Alpha 2 adrenoceptor agonist - Dexmedetomidine role in anaesthesia and intensive care: A clinical review

Journal of Anaesthesiology Clinical Pharmacology

Volumn 25, Issue 3, 2009, Pages 267-272

  Murthy, T V S P ^a   Singh, Ranju ^b  

^a Command Hospital ^*  (India)

^b LADY HARDINGE MEDICAL COLLEGE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ATIPAMEZOLE; CLONIDINE; DEXMEDETOMIDINE; THIOPENTAL;

ANESTHESIA; ANESTHETIC RECOVERY; BARIATRIC SURGERY; BRADYCARDIA; DISTRIBUTION VOLUME; DRUG EFFICACY; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG OVERDOSE; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG TRANSFORMATION; ENDOTRACHEAL INTUBATION; HEART ATRIUM FIBRILLATION; HUMAN; HYPERGLYCEMIA; HYPERTENSION; HYPOTENSION; HYPOXIA; INTENSIVE CARE; INTENSIVE CARE UNIT; INTRAOPERATIVE PERIOD; NAUSEA; NEUROSURGERY; ORTHOPEDIC SURGERY; PERIOPERATIVE PERIOD; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; RECOMMENDED DRUG DOSE; RESPIRATION DEPRESSION; REVIEW; SEDATION; SHIVERING; TERATOGENICITY; WITHDRAWAL SYNDROME;

EID: 67650519450     PISSN: 09709185     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (42)

1. Tamsen A, Gordh T. Epidural clonidine produces analgesia. Lancet 1984; 2: 231-232.
2. Nakamura M, Ferreira SH. Peripheral analgesic action of clonidine: mediation by release of endogenous enkephalin-like substances. Eur J Pharmacol 1988; 146: 223-228. (Pubitemid 18068495)
3. Hunter JC, Fontana DJ, Hedley LR, Jasper JR, Lewis R, Link RE, Secchi R, Sutton J, Eglen RM. Assessment of the role of alpha 2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 1997; 122: 1339-1344. (Pubitemid 27503923)
4. Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol 1988; 150:9-14. (Pubitemid 18134104)
5. Venn RM, Bradshaw CJ, Spencer R, Brealey D, Caudwell E, Naughton C, Vedio A, Singer M, Feneck R, Treacher D, Willatts SM, Grounds RM. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia 1999; 54: 1136-1142.
6. Housmans PR. Effects of dexmedetomidine on contractility, relaxation, and intracellular calcium transients of isolated ventricular myocardium. Anesthesiology 1990; 73: 919-922. (Pubitemid 20380937)
7. Bloor BC, Ward DS, Belleville JP, Maze M. Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes. Anesthesiology 1992; 77: 1134-1142.
8. Hall JE, Uhrich TD, Barney JA, Arain SR, Ebert TJ. Sedative, amnestic, and analgesic properties of smalldose dexmedetomidine infusions. Anesth Analg 2000; 90: 699 (Pubitemid 30117535)
9. Aho M, Erkola O, Kallio A, Scheinin H, Korttila K. Comparison of dexmedetomidine and midazolam sedation and antagonism of dexmedetomidine with atipamezole. J Clin Anesth 1993; 5: 194-203 (Pubitemid 23171952)
10. Jalonen J, Hynynen M, Kuitunen A, Heikkila H, Perttila J, Salmenpera M, Valtonen M, Aantaa R, Kallio A. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology 1997; 86:331-345. (Pubitemid 27093378)
11. Belleville JP, Ward DS, Bloor BC, Maze M. Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation, and metabolic rate. Anesthesiology 1992; 77: 1125-1133.
12. T.-F. Lin, Y.-C. Yeh, F.-S. Lin, Y.-P. Wang, C.-J. Lin, W.-Z. Sun and S.-Z. Fan: Effect of combining dexmedetomidine and morphine for intravenous patient-controlled analgesia. British Journal of Anaesthesia 2009: 102 (1): 117-122
13. Maze M, Virtanen R, Daunt D, Banks SJ, Stover EP, Feldman D. Effects of dexmedetomidine, a novel imidazole sedative-anesthetic agent, on adrenal steroidogenesis: in vivo and in vitro studies. Anesth Analg 1991; 73: 204-208.
14. Pettinger WA, Umemura S, Smyth DD, Jeffries WB. Renal alpha 2-adrenoceptors and the adenylate cyclase-cAMP system: biochemical and physiological interactions. Am J Physiol 1987; 252(2 Pt 2): F199-F208 (Pubitemid 17053118)
15. Abbott Labaratories. Precedex. Dexmedetomidine hydrochloride injection prescribing information. Abbott Labaratories, USA, 2001, 58-6388-R4, 1-11.
16. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 2000; 93: 382-394. (Pubitemid 30620311)
17. Aantaa RE, Kanto JH, Scheinin M, Kallio AM, Scheinin H. Dexmedetomidine premedication for minor gynecologic surgery. Anesth Analg 1990; 70: 407-413. (Pubitemid 20261303)
18. Aantaa R, Jaakola ML, Kallio A, Kanto J. Reduction of the minimum alveolar concentration of isoflurane by dexmedetomidine. Anesthesiology 1997; 86:1055-1060. (Pubitemid 27208902)
19. Scheinin B, Lindgren L, Randell T, Scheinin H, Scheinin M. Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and perioperative fentanyl. Br J Anaesth 1992; 68: 126-131.
20. Aho MS, Erkola OA, Scheinin H, Lehtinen AM, Korttila KT. Effect of intravenously administered dexmedetomidine on pain after laparoscopic tubal ligation. Anesth Analg 1991; 73: 112-118.
21. Xu M, Kontinen VK, Kalso E. Effects of radolmidine, a novel alpha 2-adrenergic agonist compared with dexmedetomidine in different pain models in the rat. Anesthesiology 2000; 93:473-481. (Pubitemid 30620322)
22. Zornow MH, Maze M, Dyck JB, Shafer SL. Dexmedetomidine decreases cerebral blood flow velocity in humans. J Cereb Blood Flow Metab 1993;13: 350-353 (Pubitemid 23067473)
23. Talke P, Tayefeh F, Sessler DI, Jeffrey R, Noursalehi M, Richardson C. Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds. Anesthesiology 1997; 87:835-841. (Pubitemid 27456236)
24. Jones JG, Taylor PM. Receptor-specific reversible sedation: dangers of vascular effects. Anesthesiology 1999; 90:1489-1490.
25. Scheinin H, Aantaa R, Anttila M, Hakola P, Helminen A, Karhuvaara S. Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific alpha 2- adrenoceptor antagonist atipamezole: a pharmacodynamic and kinetic study in healthy volunteers. Anesthesiology 1998; 89: 574-584. (Pubitemid 28423953)
26. Talke P. Receptor-specific reversible sedation: beginning of new era of anesthesia? Anesthesiology 1998; 89: 560-561
27. Richard R. Riker; Yahya Shehabi; Paula M. Bokesch; et al. A Randomized Trial-Dexmedetomidine vs Midazolam for Sedation of Critically Ill Patients: JAMA. 2009; 301(5): 489-499
28. Nishina K, Akamatsu H, Mikawa K, Shiga M, Maekawa N, Obara H, Niwa Y. The effects of clonidine and dexmedetomidine on human neutrophil functions. Anesth Analg 1999; 88:452-458. (Pubitemid 29070215)
29. Mangano DT, Browner WS, Hollenberg M, London MJ, Tubau JF, Tateo IM. Association of perioperative myocardial ischemia with cardiac morbidity and mortality in men undergoing noncardiac surgery. The Study of Perioperative Ischemia Research Group. N Engl J Med 1990; 323: 1781-1788.
30. Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology 1995; 82: 620-633.
31. Talke P, Chen R, Thomas B, Aggarwall A, Gottlieb A, Thorborg P, Heard S, Cheung A, Son SL, Kallio A. The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesth Analg 2000; 90: 834-839. (Pubitemid 30190786)
32. Coughlan MG, Lee JG, Bosnjak ZJ, Schmeling WT, Kampine JP, Warltier DC. Direct coronary and cerebral vascular responses to dexmedetomidine. Significance of endogenous nitric oxide synthesis. Anesthesiology 1992; 77: 998-1006.
33. Frost E, Booij L. Anesthesia in the patient for awake craniotomy. Curr Opin Anaesthesiol 2007; 20:331-335.
34. Mack PF, Perrine K, Kobylarz E, et al. Dexmedetomidine and neurocognitivetesting in awake craniotomy. J Neurosurg Anesthesiol 2004; 16:20-25.
35. Bekker A, Sturaitis MK. Dexmedetomidine for neurological surgery. Neurosurgery 2005; 57:1-10.
36. Mack PF, Perrine K, Kobylarz E, et al. Dexmedetomidine and neurocognitive testing in awake craniotomy. J Neurosurg Anesthesiol 2004; 16:20-25. (Pubitemid 38057394)
37. Korogulu A, Demirbilek S, Teksan H, et al. Sedative, haemodynamic andrespiratory effects of dexmedetomidine in children undergoing magnetic resonanceimaging examination: preliminary results. Br J Anaesth 2005; 94:821-824. (Pubitemid 40754000)
38. Shukry M, Ramadhyani U. Does dexmedetomidine prevent emergence delirium in children after sevofluranebased general anesthesia? Paediatr Anaesth 2005; 15:1098-1104.
39. Shukry M, Guruli Z, Ramadhyani U. Suspected malignant hyperthermia in a child with laminin alpha2 (merosin) deficiency in the absence of a triggering agent. Paediatr Anaesth 2006; 16:462-465.
40. Yuen V, Irwin M, Hui T, et al. A double-blind crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine. Anesth Analg 2007; 105:374-380. (Pubitemid 47196415)
41. Hofer RE, Sprung J, et al. Anesthesia for a patient with morbid obesity using dexmedetomidine without narcotics. Can J Anaesth 2005; 52:176-180. (Pubitemid 40467976)
42. Al-Metwalli RR, Mowafi HA, Ismail SA, Siddiqui AK, Al-Ghamdi AM, Shafi MA, El-Saleh AR Effect of intra-articular dexmedetomidine on postoperative analgesia after arthroscopic knee surgery. Br J Anaesth.2008, 101(3): 395-9.)