Bonanni, D.3    Iona, E.4    Freer, G.5    Tan, D.6    Deho, G.7    Orefici, G.8    Garzelli, C.9
  • 23
    • 3042666893 scopus 로고    scopus 로고
    • Requirement of gene fadD33 for the growth of Mycobacterium tuberculosis in a hepatocyte cell line
    • L. Rindi, D. Bonanni, N. Lari, and C. Garzelli Requirement of gene fadD33 for the growth of Mycobacterium tuberculosis in a hepatocyte cell line New Microbiol. 27 2004 125 131 (Pubitemid 40091008)
    • (2004) New Microbiologica , vol.27 , Issue.2 , pp. 125-131
    • Rindi, L.1    Bonanni, D.2    Lari, N.3    Garzelli, C.4
  • 25
    • 0036952487 scopus 로고    scopus 로고
    • Regulation of expression of mas and fadD28, two genes involved in production of dimycocerosyl phthiocerol, a virulence factor of mycobacterium tuberculosis
    • DOI 10.1128/JB.184.24.6796-6802.2002
    • T.D. Sirakova, A.M. Fitzmaurice, and P. Kolattukudy Regulation of expression of mas and fadD28, two genes involved in production of dimycocerosyl phthiocerol, a virulence factor of Mycobacterium tuberculosis J. Bacteriol. 184 2002 6796 6802 (Pubitemid 36356114)
    • (2002) Journal of Bacteriology , vol.184 , Issue.24 , pp. 6796-6802
    • Sirakova, T.D.1    Fitzmaurice, A.M.2    Kolattukudy, P.3
  • 27
    • 77953200061 scopus 로고    scopus 로고
    • Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis
    • R. Simeone, M. Leger, P. Constant, W. Malaga, H. Marrakchi, M. Daffe, C. Guilhot, and C. Chalut Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis FEBS J. 277 2010 2715 2725
    • (2010) FEBS J. , vol.277 , pp. 2715-2725
    • Simeone, R.1    Leger, M.2    Constant, P.3    Malaga, W.4    Marrakchi, H.5    Daffe, M.6    Guilhot, C.7    Chalut, C.8
  • 28
    • 38349074340 scopus 로고    scopus 로고
    • Mycobacterial phenolic glycolipid virulence factor biosynthesis: Mechanism and small-molecule inhibition of polyketide chain initiation
    • J.A. Ferreras, K.L. Stirrett, X. Lu, J.S. Ryu, C.E. Soll, D.S. Tan, and L.E. Quadri Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation Chem. Biol. 15 2008 51 61
    • (2008) Chem. Biol. , vol.15 , pp. 51-61
    • Ferreras, J.A.1    Stirrett, K.L.2    Lu, X.3    Ryu, J.S.4    Soll, C.E.5    Tan, D.S.6    Quadri, L.E.7
  • 29
    • 34948863376 scopus 로고    scopus 로고
    • Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages
    • DOI 10.1099/mic.0.2007/007864-0
    • J. Lynett, and R.W. Stokes Selection of transposon mutants of Mycobacterium tuberculosis with increased macrophage infectivity identifies fadD23 to be involved in sulfolipid production and association with macrophages Microbiology 153 2007 3133 3140 (Pubitemid 47517073)
    • (2007) Microbiology , vol.153 , Issue.9 , pp. 3133-3140
    • Lynett, J.1    Stokes, R.W.2
  • 30
    • 77954086090 scopus 로고    scopus 로고
    • A continuous kinetic assay for adenylation enzyme activity and inhibition
    • D.J. Wilson, and C.C. Aldrich A continuous kinetic assay for adenylation enzyme activity and inhibition Anal. Biochem. 404 2010 56 63
    • (2010) Anal. Biochem. , vol.404 , pp. 56-63
    • Wilson, D.J.1    Aldrich, C.C.2
  • 32
    • 42049112740 scopus 로고    scopus 로고
    • Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization
    • DOI 10.1038/nprot.2008.15, PII NPROT.2008.15
    • M. Hafner, E. Vianini, B. Albertoni, L. Marchetti, I. Grune, C. Gloeckner, and M. Famulok Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization Nat. Protoc. 3 2008 579 587 (Pubitemid 351516753)
    • (2008) Nature Protocols , vol.3 , Issue.4 , pp. 579-587
    • Hafner, M.1    Vianini, E.2    Albertoni, B.3    Marchetti, L.4    Grune, I.5    Gloeckner, C.6    Famulok, M.7
  • 33
    • 11144265736 scopus 로고    scopus 로고
    • A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization
    • DOI 10.1021/bi048233g
    • M.H. Roehrl, J.Y. Wang, and G. Wagner A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization Biochemistry 43 2004 16056 16066 (Pubitemid 40041019)
    • (2004) Biochemistry , vol.43 , Issue.51 , pp. 16056-16066
    • Roehrl, M.H.A.1    Wang, J.Y.2    Wagner, G.3
  • 35
    • 0030249424 scopus 로고    scopus 로고
    • Synthesis and aminoacyl-tRNA synthetase inhibitory activity of prolyl adenylate analogs
    • DOI 10.1006/bioo.1996.0025
    • D. Heacock, C.J. Forsyth, K. Shiba, and K. Musier-Forsyth Synthesis and aminoacyl-tRNA synthetase inhibitory activity of prolyl adenylate analogs Bioorg. Chem. 24 1996 273 289 (Pubitemid 26352682)
    • (1996) Bioorganic Chemistry , vol.24 , Issue.3 , pp. 273-289
    • Heacock, D.1    Forsyth, C.J.2    Shiba, K.3    Musier-Forsyth, K.4
  • 36
    • 0026514219 scopus 로고
    • Nucleosides and nucleotides. 103. 2-Alkynyladenosines: A novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects
    • A. Matsuda, M. Shinozaki, T. Yamaguchi, H. Homma, R. Nomoto, T. Miyasaka, Y. Watanabe, and T. Abiru Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects J. Med. Chem. 35 1992 241 252
    • (1992) J. Med. Chem. , vol.35 , pp. 241-252
    • Matsuda, A.1    Shinozaki, M.2    Yamaguchi, T.3    Homma, H.4    Nomoto, R.5    Miyasaka, T.6    Watanabe, Y.7    Abiru, T.8
  • 38
    • 0000432369 scopus 로고
    • Synthesis of new phospholipids linked to steroid-hormone derivatives designed for two-dimensional crystallization of proteins
    • L. Lebeau, P. Oudet, and C. Mioskowski Synthesis of new phospholipids linked to steroid-hormone derivatives designed for two-dimensional crystallization of proteins Helv. Chim. Acta 74 1991 1697 1706
    • (1991) Helv. Chim. Acta , vol.74 , pp. 1697-1706
    • Lebeau, L.1    Oudet, P.2    Mioskowski, C.3
  • 40
    • 0042468972 scopus 로고    scopus 로고
    • Fluorescence polarization competition assay: The range of resolvable inhibitor potency is limited by the affinity of the fluorescent ligand
    • X. Huang Fluorescence polarization competition assay: the range of resolvable inhibitor potency is limited by the affinity of the fluorescent ligand J. Biomol. Screen. 8 2003 34 38
    • (2003) J. Biomol. Screen. , vol.8 , pp. 34-38
    • Huang, X.1
  • 43
    • 33645317338 scopus 로고    scopus 로고
    • A fluorescence polarization assay for screening inhibitors against the ribonuclease H activity of HIV-1 reverse transcriptase
    • G.R. Nakayama, P. Bingham, D. Tan, and K.A. Maegley A fluorescence polarization assay for screening inhibitors against the ribonuclease H activity of HIV-1 reverse transcriptase Anal. Biochem. 351 2006 260 265
    • (2006) Anal. Biochem. , vol.351 , pp. 260-265
    • Nakayama, G.R.1    Bingham, P.2    Tan, D.3    Maegley, K.A.4
  • 44
    • 57749192043 scopus 로고    scopus 로고
    • High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK
    • A. Vaasa, I. Viil, E. Enkvist, K. Viht, G. Raidaru, D. Lavogina, and A. Uri High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK Anal. Biochem. 385 2009 85 93
    • (2009) Anal. Biochem. , vol.385 , pp. 85-93
    • Vaasa, A.1    Viil, I.2    Enkvist, E.3    Viht, K.4    Raidaru, G.5    Lavogina, D.6    Uri, A.7
  • 47
    • 11144347825 scopus 로고    scopus 로고
    • Discovery of small-molecule inhibitors of the NFAT-calcineurin interaction by competitive high-throughput fluorescence polarization screening
    • DOI 10.1021/bi048232o
    • M.H. Roehrl, J.Y. Wang, and G. Wagner Discovery of small-molecule inhibitors of the NFAT-calcineurin interaction by competitive high-throughput fluorescence polarization screening Biochemistry 43 2004 16067 16075 (Pubitemid 40041020)
    • (2004) Biochemistry , vol.43 , Issue.51 , pp. 16067-16075
    • Roehrl, M.H.A.1    Wang, J.Y.2    Wagner, G.3
  • 48
    • 55849088001 scopus 로고    scopus 로고
    • Aryl acid adenylating enzymes involved in siderophore biosynthesis: Fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening
    • J. Neres, D.J. Wilson, L. Celia, B.J. Beck, and C.C. Aldrich Aryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening Biochemistry 47 2008 11735 11749
    • (2008) Biochemistry , vol.47 , pp. 11735-11749
    • Neres, J.1    Wilson, D.J.2    Celia, L.3    Beck, B.J.4    Aldrich, C.C.5
  • 50
    • 33751321865 scopus 로고    scopus 로고
    • A detergent-based assay for the detection of promiscuous inhibitors
    • B.Y. Feng, and B.K. Shoichet A detergent-based assay for the detection of promiscuous inhibitors Nat. Protoc. 1 2006 550 553
    • (2006) Nat. Protoc. , vol.1 , pp. 550-553
    • Feng, B.Y.1    Shoichet, B.K.2
  • 52
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • DOI 10.1177/108705719900400206
    • J.H. Zhang, T.D. Chung, and K.R. Oldenburg A simple statistical parameter for use in evaluation and validation of high throughput screening assays J. Biomol. Screen. 4 1999 67 73 (Pubitemid 29278954)
    • (1999) Journal of Biomolecular Screening , vol.4 , Issue.2 , pp. 67-73
    • Zhang, J.-H.1    Chung, T.D.Y.2    Oldenburg, K.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.