Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 24, 2005, Pages 6810-6822

  Kalgutkar, Amit S ^a   Crews, Brenda C ^c   Saleh, Sam ^c   Prudhomme, Daniel ^b   Marnett, Lawrence J ^c  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b Formulation Development Services   (India)

^c NONE

Author keywords

COX 2; Indolylamide; Indolylester; Indomethacin

Indexed keywords

AMIDE; BENZYL DERIVATIVE; CARBOXYLIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ESTER DERIVATIVE; INDOLE DERIVATIVE; INDOLE NITROGEN; INDOMETACIN; INDOMETACIN DERIVATIVE; LM 4108; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; IC 50; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN;

AMIDES; ANIMALS; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; ESTERS; HUMANS; INDOLES; INDOMETHACIN; INHIBITORY CONCENTRATION 50; MICE; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 27644575900     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.07.073     Document Type: Article

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