Synthesis and topoisomerase i inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 16, 2011, Pages 4971-4984

  Cananzi, Salvatore ^a   Merlini, Lucio ^a   Artali, Roberto ^a   Beretta, Giovanni Luca ^b   Zaffaroni, Nadia ^b   Dallavalle, Sabrina ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Antitumor; Lamellarin; Molecular modeling; Synthesis; Topoisomerase I

Indexed keywords

(4 ISOPROPOXY 3 METHOXYBENZOYL) (4 ISOPROPOXY 3 METHOXYBENZYL)CARBAMIC ACID TERT BUTYL ESTER; (4 ISOPROPOXY 3 METHOXYPHENYL)METHANAMINE; 1 BENZYL 5 (BENZYLOXY) 6 METHOXY 1H INDOLE 2 CARBOXYLIC ACID; 1 BENZYL 6 (BENZYLOXY) 5 METHOXY 1H INDOLE 2 CARBOXYLIC ACID; 2 AMINO 1,2 BIS(4 ISOPROPOXY 3 METHOXYPHENYL)ETHANONE TRIFLUOROACETATE; 2 HYDROXY 4 ISOPROPOXY 5 METHOXY BENZALDEHYDE; 2,4 DIHYDROXY 5 METHOXY BENZALDEHYDE; 3,4 BIS(4 HYDROXY 3 METHOXYPHENYL) 9 METHYL 2H PYRIDO[3,4 B]INDOL 1(9H) ONE; 3,4 BIS(4 ISOPROPOXY 3 METHOXYPHENYL) 9 METHYL 2H PYRIDO[3,4 B]INDOL 1(9H) ONE; 4 ISOPROPOXY 3 METHOXYBENZALDEHYDE; 4 ISOPROPOXY 3 METHOXYBENZOIC ACID; 4 ISOPROPOXY 5 METHOXY 2 (2 METHOXYETHOXYMETHOXY)BENZALDEHYDE; 4 ISOPROPOXY 5 METHOXY 2 (2 METHOXYETHOXYMETHOXY)BENZYLAMINE; 5 OXA 6A,8 DIAZAINDENO[2,1 B]PHENANTHREN 7 ONE; 6 HYDROXY 3,4 BIS(4 HYDROXY 3 METHOXYPHENYL) 7 METHOXY 2H PYRIDO[3,4 B]INDOL 1(9H) ONE; 7 HYDROXY 3,4 BIS(4 HYDROXY 3 METHOXYPHENYL) 6 METHOXY 2H PYRIDO[3,4 B]INDOL 1(9H) ONE; 9 BENZYL 6 (BENZYLOXY) 3,4 BIS(4 ISOPROPOXY 3 METHOXYPHENYL) 7 METHOXY 2H PYRIDO[3,4 B]INDOL 1(9H) ONE; 9 BENZYL 7 (BENZYLOXY) 3,4 BIS(4 ISOPROPOXY 3 METHOXYPHENYL) 6 METHOXY 2H PYRIDO[3,4 B]INDOL 1(9H) ONE; 9 BENZYL 7 HYDROXY 3,4 BIS(4 HYDROXY 3 METHOXYPHENYL) 6 METHOXY 2H PYRIDO[3,4 B]INDOL 1(9H) ONE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR; ETHYL 5 (BENZYLOXY) 6 METHOXY 1H INDOLE 2 CARBOXYLATE; ETHYL 6 (BENZYLOXY) 5 METHOXY 1H INDOLE 2 CARBOXYLATE; LAMELLARIN D DERIVATIVE; N (4 ISOPROPOXY 3 METHOXYBENZYL) 4 ISOPROPOXY 3 METHOXYBENZAMIDE; N [1,2 BIS(4 ISOPROPOXY 3 METHOXYPHENYL) 2 OXOETHYL] 1 BENZYL 5 (BENZYLOXY) 6 METHOXY 1H INDOLE 2 CARBOXAMIDE; N [1,2 BIS(4 ISOPROPOXY 3 METHOXYPHENYL) 2 OXOETHYL] 1 BENZYL 6 (BENZYLOXY) 5 METHOXY 1H INDOLE 2 CARBOXAMIDE; N [1,2 BIS(4 ISOPROPOXY 3 METHOXYPHENYL) 2 OXOETHYL] 1 METHYL 1H INDOLE 2 CARBOXAMIDE; TERT BUTYL 1,2 BIS(4 ISOPROPOXY 3 METHOXYPHENYL) 2 OXOETHYLCARBAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FRIEDEL CRAFTS REACTION; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR MODEL;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COUMARINS; DNA TOPOISOMERASES, TYPE I; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; ISOQUINOLINES; MODELS, MOLECULAR; MOLLUSCA; OCEANS AND SEAS; SIMIAN VIRUS 40; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS;

EID: 79961170869     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.056     Document Type: Article

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