Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors

International Journal of Cancer

Volumn 120, Issue 5, 2007, Pages 1150-1153

  Pereira, Michael A ^a   Tao, Lianhui ^a   Liu, Yue ^a   Li, Long ^a   Steele, Vernon E ^b   Lubet, Ronald A ^b  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Biomarkers; Budesonide; Chemoprevention; DNA hypomethylation; Lung cancer; Mouse lung tumors; mRNA expression

Indexed keywords

BIOLOGICAL MARKER; BUDESONIDE; CARBAMIC ACID DERIVATIVE; CARBAMIC ACID VINYL ESTER; CASPASE 3; CYCLIN B2; CYCLIN E; CYCLIN E1; INDUCIBLE NITRIC OXIDE SYNTHASE; RNA 18S; SURVIVIN; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DRUG EFFICACY; DRUG MECHANISM; FEMALE; GENE EXPRESSION; LUNG TUMOR; MAINTENANCE THERAPY; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; TUMOR VOLUME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BODY WEIGHT; BUDESONIDE; CASPASE 3; CELL PROLIFERATION; CYCLIN B; CYCLIN E; DNA METHYLATION; FEMALE; GENE EXPRESSION; LUNG NEOPLASMS; MICE; MICE, INBRED STRAINS; MICROTUBULE-ASSOCIATED PROTEINS; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; RNA, RIBOSOMAL, 18S; TUMOR MARKERS, BIOLOGICAL; URETHANE;

EID: 33846844870     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22468     Document Type: Article

References (17)

1. Banov CH. The role of budesonide in adults and children with mild-to-moderate persistent asthma. J Asthma 2004;41:5-17.
2. Wattenberg LW, Wiedmann TS, Estensen RD, Zimmerman CL, Steele VE, Kelloff GJ. Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice. Cancer Res 1197;57:5489-92.
3. Wattenberg LW, Wiedmann TS, Estensen RD, Zimmerman CL, Galbraith AR, Steele VE, Kelloff GJ. Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol. Carcinogenesis 2000;21:179-82.
4. Pereira MA, Li Y, Gunning WT, Kramer PM, Alyaqoub FS, Lubet RA, Steele VE, Szabo E, Tao L. Prevention of mouse lung tumors by budesonide and its modulation of biomarkers. Carcinogenesis 2002;23:1185-92.
5. Pereira MA, Tao LH, Wang W, Gunning WTY, Lubet RA. Chemoprevention: mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker. Exp Lung Res 2005;31:155-63.
6. Wang Y, Zhang Z, Kastens E, Lubet RA, You M. Mice with alteration in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice. Cancer Res 2003;63:4389-95.
7. Estensen RD, Jordan MM, Wiedmann TS, Galbraith AR, Steele VE, Wattenberg LW. Effect of chemopreventive agents on separate stages of progression of benzo[α]pyrene induced lung tumors in A/J mice. Carcinogenesis 2004;25:197-201.
8. Yao R, Wang Y, Lemon WJ, Lubet RA, You M. Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions. Oncogene 2004;23:7746-52.
9. Alyaqoub FS, Tao L, Kramer PM, Steele VE, Lubet LA, Gunning WT, Pereira MA. Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra™). Carcinogenesis, in press.
10. -ΔΔCT method. Methods 2000;25:402-8.
11. Liu Y, Alyaqoub FS, Tao L, Steele VE, Lubet RA, Pereira MA. Effect of long- and short-term treatment with targretin on DNA methylation and mRNA expression in vinyl carbamate-induced mouse lung tumors. Fourth Ann Frontiers Cancer Prev Res 2005;166.
12. Dunn BK. Hypomethylation: one side of a larger picture. Ann NY Acad Sci 2003;983:28-42.
13. Cui H, Onyango P, Brandenburg S, Wu Y, Hsieh C-L, Feinberg AP. Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res 2002;62:6442-6.
14. Esfandiari F, Green R, Cotterman RF, Pogribny IP, James SJ, Miller JW. Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver. Carcinogenesis 2003;24:1935-40.
15. Jackson M, Krassowska A, Gilbert N, Chevassut T, Forrester L, Ansell J, Ramsahoye B. Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells. Mol Cell Biol 2004;24:8862-71.
16. Gilbert J, Gore SD, Herman JG, Carducci MA. The clinical application of targeting cancer through histone acetylation and hypomethylation. Clin Cancer Res 2004;10:4589-96.
17. Feinberg AP, Cui H, Ohlsson R. DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms. Semin Cancer Biol 2002;12:389-98.