Growth suppression of HER2-overexpressing breast cancer cells by berberine via modulation of the HER2/PI3K/Akt signaling pathway

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 15, 2011, Pages 8216-8224

  Kuo, Han Peng ^a   Chuang, Tzu Chao ^b   Yeh, Ming Han ^a   Hsu, Shih Chung ^c   Way, Tzong Der ^d   Chen, Po Yuan ^d   Wang, Shan Shue ^e   Chang, Yung Hsien ^d   Kao, Ming Ching ^a,d   Liu, Jah Yao ^a,f  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TAMKANG UNIVERSITY   (Taiwan)

^c Kang Ning Junior College   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e KAO YUAN UNIVERSITY   (Taiwan)

^f TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

apoptosis, cell cycle arrest; berberine; breast cancer; HER2; PI3K Akt signaling cascade

Indexed keywords

BERBERINE; BREAST CANCER; CELL-CYCLE ARREST; HER2; PI3K/AKT SIGNALING CASCADE;

CELL DEATH; SIGNALING;

DISEASES;

BERBERINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GROWTH PROMOTOR; HER2 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ARTICLE; BREAST TUMOR; CELL PROLIFERATION; DOWN REGULATION; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BERBERINE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH SUBSTANCES; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION;

EID: 79961132108     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf2012584     Document Type: Article

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