Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats

Peptides

Volumn 32, Issue 8, 2011, Pages 1575-1580

  Jackson, M A ^a   Iwaniec, U T ^a   Turner, R T ^a   Wronski, T J ^b   Kalra, S P ^b  

^a OREGON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

CT; Bone marrow adiposity; Histomorphometry; Osteoblasts; Osteoclasts; White adipose tissue

Indexed keywords

ADENO ASSOCIATED VIRUS LEPTIN; HYPOTHALAMUS HORMONE; LEPTIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADENOVIRUS; ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; BONE MASS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE THERAPY; LUMBAR VERTEBRA; MORPHOMETRICS; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY; PERIMETER; PRIORITY JOURNAL; RAT; TIBIA;

ANIMALS; BONE AND BONES; BONE DENSITY; FEMALE; GENE EXPRESSION; HYPOTHALAMUS; LEPTIN; OVARIECTOMY; RATS; RATS, INBRED STRAINS; RATS, SPRAGUE-DAWLEY; TIBIA; TRANSGENES;

ADENO-ASSOCIATED VIRUS; RATTUS;

EID: 80051546618     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.04.029     Document Type: Article

References (53)

1. P. Astudillo, S. Rios, L. Pastenes, A.M. Pino, and J.P. Rodriguez Increased adipogenesis of osteoporotic human-mesenchymal stem cells (MSCs) characterizes by impaired leptin action J Cell Biochem 103 2008 1054 1065 (Pubitemid 351342599)
2. E. Beretta, M.G. Dube, P.S. Kalra, and S.P. Kalra Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes Pediatr Res 52 2002 189 198 (Pubitemid 34827239)
3. S. Boghossian, A. Lecklin, R. Torto, P.S. Kalra, and S.P. Kalra Suppression of fat deposition for the life time with gene therapy Peptides 26 2005 1512 1519 (Pubitemid 41021489)
4. M.A. Bredella, M. Torriani, R.H. Ghomi, B.J. Thomas, D.J. Brick, and A.V. Gerweck Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women Obesity (Silver Spring) 19 2011 49 53
5. B. Burguera, L.C. Hofbauer, T. Thomas, F. Gori, G.L. Evans, and S. Khosla Leptin reduces ovariectomy-induced bone loss in rats Endocrinology 142 2001 3546 3553 (Pubitemid 32681763)
6. J. Cornish, K.E. Callon, U. Bava, C. Lin, D. Naot, and B.L. Hill Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo J Endocrinol 175 2002 405 415 (Pubitemid 35414387)
7. C. De Laet, J.A. Kanis, A. Oden, H. Johanson, O. Johnell, and P. Delmas Body mass index as a predictor of fracture risk: a meta-analysis Osteoporos Int 16 2005 1330 1338 (Pubitemid 41532085)
8. D.P. Desimone, V.S. Greene, K.S. Hannon, R.T. Turner, and N.H. Bell Prostaglandin E2 administered by subcutaneous pellets causes local inflammation and systemic bone loss: a model for inflammation-induced bone disease J Bone Miner Res 8 1993 625 634 (Pubitemid 23127923)
9. H. Dhillon Effects of recombinant adeno-associated virus encoding leptin on body weight regulation and energy homeostasis 2000 University of Florida Gainesville
10. H. Dhillon, S.P. Kalra, and P.S. Kalra Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus Mol Ther 4 2001 139 145 (Pubitemid 32776505)
11. H. Dhillon, S.P. Kalra, V. Prima, S. Zolotukhin, P.J. Scarpace, and L.L. Moldawer Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study Regul Pept 99 2001 69 77 (Pubitemid 32522533)
12. M.G. Dube, R. Torto, and S.P. Kalra Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice Peptides 29 2008 593 598
13. K. Ecklund, S. Vajapeyam, H.A. Feldman, C.D. Buzney, R.V. Mulkern, and P.K. Kleinman Bone marrow changes in adolescent girls with anorexia nervosa J Bone Miner Res 25 2010 298 304
14. R. El Hage, C. Jacob, E. Moussa, C.L. Benhamou, and C. Jaffre Total body, lumbar spine and hip bone mineral density in overweight adolescent girls: decreased or increased? J Bone Miner Metab 27 2009 629 633
15. I.S. Farooqi, and S. O'Rahilly Leptin: a pivotal regulator of human energy homeostasis Am J Clin Nutr 89 2009 980S 984S
16. G.M. Fogelholm, H.T. Sievanen, T.K. Kukkonen-Harjula, and M.E. Pasanen Bone mineral density during reduction, maintenance and regain of body weight in premenopausal, obese women Osteoporos Int 12 2001 199 206 (Pubitemid 32288936)
17. G. Friedl, R.T. Turner, G.L. Evans, and H. Dobnig Intermittent parathyroid hormone (PTH) treatment and age-dependent effects on rat cancellous bone and mineral metabolism J Orthop Res 25 2007 1454 1464 (Pubitemid 350205593)
18. J.M. Friedman, and J.L. Halaas Leptin and the regulation of body weight in mammals Nature 395 1998 763 770 (Pubitemid 28485436)
19. M.W. Hamrick, M.A. Della Fera, Y.H. Choi, D. Hartzell, C. Pennington, and C.A. Baile Injections of leptin into rat ventromedial hypothalamus increase adipocyte apoptosis in peripheral fat and in bone marrow Cell Tissue Res 327 2007 133 141 (Pubitemid 44833056)
20. M.W. Hamrick, and S.L. Ferrari Leptin and the sympathetic connection of fat to bone Osteoporos Int 19 2008 905 912 (Pubitemid 351758616)
21. W.R. Holloway, F.M. Collier, C.J. Aitken, D.E. Myers, J.M. Hodge, and M. Malakellis Leptin inhibits osteoclast generation J Bone Miner Res 17 2002 200 209 (Pubitemid 34087652)
22. Iwaniec UT, Boghossian S, Trevisiol CH, Wronski TJ, Turner RT, Kalra SP. Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats. J Bone Miner Res, in press.
23. U.T. Iwaniec, and R.T. Turner Animal models of osteoporosis R. Marcus, D. Feldman, D.A. Nelson, C. Rosen, Osteoporosis 3rd ed. 2008 Elsevier Amsterdam 985 1110
24. U.T. Iwaniec, T.J. Wronski, and R.T. Turner Histological analysis of bone Methods Mol Biol 447 2008 325 341
25. S.P. Kalra Global life-long health benefits of repression of hypothalamic NPY system by central leptin gene therapy Curr Top Med Chem 7 2007 1675 1681 (Pubitemid 350131004)
26. S.P. Kalra, and P.S. Kalra Neuroendocrine control of energy homeostasis: update on new insights Prog Brain Res 181 2010 17 33
27. M. Lamghari, L. Tavares, N. Camboa, and M.A. Barbosa Leptin effect on RANKL and OPG expression in MC3T3-E1 osteoblasts J Cell Biochem 98 2006 1123 1129 (Pubitemid 44128354)
28. A. Lecklin, M.G. Dube, R.N. Torto, P.S. Kalra, and S.P. Kalra Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation Peptides 26 2005 1176 1187 (Pubitemid 40798074)
29. Y.J. Lee, J.H. Park, S.K. Ju, K.H. You, J.S. Ko, and H.M. Kim Leptin receptor isoform expression in rat osteoblasts and their functional analysis FEBS Lett 528 2002 43 47 (Pubitemid 35257997)
30. R. Lorentzon, U. Alehagen, and L. Boquist Osteopenia in mice with genetic diabetes Diabetes Res Clin Pract 2 1986 157 163 (Pubitemid 17231071)
31. P. Magni, E. Dozio, E. Galliera, M. Ruscica, and M.M. Corsi Molecular aspects of adipokine-bone interactions Curr Mol Med 10 2010 522 532
32. L.M. Maness, A.J. Kastin, C.L. Farrell, and W.A. Banks Fate of leptin after intracerebroventricular injection into the mouse brain Endocrinology 139 1998 4556 4562 (Pubitemid 28487772)
33. P.J. Menagh, R.T. Turner, D.B. Jump, C.P. Wong, M.B. Lowry, and S. Yakar Growth hormone regulates the balance between bone formation and bone marrow adiposity J Bone Miner Res 25 2010 757 768
34. C.T. Montague, I.S. Farooqi, J.P. Whitehead, M.A. Soos, H. Rau, and N.J. Wareham Congenital leptin deficiency is associated with severe early-onset obesity in humans Nature 387 1997 903 908 (Pubitemid 27289591)
35. M.E. Nuttall, and J.M. Gimble Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications Curr Opin Pharmacol 4 2004 290 294 (Pubitemid 38585315)
36. A.M. Parfitt, M.K. Drezner, F.H. Glorieux, J.A. Kanis, H. Malluche, and P.J. Meunier Bone histomorphometry: standardization of nomenclature, symbols, and units, Report of the ASBMR Histomorphometry Nomenclature Committee J Bone Miner Res 2 1987 595 610
37. D. Rachon, and H. Teede Ovarian function and obesity - interrelationship, impact on women's reproductive lifespan and treatment options Mol Cell Endocrinol 316 2010 172 179
38. I.R. Reid Fat and bone Arch Biochem Biophys 503 2010 22 27
39. C.J. Rosen, and A. Klibanski Bone, fat, and body composition: evolving concepts in the pathogenesis of osteoporosis Am J Med 122 2009 409 414
40. J.C. Sharp, J.C. Copps, Q. Liu, L.N. Ryner, R.A. Sebastian, and G.Q. Zeng Analysis of ovariectomy and estrogen effects on body composition in rats by X-ray and magnetic resonance imaging techniques J Bone Miner Res 15 2000 138 146 (Pubitemid 30026941)
41. J.D. Sibonga, M. Zhang, E.L. Ritman, and R.T. Turner Restoration of bone mass in the severely osteopenic senescent rat J Gerontol A: Biol Sci Med Sci 55 2000 B71 B78 discussion B9-84
42. C.K. Smith, and D.R. Romsos Cold acclimation of obese (ob/ob) mice: effects of energy balance Metabolism 33 1984 853 857 (Pubitemid 14026199)
43. C.M. Steppan, D.T. Crawford, K.L. Chidsey-Frink, H. Ke, and A.G. Swick Leptin is a potent stimulator of bone growth in ob/ob mice Regul Pept 92 2000 73 78
44. I. Takada, A.P. Kouzmenko, and S. Kato Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies Expert Opin Ther Targets 13 2009 593 603
45. J.A. Tamasi, B.J. Arey, D.R. Bertolini, and J.H. Feyen Characterization of bone structure in leptin receptor-deficient Zucker (fa/fa) rats J Bone Miner Res 18 2003 1605 1611 (Pubitemid 37022918)
46. T. Thomas, B. Burguera, L.J. Melton 3rd, E.J. Atkinson, W.M. O'Fallon, and B.L. Riggs Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women Bone 29 2001 114 120 (Pubitemid 32734491)
47. R. Torto, S. Boghossian, M.G. Dube, P.S. Kalra, and S.P. Kalra Central leptin gene therapy blocks ovariectomy-induced adiposity Obesity (Silver Spring) 14 2006 1312 1319 (Pubitemid 46219656)
48. R.T. Turner, D.J. Rickard, U.T. Iwaniec, and T.C. Spelsberg Estrogens and progestins J.P. Bilezikian, L.G. Raisz, J. Martin, Principles of bone biology 3rd ed. 2008 Academic Press San Diego 847 877
49. R.T. Turner, B.L. Riggs, and T.C. Spelsberg Skeletal effects of estrogen Endocr Rev 15 1994 275 300 (Pubitemid 24180788)
50. N. Ueno, M.G. Dube, A. Inui, P.S. Kalra, and S.P. Kalra Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy Endocrinology 145 2004 4176 4184 (Pubitemid 39120566)
51. K.C. Westerlind, T.J. Wronski, E.L. Ritman, Z.P. Luo, K.N. An, and N.H. Bell Estrogen regulates the rate of bone turnover but bone balance in ovariectomized rats is modulated by prevailing mechanical strain Proc Natl Acad Sci U S A 94 1997 4199 4204 (Pubitemid 27180523)
52. Williams GA, Callon KE, Watson M, Costa JL, Ding Y, Dickinson M, et al. Skeletal phenotype of the leptin receptor-deficient db/db mouse. J Bone Miner Res, in press.
53. M. Yamauchi, T. Sugimoto, T. Yamaguchi, D. Nakaoka, M. Kanzawa, and S. Yano Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women Clin Endocrinol (Oxf) 55 2001 341 347 (Pubitemid 32823044)