Anti-inflammatory effect of licofelone against various inflammatory challenges

Fundamental and Clinical Pharmacology

Volumn 20, Issue 1, 2006, Pages 65-71

  Singh, Vijay Pal ^a   Patil, Chandrashekhar S ^b   Kulkarni, Shrinivas K ^a  

^a PANJAB UNIVERSITY   (India)

^b Panacea Biotec Ltd   (India)

Author keywords

Dual inhibitor; Hyperalgesia; Inflammation; Licofelone

Indexed keywords

ARACHIDONIC ACID; BRADYKININ; CARRAGEENAN; FREUND ADJUVANT; INDOMETACIN; LICOFELONE; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG POTENCY; FEMALE; HYPERALGESIA; INFLAMMATION; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROVOCATION TEST; RAT; STATISTICAL SIGNIFICANCE; VASCULARIZATION;

ACETIC ACIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FEMALE; FREUND'S ADJUVANT; GRANULOMA; HYPERALGESIA; INDOMETHACIN; LIPOXYGENASE INHIBITORS; MICE; PAIN MEASUREMENT; PAIN THRESHOLD; PYRROLES; RATS; RATS, WISTAR; TIME FACTORS; TOUCH;

EID: 33645018843     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2005.00387.x     Document Type: Article

References (19)

1. Laufer S. Tries S. Augustin R. et al. Acute and chronic anti-inflammatory properties of [2-2, dimethyl-6-(4-chlorophenyl)-7phenyl-2,3-dihydro-1H- pyrrolizine-5-yl]-acetic acid Drug Res. 1995 45 27 32
2. Laufer S. Tries S. Augustin R. Dannhardt G. Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclooxygenase and 5-lipoxygenase Drug Res. 1994 44 629 636
3. Laufer S Tries S Augustin J et al. Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl] -acetic acid in the rat Drug Res. 1994 44 1329 1333
4. Jain N.K. Kulkarni S.K. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats J. Ethnopharmacol. 1999 15 251 259
5. Singh V.P. Patil C.S. Kulkarni S.K. Effect of licofelone against mechanical hyperalgesia and cold allodynia in the rat model of incisional pain Pol. J. Pharmacol. 2005 57 380 384
6. Olajide O.A. Makinde J.M. Okpako D.T. Evaluation of antiinflammatory property of the extract of Combertum micranthum G.Don (Combretaceae) Inflammopharmacology 2003 11 293 298
7. Singh V.P. Patil C.S. Kulkarni S.K. Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation Indian J. Exp. Biol. 2005 43 247 53
8. Wallace J.L. Ma L. Inflammatory mediators in gastrointestinal defense and injury Exp. Biol. Med (Maywood). 2001 226 1003 1015
9. Steinhilber D. 5-Lipoxygenase: a target for anti-inflammatory drugs revisited Curr. Med. 1999 6 71 85
10. Peskar B. M. Trautmann M. Nowak P. Perskar B.A. Release of15-hydroxy-5,8,11,13-eicosatetraenoic acid and cysteinyl-leukotrienes in carrageenan-induced inflammation: effect of nonsteroidal anti-inflammatory drugs Agents Actions 1991 33 240 246
11. Pichat P. Angel I. Arbilla S. Anti-inflammatory properties of mizolastine after oral administration on arachidonic acid-induced cutaneous reaction in the rat Arzneimittelforschung. 1998 48 173 178
12. Ferreira J. de Silva G.L. Calixto J.B. Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice Br. J. Pharmacol. 2004 141 787 794
13. Haines K.A. Giedd K.N. Rich A.M. Korchak H.M. Weissmann G. The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites Biochem. J. 1987 241 55 62
14. Oka S. Ikeda S. Kishimoto S. et al. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils J. Leukoc. Biol. 2004 76 1002 1009
15. Gillard J. Ford-Hutchinson A.W. Chan C. et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor Can. J. Physiol. Pharmacol. 1989 67 456 464
16. Singh V.P. Patil C.S. Kulkarni S.K. Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats Pharmacol. Biochem. Behav. 2005 81 433 439
17. Ding C. Cicuttini F. Licofelone (Merckle) IDrugs 2003 6 802 808
18. Pelletier J.M. Lajeunesse D. Reboul P. Pelletier J.P. Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs Ann. Rheum. Dis. 2003 62 501 509
19. Whiteside G.T. Harrison J. Boulet J. et al. Pharmacologic characterization of a rat model of incisional pain Br. J. Pharmacol. 2004 141 85 91