Dissecting the role of critical residues and substrate preference of a fatty Acyl-CoA synthetase (FadD13) of Mycobacterium tuberculosis

PLoS ONE

Volumn 4, Issue 12, 2009, Pages

  Khare, Garima ^a   Gupta, Vibha ^a   Gupta, Rakesh K ^a   Gupta, Radhika ^a   Bhat, Rajiv ^b   Tyagi, Anil K ^a  

^a UNIVERSITY OF DELHI   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN; COENZYME A; LONG CHAIN FATTY ACID COENZYME A LIGASE; MYMA PROTEIN; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID; ACYL COENZYME A; AMINO ACID; FATTY ACID; LIGAND; MUTANT PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; BACTERIAL MEMBRANE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; INTRACELLULAR BACTERIUM; LIGAND BINDING; MOLECULAR DOCKING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPERON; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COENZYME; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYMOLOGY; FLUORESCENCE; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN ENGINEERING; PROTEIN QUATERNARY STRUCTURE; STRUCTURAL HOMOLOGY; TEMPERATURE;

MYCOBACTERIUM TUBERCULOSIS;

ACYL COENZYME A; AMINO ACID SEQUENCE; AMINO ACIDS; BACTERIAL PROTEINS; BINDING SITES; COENZYME A LIGASES; COENZYMES; ENZYME STABILITY; FATTY ACIDS; FLUORESCENCE; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN ENGINEERING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY; TEMPERATURE;

EID: 77949511370     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008387     Document Type: Article

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