Berberine inhibits growth of the breast cancer cell lines MCF-7 and MDA-MB-231

Planta Medica

Volumn 74, Issue 1, 2008, Pages 39-42

  Jong, Bin Kim ^a   Lee, Kyung Min ^a   Ko, Eunyoung ^a   Han, Wonshik ^a   Jeong, Eon Lee ^a   Shin, Incheol ^b   Bae, Ji Yeon ^a   Kim, Sangmin ^a   Noh, Dong Young ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Apoptosis; Berberine; Breast cancer; MCF 7; MDA MB 231

Indexed keywords

BERBERINE; LIPOCORTIN 5;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG INHIBITION; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BERBERINE; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 39149132069     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-993779     Document Type: Article

References (19)

1. Jantova S, Cipak L, Cernakova M, Kost'alova D. Effect of berberine on proliferation, cell cycle and apoptosis in HeLa and L1210 cells. J Pharm Pharmacol 2003; 55: 1143-9
2. Lee S, Lim HJ, Park HY, Lee KS, Park JH, Jang Y. Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model. Atherosclerosis 2006; 186: 29-37
3. Abidi P, Zhou Y, Jiang JD, Liu J. Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. Arterioscler Thromb Vasc Biol 2005; 25: 2170-6
4. Issat T, Jakobisiak M, Golab J. Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. Oncol Rep 2006; 16: 1273-6
5. Kuo CL, Chi CW, Liu TY. Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells. In Vivo 2005; 19: 247-52
6. Leng SH, Lu FE, Xu LJ. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin 2004; 25: 496-502
7. Jantova S, Letasiova S, Brezova V, Cipak L, Labaj J. Photochemical and phototoxic activity of berberine on murine fibroblast NIH-3T3 and Ehrlich ascites carcinoma cells. J Photochem Photobiol B 2006; 85: 163-76
8. Inoue K, Kulsum U, Chowdhury SA, Fujisawa S, Ishihara M, Yokoe I et al. Tumor-specific cytotoxicity and apoptosis-inducing activity of berberines. Anticancer Res 2005; 25: 4053-9
9. Mantena SK, Sharma SD, Katiyar SK. Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. Carcinogenesis 2006; 27: 2018-27
10. Lin CC, Kao ST, Chen GW, Ho HC, Chung JG. Apoptosis of human leukemia HL 60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Anticancer Res 2006; 26: 227-42
11. Letasiova S, Jantova S, Miko M, Ovadekova R, Horvathova M. Effect of berberine on proliferation, biosynthesis of macromolecules, cell cycle and induction of intercalation with DNA, dsDNA damage and apoptosis in Ehrlich ascites carcinoma cells. J Pharm Pharmacol 2006; 58: 263-70
12. Peng PL, Hsieh YS, Wang CJ, Hsu JL, Chou FP. Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase plasminogen activator and matrix metalloproteinase-2. Toxicol Appl Pharmacol 2006; 214: 8-15
13. Orfila L, Rodriguez M, Colman T, Hasegawa M, Merentes E, Arvelo F. Structural modification of berberine alkaloids in relation to cytotoxic activity in vitro. J Ethnopharmacol 2000; 71: 449-56
14. Lin JG, Chung JG, Wu LT, Chen GW, Chang HL, Wang TF. Effects of berberine on arylamine N-acetyltransferase activity in human colon tumor cells. Am J Chin Med 1999; 27: 265-75
15. Kang MR, Chung IK. Down-regulation of DNA topoisomerase IIalpha in human colorectal carcinoma cells resistant to a protoberberine alkaloid, berberrubine. Mol Pharmacol 2002; 61: 879-84
16. Kim SA, Kwon Y, Kim JH, Muller MT, Chung IK. Induction of topoisomerase II mediated DNA cleavage by a protoberberine alkaloid, berberrubine. Biochemistry 1998; 37: 16316-24
17. Wu SN, Yu HS, Jan CR, Li HF, Yu CL. Inhibitory effects of berberine on voltage- and calcium-activated potassium currents in human myeloma cells. Life Sci 1998; 62: 2283-94
18. Sheridan C, Kishimoto H, Fuchs RK, Mehrotra S, Bhat-Nakshatri P, Turner CH et al. CD44+/CD24-breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res 2006; 8: R59
19. Lin CC, Lin SY, Chung JG, Lin JP, Chen GW, Kao ST. Down-regulation of cyclin B1 and up-regulation of Wee1 by berberine promotes entry of leukemia cells into the G2/M-phase of the cell cycle. Anticancer Res 2006; 26: 1097-104