Genistein inhibits the activity of Kv1.3 potassium channels in human T lymphocytes

Journal of Membrane Biology

Volumn 205, Issue 2, 2005, Pages 71-79

  Teisseyre, A ^a   Michalak, K ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Cancer cell proliferation; Genistein; Patch clamp; Potassium channel; T lymphocyte; Tyrosine kinase

Indexed keywords

ANTINEOPLASTIC AGENT; DAIDZEIN; ENZYME INHIBITOR; GENISTEIN; PROTEIN TYROSINE KINASE INHIBITOR; VANADATE SODIUM; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; ELECTRIC POTENTIAL; HUMAN; HUMAN CELL; INHIBITION KINETICS; NORMAL HUMAN; PATCH CLAMP; POTASSIUM CURRENT; T LYMPHOCYTE; WHOLE CELL;

ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENISTEIN; HUMANS; KV1.3 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; T-LYMPHOCYTES;

EID: 27744560337     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-005-0764-5     Document Type: Article

References (44)

1. Abdul, M., Hoosein, N. 2002. Expression and activity of potassium ion channels in human prostate cancer. Cancer Lett. 186:99-105
2. Abdul, M., Santo, A., Hoosein, N. 2003. Activity of potassium channel-blockers in breast cancer. Anticancer Res. 23:3347-3351
3. Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., Watanabe, S., Itoh, N., Shibuya, M., Fukami, Y. 1987. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262:5592-5595
4. 1-integrins on the plasma membrane of melanoma cells: effects of cell adherence and channel blockers. J. Gen. Physiol. 120:29-37
5. Bobrowska - Hägerstrand, M., Wróbel, A., Rychlik, B., Bartosz, G., Söderstöm, T., Shirataki, Y., Motohashi N., Molnar, J., Michalak, K., Hägerstrand, H. 2001. Monitoring of MRP-like Activity in Human Erythrocytes - Inhibitory Effect of Isoflavones. Blood Cells, Molecules, and Diseases 27:894-900
6. Cahalan, M., Wulff, H., Chandy, K. 2001. Molecular properties and physiological roles of ion channels in the immune system. J. Clin. Immunol. 21:235-252
7. + current by Src Tyrosine kinase. J. Biol. Chem. 277:13673-13681
8. + channel as targets for specific immunomodulation. TIPS 25:280-9
9. Colley, B., Tucker, K., Fadool, D. 2004. Comparison of modulation of Kv1.3 channel by two receptor tyrosine kinases in olfactory bulb neurons of rodents. Rec Channels 10:25-36
10. + channels for cancer therapy. Exp. Ther. Oncol. 4:161-166
11. Fadool, D., Holmes, T., Berman, K., Dagan, D., Levitan, I. 1997. Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel. J. Neurophysiol. 78:1563-1573
12. Fraser, S., Grimes, J., Diss, J., Stewart, D., Dolly, J., Djamgoz, M. 2003. Predominant expression of Kv1.3 voltage-gated K+ channel subunit in rat prostate cancer cell lines: electrophysiological, pharmacological and molecular characterisation. Pfuegers Arch. 446:559-571
13. Grissmer, S., Nguyen, A., Cahalan, M. 1993. Calcium-activated potassium channels in resting and activated human T lymphocytes. J. Gen. Physiol. 102:601-630
14. Grunnet, M., Rasmussen, H., Hay-Schmidt, A., Klaerke, D. 2003. The voltage-gated potassium channel subunit, Kv1.3, is expressed in epithelia. BBA 1616:85-94
15. Gulbins, E., Szabo, E., Baltzer, K., Lang, F. 1997. Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases. Proc. Natl. Acad. Sci. USA 94:7661-7666
16. Hamill, O.P., Marty, A., Neher, E., Sakmann, B., Sigworth, F.J. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfuegers Arch. 39:85-100
17. Hirano, T., Kuritani, T., Kishimoto, Y., Yamamura, Y. 1977. T cell dependency of PWM-induced Ig production by B cells. J Jmmunol. 119:1235-1242
18. Hool, L., Middleton, L., Harvey, R. 1998. Genistein increases the sensitivity of cardiac ion channels to β-adrenergic receptor stimulation. Circ. Res. 83:33-42
19. Hwang, T., Koeppe, R., Andersen, O. 2003. Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics. Biochemistry 42:13646-13658
20. Kupper, J., Prinz, A., Fromherz, P. 2002. Recombinant Kv1.3 potassium channels stabilize tonic firing of cultured rat hippocampal neurons. Pflügers Arch. 443:541-547
21. Łania-Pietrzak, B., Hendrich, A., Żugaj, J., Michalak, K. 2005. Metabolic O-demethylation does not alter the influence of isoflavones on the biophysical properties of membranes and MRP1-like protein transport activity. Arch. Biochem. Biophys. 433:428-434
22. Mackenzie, A., Chirakkal, H., North, A. 2003. Kv1.3 potassium channels in human alveolar macrophages. Am. J. Physiol. 285:L862-L868
23. Ogata, R., Kitamura, K., Ito, Y., Nakano, H. 1997. Inhibitory effect of genistein on ATP-sensitive K+ channels in rabbit portal vein smooth muscle. Br. J. Pharmacol 122:1395-1404
24. Panyi, G., Gaspar, R., Krasznai, J., Ameloot, M., Aszalos, A., Steels, P., Damjanovich, S. 1996. Immunosuppressors inhibit voltage-gated potassium channels in human peripheral blood lymphocytes. Biochem. Biophys.Res. Commun. 221:254-258
25. Pardo, L.A. 2004. Voltage-gated potassium channels in cell proliferation. Physiology (Bethesda) 19:285-292
26. + channel gating in mouse Schwann cells. J. Physiol. 519:373-384
27. Preußat., K., Beetz, Ch., Schrey, M., Kraft, R., Wölfl, S., Kalff, R., Patt, S. 2003. Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas. Neurosci. Lett. 346:33-36
28. Rouzaire-Dubois, B., Dubois, J.M. 1990. Tamoxifen blocks both proliferation and voltage-dependent K channels of neuroblastoma cells. Cell. Signal. 2:387-393
29. Rouzaire-Dubois, B., Gerard, V., Dubois, J.M. 1993. Involvement of K channels in quercetin-induced inhibition of neuroblastoma cell growth. Pfluegers Arch. 423:202-205
30. + channel gating. Mol. Pharmacol. 59:1376-1387
31. + currents by tyrosine kinase inhibitors genistein and ST 638. Circ. Res. 76:310-316
32. Speake, T., Kibble, J., Brown, P. 2004. Kv1.1 and Kv1.3 channels contribute to the delayed-rectifying conductance in rat choroid plexus epithelial cells. Am. J. Physiol 286:C611-C620
33. Storey, N.M., Gomez-Angelats, M., Bortner, C.D., Armstrong, D.L., Cidlowski, J.A. 2003. Stimulation of Kv1.3 potassium channels by death receptors during apoptosis in Jurkat T lymphocytes. J. Biol. Chem. 278:33319-33326
34. Su, S.J., Yeh, T.M., Chuang, W.J., Ho, Ch.L., Chang, K.L., Cheng, H.L., Liu, H.Sh., Cheng, H.L., Hsu, P.Y., Chow, N.H. 2005. The novel targets for anti-angiogenesis of genistein on human cancer cells. Biochem. Pharmacol. 69:307-318
35. Teisseyre, A., Michalak, K. 2004. The inhibitory effect of genistein on Kv1.3 channels in human T lymphocytes. Abstracts of the XII Conference of Polish Biophysical Society, Wroctaw, Poland, 15-17 September 2004. Curr. Top. Biophys. 28:A-57
36. Veh, R., Lichtinghagen, R., Sewing, S., Wunder, F., Grumbach, L., Pongs, O. 1995. Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain. Eur. J. Neurosci. 7:2189-2205
37. Wang, Z. 2004. Roles of K+ channels in regulating tumour cell proliferation and apoptosis. Pfluegers Arch 448:274-286
38. Wang, Y., Jia, H., Walker, A.M., Cukierman, S. 1992. K-current mediation of prolactin-induced proliferation of malignant (Nb2) lymphocytes. J. Cell. Physiol 1532:185-189
39. Washizuka, T., Horie, M., Obayashi, K., Sasayama, S. 1998. Genistein inhibits slow component delayed-rectifier K currents via a tyrosine kinase-independent pathway. J. Mol. Cell. Cardial. 30:2577-2590
40. Xu, J., Koni, P., Wang, P., Li, G., Kaczmarek, L., Wu, Y., Li, Y., Flavell, R., Desir, G. 2003. The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Hum. Mol. Genetics. 12:551-559
41. Xu, J., Wang, P., Li, Y., Kaczmarek, L., Wu, Y., Koni, P., Flavell, R., Desir, G. 2004. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proc. Natl. Acad. Sci. USA 101:3112-3117
42. Yu, Z., Li, W., Liu, F. 2004. Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett. 215:159-166
43. + channels involved in the control of the resting potential in CEM lymphocytes. J. Immunol. 162:5359-5366
44. Zhang, Z., Wang, Q. 2000. Modulation of a cloned human A-type voltage-gated potassium channel (hKv1.4) by the protein kinase inhibitor genistein. Pfluegers Arch. 440:784-792