The life and death of breast cancer cells: Proposing a role for the effects of phytoestrogens on potassium channels

Journal of Membrane Biology

Volumn 242, Issue 2, 2011, Pages 53-67

  Wallace, Joanne L ^a   Gow, Iain F ^a   Warnock, Mary ^a  

^a QUEEN MARGARET UNIVERSITY   (United Kingdom)

Author keywords

Breast cancer; Daidzein; Genistein; hEAG; hERG; Isoflavone; K v1.1; K v1.3; MCF7; Potassium channel

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 4 AMINOPYRIDINE; AMIODARONE; ASTEMIZOLE; CASPASE; CHARYBDOTOXIN; CLOTRIMAZOLE; DAIDZEIN; DENDROTOXIN; DEQUALINIUM; GENISTEIN; GLIBENCLAMIDE; IBERIOTOXIN; ISOFLAVONE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; N (4 BUTYLPHENYL) ALPHA CYANOCAFFEIC ACID AMIDE; PHYTOESTROGEN; POTASSIUM CHANNEL; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.3; POTASSIUM ION; PROTEIN TYROSINE KINASE INHIBITOR; PUERARIN; RESVERATROL; SMALL INTERFERING RNA; TAMOXIFEN; TETRYLAMMONIUM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER GENE THERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER TISSUE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; IC 50; INTRACELLULAR SIGNALING; NONHUMAN; PATCH CLAMP; POTASSIUM TRANSPORT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVIEW; RNA INTERFERENCE;

BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; GENISTEIN; HUMANS; ISOFLAVONES; PHYTOESTROGENS; POTASSIUM CHANNELS;

EID: 79961169661     PISSN: 00222631     EISSN: 14321424     Source Type: Journal    
DOI: 10.1007/s00232-011-9376-4     Document Type: Review

References (101)

1. M Abdul A Santo N Hoosein 2003 Activity of potassium channel-blockers in breast cancer Anticancer Res 23 3347 3351 12926074 1:CAS:528: DC%2BD3sXntVCgsLw%3D (Pubitemid 36975434)
2. Y Arai M Uehara Y Sato M Kimira A Eboshida H Adlercreutz S Watanabe 2000 Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake J Epidemiol 10 127 135 10778038 1:STN:280:DC%2BD3c3ktVGjtA%3D%3D
3. GT Baxter RC Kuo OJ Jupp P Vandenabeele DJ MacEwan 1999 Tumor necrosis factor-alpha mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression J Biol Chem 274 9539 9547 10092639 10.1074/jbc.274.14.9539 1:CAS:528:DyaK1MXisVWltbY%3D (Pubitemid 29180272)
4. + current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells? Cancer Res 58 815 822 9485040 1:CAS:528:DyaK1cXht1anu7Y%3D (Pubitemid 28099497)
5. PJ Birch LV Dekker IF James A Southan D Cronk 2004 Strategies to identify ion channel modulators: current and novel approaches to target neuropathic pain Drug Discov Today 9 410 418 15081958 10.1016/S1359-6446(04)03043-0 1:CAS:528:DC%2BD2cXjtVCgtbw%3D (Pubitemid 38479686)
6. AS Borowiec F Hague N Harir S Guenin F Guerineau F Gouilleux M Roudbaraki K Lassoued H Ouadid-Ahidouch 2007 IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation J Cell Physiol 212 690 701 17520698 10.1002/jcp.21065 1:CAS:528:DC%2BD2sXpsVGqtr8%3D (Pubitemid 47267539)
7. CD Bortner JA Cidlowski 1999 Caspase independent/dependent regulation of K(+), cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis J Biol Chem 274 21953 21962 10419518 10.1074/jbc.274.31.21953 1:CAS:528:DyaK1MXltVymtLs%3D (Pubitemid 29360033)
8. + channels in normal and cancerous human breast Histol Histopathol 23 965 972 18498071
9. MD Cahalan H Wulff KG Chandy 2001 Molecular properties and physiological roles of ion channels in the immune system J Clin Immunol 21 235 252 11506193 10.1023/A:1010958907271 1:CAS:528:DC%2BD3MXmtVOktbw%3D (Pubitemid 32652595)
10. + current by Src tyrosine kinase J Biol Chem 277 13673 13681 11834728 10.1074/jbc.M108211200 1:CAS:528:DC%2BD38XjsFWnsrk%3D (Pubitemid 34967968)
11. + channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum Naunyn Schmiedebergs Arch Pharmacol 369 602 615 15127180 10.1007/s00210-004-0934-5 1:CAS:528:DC%2BD2cXks1Kmtb8%3D (Pubitemid 38823993)
12. + channel expression-related chemosensitivity in cancer cells and its modulation by erythromycin Cancer Chemother Pharmacol 56 212 220 15812674 10.1007/s00280-004- 0960-5 1:CAS:528:DC%2BD2MXksl2hu70%3D (Pubitemid 40884277)
13. A Cherubini GL Taddei O Crociani M Paglierani AM Buccoliero L Fontana I Noci P Borri E Borrani M Giachi A Becchetti B Rosati E Wanke M Olivotto A Arcangeli 2000 HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium Br J Cancer 83 1722 1729 11104572 10.1054/bjoc.2000.1497 1:CAS:528:DC%2BD3MXktFCkug%3D%3D (Pubitemid 32001720)
14. CE Chiang HN Luk LL Chen TM Wang PYA Ding 2002 Genistein inhibits the inward rectifying potassium current in guinea pig ventricular myocytes J Biomed Sci 9 321 326 12145529 10.1007/BF02256587 1:CAS:528:DC%2BD38Xlslantb4%3D
15. G Coiret F Matifat F Hague H Ouadid-Ahidouch 2005 17-Beta-estradiol activates maxi-K channels through a non-genomic pathway in human breast cancer cells FEBS Lett 579 2995 3000 15893312 10.1016/j.febslet.2005.02.085 1:CAS:528:DC%2BD2MXltVKgsbs%3D (Pubitemid 40797825)
16. G Coiret AS Borowiec P Mariot H Ouadid-Ahidouch F Matifat 2007 The antiestrogen tamoxifen activates BK channels and stimulates proliferation of MCF-7 breast cancer cells Mol Pharmacol 71 843 851 17164406 10.1124/mol.106. 028290 1:CAS:528:DC%2BD2sXis1aqurs%3D (Pubitemid 46294096)
17. MJ Davis X Wu TR Nurkiewicz J Kawasaki P Gui MA Hill E Wilson 2001 Regulation of ion channels by protein tyrosine phosphorylation Am J Physiol Heart Circ Physiol 281 H1835 H1862 11668044 1:CAS:528:DC%2BD3MXosFyls7w%3D
18. MS Dhar HK Plummer III 2006 Protein expression of G-protein inwardly rectifying potassium channels (GIRK) in breast cancer cells BMC Physiol 6 8 16945134 10.1186/1472-6793-6-8 (Pubitemid 44440839)
19. RA Dixon 2004 Phytoestrogens Annu Rev Plant Biol 55 225 261 15377220 10.1146/annurev.arplant.55.031903.141729 1:CAS:528:DC%2BD2cXlvFeis7Y%3D (Pubitemid 38940932)
20. MQ Dong HY Sun Q Tang HF Tse CP Lau GR Li 2010 Regulation of human cardiac KCNQ1/KCNE1 channel by epidermal growth factor receptor kinase Biochim Biophys Acta 1798 995 1001 20085748 10.1016/j.bbamem.2010.01.010 1:CAS:528:DC%2BC3cXjt1Whs74%3D
21. + currents: two-pore domain potassium channels Physiol Rev 90 559 605 20393194 10.1152/physrev.00029.2009 1:CAS:528:DC%2BC3cXht1erurnO
22. CM Fanger S Ghanshani NJ Logsdon H Rauer K Kalman J Zhou K Beckingham KG Chandy MD Cahalan J Aiyar 1999 Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1 J Biol Chem 274 5746 5754 10026195 10.1074/jbc.274.9.5746 1:CAS:528:DyaK1MXhsFejtrs%3D (Pubitemid 29109229)
23. A Felipe R Vicente N Villalonga M Roura-Ferrer R Martinez-Marmol L Sole JC Ferreres E Condom 2006 Potassium channels: new targets in cancer therapy Cancer Detect Prev 30 375 385 16971052 10.1016/j.cdp.2006.06.002 1:CAS:528:DC%2BD28XhtFynsrjE (Pubitemid 44402898)
24. Z Gao CP Lau TM Wong GR Li 2004 Protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes Cell Signal 16 333 341 14687663 10.1016/j.cellsig.2003.08. 003 1:CAS:528:DC%2BD3sXpvVaisLk%3D (Pubitemid 37542408)
25. + channels by imipramine and astemizole J Gen Physiol 124 301 317 15365094 10.1085/jgp.200409041 1:CAS:528:DC%2BD2cXpt1ahsLg%3D (Pubitemid 39346636)
26. J Gierten E Ficker R Bloehs K Schlomer S Kathofer E Scholz E Zitron C Kiesecker A Bauer R Becker HA Katus CA Karle D Thomas 2008 Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein Br J Pharmacol 154 1680 1690 18516069 10.1038/bjp.2008.213 1:CAS:528:DC%2BD1cXps1GrtLw%3D
27. SAN Goldstein DA Bayliss D Kim F Lesage LD Plant S Rajan 2005 International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels Pharmacol Rev 57 527 540 16382106 10.1124/pr.57.4.12 1:CAS:528:DC%2BD28XhtFWnsro%3D (Pubitemid 43036439)
28. +) efflux from cultured human breast cancer cells Biochim Biophys Acta 1712 52 61 15890311 10.1016/j.bbamem.2005.04.002 1:CAS:528:DC%2BD2MXltFSkurg%3D (Pubitemid 40799280)
29. PB Grace JI Taylor YL Low RN Luben AA Mulligan NP Botting M Dowsett AA Welch KT Khaw NJ Wareham NE Day SA Bingham 2004 Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European Prospective Investigation of Cancer and Nutrition-Norfolk Cancer Epidemiol Biomarkers Prev 13 698 708 15159299 1:CAS:528:DC%2BD2cXkt1Ght7w%3D (Pubitemid 38737856)
30. + channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines Mol Pharmacol 45 1227 1234 7517498 1:CAS:528:DyaK2cXkslers7c%3D (Pubitemid 24195583)
31. GA Gutman KG Chandy S Grissmer M Lazdunski D McKinnon LA Pardo GA Robertson B Rudy MC Sanguinetti W Stuhmer X Wang 2005 International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels Pharmacol Rev 57 473 508 16382104 10.1124/pr.57.4.10 1:CAS:528:DC%2BD28XhtFWnsr4%3D (Pubitemid 43036437)
32. DL Hadsell 2003 The insulin-like growth factor system in normal mammary gland function Breast Dis 17 3 14 15687673 1:CAS:528:DC%2BD2cXnsFGrsw%3D%3D (Pubitemid 38180804)
33. S Haider M Knofler 2009 Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium Placenta 30 111 123 19027157 10.1016/j.placenta.2008.10.012 1:CAS:528:DC%2BD1MXhtVCnurk%3D
34. + channels are expressed and functional in breast adenocarcinomas: correlation with tumour grade and metastasis status Histol Histopathol 25 1247 1255 20712009 1:CAS:528:DC%2BC3cXhsFSrt7fI
35. AL Harvey B Robertson 2004 Dendrotoxins: structure-activity relationships and effects on potassium ion channels Curr Med Chem 11 3065 3072 15579000 1:CAS:528:DC%2BD2cXpvV2isLw%3D (Pubitemid 39545575)
36. B Hemmerlein RM Weseloh F Mello de Queiroz H Knotgen A Sanchez ME Rubio S Martin T Schliephacke M Jenke JR Heinz W Stuhmer LA Pardo 2006 Overexpression of Eag1 potassium channels in clinical tumours Mol Cancer 5 41 17022810 10.1186/1476-4598-5-41 (Pubitemid 44642556)
37. Hille B (2001) Ion channels of excitable membranes, 3rd edn. Sinauer Associates, Sunderland, MA
38. + suppresses the activation of apoptosis in lymphocytes J Biol Chem 272 30567 30576 9374553 10.1074/jbc.272.48.30567 1:CAS:528:DyaK2sXnslGgsLc%3D (Pubitemid 27512272)
39. HUGO Gene Nomenclature Committee (2011) HUGO Gene Nomenclature Committee Database. http://www.genenames.org
40. CS Hwang HS Kwak HJ Lim SH Lee YS Kang TB Choe HG Hur KO Han 2006 Isoflavone metabolites and their in vitro dual functions: they can act as an estrogenic agonist or antagonist depending on the estrogen concentration J Steroid Biochem Mol Biol 101 246 253 16965913 10.1016/j.jsbmb.2006.06.020 1:CAS:528:DC%2BD28XhtFSrtbvO (Pubitemid 44604448)
41. International Union of Pharmacology (2011) IUPHAR Committee on Receptor Nomenclature and Drug Classification Database. http://www.iuphar-db.org
42. M Iwasaki M Inoue T Otani S Sasazuki N Kurahashi T Miura S Yamamoto S Tsugane 2008 Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group J Clin Oncol 26 1677 1683 18316793 10.1200/JCO.2007.13.9964 1:CAS:528:DC%2BD1cXltlWhsrY%3D
43. SH Jang KS Kang PD Ryu SY Lee 2009 Kv1.3 voltage-gated K(+) channel subunit as a potential diagnostic marker and therapeutic target for breast cancer BMB Rep 42 535 539 19712592 10.5483/BMBRep.2009.42.8.535 1:CAS:528:DC%2BD1MXhtFCjs7jK
44. Q Jin FJ Esteva 2008 Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer J Mammary Gland Biol Neoplasia 13 485 498 19034632 10.1007/s10911-008-9107-3
45. D Khaitan UT Sankpal B Weksler EA Meister IA Romero PO Couraud NS Ningaraj 2009 Role of KCNMA1 gene in breast cancer invasion and metastasis to brain BMC Cancer 9 258 19640305 10.1186/1471-2407-9-258
46. PD Koeberle Y Wang LC Schlichter 2010 Kv1.1 and Kv1.3 channels contribute to the degeneration of retinal ganglion cells after optic nerve transection in vivo Cell Death Differ 17 134 144 19696788 10.1038/cdd.2009.113 1:CAS:528:DC%2BD1MXhsFGnurjF
47. Y Kubo JP Adelman DE Clapham LY Jan A Karschin Y Kurachi M Lazdunski CG Nichols S Seino CA Vandenberg 2005 International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels Pharmacol Rev 57 509 526 16382105 10.1124/pr.57.4.11 1:CAS:528:DC%2BD28XhtFWnsrw%3D (Pubitemid 43036438)
48. GG Kuiper JG Lemmen B Carlsson JC Corton SH Safe PT van der Saag B van der Burg JA Gustafsson 1998 Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta Endocrinology 139 4252 4263 9751507 10.1210/en.139.10.4252 1:CAS:528:DyaK1cXmsVGmsrw%3D (Pubitemid 28513713)
49. E Lastraioli L Guasti O Crociani S Polvani G Hofmann H Witchel L Bencini M Calistri L Messerini M Scatizzi R Moretti E Wanke M Olivotto G Mugnai A Arcangeli 2004 herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells Cancer Res 64 606 611 14744775 10.1158/0008-5472.CAN-03-2360 1:CAS:528:DC%2BD2cXmsVajug%3D%3D (Pubitemid 38120900)
50. SA Lee XO Shu H Li G Yang H Cai W Wen BT Ji J Gao YT Gao W Zheng 2009 Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study Am J Clin Nutr 89 1920 1926 19403632 10.3945/ajcn.2008.27361 1:CAS:528:DC%2BD1MXms1ejtrg%3D
51. HF Li SA Chen SN Wu 2000 Evidence for the stimulatory effect of resveratrol on Ca(2+)-activated K+ current in vascular endothelial cells Cardiovasc Res 45 1035 1045 10728430 10.1016/S0008-6363(99)00397-1 1:CAS:528:DC%2BD3cXhtFaltrs%3D (Pubitemid 30089666)
52. Z Li JL Joyal DB Sacks 2001 Calmodulin enhances the stability of the estrogen receptor J Biol Chem 276 17354 17360 11278648 10.1074/jbc.M010238200 1:CAS:528:DC%2BD3MXjvFGitbY%3D
53. X Li S Zhang S Safe 2006 Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds J Steroid Biochem Mol Biol 98 122 132 16413991 10.1016/j.jsbmb.2005.08.018 1:CAS:528: DC%2BD28XhtFWitrs%3D (Pubitemid 43153783)
54. Z Li J Li B Mo C Hu H Liu H Qi X Wang J Xu 2008 Genistein induces cell apoptosis in MDA-MB-231 breast cancer cells via the mitogen-activated protein kinase pathway Toxicol In Vitro 22 1749 1753 18761399 10.1016/j.tiv.2008.08.001 1:CAS:528:DC%2BD1cXhtFCksbnF
55. M Maggiolini D Bonofiglio S Marsico ML Panno B Cenni D Picard S Ando 2001 Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells Mol Pharmacol 60 595 602 11502892 1:CAS:528:DC%2BD3MXmtFams7s%3D (Pubitemid 32782656)
56. A Matsumura A Ghosh GS Pope PD Darbre 2005 Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells J Steroid Biochem Mol Biol 94 431 443 15876408 10.1016/j.jsbmb.2004.12.041 1:CAS:528:DC%2BD2MXjvVKktr0%3D (Pubitemid 40616404)
57. JP Medema C Scaffidi FC Kischkel A Shevchenko M Mann PH Krammer ME Peter 1997 FLICE is activated by association with the CD95 death-inducing signaling complex (DISC) EMBO J 16 2794 2804 9184224 10.1093/emboj/16.10.2794 1:CAS:528:DyaK2sXjsF2mtL0%3D (Pubitemid 27226216)
58. + current in guinea-pig ventricular myocytes J Physiol 573 pt 2 469 482 16581870 10.1113/jphysiol.2005. 104422 1:CAS:528:DC%2BD28XmtVaitrs%3D (Pubitemid 43871060)
59. D Mu L Chen X Zhang LH See CM Koch C Yen JJ Tong L Spiegel KCQ Nguyen A Servoss Y Peng L Pei JR Marks S Lowe T Hoey LY Jan WR McCombie MH Wigler S Powers 2003 Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene Cancer Cell 3 297 302 12676587 10.1016/S1535-6108(03) 00054-0 1:CAS:528:DC%2BD3sXislOrtbY%3D (Pubitemid 37443884)
60. + channel expression in human breast cancer cells: involvement in cell cycle regulation and carcinogenesis J Membr Biol 221 1 6 18060344 10.1007/s00232-007-9080-6 1:CAS:528:DC%2BD1cXlt1Oiug%3D%3D
61. H Ouadid-Ahidouch F Chaussade M Roudbaraki C Slomianny E Dewailly P Delcourt N Prevarskaya 2000 KV1.1 K(+) channels identification in human breast carcinoma cells: involvement in cell proliferation Biochem Biophys Res Commun 278 272 277 11097830 10.1006/bbrc.2000.3790 1:CAS:528:DC%2BD3cXotlKks70%3D
62. + channels in breast cancer cells Biochem Biophys Res Commun 316 244 251 15003537 10.1016/j.bbrc.2004.02.041 1:CAS:528:DC%2BD2cXhslentLg%3D (Pubitemid 38299152)
63. H Ouadid-Ahidouch M Roudbaraki P Delcourt A Ahidouch N Joury N Prevarskaya 2004 Functional and molecular identification of intermediate- conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression Am J Physiol Cell Physiol 287 C125 C134 14985237 10.1152/ajpcell.00488.2003 1:CAS:528:DC%2BD2cXlvFOht7k%3D (Pubitemid 38780160)
64. LA Pardo 2004 Voltage-gated potassium channels in cell proliferation Physiology 19 285 292 15381757 10.1152/physiol.00011.2004 1:CAS:528: DC%2BD2MXksFymsr4%3D (Pubitemid 39472640)
65. LA Pardo C Contreras-Jurado M Zientkowska F Alves W Stuhmer 2005 Role of voltage-gated potassium channels in cancer J Membr Biol 205 115 124 16362499 10.1007/s00232-005-0776-1 1:CAS:528:DC%2BD2MXhtlWrsrvE (Pubitemid 41803688)
66. + channels in pulmonary arterial smooth muscle cells J Smooth Muscle Res 46 89 105 20551590 10.1540/jsmr.46.89
67. G Peterson S Barnes 1996 Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells Cell Growth Differ 7 1345 1351 8891338 1:CAS:528:DyaK28Xmt1Cis74%3D (Pubitemid 26360683)
68. S Pillozzi MF Brizzi M Balzi O Crociani A Cherubini L Guasti B Bartolozzi A Becchetti E Wanke PA Bernabei M Olivotto L Pegoraro A Arcangeli 2002 HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors Leukemia 16 1791 1798 12200695 10.1038/sj.leu.2402572 1:CAS:528:DC%2BD38XmsV2lsLs%3D
69. OG Rodriguez-Mora MM LaHair JA McCubrey RA Franklin 2005 Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells Cancer Res 65 5408 5416 15958590 10.1158/0008-5472.CAN-05- 0271 1:CAS:528:DC%2BD2MXltFels70%3D (Pubitemid 40827354)
70. S Roger M Potier C Vandier JY Le Guennec P Besson 2004 Description and role in proliferation of iberiotoxin-sensitive currents in different human mammary epithelial normal and cancerous cells Biochim Biophys Acta 1667 190 199 15581855 10.1016/j.bbamem.2004.10.002 1:CAS:528:DC%2BD2cXhtVClt73J (Pubitemid 39576083)
71. + channel function in the human mammary carcinoma cell line MCF-7 Oncol Rep 19 1511 1516 18497958 1:CAS:528: DC%2BD1cXnvVCqs7o%3D
72. T Sakamoto H Horiguchi E Oguma F Kayama 2010 Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor- positive breast cancer cells J Nutr Biochem 21 856 864 19800779 10.1016/j.jnutbio.2009.06.010 1:CAS:528:DC%2BC3cXhtVKgsbzE
73. JJ Salata NK Jurkiewicz AA Wallace RF Stupienski III PJ Guinosso Jr JJ Lynch Jr 1995 Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine Circ Res 76 110 119 8001268 1:CAS:528:DyaK2MXkt1Sjsbs%3D
74. X Shi Y Cheng L Zou D Xiong Y Zhou M Yang D Fan X Dai C Yang H Zhu 2011 Influence of the calmodulin antagonist EBB on cyclin B1 and cdc2-p34 in human drug-resistant breast cancer MCF-7/ADR cells Chin J Clin Oncol 5 108 112 10.1007/s11805-008-0108-1
75. HY Shim JH Park HD Paik SY Nah DSHL Kim YS Han 2007 Genistein-induced apoptosis of human breast cancer MCF-7 cells involves calpain-caspase and apoptosis signaling kinase 1-p38 mitogen-activated protein kinase activation cascades Anticancer Drugs 18 649 657 17762393 10.1097/CAD.0b013e3280825573 1:CAS:528:DC%2BD2sXmvVWrtrg%3D (Pubitemid 47343657)
76. FV So N Guthrie AF Chambers KK Carroll 1997 Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen Cancer Lett 112 127 133 9066718 10.1016/S0304-3835(96)04557-0 1:CAS:528:DyaK2sXpt12msw%3D%3D (Pubitemid 27104286)
77. D Stephan M Winkler P Kuhner U Russ U Quast 2006 Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K(ATP) channels Diabetologia 49 2039 2048 16865362 10.1007/s00125-006-0307-3 1:CAS:528:DC%2BD28XnslSiurg%3D (Pubitemid 44168470)
78. BK Stringer AG Cooper SB Shepard 2001 Overexpression of the G-protein inwardly rectifying potassium channel 1 (GIRK1) in primary breast carcinomas correlates with axillary lymph node metastasis Cancer Res 61 582 588 11212253 1:CAS:528:DC%2BD3MXht1GmsLg%3D (Pubitemid 32128618)
79. JS Strobl WF Wonderlin DC Flynn 1995 Mitogenic signal transduction in human breast cancer cells Gen Pharmacol 26 1643 1649 8745151 1:CAS:528:DyaK28XksFGruw%3D%3D (Pubitemid 26033840)
80. XH Sun JP Ding H Li N Pan L Gan XL Yang HB Xu 2007 Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation J Pharmacol Exp Ther 323 391 397 17652634 10.1124/jpet.107.125567 1:CAS:528:DC%2BD2sXhtFahsb%2FL (Pubitemid 47443248)
81. T Suzuki K Matsuo N Tsunoda K Hirose A Hiraki T Kawase T Yamashita H Iwata H Tanaka K Tajima 2008 Effect of soybean on breast cancer according to receptor status: a case-control study in Japan Int J Cancer 123 1674 1680 18623079 10.1002/ijc.23644 1:CAS:528:DC%2BD1cXhtV2ru7zK
82. I Szabo J Bock H Grassme M Soddemann B Wilker F Lang M Zoratti E Gulbins 2008 Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes Proc Natl Acad Sci USA 105 14861 14866 18818304 10.1073/pnas. 0804236105 1:CAS:528:DC%2BD1cXht1aqur7O
83. A Teisseyre K Michalak 2005 Genistein inhibits the activity of kv1.3 potassium channels in human T lymphocytes J Membr Biol 205 71 79 16283587 10.1007/s00232-005-0764-5 1:CAS:528:DC%2BD2MXht1SqtbnI (Pubitemid 41618643)
84. A Teisseyre K Michalak 2006 Inhibition of the activity of human lymphocyte Kv1.3 potassium channels by resveratrol J Membr Biol 214 123 129 17557164 10.1007/s00232-007-0043-8 1:CAS:528:DC%2BD2sXns1amsb8%3D (Pubitemid 47063505)
85. BJ Trock L Hilakivi-Clarke R Clarke 2006 Meta-analysis of soy intake and breast cancer risk J Natl Cancer Inst 98 459 471 16595782 10.1093/jnci/djj102 1:CAS:528:DC%2BD28Xjtlamt7Y%3D
86. R Vaidyanathan SM Taffet KL Vikstrom JMB Anumonwo 2010 Regulation of cardiac inward rectifier potassium current (I(K1)) by synapse-associated protein-97 J Biol Chem 285 28000 28009 20530486 10.1074/jbc.M110.110858 1:CAS:528:DC%2BC3cXhtVOnsLrL
87. PK Verkasalo PN Appleby NE Allen G Davey H Adlercreutz TJ Key 2001 Soya intake and plasma concentrations of daidzein and genistein: validity of dietary assessment among eighty British women (Oxford arm of the European Prospective Investigation into Cancer and Nutrition) Br J Nutr 86 415 421 11570994 10.1079/BJN2001424 1:CAS:528:DC%2BD3MXnsFKktr0%3D (Pubitemid 32916199)
88. CC Vu CD Bortner JA Cidlowski 2001 Differential involvement of initiator caspases in apoptotic volume decrease and potassium efflux during Fas- and UV-induced cell death J Biol Chem 276 37602 37611 11431480 10.1074/jbc. M104810200 1:CAS:528:DC%2BD3MXns1eksbw%3D
89. + channels in regulating tumour cell proliferation and apoptosis Eur J Physiol 448 274 286 10.1007/s00424-004-1258-5 1:CAS:528:DC%2BD2cXjvFKnsrk%3D (Pubitemid 40895596)
90. + channel, a regulator of tumor cell apoptosis and proliferation Cancer Res 62 4843 4848 12208728 1:CAS:528:DC%2BD38XmslyltbY%3D (Pubitemid 34984401)
91. C Weber F Mello de Queiroz BR Downie A Suckow W Stuhmer LA Pardo 2006 Silencing the activity and proliferative properties of the human EagI potassium channel by RNA interference J Biol Chem 281 13030 13037 16537547 10.1074/jbc.M600883200 1:CAS:528:DC%2BD28Xkt1ymsr8%3D (Pubitemid 43855212)
92. AD Wei GA Gutman R Aldrich KG Chandy S Grissmer H Wulff 2005 International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels Pharmacol Rev 57 463 472 16382103 10.1124/pr.57.4.9 1:CAS:528:DC%2BD28XhtFWgu7c%3D (Pubitemid 43036436)
93. D Weinstein M Simon E Yehezkel Z Laron H Werner 2009 Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells Diabetes Metab Res Rev 25 41 49 19145584 10.1002/dmrr.912 1:CAS:528:DC%2BD1MXivFWjurg%3D
94. WF Wonderlin JS Strobl 1996 Potassium channels, proliferation and G1 progression J Membr Biol 154 91 107 8929284 10.1007/s002329900135 1:CAS:528:DyaK28XntlCrurY%3D (Pubitemid 26413993)
95. WKK Wu GR Li HPS Wong MKC Hui EKK Tai EKY Lam VY Shin YN Ye P Li YH Yang JC Luo CH Cho 2006 Involvement of Kv1.1 and Nav1.5 in proliferation of gastric epithelial cells J Cell Physiol 207 437 444 16331678 10.1002/jcp.20576 1:CAS:528:DC%2BD28Xjs1yltLY%3D
96. 2+ influx in carcinoma cells of colon cancer Life Sci 65 55 62 10403493 10.1016/S0024-3205(99)00218-0 1:CAS:528:DyaK1MXjvFegu7Y%3D (Pubitemid 29292805)
97. DT Zava G Duwe 1997 Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro Nutr Cancer 27 31 40 8970179 10.1080/01635589709514498 1:CAS:528:DyaK2sXit1eitg%3D%3D (Pubitemid 26424313)
98. ZH Zhang Q Wang 2000 Modulation of a cloned human A-type voltage-gated potassium channel (hKv1.4) by the protein tyrosine kinase inhibitor genistein Pflugers Arch 440 784 792 11007322 10.1007/s004240000360 1:CAS:528: DC%2BD3cXlvVKrs78%3D
99. DY Zhang Y Wang CP Lau HF Tse GR Li 2008 Both EGFR kinase and Src-related tyrosine kinases regulate human ether-á-go-go-related gene potassium channels Cell Signal 20 1815 1821 18617000 10.1016/j.cellsig.2008.06.006 1:CAS:528:DC%2BD1cXhtVejt7rP
100. Z Zhou Q Gong B Ye Z Fan JC Makielski GA Robertson CT January 1998 Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature Biophys J 74 230 241 9449325 10.1016/S0006-3495(98) 77782-3 1:CAS:528:DyaK1cXhvFWjurg%3D (Pubitemid 28041752)
101. 2+/calmodulin binding to the cytosolic N- and C-termini FEBS J 273 1074 1086 16478480 10.1111/j.1742-4658.2006.05134.x 1:CAS:528:DC%2BD28Xjs1Olt7k%3D