11C-labeled analogs of indomethacin esters and amides for brain cyclooxygenase-2 imaging: Radiosynthesis, in vitro evaluation and in vivo characteristics in mice

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 8, 2011, Pages 938-946

  Yamamoto, Yumi ^a   Toyohara, Jun ^b   Ishiwata, Kiichi ^b   Sano, Kohei ^a   Yamamoto, Fumihiko ^a   Mukai, Takahiro ^a,c   Maeda, Minoru ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Biodistribution; Brain; Carbon 11; Cyclooxygenase type 2; Indomethacin; Mouse

Indexed keywords

AMIDE; BRAIN ENZYME; BUTYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 YL METHYLCARBAMATE; BUTYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 YL METHYLCARBAMATE C 11; CARBON 11; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYCLOSPORIN A; DRUG METABOLITE; ESTER DERIVATIVE; INDOMETACIN; INDOMETACIN DERIVATIVE; METHYL TRIFLATE C 11; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N 2 ETHOXYETHYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 ACETAMIDE; N 2 ETHOXYETHYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 ACETAMIDE C 11; N 3 METHOXYPROPYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 ACETAMIDE; N 3 METHOXYPROPYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 ACETAMIDE C 11; N OCTYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 ACETAMIDE; N OCTYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 ACETAMIDE C 11; N PENTYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 ACETAMIDE; N PENTYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 ACETAMIDE C 11; N PENTYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 ACETATE; N PENTYL (1 PARACHLOROBENZOYL 5 METHOXY 2 METHYLINDOLE) 3 ACETATE C 11; TRACER; UNCLASSIFIED DRUG; CARBON; DRUG DERIVATIVE; ESTER; PROSTAGLANDIN SYNTHASE INHIBITOR; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD; BRAIN; CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG INHIBITION; DRUG METABOLISM; DRUG PURIFICATION; DRUG PURITY; DRUG RETENTION; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; DRUG UPTAKE; ENZYME ACTIVITY; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; KIDNEY; LIPOPHILICITY; LIVER; LUNG; MALE; MOLECULAR IMAGING; MOUSE; NEUROIMAGING; NONHUMAN; PHARMACOLOGICAL BLOCKING; POSITRON EMISSION TOMOGRAPHY; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; RADIOCHEMISTRY; SMALL INTESTINE; ANIMAL; CHEMISTRY; METABOLISM; METHODOLOGY; PROTEIN BINDING; SCINTISCANNING;

AMIDES; ANIMALS; BRAIN; CARBON RADIOISOTOPES; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; ESTERS; INDOMETHACIN; ISOTOPE LABELING; MALE; MICE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS;

EID: 79961100186     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.938     Document Type: Article

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