Kv1.3 voltage-gated K+ channel subunit as a potential diagnostic marker and therapeutic target for breast cancer

BMB Reports

Volumn 42, Issue 8, 2009, Pages 535-539

  Jang, Soo Hwa ^a   Kang, Kyung Sun ^a   Ryu, Pan Dong ^a   Lee, So Yeong ^a  

^a Seoul National University   (South Korea)

Author keywords

Kv channels; Mammary epithelial cells; Molecular target; Proliferation

Indexed keywords

MESSENGER RNA; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.3; PROTEIN SUBUNIT; TUMOR MARKER;

ARTICLE; BREAST TUMOR; CELL PROLIFERATION; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KV1.3 POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKERS; PROTEIN SUBUNITS; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 70349564255     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2009.42.8.535     Document Type: Article

References (18)

1. Ouadid-Ahidouch, H., Chaussade, F., Roudbaraki, M., Slomianny, C., Dewailly, E., Delcourt, P. and Prevarskaya, N. (2000) KV1.1 K(+) channels identification in human breast carcinoma cells: involvement in cell proliferation. Biochem. Biophys. Res. Commun. 278, 272-277.
2. Abdul, M., Santo, A. and Hoosein, N. (2003) Activity of potassium channel-blockers in breast cancer. Anticancer Res. 23, 3347-3351.
3. Lan, M., Shi, Y., Han, Z., Hao, Z., Pan, Y., Liu, N., Guo, C., Hong, L., Wang, J., Qiao, T. and Fan, D. (2005) Expression of delayed rectifier potassium channels and their possible roles in proliferation of human gastric cancer cells. Cancer Biol. Ther. 4, 1342-1347.
4. Abdul, M. and Hoosein, N. (2002) Expression and activity of potassium ion channels in human prostate cancer. Cancer Lett. 186, 99-105.
5. Abdul, M. and Hoosein, N. (2006) Reduced Kv1.3 potassium channel expression in human prostate cancer. J. Membr. Biol. 214, 99-102.
6. Szabo, I., Adams, C. and Gulbins, E. (2004) Ion channels and membrane rafts in apoptosis. Pflugers. Arch. 448, 304-312.
7. Brevet, M., Ahidouch, A., Sevestre, H., Merviel, P., El Hiani, Y., Robbe, M. and Ouadid-Ahidouch, H. (2008) Expression of K+ channels in normal and cancerous human breast. Histol. Histopathol. 23, 965-972.
8. Kang, K. S., Sun, W., Nomata, K., Morita, I., Cruz, A., Liu, C. J., Trosko, J. E. and Chang, C. C. (1998) Involvement of tyrosine phosphorylation of p185 (c-erbB2/neu) in tumorigenicity induced by X-rays and the neu oncogene in human breast epithelial cells. Mol. Carcinog 21, 225-233.
9. Ohya, S., Kimura, K., Niwa, S., Ohno, A., Kojima, Y., Sasaki, S., Kohri, K. and Imaizumi, Y. (2009) Malignancy grade-dependent expression of K(+)-channel subtypes in human prostate cancer. J. Pharmacol. Sci. 109, 148-151.
10. Wood, L. D., Parsons, D. W., Jones, S., Lin, J., Sjoblom, T., Leary, R. J., Shen, D., Boca, S. M., Barber, T., Ptak, J., Silliman, N., Szabo, S., Dezso, Z., Ustyanksky, V., Nikolskaya, T., Nikolsky, Y., Karchin, R., Wilson, P. A., Kaminker, J. S., Zhang, Z., Croshaw, R., Willis, J., Dawson, D., Shipitsin, M., Willson, J. K., Sukumar, S., Polyak, K., Park, B. H., Pethiyagoda, C. L., Pant, P. V., Ballinger, D. G., Sparks, A. B., Hartigan, J., Smith, D. R., Suh, E., Papadopoulos, N., Buckhaults, P., Markowitz, S. D., Parmigiani, G., Kinzler, K. W., Velculescu, V. E. and Vogelstein, B. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318, 1108-1113.
11. Harris, L., Fritsche, H., Mennel, R., Norton, L., Ravdin, P., Taube, S., Somerfield, M. R., Hayes, D. F. and Bast, R. C., Jr. (2007) American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J. Clin. Oncol. 25, 5287-5312.
12. Andersson, I. and Ryden, S. (2001) Early detection and prevention: benefits, costs and limitations of screening; In: Tobias, J. S., Houghton, J., Henderson, I. C. (eds.), pp. 105- 117, Breast cancer, Arnold, London.
13. Nie, L., Wu, G. and Zhang, W. (2006) Correlation of mRNA expression and protein abundance affected by multiple sequence features related to translational efficiency in Desulfovibrio vulgaris: a quantitative analysis. Genetics 174, 2229-2243.
14. Chen, G., Gharib, T. G., Huang, C. C., Taylor, J. M., Misek, D. E., Kardia, S. L., Giordano, T. J., Iannettoni, M. D., Orringer, M. B., Hanash, S. M. and Beer, D. G. (2002) Discordant protein and mRNA expression in lung adenocarcinomas. Mol. Cell Proteomics 1, 304-313.
15. Spitzner, M., Ousingsawat, J., Scheidt, K., Kunzelmann, K. and Schreiber, R. (2007) Voltage-gated K+ channels support proliferation of colonic carcinoma cells. Faseb. J. 21, 35-44.
16. Shon, Y. H., Park, S. D. and Nam, K. S. (2006) Effective chemopreventive activity of genistein against human breast cancer cells. BMB Rep. 39, 448-451.
17. Eling, T. E., Baek, S. J., Shim, M. S. and Lee, C. H. (2006) NSAID activated gene (NAG-1), as modulator of tumorigenesis. BMB Rep. 39, 649-655.
18. Kao, C. Y., Nomata, K., Oakley, C. S., Welsch, C. W. and Chang, C. C. (1995) Two types of normal human breast epithelial cells derived from reduction mammoplasty: phenotypic characterization and response to SV40 transfection. Carcinogenesis 16, 531-538.