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Volumn 71, Issue 11, 2011, Pages 1481-1501

Dexmedetomidine: A review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation

Author keywords

Adis Drug Evaluations; Dexmedetomidine, general; Intensive care units; Sedation

Indexed keywords

ATROPINE; BENZODIAZEPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYTOCHROME P450; DEXMEDETOMIDINE; FENTANYL; INOTROPIC AGENT; LORAZEPAM; MIDAZOLAM; MORPHINE; NORADRENALIN; OPIATE; PARACETAMOL; PLACEBO; PROPOFOL;

EID: 79961139017     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11207190-000000000-00000     Document Type: Review
Times cited : (170)

References (66)
  • 1
    • 0036204179 scopus 로고    scopus 로고
    • Practice guidelines for sedation and analgesia by nonanesthesiologists
    • Apr
    • Practice guidelines for sedation and analgesia by nonanesthesiologists. Anesthesiology 2002 Apr; 96 (4): 1004-17.
    • (2002) Anesthesiology , vol.96 , Issue.4 , pp. 1004-1017
  • 2
    • 11844288880 scopus 로고    scopus 로고
    • Procedural sedation in the acute care setting
    • Brown TB, Lovato LM, Parker D. Procedural sedation in the acute care setting. Am Fam Physician 2005 Jan 1; 71 (1): 85-90. (Pubitemid 40096057)
    • (2005) American Family Physician , vol.71 , Issue.1 , pp. 85-90
    • Brown, T.B.1    Lovato, L.M.2    Parker, D.3
  • 3
    • 72249105873 scopus 로고    scopus 로고
    • Use of intravenous infusion sedation among mechanically ventilated patients in the United States
    • Dec 1
    • Wunsch H, Kahn JM, Kramer AA, et al. Use of intravenous infusion sedation among mechanically ventilated patients in the United States. Crit Care Med 2009Dec 1; 37 (12): 3031-9.
    • (2009) Crit Care Med , vol.37 , Issue.12 , pp. 3031-3039
    • Wunsch, H.1    Kahn, J.M.2    Kramer, A.A.3
  • 4
    • 33748086044 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic characteristics of medications used for moderate sedation
    • Gan TG. Pharmacokinetic and pharmacodynamic characteristics of medications used for moderate sedation. Clin Pharmacokinet 2006; 45 (9): 855-69.
    • (2006) Clin Pharmacokinet , vol.45 , Issue.9 , pp. 855-869
    • Gan, T.G.1
  • 5
    • 59649118745 scopus 로고    scopus 로고
    • A new era for sedation in ICU patients
    • Feb
    • Wunsch H, Kress JP. A new era for sedation in ICU patients. JAMA 2009 Feb; 301 (5): 542-4.
    • (2009) JAMA , vol.301 , Issue.5 , pp. 542-544
    • Wunsch, H.1    Kress, J.P.2
  • 6
    • 0034106127 scopus 로고    scopus 로고
    • Dexmedetomidine
    • Bhana N, Goa KL, McClellan KJ. Dexmedetomidine. Drugs 2000 Feb; 59 (2): 263-8; discussion 269-70. (Pubitemid 30168513)
    • (2000) Drugs , vol.59 , Issue.2 , pp. 263-268
    • Bhana, N.1    Goa, K.L.2    McClellan, K.J.3
  • 8
    • 77954459092 scopus 로고    scopus 로고
    • Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: A metaanalysis
    • Jun
    • Tan JA, Ho KM. Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a metaanalysis. Intensive Care Med 2010 Jun; 36 (6): 926-39.
    • (2010) Intensive Care Med , vol.36 , Issue.6 , pp. 926-939
    • Tan, J.A.1    Ho, K.M.2
  • 9
    • 67650519450 scopus 로고    scopus 로고
    • Alpha 2 adrenoceptor agonist-dexmedetomidine role in anaesthesia and intensive care: A clinical review
    • Murthy TVSP, Singh R. Alpha 2 adrenoceptor agonist-dexmedetomidine role in anaesthesia and intensive care: a clinical review. J Anaesthesiol Clin Pharmacol 2009; 25 (3): 267-72.
    • (2009) J Anaesthesiol Clin Pharmacol , vol.25 , Issue.3 , pp. 267-272
    • Murthy, T.V.S.P.1    Singh, R.2
  • 10
    • 53749086162 scopus 로고    scopus 로고
    • Dexmedetomidine: A useful adjunct to consider in some high-risk situations
    • Oct
    • Haselman MA. Dexmedetomidine: a useful adjunct to consider in some high-risk situations. AANA J 2008 Oct; 76 (5): 335-9.
    • (2008) AANA J , vol.76 , Issue.5 , pp. 335-339
    • Ma, H.1
  • 11
    • 67649354229 scopus 로고    scopus 로고
    • Pharmacology of sedativeanalgesic agents: Dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists
    • Jul
    • Panzer O, Moitra V, Sladen RN. Pharmacology of sedativeanalgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists. Crit Care Clin 2009 Jul; 25 (3): 451-69.
    • (2009) Crit Care Clin , vol.25 , Issue.3 , pp. 451-469
    • Panzer, O.1    Moitra, V.2    Sladen, R.N.3
  • 12
    • 70350780388 scopus 로고    scopus 로고
    • Dexmedetomidine use in general anaesthesia
    • Aug
    • Arcangeli A, D'Alò C, et al. Dexmedetomidine use in general anaesthesia. Curr Drug Targets 2009 Aug; 10 (8): 687-95.
    • (2009) Curr Drug Targets , vol.10 , Issue.8 , pp. 687-695
    • Arcangeli, A.1    D'Alò, C.2
  • 13
    • 0026780486 scopus 로고
    • A hypnotic response to dexmedetomidine, an a2 agonist, is mediated in the locus coeruleus in rats
    • Jun
    • Correa-Sales C, Rabin BC, Maze M. A hypnotic response to dexmedetomidine, an a2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology 1992 Jun; 76 (6): 948-52.
    • (1992) Anesthesiology , vol.76 , Issue.6 , pp. 948-952
    • Correa-Sales, C.1    Rabin, B.C.2    Maze, M.3
  • 14
    • 0033860761 scopus 로고    scopus 로고
    • The effects of increasing plasma concentrations of dexmedetomidine in humans
    • Ebert TJ, Hall JE, Barney JA, et al. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 2000 Aug; 93 (2): 382-94. (Pubitemid 30620311)
    • (2000) Anesthesiology , vol.93 , Issue.2 , pp. 382-394
    • Ebert, T.J.1    Hall, J.E.2    Barney, J.A.3    Uhrich, T.D.4    Colinco, M.D.5
  • 17
    • 0032855010 scopus 로고    scopus 로고
    • Effects of dexmedetomidine on isoflurane requirements in healthy volunteers. 1: Pharmacodynamic and pharmacokinetic interactions
    • Khan ZP, Munday IT, Jones RM, et al. Effects of dexmedetomidine on isoflurane requirements in healthy volunteers. 1: pharmacodynamic and pharmacokinetic interactions. Br J Anaesth 1999 Sep; 83 (3): 372-80. (Pubitemid 29412688)
    • (1999) British Journal of Anaesthesia , vol.83 , Issue.3 , pp. 372-380
    • Khan, Z.P.1    Munday, I.T.2    Jones, R.M.3    Thornton, C.4    Mant, T.G.5    Amin, D.6
  • 18
    • 0035137056 scopus 로고    scopus 로고
    • Effect of dexmedetomidine on propofol requirements in healthy subjects
    • DOI 10.1002/1520-6017(200102)90:2 <172::AID-JPS8>3.0.CO;2-J
    • Dutta S, Karol MD, Cohen T, et al. Effect of dexmedetomidine on propofol requirements in healthy subjects. J Pharm Sci 2001 Feb; 90 (2): 172-81. (Pubitemid 32158045)
    • (2001) Journal of Pharmaceutical Sciences , vol.90 , Issue.2 , pp. 172-181
    • Dutta, S.1    Karol, M.D.2    Cohen, T.3    Jones, R.M.4    Mant, T.5
  • 19
    • 0026677968 scopus 로고
    • Effects of intravenous dexmedetomidine in humans: II. Hemodynamic changes
    • Bloor BC, Ward DS, Belleville JP, et al. Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes. Anesthesiology 1992 Dec; 77 (6): 1134-42. (Pubitemid 23001124)
    • (1992) Anesthesiology , vol.77 , Issue.6 , pp. 1134-1142
    • Bloor, B.C.1    Ward, D.S.2    Belleville, J.P.3    Maze, M.4
  • 20
    • 0036784783 scopus 로고    scopus 로고
    • Dexmedetomidineinduced sedation in volunteers decreases regional and global cerebral blood flow
    • Oct
    • Prielipp RC, Wall MH, Tobin JR, et al. Dexmedetomidineinduced sedation in volunteers decreases regional and global cerebral blood flow. Anesth Analg 2002 Oct; 95 (4): 1052-9.
    • (2002) Anesth Analg , vol.95 , Issue.4 , pp. 1052-1059
    • Prielipp, R.C.1    Wall, M.H.2    Tobin, J.R.3
  • 21
    • 38549161511 scopus 로고    scopus 로고
    • Effect of dexmedetomidine on cerebral blood flow velocity, cerebral metabolic rate, and carbon dioxide response in normal humans
    • DOI 10.1097/01.anes.0000299576.00302.4c, PII 0000054220080200000010
    • Drummond JC, Dao AV, Roth DM, et al. Effect of dexmedetomidine on cerebral blood flow velocity, cerebral metabolic rate, and carbon dioxide response in normal humans. Anesthesiology 2008; 108 (2): 225-32. (Pubitemid 351156732)
    • (2008) Anesthesiology , vol.108 , Issue.2 , pp. 225-232
    • Drummond, J.C.1    Dao, A.V.2    Roth, D.M.3    Cheng, C.-R.4    Atwater, B.I.5    Minokadeh, A.6    Pasco, L.C.7    Patel, P.M.8
  • 22
    • 79952982795 scopus 로고    scopus 로고
    • Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers
    • Apr
    • Iirola T, Vilo S, Aantaa R, et al. Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers. Br J Anaesth 2011 Apr; 106 (4): 522-7.
    • (2011) Br J Anaesth , vol.106 , Issue.4 , pp. 522-527
    • Iirola, T.1    Vilo, S.2    Aantaa, R.3
  • 23
    • 34547829701 scopus 로고    scopus 로고
    • Dexmedetomidine during coronary artery bypass grafting surgery: Is it neuroprotective? - A preliminary study
    • DOI 10.1111/j.1399-6576.2007.01377.x
    • Sulemanji DS, Donmez A, Aldemir D, et al. Dexmedetomidine during coronary artery bypass grafting surgery: is it neuroprotective? A preliminary study. Acta Anaesthesiol Scand 2007 Sep; 51 (8): 1093-8. (Pubitemid 47246914)
    • (2007) Acta Anaesthesiologica Scandinavica , vol.51 , Issue.8 , pp. 1093-1098
    • Sulemanji, D.S.1    Donmez, A.2    Aldemir, D.3    Sezgin, A.4    Turkoglu, S.5
  • 24
    • 70549084701 scopus 로고    scopus 로고
    • Effects of continuous infusion of dexmedetomidine on hemodynamics and blood oxygenation
    • Shiokawa Y, Inamori M, Tsukamoto I, et al. Effects of continuous infusion of dexmedetomidine on hemodynamics and blood oxygenation. Anesth Resusc 2009; 45 (3): 65-7.
    • (2009) Anesth Resusc , vol.45 , Issue.3 , pp. 65-67
    • Shiokawa, Y.1    Inamori, M.2    Tsukamoto, I.3
  • 25
    • 67650188992 scopus 로고    scopus 로고
    • Bispectral index-guided intraoperative sedation with dexmedetomidine and midazolam infusion in outpatient cataract surgery
    • May
    • Apan A, Doganci N, Ergan A, et al. Bispectral index-guided intraoperative sedation with dexmedetomidine and midazolam infusion in outpatient cataract surgery. Minerva Anestesiol 2009 May; 75 (5): 239-44.
    • (2009) Minerva Anestesiol , vol.75 , Issue.5 , pp. 239-244
    • Apan, A.1    Doganci, N.2    Ergan, A.3
  • 26
    • 41549149971 scopus 로고    scopus 로고
    • Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy
    • DOI 10.1017/S0265021507003110, PII S0265021507003110
    • Elvan EG, Oc B, Uzun S, et al. Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy. Eur J Anaesthesiol 2008 May; 25 (5): 357-64. (Pubitemid 351465526)
    • (2008) European Journal of Anaesthesiology , vol.25 , Issue.5 , pp. 357-364
    • Elvan, E.G.1    Oc, B.2    Uzun, S.3    Karabulut, E.4    Coskun, F.5    Aypar, U.6
  • 27
    • 0032705173 scopus 로고    scopus 로고
    • Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit
    • Dec
    • Venn RM, Bradshaw CJ, Spencer R, et al. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 1999 Dec; 54 (12): 1136-42.
    • (1999) Anaesthesia , vol.54 , Issue.12 , pp. 1136-1142
    • Venn, R.M.1    Bradshaw, C.J.2    Spencer, R.3
  • 28
    • 0347363657 scopus 로고    scopus 로고
    • The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery
    • Arain SR, Ruehlow RM, Uhrich TD, et al. The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesth Analg 2004 Jan; 98 (1): 153-8. (Pubitemid 38029869)
    • (2004) Anesthesia and Analgesia , vol.98 , Issue.1 , pp. 153-158
    • Arain, S.R.1    Ruehlow, R.M.2    Uhrich, T.D.3    Ebert, T.J.4
  • 29
    • 37249031114 scopus 로고    scopus 로고
    • Effect of dexmedetomidine IV on the duration of spinal anesthesia with prilocaine: A double-blind, prospective study in adult surgical patients
    • DOI 10.1016/j.curtheres.2007.10.006, PII S0011393X07000872
    • TekinM, Kati I, Tomak Y, et al. Effect of dexmedetomidine IV on the duration of spinal anesthesia with prilocaine: a double-blind, prospective study in adult surgical patients. Curr Ther Res Clin Exp 2007; 68 (5): 313-24. (Pubitemid 350266607)
    • (2007) Current Therapeutic Research - Clinical and Experimental , vol.68 , Issue.5 , pp. 313-324
    • Tekin, M.1    Kati, I.2    Tomak, Y.3    Kisli, E.4
  • 30
    • 34249004884 scopus 로고    scopus 로고
    • Effects of dexmedetomidine on the duration of anaesthesia and wakefulness in bupivacaine epidural block
    • DOI 10.1017/S0265021506002237, PII S0265021506002237
    • Coskuner I, Tekin M, Kati I, et al. Effects of dexmedetomidine on the duration of anaesthesia and wakefulness in bupivacaine epidural block. Eur J Anaesthesiol 2007 Jun; 24 (6): 535-40. (Pubitemid 46787799)
    • (2007) European Journal of Anaesthesiology , vol.24 , Issue.6 , pp. 535-540
    • Coskuner, I.1    Tekin, M.2    Kati, I.3    Yagmur, C.4    Elcicek, K.5
  • 31
    • 0035167022 scopus 로고    scopus 로고
    • Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: Patient and clinician perceptions
    • DOI 10.1093/bja/87.5.684
    • Venn RM, Grounds RM. Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions. Br J Anaesth 2001 Nov; 87 (5): 684-90. (Pubitemid 33069556)
    • (2001) British Journal of Anaesthesia , vol.87 , Issue.5 , pp. 684-690
    • Venn, R.M.1    Grounds, R.M.2
  • 32
    • 0035030213 scopus 로고    scopus 로고
    • Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit
    • DOI 10.1093/bja/86.5.650
    • Venn RM, Bryant A, Hall GM, et al. Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit. Br J Anaesth 2001 May; 86 (5): 650-6. (Pubitemid 32409406)
    • (2001) British Journal of Anaesthesia , vol.86 , Issue.5 , pp. 650-656
    • Venn, R.M.1    Bryant, A.2    Hall, G.M.3    Grounds, R.M.4
  • 33
  • 34
    • 79961154846 scopus 로고    scopus 로고
    • Dexmedetomidine's effect on QT interval and QT dispersion undergoing total intravenous anaesthesia [abstract]
    • Mar 2-7; Cape Town
    • Inan SA, Ozkose Z. Dexmedetomidine's effect on QT interval and QT dispersion undergoing total intravenous anaesthesia [abstract]. 14th World Congress of Anaesthesiologists; 2008 Mar 2-7; Cape Town.
    • (2008) 14th World Congress of Anaesthesiologists
    • Inan, S.A.1    Ozkose, Z.2
  • 36
    • 79954420390 scopus 로고    scopus 로고
    • A randomized, controlled trial on dexmedetomidine for providing adequate sedation and hemodynamic control for awake, diagnostic transesophageal echocardiography
    • Apr
    • Cooper L, Candiotti K, Gallagher C, et al. A randomized, controlled trial on dexmedetomidine for providing adequate sedation and hemodynamic control for awake, diagnostic transesophageal echocardiography. J Cardiothorac Vasc Anesth 2011 Apr; 25 (2): 233-7.
    • (2011) J Cardiothorac Vasc Anesth , vol.25 , Issue.2 , pp. 233-237
    • Cooper, L.1    Candiotti, K.2    Gallagher, C.3
  • 37
    • 67650503408 scopus 로고    scopus 로고
    • Intravenous dexmedetomidine prolongs bupivacaine spinal analgesia
    • Jun
    • Al-MustafaMM, Badran IZ, Abu-Ali HM, et al. Intravenous dexmedetomidine prolongs bupivacaine spinal analgesia. Middle East J Anesthesiol 2009 Jun; 20 (2): 225-31.
    • (2009) Middle East J Anesthesiol , vol.20 , Issue.2 , pp. 225-231
    • Al-Mustafa, M.M.1    Badran, I.Z.2    Abu-Ali, H.M.3
  • 38
    • 74349096562 scopus 로고    scopus 로고
    • Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia
    • Jan
    • Kaya FN, Yavascaoglu B, Turker G, et al. Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia. Can J Anaesth 2010 Jan; 57 (1): 39-45.
    • (2010) Can J Anaesth , vol.57 , Issue.1 , pp. 39-45
    • Kaya, F.N.1    Yavascaoglu, B.2    Turker, G.3
  • 39
    • 9744268250 scopus 로고    scopus 로고
    • A comparative study of the use of dexmedetomidine and propofol as sedatives for mechanically ventilated patients in ICU
    • Abdulatif M, Hamed HM, el-Borolossy K, et al. A comparative study of the use of dexmedetomidine and propofol as sedatives for mechanically ventilated patients in ICU. Egypt J Anaesth 2004; 20 (4): 437-42. (Pubitemid 39585935)
    • (2004) Egyptian Journal of Anaesthesia , vol.20 , Issue.4 , pp. 437-442
    • Abdulatif, M.1    Hamed, H.M.2    El-Borolossy, K.3    Teima, D.O.4
  • 40
    • 77951088585 scopus 로고    scopus 로고
    • The effect of dexmedetomidine sedation on brachial plexus block in patients with end-stage renal disease
    • Oct
    • Rutkowska K, Knapik P, Misiolek H. The effect of dexmedetomidine sedation on brachial plexus block in patients with end-stage renal disease. Eur J Anaesthesiol 2009 Oct; 26 (10): 851-5.
    • (2009) Eur J Anaesthesiol , vol.26 , Issue.10 , pp. 851-855
    • Rutkowska, K.1    Knapik, P.2    Misiolek, H.3
  • 41
    • 0142094416 scopus 로고    scopus 로고
    • 2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit
    • DOI 10.1177/0885066602239122
    • Martin E, Ramsay G, Mantz J, et al. The role of the a2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. J Intensive Care Med 2003 Jan-2003 28; 18 (1): 29-41. (Pubitemid 44526587)
    • (2003) Journal of Intensive Care Medicine , vol.18 , Issue.1 , pp. 29-41
    • Martin, E.1    Ramsay, G.2    Mantz, J.3    Sum-Ping, S.T.J.4
  • 42
    • 78649664705 scopus 로고    scopus 로고
    • A phase IIIb, randomized, double-blind, placebo-controlled, multicenter study evaluating the safety and efficacy of dexmedetomidine for sedation during awake fiberoptic intubation
    • Nov-Dec
    • Bergese SD, Candiotti KA, Bokesch PM, et al. A phase IIIb, randomized, double-blind, placebo-controlled, multicenter study evaluating the safety and efficacy of dexmedetomidine for sedation during awake fiberoptic intubation. Am J Ther 2010 Nov-Dec; 17 (6): 586-95.
    • (2010) Am J Ther , vol.17 , Issue.6 , pp. 586-595
    • Bergese, S.D.1    Candiotti, K.A.2    Bokesch, P.M.3
  • 43
    • 74049113764 scopus 로고    scopus 로고
    • Monitored anesthesia care with dexmedetomidine: A prospective randomized double-blind multicenter trial
    • Jan
    • Candiotti KA, Bergese SD, Bokesch PM, et al. Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial. Anesth Analg 2010 Jan; 110 (1): 47-56.
    • (2010) Anesth Analg , vol.110 , Issue.1 , pp. 47-56
    • Candiotti, K.A.1    Bergese, S.D.2    Bokesch, P.M.3
  • 44
    • 0036257713 scopus 로고    scopus 로고
    • Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care
    • DOI 10.1093/bja/88.5.669
    • Venn RM, Karol MD, Grounds RM. Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive caret. Br J Anaesth 2002 May; 88 (5): 669-75. (Pubitemid 34498595)
    • (2002) British Journal of Anaesthesia , vol.88 , Issue.5 , pp. 669-675
    • Venn, R.M.1    Karol, M.D.2    Grounds, R.M.3
  • 46
    • 84856616940 scopus 로고    scopus 로고
    • US Food and Drug Administration. Center for Drug Evaluation and Research [Accessed 2011 Jul 15]
    • US Food and Drug Administration. Center for Drug Evaluation and Research. Medical review(s). Part 1 [online]. Available from URL: http://www.accessdata. fda.gov/drugsatfda-docs/nda/99/21-038-Precedex-medr-P1.pdf [Accessed 2011 Jul 15].
    • Medical Review(s). Part 1 [Online]
  • 47
    • 84856620011 scopus 로고    scopus 로고
    • US Food and Drug Administration. Center for Drug Evaluation and Research [Accessed 2011 Jul 15]
    • US Food and Drug Administration. Center for Drug Evaluation and Research. Medical review(s). Part 2 [online]. Available from URL: http://www.accessdata. fda.gov/drugsatfda-docs/nda/99/21-038-Precedex-medr-P2.pdf [Accessed 2011 Jul 15].
    • Medical Review(s). Part 2 [Online]
  • 49
    • 67650921091 scopus 로고    scopus 로고
    • Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery
    • May-Jun 30
    • Maldonado JR, Wysong A, van der Starre PJ, et al. Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics 2009 May-Jun 30; 50 (3): 206-17.
    • (2009) Psychosomatics , vol.50 , Issue.3 , pp. 206-217
    • Maldonado, J.R.1    Wysong, A.2    Van Der Starre, P.J.3
  • 50
    • 0037255106 scopus 로고    scopus 로고
    • Postoperative analgesia and sedation in the adult intensive care unit: A guide to drug selection
    • DOI 10.2165/00003495-200363080-00003
    • Liu LL, Gropper MA. Postoperative analgesia and sedation in the adult intensive care unit: a guide to drug selection. Drugs 2003; 63 (8): 755-67. (Pubitemid 36428445)
    • (2003) Drugs , vol.63 , Issue.8 , pp. 755-767
    • Liu, L.L.1    Gropper, M.A.2
  • 52
    • 77950790017 scopus 로고    scopus 로고
    • Optimizing sustained use of sedation inmechanically ventilated patients: Focus on safety
    • Jan
    • Arnold HM, Hollands JM, Skrupky LP, et al. Optimizing sustained use of sedation inmechanically ventilated patients: focus on safety. Curr Drug Saf 2010 Jan; 5 (1): 6-12.
    • (2010) Curr Drug Saf , vol.5 , Issue.1 , pp. 6-12
    • Arnold, H.M.1    Hollands, J.M.2    Skrupky, L.P.3
  • 54
    • 68049143180 scopus 로고    scopus 로고
    • Advances in sedation for critically ill patients
    • Jun
    • Morandi A, Watson PL, Trabucchi M, et al. Advances in sedation for critically ill patients. Minerva Anestesiol 2009 Jun; 75 (6): 385-91.
    • (2009) Minerva Anestesiol , vol.75 , Issue.6 , pp. 385-391
    • Morandi, A.1    Watson, P.L.2    Trabucchi, M.3
  • 55
    • 0031888397 scopus 로고    scopus 로고
    • 2-adrenoceptor agonist
    • Jaakola M-L. Dexmedetomidine as a preanaesthetic agent: phase I-III studies with a novel, specific a2-adrenoceptor agonist. Acta Anaesthesiol Scand 1998; 42 (2): 276-7. (Pubitemid 28067902)
    • (1998) Acta Anaesthesiologica Scandinavica , vol.42 , Issue.2 , pp. 276-277
    • Jaakola, M.-L.1
  • 56
    • 59649127447 scopus 로고    scopus 로고
    • Dexmedetomidine vs midazolam for sedation of critically ill patients: A randomized trial
    • Feb
    • Riker RR, Shehabi Y, Bokesch PM, et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA 2009 Feb; 301 (5): 489-99.
    • (2009) JAMA , vol.301 , Issue.5 , pp. 489-499
    • Riker, R.R.1    Shehabi, Y.2    Bokesch, P.M.3
  • 60
    • 44649125433 scopus 로고    scopus 로고
    • Dexmedetomidine infusion during laparoscopic bariatric surgery: The effect on recovery outcome variables
    • Jun
    • Tufanogullari B, White PF, Peixoto MP, et al. Dexmedetomidine infusion during laparoscopic bariatric surgery: the effect on recovery outcome variables. Anesth Analg 2008 Jun; 106 (6): 1741-8.
    • (2008) Anesth Analg , vol.106 , Issue.6 , pp. 1741-1748
    • Tufanogullari, B.1    White, P.F.2    Peixoto, M.P.3
  • 62
    • 0038265854 scopus 로고    scopus 로고
    • Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: A meta-analysis
    • DOI 10.1016/S0002-9343(03)00165-7
    • Wijeysundera DN, Naik JS, Beattie WS. Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: ameta-analysis. AmJMed 2003 Jun 15; 114 (9): 742-52. (Pubitemid 36776356)
    • (2003) American Journal of Medicine , vol.114 , Issue.9 , pp. 742-752
    • Wijeysundera, D.N.1    Naik, J.S.2    Beattie, W.S.3
  • 64
    • 33750364365 scopus 로고    scopus 로고
    • The effects of pre-operative dexmedetomidine infusion on hemodynamics in patients with pulmonary hypertension undergoing mitral valve replacement surgery
    • DOI 10.1111/j.1399-6576.2006.01136.x
    • But AK, Ozgul U, Erdil F, et al. The effects of pre-operative dexmedetomidine infusion on hemodynamics in patients with pulmonary hypertension undergoing mitral valve replacement surgery. Acta Anaesthesiol Scand 2006 Nov; 50 (10): 1207-12. (Pubitemid 44624299)
    • (2006) Acta Anaesthesiologica Scandinavica , vol.50 , Issue.10 , pp. 1207-1212
    • But, A.K.1    Ozgul, U.2    Erdil, F.3    Gulhas, N.4    Toprak, H.I.5    Durmus, M.6    Ersoy, M.O.7
  • 65
    • 74949137504 scopus 로고    scopus 로고
    • A costminimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit
    • Feb
    • Dasta JF, Kane-Gill SL, Pencina M, et al. A costminimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit. Crit Care Med 2010 Feb; 38 (2): 497-503.
    • (2010) Crit Care Med , vol.38 , Issue.2 , pp. 497-503
    • Dasta, J.F.1    Kane-Gill, S.L.2    Pencina, M.3
  • 66
    • 78650305502 scopus 로고    scopus 로고
    • Delirium duration and mortality in lightly sedated mechanically ventilated intensive care patients
    • Dec
    • Shehabi Y, Riker RR, Bokesch PM, et al. Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Crit Care Med 2010 Dec; 38 (12): 2311-8.
    • (2010) Crit Care Med , vol.38 , Issue.12 , pp. 2311-2318
    • Shehabi, Y.1    Riker, R.R.2    Bokesch, P.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.