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Volumn 4, Issue 8, 2011, Pages 1233-1242

Chemopreventive efficacy and mechanism of licofelone in a mouse lung tumor model via aspiration

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; BENZO[A]PYRENE; BUDESONIDE; CYCLINE; CYCLOOXYGENASE 2; LICOFELONE; SURVIVIN;

EID: 80051489648     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-10-0117     Document Type: Article
Times cited : (20)

References (41)
  • 1
    • 0034033954 scopus 로고    scopus 로고
    • Recent advances in cancer chemoprevention, with emphasis on breast and colorectal cancer
    • DOI 10.1016/S0959-8049(00)00040-X, PII S095980490000040X
    • Decensi A, Costa A. Recent advances in cancer chemoprevention, with emphasis on breast and colorectal cancer. Eur J Cancer 2000;36:694-709. (Pubitemid 30179740)
    • (2000) European Journal of Cancer , vol.36 , Issue.6 , pp. 694-709
    • Decensi, A.1    Costa, A.2
  • 2
    • 0034023982 scopus 로고    scopus 로고
    • Prevention of lung cancer
    • DOI 10.1016/S1040-8428(99)00074-8, PII S1040842899000748
    • Goodman GE. Prevention of lung cancer. Crit Rev Oncol Hematol 2000;33:187-97. (Pubitemid 30163071)
    • (2000) Critical Reviews in Oncology/Hematology , vol.33 , Issue.3 , pp. 187-197
    • Goodman, G.E.1
  • 3
    • 0033966392 scopus 로고    scopus 로고
    • Lung cancer chemoprevention
    • DOI 10.1002/(SICI)1098-2388(200003)18:2<100::AID-SSU3>3.0.CO;2-9
    • Khuri FR, Lippman SM. Lung cancer chemoprevention. Semin Surg Oncol 2000;18:100-5. (Pubitemid 30090450)
    • (2000) Seminars in Surgical Oncology , vol.18 , Issue.2 , pp. 100-105
    • Khuri, F.R.1    Lippman, S.M.2
  • 4
    • 0035884404 scopus 로고    scopus 로고
    • Lung cancer chemoprevention: An integrated approach
    • Lippman SM, Spitz MR. Lung cancer chemoprevention: an integrated approach. J Clin Oncol 2001;19:74S-82.
    • (2001) J Clin Oncol , vol.19
    • Lippman, S.M.1    Spitz, M.R.2
  • 5
    • 0028211015 scopus 로고
    • Retinoid chemoprevention studies in upper aerodigestive tract and lung carcinogenesis
    • Lippman SM, Benner SE, Hong WK. Retinoid chemoprevention studies in upper aerodigestive tract and lung carcinogenesis. Cancer Res 1994;54:2025S-8.
    • (1994) Cancer Res , vol.54
    • Lippman, S.M.1    Benner, S.E.2    Hong, W.K.3
  • 6
    • 0028122608 scopus 로고
    • The Alpha-Tocopherol, Beta-Carotene cancer prevention study in Finland
    • Blumberg J, Block G. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study in Finland. Nutr Rev 1994;52:242-5. (Pubitemid 24264481)
    • (1994) Nutrition Reviews , vol.52 , Issue.7 , pp. 242-245
    • Blumberg, J.1    Block, G.2
  • 8
    • 0035584272 scopus 로고    scopus 로고
    • Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy?
    • DOI 10.1016/S0006-2952(01)00747-X, PII S000629520100747X
    • Fiorucci S, Meli R, Bucci M, Cirino G. Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy? Biochem Pharmacol 2001;62:1433-8. (Pubitemid 33145286)
    • (2001) Biochemical Pharmacology , vol.62 , Issue.11 , pp. 1433-1438
    • Fiorucci, S.1    Meli, R.2    Bucci, M.3    Cirino, G.4
  • 9
    • 0038328335 scopus 로고    scopus 로고
    • First clinical results of licofelone (ML3000), an inhibitor of COX-1, COX-2 and 5-LOX, for the treatment of osteoarthritis
    • Reginster JY, Bias P, Buchner A. First clinical results of licofelone (ML3000), an inhibitor of COX-1, COX-2 and 5-LOX, for the treatment of osteoarthritis. Ann Rheum Dis 2002;61:116-7.
    • (2002) Ann Rheum Dis , vol.61 , pp. 116-117
    • Reginster, J.Y.1    Bias, P.2    Buchner, A.3
  • 10
    • 0029088388 scopus 로고
    • Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid
    • Laufer S, Tries S, Augustin J, Elsasser R, Albrecht W, Guserle R, et al. Acute and chronic anti-inflammatory properties of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid. Arzneimittelforschung 1995;45:27-32.
    • (1995) Arzneimittelforschung , vol.45 , pp. 27-32
    • Laufer, S.1    Tries, S.2    Augustin, J.3    Elsasser, R.4    Albrecht, W.5    Guserle, R.6
  • 11
    • 0031172919 scopus 로고    scopus 로고
    • The effects of ML 3000 on antigen-induced responses in sheep
    • DOI 10.1006/pupt.1997.0090
    • Abraham WM, Laufer S, Tries S. The effects of ML 3000 on antigen-induced responses in sheep. Pulm Pharmacol Ther 1997;10:167-73. (Pubitemid 29094859)
    • (1997) Pulmonary Pharmacology and Therapeutics , vol.10 , Issue.3 , pp. 167-173
    • Abraham, W.M.1    Laufer, S.2    Tries, S.3
  • 12
    • 1642397257 scopus 로고    scopus 로고
    • Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation
    • DOI 10.1016/j.ejphar.2004.02.006, PII S0014299904001384
    • Rotondo S, Krauze-Brzosko K, Manarini S, Evangelista V, Cerletti C. Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation. Eur J Pharmacol 2004;488:79-83. (Pubitemid 38388526)
    • (2004) European Journal of Pharmacology , vol.488 , Issue.1-3 , pp. 79-83
    • Rotondo, S.1    Krauze-Brzosko, K.2    Manarini, S.3    Evangelista, V.4    Cerletti, C.5
  • 13
    • 33645018843 scopus 로고    scopus 로고
    • Anti-inflammatory effect of licofelone against various inflammatory challenges
    • Singh VP, Patil CS, Kulkarni SK. Anti-inflammatory effect of licofelone against various inflammatory challenges. Fundam Clin Pharmacol 2006;20:65-71.
    • (2006) Fundam Clin Pharmacol , vol.20 , pp. 65-71
    • Singh, V.P.1    Patil, C.S.2    Kulkarni, S.K.3
  • 14
    • 0034863527 scopus 로고    scopus 로고
    • Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis
    • Gay RE, Neidhart M, Pataky F, Tries S, Laufer S, Gay S. Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis. J Rheumatol 2001;28:2060-5. (Pubitemid 32803785)
    • (2001) Journal of Rheumatology , vol.28 , Issue.9 , pp. 2060-2065
    • Gay, R.E.1    Neidhart, M.2    Pataky, F.3    Tries, S.4    Laufer, S.5    Gay, S.6
  • 15
    • 0029148708 scopus 로고
    • General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7- phenyl-2,3- dihydro-1H-pyrrolizine-5-yl]-acetic acid in experimental animals
    • Algate DR, Augustin J, Atterson PR, Beard DJ, Jobling CM, Laufer S, et al. General pharmacology of [2,2-dimethyl-6-(4-chlorophenyl)-7- phenyl-2,3- dihydro-1H-pyrrolizine-5-yl]-acetic acid in experimental animals. Arzneimittelforschung 1995;45:159-65.
    • (1995) Arzneimittelforschung , vol.45 , pp. 159-165
    • Algate, D.R.1    Augustin, J.2    Atterson, P.R.3    Beard, D.J.4    Jobling, C.M.5    Laufer, S.6
  • 16
    • 0028927986 scopus 로고
    • Studies on the in vitro and in vivo genotoxicity of [2,2-dimethyl-6-(4- chlorophenyl)-7-phenyl-2,3- dihydro-1H-pyrrolizine-5-yl]-acetic acid
    • Heidemann A, Tries S, Laufer S, Augustin J. Studies on the in vitro and in vivo genotoxicity of [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3- dihydro-1H-pyrrolizine-5-yl]-acetic acid. Arzneimittelforschung 1995;45:486-90.
    • (1995) Arzneimittelforschung , vol.45 , pp. 486-490
    • Heidemann, A.1    Tries, S.2    Laufer, S.3    Augustin, J.4
  • 17
    • 0028597003 scopus 로고
    • ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury
    • Wallace JL, Carter L, McKnight W, Tries S, Laufer S. ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury. Eur J Pharmacol 1994;271:525-31.
    • (1994) Eur J Pharmacol , vol.271 , pp. 525-531
    • Wallace, J.L.1    Carter, L.2    McKnight, W.3    Tries, S.4    Laufer, S.5
  • 18
    • 0038718727 scopus 로고    scopus 로고
    • Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin
    • Fiorucci S, Distrutti E, de Lima OM, Romano M, Mencarelli A, Barbanti M, et al. Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. FASEB J 2003;17:1171-3.
    • (2003) FASEB J , vol.17 , pp. 1171-1173
    • Fiorucci, S.1    Distrutti, E.2    De Lima, O.M.3    Romano, M.4    Mencarelli, A.5    Barbanti, M.6
  • 19
    • 1042270689 scopus 로고    scopus 로고
    • Twice the therapeutic dose of licofelone-an inhibitor of COX-1, COX-2 and 5-LOX- results in a significant lower gastrointestinal ulcer incidence than naproxen in osteoarthritis patients, when administered with or without concomitant low-dose asprin
    • Abstract FRI0214
    • Buchner A, Bias P, Lammerich A. Twice the therapeutic dose of licofelone-an inhibitor of COX-1, COX-2 and 5-LOX- results in a significant lower gastrointestinal ulcer incidence than naproxen in osteoarthritis patients, when administered with or without concomitant low-dose asprin. Ann Rheum Dis 2003;62 (Suppl. 1):261 (Abstract FRI0214).
    • (2003) Ann Rheum Dis , vol.62 , Issue.SUPPL. 1 , pp. 261
    • Buchner, A.1    Bias, P.2    Lammerich, A.3
  • 20
    • 1042270689 scopus 로고    scopus 로고
    • Licofelone, an inhibitor of COX-1, COX-2 and 5-LOX, is as effective as celecoxib and shows improved tolerability during 12 weeks of treatment in patients with osteoarthritis of the knee
    • Abstract FRI0215
    • Pavelka K, Bias P, Buchner A, Lammerich A, Schulz U. Licofelone, an inhibitor of COX-1, COX-2 and 5-LOX, is as effective as celecoxib and shows improved tolerability during 12 weeks of treatment in patients with osteoarthritis of the knee. Ann Rheum Dis 2003;62 (Suppl. 1):261 (Abstract FRI0215).
    • (2003) Ann Rheum Dis , vol.62 , Issue.SUPPL. 1 , pp. 261
    • Pavelka, K.1    Bias, P.2    Buchner, A.3    Lammerich, A.4    Schulz, U.5
  • 21
    • 0029918370 scopus 로고    scopus 로고
    • Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: Comparison with interleukin-1-synthesis inhibitors
    • Rainsford KD, Ying C, Smith F. Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors. J Pharm Pharmacol 1996;48:46-52. (Pubitemid 26129078)
    • (1996) Journal of Pharmacy and Pharmacology , vol.48 , Issue.1 , pp. 46-52
    • Rainsford, K.D.1    Ying, C.2    Smith, F.3
  • 22
    • 0034757607 scopus 로고    scopus 로고
    • In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: Suppression of collagenase 1 and interleukin-1beta synthesis
    • DOI 10.1002/1529-0131(200110)44:10<2320::AID-ART394>3.0.CO;2-P
    • Jovanovic DV, Fernandes JC, Martel-Pelletier J, Jolicoeur FC, Reboul P, Laufer S, et al. In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis. Arthritis Rheum 2001;44:2320-30. (Pubitemid 32977499)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.10 , pp. 2320-2330
    • Jovanovic, D.V.1    Fernandes, J.C.2    Martel-Pelletier, J.3    Jolicoeur, F.-C.4    Reboul, P.5    Laufer, S.6    Tries, S.7    Pelletier, J.-P.8
  • 26
    • 40549108939 scopus 로고    scopus 로고
    • Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade
    • DOI 10.1093/carcin/bgm265
    • Tavolari S, Bonafe M, Marini M, Ferreri C, Bartolini G, Brighenti E, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis 2008;29:371-80. (Pubitemid 351359677)
    • (2008) Carcinogenesis , vol.29 , Issue.2 , pp. 371-380
    • Tavolari, S.1    Bonafe, M.2    Marini, M.3    Ferreri, C.4    Bartolini, G.5    Brighenti, E.6    Manara, S.7    Tomasi, V.8    Laufer, S.9    Guarnieri, T.10
  • 27
    • 0242432561 scopus 로고    scopus 로고
    • Evaluation of nose-only aerosol inhalation chamber and comparison of experimental results with mathematical simulation of aerosol deposition in mouse lungs
    • DOI 10.1002/jps.10379
    • Nadithe V, Rahamatalla M, Finlay WH, Mercer JR, Samuel J. Evaluation of nose-only aerosol inhalation chamber and comparison of experimental results with mathematical simulation of aerosol deposition in mouse lungs. J Pharm Sci 2003;92:1066-76. (Pubitemid 36523453)
    • (2003) Journal of Pharmaceutical Sciences , vol.92 , Issue.5 , pp. 1066-1076
    • Nadithe, V.1    Rahamatalla, M.2    Finlay, W.H.3    Mercer, J.R.4    Samuel, J.5
  • 28
    • 33747876093 scopus 로고    scopus 로고
    • The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model
    • DOI 10.1093/carcin/bgl052, Special Issue on Chronic Pain
    • Sharma S, Gao P, Steele VE. The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model. Carcinogenesis 2006;27:1721-7. (Pubitemid 44288062)
    • (2006) Carcinogenesis , vol.27 , Issue.8 , pp. 1721-1727
    • Sharma, S.1    Gao, P.2    Steele, V.E.3
  • 33
    • 0000986313 scopus 로고
    • The chi-square test for heterogeneity of proportions after adjustment for stratification
    • Armitage P. The chi-square test for heterogeneity of proportions after adjustment for stratification. J R Stat Soc Ser B 1966;28:150-63.
    • (1966) J R Stat Soc Ser B , vol.28 , pp. 150-163
    • Armitage, P.1
  • 35
    • 0035403764 scopus 로고    scopus 로고
    • Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB
    • Niederberger E, Tegeder I, Vetter G, Schmidtko A, Schmidt H, Euchenhofer C, et al. Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB. FASEB J 2001;15:1622-4.
    • (2001) FASEB J , vol.15 , pp. 1622-1624
    • Niederberger, E.1    Tegeder, I.2    Vetter, G.3    Schmidtko, A.4    Schmidt, H.5    Euchenhofer, C.6
  • 36
    • 16344393138 scopus 로고    scopus 로고
    • Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib
    • DOI 10.1158/1078-0432.CCR-04-1684
    • Li N, Sood S, Wang S, Fang M, Wang P, Sun Z, et al. Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. Clin Cancer Res 2005;11:2089-96. (Pubitemid 40471876)
    • (2005) Clinical Cancer Research , vol.11 , Issue.5 , pp. 2089-2096
    • Li, N.1    Sood, S.2    Wang, S.3    Fang, M.4    Wang, P.5    Sun, Z.6    Yang, C.S.7    Chen, X.8
  • 37
    • 17844390400 scopus 로고    scopus 로고
    • Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke
    • DOI 10.1093/carcin/bgi012
    • Ye YN, Wu WK, Shin VY, Bruce IC, Wong BC, Cho CH. Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. Carcinogenesis 2005;26:827-34. (Pubitemid 41214346)
    • (2005) Carcinogenesis , vol.26 , Issue.4 , pp. 827-834
    • Ye, Y.N.1    Wu, W.K.K.2    Shin, V.Y.3    Bruce, I.C.4    Wong, B.C.Y.5    Cho, C.H.6
  • 39
    • 33846844870 scopus 로고    scopus 로고
    • Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors
    • Pereira MA, Tao L, Liu Y, Li L, Steele VE, Lubet RA. Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors. Int J Cancer 2006;120:1150-3.
    • (2006) Int J Cancer , vol.120 , pp. 1150-1153
    • Pereira, M.A.1    Tao, L.2    Liu, Y.3    Li, L.4    Steele, V.E.5    Lubet, R.A.6
  • 41
    • 34547759310 scopus 로고    scopus 로고
    • Modulation by budesonide of a CpG endonuclease in mouse lung tumors
    • DOI 10.1093/carcin/bgm056
    • Li L, Tao L, Lubet RA, Steele VE, Pereira MA. Modulation by budesonide of a CpG endonuclease in mouse lung tumors. Carcinogenesis 2007;28:1499-503. (Pubitemid 47241799)
    • (2007) Carcinogenesis , vol.28 , Issue.7 , pp. 1499-1503
    • Li, L.1    Tao, L.2    Lubet, R.A.3    Steele, V.E.4    Pereira, M.A.5


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