Ghrelin increases slow wave sleep and stage 2 sleep and decreases stage 1 sleep and REM sleep in elderly men but does not affect sleep in elderly women

Psychoneuroendocrinology

Volumn 35, Issue 2, 2010, Pages 297-304

  Kluge, Michael ^a   Gazea, Mary ^a   Schüssler, Petra ^a   Genzel, Lisa ^a   Dresler, Martin ^a   Kleyer, Sara ^a   Uhr, Manfred ^a   Yassouridis, Alexander ^a   Steiger, Axel ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Cortisol; Elderly; Ghrelin; Growth hormone; Men; Sleep; Women

Indexed keywords

GHRELIN;

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NONREM SLEEP; NORMAL HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; REM SLEEP; SEX DIFFERENCE; SLOW WAVE SLEEP;

AGED; CIRCADIAN RHYTHM; CROSS-OVER STUDIES; FEMALE; GHRELIN; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MIDDLE AGED; PITUITARY-ADRENAL SYSTEM; PLACEBOS; POLYSOMNOGRAPHY; SEX CHARACTERISTICS; SINGLE-BLIND METHOD; SLEEP; SLEEP STAGES; SLEEP, REM; WAKEFULNESS;

EID: 73949125003     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2009.07.007     Document Type: Article

References (54)

1. Akamizu T., Murayama T., Teramukai S., Miura K., Bando I., Irako T., Iwakura H., Ariyasu H., Hosoda H., Tada H., Matsuyama A., Kojima S., Wada T., Wakatsuki Y., Matsubayashi K., Kawakita T., Shimizu A., Fukushima M., Yokode M., and Kangawa K. Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure. J. Endocrinol. 188 (2006) 333-344
2. Aloi J.A., Gertz B.J., Hartman M.L., Huhn W.C., Pezzoli S.S., Wittreich J.M., Krupa D.A., and Thorner M.O. Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjects. J. Clin. Endocrinol. Metab. 79 (1994) 943-949
3. Barkan A.L., Dimaraki E.V., Jessup S.K., Symons K.V., Ermolenko M., and Jaffe C.A. Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. J. Clin. Endocrinol. Metab. 88 (2003) 2180-2184
4. Bixler E.O., Papaliaga M.N., Vgontzas A.N., Lin H.M., Pejovic S., Karataraki M., Vela-Bueno A., and Chrousos G.P. Women sleep objectively better than men and the sleep of young women is more resilient to external stressors: effects of age and menopause. J. Sleep Res. 18 (2009) 221-228
5. Bohlhalter S., Murck H., Holsboer F., and Steiger A. Cortisol enhances non-REM sleep and growth hormone secretion in elderly subjects. Neurobiol. Aging 18 (1997) 423-429
6. Broglio F., Benso A., Castiglioni C., Gottero C., Prodam F., Destefanis S., Gauna C., van der Lely A.J., Deghenghi R., Bo M., Arvat E., and Ghigo E. The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects. J. Clin. Endocrinol. Metab. 88 (2003) 1537-1542
7. Chapman I.M., Bach M.A., Van C.E., Farmer M., Krupa D., Taylor A.M., Schilling L.M., Cole K.Y., Skiles E.H., Pezzoli S.S., Hartman M.L., Veldhuis J.D., Gormley G.J., and Thorner M.O. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects. J. Clin. Endocrinol. Metab. 81 (1996) 4249-4257
8. Copinschi G., Leproult R., Van O.A., Caufriez A., Cole K.Y., Schilling L.M., Mendel C.M., De L.I., Bolognese J.A., and Van C.E. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology 66 (1997) 278-286
9. Di Vito L., Broglio F., Benso A., Gottero C., Prodam F., Papotti M., Muccioli G., Dieguez C., Casanueva F.F., Deghenghi R., Ghigo E., and Arvat E. The GH-releasing effect of ghrelin, a natural GH secretagogue, is only blunted by the infusion of exogenous somatostatin in humans. Clin. Endocrinol. (Oxf) 56 (2002) 643-648
10. Friess E., Tagaya H., Grethe C., Trachsel L., and Holsboer F. Acute cortisol administration promotes sleep intensity in man. Neuropsychopharmacology 29 (2004) 598-604
11. Giustina A., and Veldhuis J.D. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr. Rev. 19 (1998) 717-797
12. Goel N., Kim H., and Lao R.P. Gender differences in polysomnographic sleep in young healthy sleepers. Chronobiol. Int. 22 (2005) 905-915
13. Guldner J., Schier T., Friess E., Colla M., Holsboer F., and Steiger A. Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly. Neurobiol. Aging 18 (1997) 491-495
14. Hachul H., Bittencourt L.R., Andersen M.L., Haidar M.A., Baracat E.C., and Tufik S. Effects of hormone therapy with estrogen and/or progesterone on sleep pattern in postmenopausal women. Int. J. Gynaecol. Obstet. 103 (2008) 207-212
15. Hatzinger M., Brand S., Perren S., Stadelmann S., von W.A., von K.K., and Holsboer-Trachsler E. Electroencephalographic sleep profiles and hypothalamic-pituitary-adrenocortical (HPA)-activity in kindergarten children: early indication of poor sleep quality associated with increased cortisol secretion. J. Psychiatr. Res. 42 (2008) 532-543
16. Hemmeter U., Muller M., Bischof R., Annen B., and Holsboer-Trachsler E. Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers. Psychopharmacology (Berl) 147 (2000) 384-396
17. Holsboer F., von Bardeleben U., and Steiger A. Effects of intravenous corticotropin-releasing hormone upon sleep-related growth hormone surge and sleep EEG in man. Neuroendocrinology 48 (1988) 32-38
18. Kerkhofs M., Van Cauter E., Van Onderbergen A., Caufriez A., Thorner M.O., and Copinschi G. Sleep-promoting effects of growth hormone-releasing hormone in normal men. Am. J. Physiol. 264 (1993) E594-E598
19. Khosla S., Melton III L.J., Atkinson E.J., O'Fallon W.M., Klee G.G., and Riggs B.L. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J. Clin. Endocrinol. Metab. 83 (1998) 2266-2274
20. Kluge M., Schüssler P., Bleninger P., Kleyer S., Uhr M., Weikel J.C., Yassouridis A., Zuber V., and Steiger A. Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males. Psychoneuroendocrinology 33 (2008) 497-506
21. Kluge M., Schüssler P., Uhr M., Yassouridis A., and Steiger A. Ghrelin suppresses secretion of luteinizing hormone in humans. J. Clin. Endocrinol. Metab. 92 (2007) 3202-3205
22. Kluge M., Schüssler P., Zuber V., Kleyer S., Yassouridis A., Dresler M., Uhr M., and Steiger A. Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep. Psychoneuroendocrinology 32 (2007) 1079-1085
23. Kluge M., Schüssler P., Zuber V., Yassouridis A., and Steiger A. Ghrelin administered in the early morning increases secretion of cortisol and growth hormone without affecting sleep. Psychoneuroendocrinology 32 (2007) 287-292
24. Kluge M., Uhr M., Bleninger P., Yassouridis A., and Steiger A. Ghrelin suppresses secretion of follicle stimulating hormone (FSH) in males. Clin. Endocrinol. (Oxf) 70 (2009) 920-923
25. Koutkia P., Canavan B., Breu J., Johnson M.L., and Grinspoon S.K. Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men. Am. J. Physiol. Endocrinol. Metab. 287 (2004) E506-E512
26. Luisi S., Tonetti A., Bernardi F., Casarosa E., Florio P., Monteleone P., Gemignani R., Petraglia F., Luisi M., and Genazzani A.R. Effect of acute corticotropin releasing factor on pituitary-adrenocortical responsiveness in elderly women and men. J. Endocrinol. Invest. 21 (1998) 449-453
27. Luque R.M., Kineman R.D., Park S., Peng X.D., Gracia-Navarro F., Castano J.P., and Malagon M.M. Homologous and heterologous regulation of pituitary receptors for ghrelin and growth hormone-releasing hormone. Endocrinology 145 (2004) 3182-3189
28. Marshall L., Mölle M., Boschen G., Steiger A., Fehm H.L., and Born J. Greater efficacy of episodic than continuous growth hormone-releasing hormone (GHRH) administration in promoting slow-wave sleep (SWS). J. Clin. Endocrinol. Metab. 81 (1996) 1009-1013
29. Mathias S., Held K., Ising M., Weikel J.C., Yassouridis A., and Steiger A. Systemic growth hormone-releasing hormone (GHRH) impairs sleep in healthy young women. Psychoneuroendocrinology 32 (2007) 1021-1027
30. Mathias S., Zihl J., Steiger A., and Lancel M. Effect of repeated gaboxadol administration on night sleep and next-day performance in healthy elderly subjects. Neuropsychopharmacology 30 (2005) 833-841
31. Mendelson W.B., Slater S., Gold P., and Gillin J.C. The effect of growth hormone administration on human sleep: a dose-response study. Biol. Psychiatry 15 (1980) 613-618
32. Motivala S.J., Tomiyama A.J., Ziegler M., Khandrika S., and Irwin M.R. Nocturnal levels of ghrelin and leptin and sleep in chronic insomnia. Psychoneuroendocrinology 34 (2009) 540-545
33. Mozid A.M., Tringali G., Forsling M.L., Hendricks M.S., Ajodha S., Edwards R., Navarra P., Grossman A.B., and Korbonits M. Ghrelin is released from rat hypothalamic explants and stimulates corticotrophin-releasing hormone and arginine-vasopressin. Horm. Metab. Res. 35 (2003) 455-459
34. Natalucci G., Riedl S., Gleiss A., Zidek T., and Frisch H. Spontaneous 24 h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern. Eur. J. Endocrinol. 152 (2005) 845-850
35. Nicolau G.Y., Haus E., Lakatua D.J., Bogdan C., Sackett-Lundeen L., Popescu M., Berg H., Petrescu E., and Robu E. Circadian and circannual variations of FSH, LH, testosterone, dehydroepiandrosterone-sulfate (DHEA-S) and 17-hydroxy progesterone (17 OH-Prog) in elderly men and women. Endocrinologie 23 (1985) 223-246
36. Obal Jr. F., Alt J., Taishi P., Gardi J., and Krueger J.M. Sleep in mice with nonfunctional growth hormone-releasing hormone receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284 (2003) R131-R139
37. Rechtschaffen A., and Kales A. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects (1968), Brain Information Service Brain Research Institute, University of California, Los Angeles
38. Saletu-Zyhlarz G., Anderer P., Gruber G., Mandl M., Gruber D., Metka M., Huber J., Oettel M., Graser T., bu-Bakr M.H., Gratzhofer E., and Saletu B. Insomnia related to postmenopausal syndrome and hormone replacement therapy: sleep laboratory studies on baseline differences between patients and controls and double-blind, placebo-controlled investigations on the effects of a novel estrogen-progestogen combination (Climodien Lafamme) versus estrogen alone. J. Sleep Res. 12 (2003) 239-254
39. Scharf M.B., McDannold M.D., Stover R., Zaretsky N., and Berkowitz D.V. Effects of estrogen replacement therapy on rates of cyclic alternating patterns and hot-flush events during sleep in postmenopausal women: a pilot study. Clin. Ther. 19 (1997) 304-311
40. Schüssler P., Kluge M., Dresler M., Yassouridis A., and Steiger A. Effects of intravenous corticotropin-releasing hormone upon sleep EEG in young healthy women. J. Sleep Res. 17 (2008) 215-216
41. Schüssler P., Kluge M., Yassouridis A., Dresler M., Held K., Zihl J., and Steiger A. Progesterone reduces wakefulness in sleep EEG and has no effect on cognition in healthy postmenopausal women. Psychoneuroendocrinology 33 (2008) 1124-1131
42. Serra-Prat M., Alfaro S.R., Palomera E., Casamitjana R., Buquet X., Fernandez-Fernandez C., and Puig-Domingo M. Relationship between ghrelin and the metabolic syndrome in the elderly: a longitudinal population-based study. Clin. Endocrinol. (Oxf) 70 (2009) 227-232
43. Steiger A., Guldner J., Hemmeter U., Rothe B., Wiedemann K., and Holsboer F. Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinology 56 (1992) 566-573
44. Szentirmai E., Hajdu I., Obal Jr. F., and Krueger J.M. Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats. Brain Res. 1088 (2006) 131-140
45. Szentirmai E., Kapas L., and Krueger J.M. Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 (2007) R575-R585
46. Szentirmai E., Kapas L., Sun Y., Smith R.G., and Krueger J.M. Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (2007) R510-R517
47. Takaya K., Ariyasu H., Kanamoto N., Iwakura H., Yoshimoto A., Harada M., Mori K., Komatsu Y., Usui T., Shimatsu A., Ogawa Y., Hosoda K., Akamizu T., Kojima M., Kangawa K., and Nakao K. Ghrelin strongly stimulates growth hormone release in humans. J. Clin. Endocrinol. Metab. 85 (2000) 4908-4911
48. Tolle V., Bassant M.H., Zizzari P., Poindessous-Jazat F., Tomasetto C., Epelbaum J., and Bluet-Pajot M.T. Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats. Endocrinology 143 (2002) 1353-1361
49. Tonetti L., Fabbri M., and Natale V. Sex difference in sleep-time preference and sleep need: a cross-sectional survey among Italian pre-adolescents, adolescents, and adults. Chronobiol. Int. 25 (2008) 745-759
50. van der Lely A.J., Tschöp M., Heiman M.L., and Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr. Rev. 25 (2004) 426-457
51. Veldhuis J.D., Keenan D.M., Iranmanesh A., Mielke K., Miles J.M., and Bowers C.Y. Estradiol potentiates ghrelin-stimulated pulsatile growth hormone secretion in postmenopausal women. J. Clin. Endocrinol. Metab. 91 (2006) 3559-3565
52. Vgontzas A.N., Bixler E.O., Wittman A.M., Zachman K., Lin H.M., Vela-Bueno A., Kales A., and Chrousos G.P. Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications. J. Clin. Endocrinol. Metab. 86 (2001) 1489-1495
53. Vitiello M.V., Larsen L.H., and Moe K.E. Age-related sleep change: gender and estrogen effects on the subjective-objective sleep quality relationships of healthy, noncomplaining older men and women. J. Psychosom. Res. 56 (2004) 503-510
54. Weikel J.C., Wichniak A., Ising M., Brunner H., Friess E., Held K., Mathias S., Schmid D.A., Uhr M., and Steiger A. Ghrelin promotes slow-wave sleep in humans. Am. J. Physiol. Endocrinol. Metab. 284 (2003) E407-E415