Ghrelin postsynaptically depolarizes dorsal raphe neurons in rats in vitro

Peptides

Volumn 32, Issue 8, 2011, Pages 1606-1616

  Ogaya, Masaki ^a   Kim, Juhyon ^a   Sasaki, Kazuo ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Anxiolytic effect; Dorsal raphe nucleus; Feeding; Ghrelin; K + conductance; Nonselective cationic conductance; Serotonin; Sleep

Indexed keywords

GHRELIN; HORMONE RECEPTOR BLOCKING AGENT; POTASSIUM ION; SODIUM ION; TETRODOTOXIN;

ANIMAL CELL; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; ELECTROPHYSIOLOGY; IN VITRO STUDY; MALE; NERVE CELL; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; PATCH CLAMP; POSTSYNAPTIC POTENTIAL; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; RAT;

ACTION POTENTIALS; ANIMALS; GHRELIN; MALE; NEURONS; OLIGOPEPTIDES; RAPHE NUCLEI; RATS; RATS, WISTAR; SYNAPTIC MEMBRANES;

ANIMALIA; RATTUS;

EID: 80051550322     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.07.001     Document Type: Article

References (55)

1. G.K. Aghajanian, and C.P. Vandermaelen Intracellular identification of central noradrenergic and serotonergic neurons by a new double labeling procedure J Neurosci 2 1982 1786 1792 (Pubitemid 13142753)
2. D. Bajic, Q.V. Hoang, S. Nakajima, and Y. Nakajima Dissociated histaminergic neuron cultures from the tuberomammillary nucleus of rats: culture methods and ghrelin effects J Neurosci Methods 132 2004 177 184 (Pubitemid 38050171)
3. W.A. Banks, M. Tschöp, S.M. Robinson, and M.L. Heiman Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure J Pharmacol Exp Ther 302 2002 822 827 (Pubitemid 34787253)
4. S.G. Beck, Y.Z. Pan, A.C. Akanwa, and L.G. Kirby Median and dorsal raphe neurons are not electrophysiologically identical J Neurophysiol 91 2004 994 1005 (Pubitemid 38168866)
5. R.E. Brown, O. Sergeeva, K.S. Eriksson, and H.L. Haas Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat Neuropharmacology 40 2001 457 459 (Pubitemid 32144724)
6. V.P. Carlini, M.E. Monzón, M.M. Varas, A.B. Cragnolini, H.B. Schiöth, and T.N. Scimonelli Ghrelin increases anxiety-like behavior and memory retention in rats Biochem Biophys Res Commun 299 2002 739 743 (Pubitemid 36034549)
7. M.A. Cowley, R.G. Smith, S. Diano, M. Tschöp, N. Pronchuk, and K.L. Grove The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis Neuron 37 2003 649 661 (Pubitemid 36262986)
8. K.S. Eriksson, O. Sergeeva, R.E. Brown, and H.L. Haas Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus J Neurosci 21 2001 9273 9279 (Pubitemid 33096871)
9. 2+ exchanger Biochimie 70 1988 1285 1290 (Pubitemid 18259725)
10. M. Fry, and A.V. Ferguson Ghrelin modulates electrical activity of area postrema neurons Am J Physiol Regul Integr Comp Physiol 296 2009 R485 R492
11. M. Fry, and A.V. Ferguson Ghrelin: central nervous system sites of action in regulation of energy balance Int J Pept 2010 2010 616757
12. E. Ghigo, F. Broglio, E. Arvat, M. Maccario, M. Papotti, and G. Muccioli Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor Clin Endocrinol (Oxf) 62 2005 1 17 (Pubitemid 40175277)
13. S. Gnanapavan, B. Kola, S.A. Bustin, D.G. Morris, P. McGee, and P. Fairclough The tissue distribution of the mRNA of ghrelin and subtypes of its receptor. GHS-R, in humans J Clin Endocrinol Metab 87 2002 2988
14. X.M. Guan, H. Yu, O.C. Palyha, K.K. McKee, S.D. Feighner, and D.J. Sirinathsinghji Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues Brain Res Mol Brain Res 48 1997 23 29 (Pubitemid 27298124)
15. Hansson C, Haage D, Taube M, Egecioglu E, Salomé N, Dickson SL. Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence. Neuroscience; in press.
16. H. Hosoda, M. Kojima, and K. Kangawa Biological, physiological, and pharmacological aspects of ghrelin J Pharmacol Sci 100 2006 398 410 (Pubitemid 44609531)
17. A.D. Howard, S.D. Feighner, D.F. Cully, J.P. Arena, P.A. Liberator, and C.I. Rosenblum A receptor in pituitary and hypothalamus that functions in growth hormone release Science 273 1996 974 977 (Pubitemid 26275178)
18. 2+ exchange in cells expressing NCX1 J Biol Chem 271 1996 22391 22397 (Pubitemid 26304672)
19. J. Kim, K. Nakajima, Y. Oomura, M.J. Wayner, and K. Sasaki Electrophysiological effects of ghrelin on pedunculopontine tegmental neurons in rats: an in vitro study Peptides 30 2009 745 757
20. J. Kim, K. Nakajima, Y. Oomura, M.J. Wayner, and K. Sasaki Orexin-A and ghrelin depolarize the same pedunculopontine tegmental neurons in rats: an in vitro study Peptides 30 2009 1328 1335
21. T.R. Kleyman, and E.J. Cragoe Jr. Amiloride and its analogs as tools in the study of ion transport J Membr Biol 105 1988 1 21
22. M. Kluge, M. Gazea, P. Schüssler, L. Genzel, M. Dresler, and S. Kleyer Ghrelin increases slow wave sleep and stage 2 sleep and decreases stage 1 sleep and REM sleep in elderly men but does not affect sleep in elderly women Psychoneuroendocrinology 35 2010 297 304
23. M. Kluge, P. Schüssler, M. Dresler, D. Schmidt, A. Yassouridis, and M. Uhr Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression J Psychiatr Res 45 2011 421 426
24. M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660 (Pubitemid 129516334)
25. A.W. Lee, A. Kyrozis, V. Chevaleyre, L.M. Kow, N. Devidze, and Q. Zhang Estradiol modulation of phenylephrine-induced excitatory responses in ventromedial hypothalamic neurons of female rats Proc Natl Acad Sci U S A 105 2008 7333 7338 (Pubitemid 351754478)
26. S.F. Leibowitz, and J.T. Alexander Hypothalamic serotonin in control of eating behavior, meal size, and body weight Biol Psychiatry 44 1998 851 864 (Pubitemid 28520223)
27. R.-J. Liu, A.N. van den Pol, and G.K. Aghajanian Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions J Neurosci 22 2002 9453 9464 (Pubitemid 35356188)
28. C.J. Lobb, C.J. Wilson, and C.A. Paladini A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons J Neurophysiol 104 2010 403 413
29. S. Lu, J.L. Guan, Q.P. Wang, K. Uehara, S. Yamada, and N. Goto Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus Neurosci Lett 321 2002 157 160 (Pubitemid 34203823)
30. M. Lutter, I. Sakata, S. Osborne-Lawrence, S.A. Rovinsky, J.G. Anderson, and S. Jung The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress Nat Neurosci 11 2008 752 753 (Pubitemid 351896679)
31. M.A. Medeiros, R.H. Costa-e-Sousa, E.L. Olivares, W.S. Côrtes, and L.C. Reis A reassessment of the role of serotonergic system in the control of feeding behavior An Acad Bras Cienc 77 2005 103 111 (Pubitemid 40217359)
32. K.A. Michelsen, C. Schmitz, and H.W. Steinbusch The dorsal raphe nucleus - from silver stainings to a role in depression Brain Res Rev 55 2007 329 342 (Pubitemid 47554453)
33. V. Mitchell, S. Bouret, J.C. Beauvillain, A. Schilling, M. Perret, and C. Kordon Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary J Comp Neurol 429 2001 469 489 (Pubitemid 32010051)
34. J.M. Monti, and H. Jantos The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking Prog Brain Res 172 2008 625 646
35. K. Mori, J. Kim, and K. Sasaki Electrophysiological effect of ghrelin and somatostatin on rat hypothalamic arcuate neurons in vitro Peptides 31 2010 1139 1145
36. M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, and K. Kangawa A role for ghrelin in the central regulation of feeding Nature 409 2001 194 198 (Pubitemid 32144284)
37. F. Obal Jr., J. Alt, P. Taishi, J. Gardi, and J.M. Krueger Sleep in mice with nonfunctional growth hormone-releasing hormone receptors Am J Physiol Regul Integr Comp Physiol 284 2003 R131 R139
38. M.J. Owens Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond J Clin Psychiatry 65 Suppl. 4 2004 5 10
39. C.M. Portas, M. Thakkar, D. Rainnie, and R.W. McCarley Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat J Neurosci 16 1996 2820 2828 (Pubitemid 26124354)
40. K.J. Pulman, W.M. Fry, G.T. Cottrell, and A.V. Ferguson The subfornical organ: a central target for circulating feeding signals J Neurosci 26 2006 2022 2030
41. Y. Shuto, T. Shibasaki, K. Wada, I. Parhar, J. Kamegai, and H. Sugihara Generation of polyclonal antiserum against the growth hormone secretagogue receptor (GHS-R): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach of rats Life Sci 68 2001 991 996 (Pubitemid 32168050)
42. E. Sørensen, J. Grønli, B. Bjorvatn, A. Bjørkum, and R. Ursin Sleep and waking following microdialysis perfusion of the selective 5-HT1A receptor antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat Brain Res 897 2001 122 130 (Pubitemid 32244359)
43. J.S. Sprouse, and G.K. Aghajanian Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists Synapse 1 1987 3 9 (Pubitemid 17114243)
44. E. Szentirmai, I. Hajdu, F. Obal Jr., and J.M. Krueger Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats Brain Res 1088 2006 131 140 (Pubitemid 43729419)
45. E. Szentirmai, L. Kapás, Y. Sun, R.G. Smith, and J.M. Krueger Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice Am J Physiol Regul Integr Comp Physiol 293 2007 R510 R517
46. S. Takano, J. Kim, Y. Ikari, M. Ogaya, K. Nakajima, and Y. Oomura Electrophysiological effects of ghrelin on laterodorsal tegmental neurons in rats: an in vitro study Peptides 30 2009 1901 1908
47. R. Tao, and S.B. Auerbach Differential effect of NMDA on extracellular serotonin in rat midbrain raphe and forebrain sites J Neurochem 66 1996 1067 1075 (Pubitemid 26065904)
48. R. Tao, Z. Ma, and S.B. Auerbach Influence of AMPA/kainate receptors on extracellular 5-hydroxytryptamine in rat midbrain raphe and forebrain Br J Pharmacol 121 1997 1707 1715 (Pubitemid 27343400)
49. R. Tao, Z. Ma, J.T. McKenna, M.M. Thakkar, S. Winston, and R.E. Strecker Differential effect of orexins (hypocretins) on serotonin release in the dorsal and median raphe nuclei of freely behaving rats Neuroscience 141 2006 1101 1105 (Pubitemid 44128693)
50. M. Traebert, T. Riediger, S. Whitebread, E. Scharrer, and H.A. Schmid Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus J Neuroendocrinol 14 2002 580 586 (Pubitemid 34679222)
51. A.J. van der Lely, M. Tschop, M.L. Heiman, and E. Ghigo Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin Endocr Rev 25 2004 426 457 (Pubitemid 38780667)
52. C.P. Vandermaelen, and G.K. Aghajanian Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices Brain Res 289 1983 109 119 (Pubitemid 14222511)
53. J.C. Weikel, A. Wichniak, M. Ising, H. Brunner, E. Friess, and K. Held Ghrelin promotes slow-wave sleep in humans Am J Physiol Endocrinol Metab 284 2003 E407 E415
54. H. Yanagida, T. Morita, J. Kim, K. Yoshida, K. Nakajima, and Y. Oomura Effects of ghrelin on neuronal activity in the ventromedial nucleus of the hypothalamus in infantile rats: an in vitro study Peptides 29 2008 912 918
55. J.M. Zigman, J.E. Jones, C.E. Lee, C.B. Saper, and J.K. Elmquist Expression of ghrelin receptor mRNA in the rat and the mouse brain J Comp Neurol 494 2006 528 548 (Pubitemid 41791000)