Ghrelin promotes slow-wave sleep in humans

American Journal of Physiology - Endocrinology and Metabolism

Volumn 284, Issue 2 47-2, 2003, Pages

  Weikel, J C ^a   Wichniak, A ^a   Ising, M ^a   Brunner, H ^a   Friess, E ^a   Held, K ^a   Mathias, S ^a   Schmid, D A ^a   Uhr, M ^a   Steiger, A ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Adrenocorticotropic hormone; Cortisol; Growth hormone; Leptin; Prolactin; Sleep endocrinology

Indexed keywords

CORTICOTROPIN; GHRELIN; GROWTH HORMONE; HYDROCORTISONE; LEPTIN; PROLACTIN;

ADULT; ARTICLE; ELECTROENCEPHALOGRAPHY; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REM SLEEP; SLOW WAVE SLEEP;

EID: 0037304223     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00184.2002     Document Type: Article

References (55)

1. American Sleep Disorders Association. EEG arousals: scoring rules and examples. A preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 15: 173-184, 1992.
2. Antonijevic IA, Murck H, Bohlhalter S, Frieboes RM, Holsboer F, and Steiger A. NPY promotes sleep and inhibits ACTH and cortisol release in young men. Neuropharmacology 39: 1474-1481, 2000.
3. Arnauld E, Bibene V, Meynard J, Rodriguez F, and Vincent JD. Effects of chronic icv infusion of vasopressin on sleepwaking cycle of rats. Am J Physiol Regul Integr Comp Physiol 256: R674-R684, 1989.
4. Arvat E, Maccagno B, Ramunni J, Di Vito L, Gianotti L, Broglio F, Benso A, Deghenghi R, Camanni F, and Ghigo E. Effects of dexamethasone and alprazolam, a benzodiazepine, on the stimulatory effect of hexarelin, a synthetic GRHP, on ACTH, cortisol and GH secretion in humans. Neuroendocrinology 67: 310-316, 1998.
5. Arvat E, Maccario M, Di Vito L, Broglio F, Benso A, Gottero C, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, and Ghigo E. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab 86: 1169-1174, 2001.
6. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Fujimiya M, Katsuura G, Makino S, Fujino MA, and Kasuga M. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology 74: 143-147, 2001.
7. Beranek L, Hajdu I, Gardi J, Taishi P, Obál F Jr, and Krueger JM. Central administration of the somatostatin analog octreotide induces captopril-insensitive sleep responses. Am J Physiol Regul Integr Comp Physiol 277: R1297-R1304, 1999.
8. Bluet-Pajot MT, Tolle V, Zizzari P, Robert C, Hammond C, Mitchell V, Beauvillain JC, Viollet C, Epelbaum J, and Kordon C. Growth hormone secretagogues and hypothalamic networks. Endocrine 14: 1-8, 2001.
9. Chang FC and Opp MR. Blockade of corticotropin-releasing hormone receptors reduces spontaneous waking in the rat. Am J Physiol Regul Integr Comp Physiol 275: R793-R802, 1998.
10. Copinschi G, Leproult R, Van Onderbergen A, Caufriez A, Cole KY, Schilling LM, Mendel CM, De Lepeleire I, Bolognese JA, and Van Cauter E. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology 66: 278-286, 1997.
11. Ehlers CL and Kupfer DJ. Hypothalamic peptide modulation of EEG sleep in depression: a further application of the S-process hypothesis. Biol Psychiatry 22: 513-517, 1987.
12. Ehlers CL, Reed TK, and Henriksen SJ. Effects of corticotropin-releasing factor and growth hormone-releasing factor on sleep and activity in rats. Neuroendocrinology 42: 467-474, 1986.
13. Ehlers CL, Somes C, Lopez A, Kirby D, and Rivier JE. Electrophysiological actions of neuropeptide Y and its analogs: new measures for anxiolytic therapy? Neuropsychopharmacology 17: 34-43, 1997.
14. Frieboes RM, Murck H, Maier P, Schier T, Holsboer F, and Steiger A. Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology 61: 584-589, 1995.
15. Frieboes RM, Murck H, Schier T, Holsboer F, and Steiger A. Somatostatin impairs sleep in elderly human subjects. Neuropsychopharmacology 16: 339-345, 1997.
16. Frieboes RM, Murck H, Stalla GK, Antonijevic IA, and Steiger A. Enhanced slow wave sleep in patients with prolactinoma. J Clin Endocrinol Metab 83: 2706-2710, 1998.
17. Friess E, Wiedemann K, Steiger A, and Holsboer F. The hypothalamic-pituitary-adrenocortical system and sleep in man. Adv Neuroimmunol 5: 111-125, 1995.
18. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, and Korbonits M. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 87: 2988, 2002.
19. Hewson AK and Dickson SL. Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats. J Neuroendocrinol 12: 1047-1049, 2000.
20. Holsboer F, von Bardeleben U, and Steiger A. Effects of intravenous corticotropin-releasing hormone upon sleep-related growth hormone surge and sleep EEG in man. Neuroendocrinology 48: 32-38, 1988.
21. Horvath TL, Diano S, Sotonyi P, Heiman M, and Tschöp M. Minireview: ghrelin and the regulation of energy balance - a hypothalamic perspective. Endocrinology 142: 4163-4169, 2001.
22. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJS, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, De Martino JA, Gupta SK, Schaeffer JM, Smith RG, and Van der Ploeg LH. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273: 974-977, 1996.
23. Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, and Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats. Diabetes 50: 2438-2443, 2001.
24. Kerkhofs M, Linkowski P, and Mendlewicz J. Effects of intravenous catheter on sleep in healthy men and in depressed patients. Sleep 12: 113-119, 1989.
25. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, and Kangawa K. Ghrelin is a growth hormone-releasing acylated peptide from stomach. Nature 402: 656-660, 1999.
26. Korbonits M, Kaltsas G, Perry LA, Putignano P, Grossman AB, Besser GM, and Trainer PJ. The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin. J Clin Endocrinol Metab 84: 2489-2495, 1999.
27. Lancel M and Steiger A. Sleep and its modulation by drugs that affect GABA(A) receptor function. Angew Chem Int Ed Engl 38: 2852-2864, 1999.
28. Mendelson WB. Studies of human growth hormone secretion in sleep and waking. Int Rev Neurobiol 23: 367-389, 1982.
29. Moreno-Reyes R, Kerkhofs M, L'Hermite-Balériaux M, Thorner MO, Van Cauter E, and Copinschi G. Evidence against a role for the growth hormone-releasing peptide axis in human slow-wave sleep regulation. Am J Physiol Endocrinol Metab 274: E779-E784, 1998.
30. Murck H, Guldner J, Colla-Müller M, Frieboes RM, Schier T, Wiedemann K, Holsboer F, and Steiger A. VIP decelerates non-REM-REM cycles and modulates hormone secretion during sleep in men. Am J Physiol Regul Integr Comp Physiol 271: R905-R911, 1996.
31. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, and Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 409: 194-198, 2001.
32. Obál F Jr, Alt J, Taishi P, Gardi J, and Krueger JM. Sleep in mice with nonfunctional growth hormone-releasing hormone receptors. Am J Physiol. In press.
33. Obál F Jr and Krueger JM. The somatotropic axis and sleep. Rev Neurol (Paris) 157: S12-S15, 2001.
34. Opp M, Obál F Jr, and Krueger JM. Corticotropin-releasing factor attenuates interleukin 1-induced sleep and fever in rabbits. Am J Physiol Regul Integr Comp Physiol 257: R528-R535, 1989.
35. Opp MR. Rat strain differences suggest a role for corticotropin-releasing hormone in modulating sleep. Physiol Behav 63: 6774, 1997.
36. Peino R, Baldelli R, Rodriguez-Garcia J, Rodriguez-Segade S, Kojima M, Kangawa K, Arvat E, Ghigo E, Dieguez C, and Casanueva FF. Ghrelin-induced growth hormone secretion in humans. Eur J Endocrinol 143: R11-R14, 2000.
37. Rechtschaffen A and Kales A. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Bethesda, MD: US Department of Health, Education and Welfare, Neurological Information Network, 1968.
38. Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K, and Nakao K. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50: 227-232, 2001.
39. Steiger A. Sleep and the hypothalamo-pituitary-adrenocortical system. Sleep Med Rev 6: 125-138, 2002.
40. Steiger A, Frieboes RM, Held K, and Murck H. Effects of hexarelin on sleep-endocrine activity in man (Abstract). Naunyn-Schmiedebergs Arch Pharmacol 359, Suppl 3: R129, 1999.
41. Steiger A, Guldner J, Hemmeter U, Rothe B, Wiedemann K, and Holsboer F. Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinology 56: 566-573, 1992.
42. Steiger A and Holsboer F. Neuropeptides and human sleep. Sleep 20: 1038-1052, 1997.
43. Steiger A, Schmid DA, Held K, and Weikel J. Ghrelin stimulates appetite in normal controls (Abstract). Naunyn-Schmiedebergs Arch Pharmacol 365, Suppl 1: R107, 2002.
44. A-receptor modulation. Brain Res 615: 267-274, 1993.
45. Steiger A, Ziegenbein M, Künzel HE, Held K, Murck H, and Antonijevic IA. Effects of the long lasting somatostatin analogue octreotide on sleep EEG in young men (Abstract). J Sleep Res 9, Suppl 1: 182, 2000.
46. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, and Nakao K. Ghrelin strongly stimulates growth hormone (GH) release in humans. J Clin Endocrinol Metab 85: 4908-4911, 2000.
47. Tannenbaum GS and Bowers CY. Interactions of growth hormone secretagogues and growth hormone-releasing hormone/somatostatin. Endocrine 14: 21-27, 2001.
48. Tolle V, Bassant MH, Zizzari P, Poindessous-Jazat F, Tomasetto C, Epelbaum J, and Bluet-Pajot MT. Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats. Endocrinology 143: 1353-1361, 2002.
49. Tolle V, Zizzari P, Tomasetto C, Rio MC, Epelbaum J, and Bluet-Pajot MT. In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat. Neuroendocrinology 73: 54-61, 2001.
50. Tschöp M, Smiley DL, and Heiman ML. Ghrelin induces adiposity in rodents. Nature 407: 908-913, 2000.
51. Wang LX, Saint-Pierre DH, and Tache Y. Peripheral ghrelin selectively increases Fos expression in neuropeptide Y-synthesizing neurons in mouse hypothalamic arcuate nucleus. Neurosci Lett 325: 47-51, 2002.
52. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, and Bloom SR. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86: 5992-5995, 2001.
53. Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, and Bloom SR. Ghrelin causes hyperphagia and obesity in rats. Diabetes 50: 2540-2547, 2001.
54. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DGA, Ghatei MA, and Bloom SR. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141: 4325-4328, 2000.
55. Yeh KC and Kwan KC. Comparison of numerical integrating algorithms by trapezoidal, lagrange, and spline approximation. J Pharmacokinet Biopharm 6: 79-98, 1978.