Arvelexin from Brassica rapa suppresses NF-κB-regulated pro-inflammatory gene expression by inhibiting activation of IκB kinase

British Journal of Pharmacology

Volumn 164, Issue 1, 2011, Pages 145-158

  Shin, Ji Sun ^a   Noh, Young Su ^a   Lee, Yong Sup ^a   Cho, Young Wuk ^a   Baek, Nam In ^a   Choi, Myung Sook ^b   Jeong, Tae Sook ^c   Kang, Eunkyung ^d   Chung, Hae Gon ^d   Lee, Kyung Tae ^a  

^a Kyung Hee University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d GangHwa Agricultural R and D Center   (South Korea)

Author keywords

arvelexin; Brassica rapa; cyclooxygenase 2; IKK; inducible nitric oxide; inflammation; NF B; paw oedema

Indexed keywords

ARVELEXIN; CYCLOOXYGENASE 2; CYTOKINE; I KAPPA B ALPHA; I KAPPA B KINASE; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NITRIC OXIDE; PHYTOALEXIN; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASSAY; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENDOTOXEMIA; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; IN VIVO STUDY; INFLAMMATION; MACROPHAGE ACTIVATION; MALE; MORTALITY; MOUSE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SEPTIC SHOCK; SIGNAL TRANSDUCTION; TURNIP; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRASSICA RAPA; CELL LINE, TUMOR; CYCLOOXYGENASE 2; DINOPROSTONE; GENE EXPRESSION REGULATION; I-KAPPA B KINASE; INDOLES; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; NITROGEN OXIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS, GENETIC; SHOCK, SEPTIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79961213846     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01351.x     Document Type: Article

References (40)

1. Adhikari A, Xu M, Chen ZJ, (2007). Ubiquitin-mediated activation of TAK1 and IKK. Oncogene 26: 3214-3226. (Pubitemid 46763016)
2. Bonizzi G, Karin M, (2004). The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25: 280-288. (Pubitemid 38610351)
3. Carter AB, Knudtson KL, Monick MM, Hunninghake GW, (1999). The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP). J Biol Chem 274: 30858-30863.
4. Corriveau CC, Danner RL, (1993). Antiendotoxin therapies for septic shock. Infect Agents Dis 2: 44-52. (Pubitemid 23111835)
5. De Bosscher K, Vanden Berghe W, Vermeulen L, Plaisance S, Boone E, Haegeman G, (2000). Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc Natl Acad Sci USA 97: 3919-3924. (Pubitemid 30226062)
6. Ghosh S, Karin M, (2002). Missing pieces in the NF-kappaB puzzle. Cell 109 (Suppl.): S81-S96.
7. Guzik TJ, Korbut R, Adamek-Guzik T, (2003). Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol 54: 469-487. (Pubitemid 38029745)
8. Hacker H, Karin M, (2006). Regulation and function of IKK and IKK-related kinases. Sci STKE 2006: re13.
9. Janeway CA Jr, Medzhitov R, (2002). Innate immune recognition. Annu Rev Immunol 20: 197-216. (Pubitemid 34293424)
10. Jung UJ, Baek NI, Chung HG, Bang MH, Jeong TS, Lee KT, et al,. (2008). Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice. Clin Nutr 27: 158-167. (Pubitemid 351216895)
11. Karin M, (2005). Inflammation-activated protein kinases as targets for drug development. Proc Am Thorac Soc 2: 386-390; discussion 394-395. (Pubitemid 41699701)
12. Karin M, Ben-Neriah Y, (2000). Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18: 621-663. (Pubitemid 30365393)
13. Kefaloyianni E, Gaitanaki C, Beis I, (2006). ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts. Cell Signal 18: 2238-2251. (Pubitemid 44740489)
14. Kim SJ, Choi YH, Seo JH, Lee JW, Kim YS, Ryu SY, et al,. (2004). Chemical constituents from the root of Brassica campestris ssp rapa. Kor J pharmocon 35: 259-263. (Pubitemid 39361733)
15. Kim JY, Park SJ, Yun KJ, Cho YW, Park HJ, Lee KT, (2008). Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages. Eur J Pharmacol 584: 175-184.
16. Kong X, Thimmulappa R, Kombairaju P, Biswal S, (2010). NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice. J Immunol 185: 569-577.
17. Kraemer SA, Arthur KA, Denison MS, Smith WL, DeWitt DL, (1996). Regulation of prostaglandin endoperoxide H synthase-2 expression by 2,3,7,8,-tetrachlorodibenzo-p-dioxin. Arch Biochem Biophys 330: 319-328. (Pubitemid 26172368)
18. Lee JY, Kim H, Cha MY, Park HG, Kim YJ, Kim IY, et al,. (2009). Clostridium difficile toxin A promotes dendritic cell maturation and chemokine CXCL2 expression through p38, IKK, and the NF-kappaB signaling pathway. J Mol Med 87: 169-180.
19. Li Q, Verma IM, (2002). NF-kappaB regulation in the immune system. Nat Rev Immunol 2: 725-734.
20. Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH, Russell SW, et al,. (1993). Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc Natl Acad Sci USA 90: 9730-9734. (Pubitemid 23315860)
21. McInnes IB, Schett G, (2007). Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7: 429-442. (Pubitemid 46834849)
22. Moncada S, Palmer RM, Higgs EA, (1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142.
23. Mukaida N, (2000). The roles of cytokine receptors in diseases. Rinsho Byori 48: 409-415.
24. Opal SM, (2007). The host response to endotoxin, antilipopolysaccharide strategies, and the management of severe sepsis. Int J Med Microbiol 297: 365-377. (Pubitemid 47188050)
25. Pedras MS, Chumala PB, Suchy M, (2003). Phytoalexins from Thlaspi arvense, a wild crucifer resistant to virulent Leptosphaeria maculans: structures, syntheses and antifungal activity. Phytochemistry 64: 949-956. (Pubitemid 37295347)
26. Pedras MS, Zheng QA, Gadagi RS, Rimmer SR, (2008). Phytoalexins and polar metabolites from the oilseeds canola and rapeseed: differential metabolic responses to the biotroph Albugo candida and to abiotic stress. Phytochemistry 69: 894-910. (Pubitemid 351222604)
27. Perkins ND, (2007). Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8: 49-62. (Pubitemid 46012014)
28. Romani A, Vignolini P, Isolani L, Ieri F, Heimler D, (2006). HPLC-DAD/MS characterization of flavonoids and hydroxycinnamic derivatives in turnip tops (Brassica rapa L. Subsp. sylvestris L.). J Agric Food Chem 54: 1342-1346. (Pubitemid 43374228)
29. Roy PK, Rashid F, Bragg J, Ibdah JA, (2008). Role of the JNK signal transduction pathway in inflammatory bowel disease. World J Gastroenterol 14: 200-202. (Pubitemid 351314299)
30. Sadruddin S, Arora R, (2009). Resveratrol: biologic and therapeutic implications. J Cardiometab Syndr 4: 102-106.
31. Schonhof I, Krumbein A, Bruckner B, (2004). Genotypic effects on glucosinolates and sensory properties of broccoli and cauliflower. Nahrung 48: 25-33. (Pubitemid 38368283)
32. Shibata W, Maeda S, Hikiba Y, Yanai A, Ohmae T, Sakamoto K, et al,. (2007). Cutting edge: the IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis. J Immunol 179: 2681-2685.
33. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, et al,. (2001). Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 480-481: 243-268. (Pubitemid 32744832)
34. Takada Y, Kobayashi Y, Aggarwal BB, (2005). Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion. J Biol Chem 280: 17203-17212. (Pubitemid 41389187)
35. Vanden Berghe W, Plaisance S, Boone E, De Bosscher K, Schmitz ML, Fiers W, et al,. (1998). p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. J Biol Chem 273: 3285-3290. (Pubitemid 28109741)
36. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G, (2003). Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J 22: 1313-1324. (Pubitemid 36362695)
37. Yamamoto Y, Gaynor RB, (2001). Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest 107: 135-142. (Pubitemid 32096826)
38. Yamamoto Y, Gaynor RB, (2004). IkappaB kinases: key regulators of the NF-kappaB pathway. Trends Biochem Sci 29: 72-79. (Pubitemid 38186577)
39. Yoon YM, Lee JY, Yoo D, Sim YS, Kim YJ, Oh YK, et al,. (2010). Bacteroides fragilis enterotoxin induces human beta-defensin-2 expression in intestinal epithelial cells via a mitogen-activated protein kinase/I kappaB kinase/NF-kappaB-dependent pathway. Infect Immun 78: 2024-2033.
40. Zhang G, Ghosh S, (2001). Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest 107: 13-19. (Pubitemid 32047406)