Regulation of gap junction function and Connexin 43 expression by cytochrome P450 oxidoreductase (CYPOR)

Biochemical and Biophysical Research Communications

Volumn 411, Issue 3, 2011, Pages 490-495

  Polusani, Srikanth R ^a   Kar, Rekha ^a   Riquelme, Manuel A ^a   Masters, Bettie Sue ^a   Panda, Satya P ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Connexins; Gap junctions; Hemichannels; NADPH cytochrome P450 reductase (CYPOR); Osteoblasts

Indexed keywords

CONNEXIN 43; CYTOCHROME P450 REDUCTASE; GAP JUNCTION PROTEIN; LUCIFERASE;

ANIMAL CELL; ANTLEY BIXLER LIKE SYNDROME; ARTICLE; ASSAY; BONE DEFECT; CALVARIA; CELL COMMUNICATION; CELL ISOLATION; CELL LINE; FRACTURE; GAP JUNCTION; HUMAN; HUMAN CELL; MOUSE; MUTATION; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE;

ANIMALS; CELL LINE, TUMOR; CONNEXIN 43; GAP JUNCTIONS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; MICE, KNOCKOUT; NADPH-FERRIHEMOPROTEIN REDUCTASE; OSTEOGENESIS;

MUS;

EID: 79961126544     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.06.132     Document Type: Article

References (42)

1. Kuriyama Y., Omura T., Siekevitz P., et al. Effects of phenobarbital on the synthesis and degradation of the protein components of rat liver microsomal membranes. J. Biol. Chem. 1969, 244:2017-2026.
2. Lu A.Y., Junk K.W., Coon M.J. Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components. J. Biol. Chem. 1969, 244:3714-3721.
3. Masters B.S., Baron J., Taylor W.E., et al. Immunochemical studies on electron transport chains involving cytochrome P-450. I. Effects of antibodies to pig liver microsomal reduced triphosphopyridine nucleotide-cytochrome c reductase and the non-heme iron protein from bovine adrenocortical mitochondria. J. Biol. Chem. 1971, 246:4143-4150.
4. Schacter B.A., Nelson E.B., Marver H.S., et al. Immunochemical evidence for an association of heme oxygenase with the microsomal electron transport system. J. Biol. Chem. 1972, 247:3601-3607.
5. Maines M.D., Kappas A. Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-40 is not essential for this enzyme activity. Proc. Natl. Acad. Sci. USA 1974, 71:4293-4297.
6. Li L., Porter T.D. Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase. Arch. Biochem. Biophys. 2007, 461:76-84.
7. Ilan Z., Ilan R., Cinti D.L. Evidence for a new physiological role of hepatic NADPH: ferricytochrome (P-450) oxidoreductase. Direct electron input to the microsomal fatty acid chain elongation system. J. Biol. Chem. 1981, 256:10066-10072.
8. Ono T., Takahashi K., Odani S., et al. Purification of squalene epoxidase from rat liver microsomes. Biochem. Biophys. Res. Commun. 1980, 96:522-528.
9. Gu J., Weng Y., Zhang Q.Y., et al. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J. Biol. Chem. 2003, 278:25895-25901.
10. Henderson C.J., Otto D.M., Carrie D., et al. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J. Biol. Chem. 2003, 278:13480-13486.
11. Adachi M., Asakura Y., Matsuo M., et al. POR R457H is a global founder mutation causing Antley-Bixler syndrome with autosomal recessive trait. Am. J. Med. Genet. A 2006, 140:633-635.
12. Arlt W., Walker E.A., Draper N., et al. Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study. Lancet 2004, 363:2128-2135.
13. Fukami M., Horikawa R., Nagai T., et al. Cytochrome P450 oxidoreductase gene mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients. J. Clin. Endocrinol. Metab. 2005, 90:414-426.
14. Kelley R.I., Kratz L.E., Glaser R.L., et al. Abnormal sterol metabolism in a patient with Antley-Bixler syndrome and ambiguous genitalia. Am. J. Med. Genet. 2002, 110:95-102.
15. Stains J.P., Civitelli R. Gap junctions in skeletal development and function. Biochim. Biophys. Acta 2005, 1719:69-81.
16. Paznekas W.A., Boyadjiev S.A., Shapiro R.E., et al. Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia. Am. J. Hum. Genet. 2003, 72:408-418.
17. McLachlan E., Plante I., Shao Q., et al. ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation. J. Bone Miner. Res. 2008, 23:928-938.
18. Lecanda F., Towler D.A., Ziambaras K., et al. Gap junctional communication modulates gene expression in osteoblastic cells. Mol. Biol. Cell 1998, 9:2249-2258.
19. Li Z., Zhou Z., Yellowley C.E., et al. Inhibiting gap junctional intercellular communication alters expression of differentiation markers in osteoblastic cells. Bone 1999, 25:661-666.
20. Schiller P.C., D'Ippolito G., Balkan W., et al. Gap-junctional communication is required for the maturation process of osteoblastic cells in culture. Bone 2001, 28:362-369.
21. Chung D.J., Castro C.H., Watkins M., et al. Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43. J. Cell Sci. 2006, 119:4187-4198.
22. Yeh L.C., Adamo M.L., Kitten A.M., et al. Osteogenic protein-1-mediated insulin-like growth factor gene expression in primary cultures of rat osteoblastic cells. Endocrinology 1996, 137:1921-1931.
23. Cherian P.P., Siller-Jackson A.J., Gu S., et al. Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol. Biol. Cell 2005, 16:3100-3106.
24. Goodenough D.A., Paul D.L. Beyond the gap: functions of unpaired connexon channels. Nat. Rev. Mol. Cell Biol. 2003, 4:285-294.
25. Yao J., Hiramatsu N., Zhu Y., et al. Nitric oxide-mediated regulation of connexin43 expression and gap junctional intercellular communication in mesangial cells. J. Am. Soc. Nephrol. 2005, 16:58-67.
26. Lau A.F., Kanemitsu M.Y., Kurata W.E., et al. Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine. Mol. Biol. Cell 1992, 3:865-874.
27. Shiokawa-Sawada M., Mano H., Hanada K., et al. Down-regulation of gap junctional intercellular communication between osteoblastic MC3T3-E1 cells by basic fibroblast growth factor and a phorbol ester (12-O-tetradecanoylphorbol-13-acetate). J. Bone Miner. Res. 1997, 12:1165-1173.
28. van Zoelen E.J., Tertoolen L.G. Transforming growth factor-beta enhances the extent of intercellular communication between normal rat kidney cells. J. Biol. Chem. 1991, 266:12075-12081.
29. Burt J.M., Steele T.D. Selective effect of PDGF on connexin43 versus connexin40 comprised gap junction channels. Cell Commun. Adhes. 2003, 10:287-291.
30. Rogers M., Berestecky J.M., Hossain M.Z., et al. Retinoid-enhanced gap junctional communication is achieved by increased levels of connexin 43 mRNA and protein. Mol. Carcinog. 1990, 3:335-343.
31. You S., Li W., Lin T. Expression and regulation of connexin43 in rat Leydig cells. J. Endocrinol. 2000, 166:447-453.
32. Acevedo P., Bertram J.S. Liarozole potentiates the cancer chemopreventive activity of and the up-regulation of gap junctional communication and connexin43 expression by retinoic acid and beta-carotene in 10T1/2 cells. Carcinogenesis 1995, 16:2215-2222.
33. Wang X.J., Chamberlain M., Vassieva O., et al. Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice. Biochem. J. 2005, 388:857-867.
34. Weng Y., DiRusso C.C., Reilly A.A., et al. Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype. J. Biol. Chem. 2005, 280:31686-31698.
35. Berthoud V.M., Beyer E.C. Oxidative stress, lens gap junctions, and cataracts. Antioxid. Redox Signal 2009, 11:339-353.
36. Fluck C.E., Tajima T., Pandey A.V., et al. Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome. Nat. Genet. 2004, 36:228-230.
37. Huang N., Pandey A.V., Agrawal V., et al. Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis. Am. J. Hum. Genet. 2005, 76:729-749.
38. Chun K., Siegel-Bartelt J., Chitayat D., et al. FGFR2 mutation associated with clinical manifestations consistent with Antley-Bixler syndrome. Am. J. Med. Genet. 1998, 77:219-224.
39. Schmidt K., Hughes C., Chudek J.A., et al. Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb. Mol. Cell Biol. 2009, 29:2716-2729.
40. Porter J.A., Young K.E., Beachy P.A. Cholesterol modification of hedgehog signaling proteins in animal development. Science 1996, 274:255-259.
41. St-Jacques B., Hammerschmidt M., McMahon A.P. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 1999, 13:2072-2086.
42. Aguilar A., Wu S., De Luca F. P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms. Endocrinology 2009, 150:2732-2739.