Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine- pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: A report of two in-vivo studies

Malaria Journal

Volumn 8, Issue 1, 2009, Pages

  Bonnet, Maryline ^a   Van Den Broek, Ingrid ^a,b   Van Herp, Michel ^c   Urrutia, Pedro Pablo Palma ^d   Van Overmeir, Chantal ^e   Kyomuhendo, Juliet ^f   Ndosimao, Célestin Nsibu ^g   Ashley, Elizabeth ^a   Guthmann, Jean Paul ^a,h  

^a EPICENTRE   (France)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c MÉDECINS SANS FRONTIÈRES   (Belgium)

^d MÉDECINS SANS FRONTIÈRES   (Switzerland)

^e INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^f MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Uganda)

^g National Malaria Control Programme   (Democratic Republic Congo)

^h INSTITUT DE VEILLE SANITAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ANTIMALARIAL AGENT; ARTESUNATE; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FANSIDAR; HEMOGLOBIN; QUININE; ARTEMISININ DERIVATIVE; ARTESUNATE AMODIAQUINE COMBINATION; ARTESUNATE-AMODIAQUINE COMBINATION; PYRIMETHAMINE; SULFADOXINE; SULFADOXINE-PYRIMETHAMINE;

ARTICLE; CHILD; COMBINATION CHEMOTHERAPY; CONGO; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FEVER; GENE MUTATION; GENOTYPE; HUMAN; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MALNUTRITION; MONOTHERAPY; PARASITEMIA; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; TREATMENT FAILURE; CLINICAL TRIAL; DEMOCRATIC REPUBLIC CONGO; DRUG COMBINATION; INFANT; TREATMENT OUTCOME;

AMODIAQUINE; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; DEMOCRATIC REPUBLIC OF THE CONGO; DRUG COMBINATIONS; FEMALE; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; PYRIMETHAMINE; SULFADOXINE; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 69549118833     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-8-192     Document Type: Article

References (26)

1. World malaria report 2008. Country profile by WHO region. World Health Organization, WHO Geneva 10.1111/j.1365-3156.2006.01710.x
2. Artesunate + amodiaquine and artesunate + sulphadoxine-pyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine-resistant haplotypes. TB Swarthout IV van den Broek G Kayembe H Pota C Roper, TMIH 2006 11 1503 1511 10.1111/j.1365-3156.2008.02150.x
3. dhfr and dhps genotype and sulfadoxine-pyrimethaminetreatment failure in children with falciparum malaria in the Democratic Republic of Congo. AP Alker WM Kazadi AK Kutelemeni PB Bloland AK Tshefu SR Meshnick, Tropical Medicine and International Health 2008 13 1384 1391 10.1016/S0140-6736(98)24022-0 19055622
4. Molecular assays for surveillance of antifolate-resistant malaria. JG Kublin RS Witzig AH Shankar JQ Zurita RH Gilman JA Guarda JF Cortese CV Plowe, Lancet 1998 351 1629 1630 10.1016/j.meegid.2004.04.002 9620719
5. Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria. AO Talisuna A Nalunkuma-Kazibwe P Langi TK Mutabingwa WW Watkins E Van Marck TG Egwang U D'Alessandro, Infect Genet Evol 2004 4 321 327 10.1016/j.meegid.2004.04.002 15374529 (Pubitemid 39232982)
6. Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. World Health Organization, WHO Geneva
7. Application of genetic markers to the identification of recrudescent Plasmodium falciparum infections on the north western border of Thailand. A Brockman REL Paul T Anderson I Hackford L Phaiphun F Nosten KP Day, Am J Trop Med Hyg 1999 60 14 21 10.1016/S0035-9203(99)90120-7 9988316 (Pubitemid 29405860)
8. Biased distribution of msp1 and msp2 allelic variants in plasmodium falicparum populations in Thailand. G Snounou X Zhu N Siripon W Jara S Thathong KN Brown S Viriyakosol, Trans R Soc Trop Med Hyg 1999 93 369 374 10.1016/S0035-9203(99)90120-7 10674079 (Pubitemid 29405860)
9. Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction Methods for surveillance in Africa. CV Plowe A Djimde M Bouare O Doumbo TE Wellems, Am J Trop Med Hyg 1995 52 565 568 10.1017/S003118200007935X 7611566
10. Frequency of cross-fertilization in the human malaria parasite Plasmodium falciparum. LC Ranford-Cartwright P Balfe R Carter D Walliker, Parasitology 1993 107 11 18 10.1086/338566 8355994
11. Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. JG Kublin FK Dzinjalamala DD Kamwendo EM Malkin JF Cortese LM Martino RA Mukadam SJ Rogerson AG Lescano ME Molyneux PA Winstanley P Chimpeni TE Taylor CV Plowe, J Infect Dis 2002 185 380 388 10.1086/338566 11807721 (Pubitemid 34107252)
12. Molecular markers associated with Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in the democratic republic of Congo. S Cohuet M Bonnet M van Herp C van Overmeir U D'Alessandro JP Guthmann, AJTMH 2006 75 152 154 10.1371/journal.pmed.1000055
13. Multiple origins and regional dispersal of resistant dhps in African P. falciparum malaria. R Pearce H Pota MB Evehe B El Hadj G Mombo-Ngoma A Malisa R Ord W Inojosa A Matondo DA Diallo W Mbacham IV van den Broek TD Swarthout A Assefa S Dejene MP Grobusch F Njie S Dunyo M Kweku S Owusu-Agyei D Chandramohan M Bonnet J-P Guthmann S Clarke KI Barnes E Streat ST Katokele P Uusiku CO Agboghoroma OY Elegba B Cissé IE A-Elbasit HA Giha SP Kachur C Lynch J Rwakimari P Chanda M Hawela B Sharp I Naidoo C Roper, Plos med 2009 6 e1000055 19365539 10.1371/journal.pmed.1000055
14. Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine- pyrimethamine, and the combinations of amodiaquine + artesunate and sulfadoxine-pyrimethamine + artesunate in Huambo and Bie provinces, central Angola. JP Guthmann J Ampuero F Fortes C van Overmeir V Gaboulaud S Tobback J Dunand N Saraiva P Gillet J Franco A Denoncin M van Herp S Balkan JC Dujardin U D'Alessandro D Legros, Trans Royal Soc Trop Med Hyg 2005 99 485 492 10.1186/1475-2875-6-170
15. Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa. A Nahum A Erhart D Gazard C Agbowai C van Overmeir H van Loen J Menten M Akogbeto M Coosemans A Massougbodji U D'Alessandro, Malaria Journal 2007 6 170 10.1128/AAC.00159-07 18154655 (Pubitemid 350067514)
16. Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials. B Greenhouse C Dokomajilar A Hubbard PJ Rosenthal G Dorsey, Antimicrob Agents Chemother 2007 51 3096 3103 10.1371/journal.pmed.0050169 17591848
17. Assessing Antimalarial Efficacy in a Time of Change to Artemisinin-Based Combination Therapies: The Role of Médecins Sans Frontières. Jean-Paul Guthmann Francesco Checchi Ingrid van den Broek Suna Balkan Michel van Herp Eric Comte Oscar Bernal Jean-Marie Kindermans Sarah Venis Dominique Legros Philippe J Guerin, Plos medicine 2008 5 169 177 10.1086/500951
18. Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. D Francis SL Nsobya A Talisuna A Yeka MR Kamya R Machekano C Dokomajilar PJ Rosenthal G Dorsey, J Infect Dis 2006 193 978 86 10.1086/500951 16518760
19. Therapeutic efficacy of sulfadoxine-pyrimethamine and the prevalence of molecular markers of resistance in under 5-year olds in Brazzaville, Congo. M Ndounga R Tahar LK Basco PN Casimiro DA Malonga F Ntoumi, TMIH 2007 12 1164 1171 10.1016/j.actatropica.2007.06.002 (Pubitemid 47307325)
20. Efficacy of sulfadoxine-pyrimethamine, amodiaquine, and sulfadoxine-pyrimethamine-amodiaquine combination for the treatment of uncomplicated falciparum malaria in the urban and suburban areas of Brazzaville (Congo). M Ndounga PI Mayengue R Tahar PN Casimiro DW Matondo Maya V Miakassissa-Mpassi DA Malonga F Nsonde-Ntandou G Mallanda P Ringwald LK Basco F Ntoumi, Acta Trop 2007 103 163 71 10.1111/j.1365-3156.2004.01255.x 17645863
21. Efficacité de combinaisons thérapeutiques avec des dérives de l'artémisinine dans le traitement de l'accès palustre non-complique au Burundi. A Ndayiragije De'o Niyungeko J Karenzo E Niyungeko M Barutwanayo A Ciza A Bosman R Moyou-Somo A Nahimana JP Nyarushatsi T Barihuta L Mizero J Ndaruhutse C Delacollette P Ringwald J Kamana, TMIH 2004 9 673 679 10.1186/1475-2875-6-146
22. Efficacy and safety of artemisinin-based antimalarial in the treatment of uncomplicated malaria in children in southern Tanzania. AM Kabanywanyi A Mwita A Sumari R Mandike K Mugittu S Abdulla, Malaria Journal 2007 6 146 10.1016/S0140-6736(05)66416-1 17996121
23. Guideline for the treatment of malaria. World Health Organization, WHO Geneva 2006 WHO/HTM/MAL/2006.110.
24. Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial. P Piola C Fogg F Bajunirwe S Biraro F Grandesso E Ruzagira J Babigumira I Kigozi J Kiguli J Kyomuhendo L Ferradini W Taylor F Checchi JP Guthmann, Lancet 2005 365 1467 1473 10.1371/journal.pctr.0020020 15850630
25. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. MR Kamya A Yeka H Bukirwa M Lugemwa JB Rwakimari SG Staedke AO Talisuna B Greenhouse F Nosten PJ Rosenthal F Wabwire-Mangen G Dorsey, PLoS Clin Trials 2007 2 e20 10.1186/1475-2875-6-119 17525792 (Pubitemid 47561493)
26. World antimalarial resistance network I: Clinical efficacy of antimalarial drugs. RN Price G Dorsey EA Ashley KI Barnes JK Baird U d'Alessandro PJ Guerin MK Laufer I Naidoo F Nosten P Olliaro CV Plowe P Ringwald CH Sibley K Stepniewska NJ White, Malaria Journal 2007 6 119 127 17822532 10.1186/1475-2875-6-119 (Pubitemid 47561493)